AU3042697A - Thrombin inhibitors - Google Patents

Thrombin inhibitors

Info

Publication number
AU3042697A
AU3042697A AU30426/97A AU3042697A AU3042697A AU 3042697 A AU3042697 A AU 3042697A AU 30426/97 A AU30426/97 A AU 30426/97A AU 3042697 A AU3042697 A AU 3042697A AU 3042697 A AU3042697 A AU 3042697A
Authority
AU
Australia
Prior art keywords
thrombin inhibitors
thrombin
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU30426/97A
Inventor
John Joseph Deadman
Said Elgendy
Christopher Andrew Goodwin
Donovan Green
Vijay Vir Kakkar
Michael Finbarr Scully
Emmanuel Skordalakes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Thrombosis Research Institute
Original Assignee
Thrombosis Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thrombosis Research Institute filed Critical Thrombosis Research Institute
Publication of AU3042697A publication Critical patent/AU3042697A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AU30426/97A 1996-06-29 1997-06-11 Thrombin inhibitors Abandoned AU3042697A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9613718.7A GB9613718D0 (en) 1996-06-29 1996-06-29 Thrombin inhibitors
GB9613718 1996-06-29
PCT/GB1997/001575 WO1998000443A1 (en) 1996-06-29 1997-06-11 Thrombin inhibitors

Publications (1)

Publication Number Publication Date
AU3042697A true AU3042697A (en) 1998-01-21

Family

ID=10796126

Family Applications (1)

Application Number Title Priority Date Filing Date
AU30426/97A Abandoned AU3042697A (en) 1996-06-29 1997-06-11 Thrombin inhibitors

Country Status (5)

Country Link
EP (1) EP0910583A1 (en)
JP (1) JP2000516203A (en)
AU (1) AU3042697A (en)
GB (1) GB9613718D0 (en)
WO (1) WO1998000443A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7112572B2 (en) 2002-09-09 2006-09-26 Trigen Limited Multivalent metal salts of boronic acids
EP1466916B1 (en) * 2002-09-09 2007-10-24 Trigen Limited Peptide boronic acids useful in making salts thereof
US20070022556A1 (en) * 2005-07-28 2007-02-01 Walworth Van T Wind deflector with symmetrical geometry
GB0711779D0 (en) 2007-06-18 2007-07-25 Univ Singapore Thrombin inhibitor
RU2353619C2 (en) * 2007-06-28 2009-04-27 Общество С Ограниченной Ответственностью "Бионика" Novel compounds possessing anticoagulant function, based on them pharmaceutical compositions for treatment of thrombotic conditions and plasma-substituting solution for correction of hypercoagulation disorders in hemodilution
US9518128B2 (en) 2011-12-14 2016-12-13 Janssen Pharmaceuticals, Inc. Thrombin-binding antibody molecules
GB201121513D0 (en) 2011-12-14 2012-01-25 Cambridge Entpr Ltd Thrombin-binding antibody molecules and uses thereof
WO2019030706A1 (en) 2017-08-10 2019-02-14 Janssen Pharmaceutica Nv Anti-thrombin antibody molecules and methods for use in orthopedic surgery
WO2019035055A1 (en) 2017-08-16 2019-02-21 Janssen Pharmaceutica Nv Anti-thrombin antibody molecules and methods for use with antiplatelet agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5196404B1 (en) * 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin
US5240913A (en) * 1989-08-18 1993-08-31 Biogen, Inc. Inhibitors of thrombin
US6060451A (en) * 1990-06-15 2000-05-09 The National Research Council Of Canada Thrombin inhibitors based on the amino acid sequence of hirudin
GB9506212D0 (en) * 1995-03-27 1995-05-17 Iaf Biochem Int Bifunctional thrombin inhibitors bearing highly truncated fibrinogen recognition exosite binding component

Also Published As

Publication number Publication date
JP2000516203A (en) 2000-12-05
EP0910583A1 (en) 1999-04-28
WO1998000443A1 (en) 1998-01-08
GB9613718D0 (en) 1996-08-28

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