IL122346A - תכשירים להמרצת גידול של ניורית - Google Patents
תכשירים להמרצת גידול של ניוריתInfo
- Publication number
- IL122346A IL122346A IL12234696A IL12234696A IL122346A IL 122346 A IL122346 A IL 122346A IL 12234696 A IL12234696 A IL 12234696A IL 12234696 A IL12234696 A IL 12234696A IL 122346 A IL122346 A IL 122346A
- Authority
- IL
- Israel
- Prior art keywords
- straight
- branched
- substituted
- alkenyl
- alkyl
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 35
- 230000004936 stimulating effect Effects 0.000 title claims abstract description 10
- 230000014511 neuron projection development Effects 0.000 title claims description 17
- 150000001875 compounds Chemical class 0.000 claims abstract description 62
- 108010025020 Nerve Growth Factor Proteins 0.000 claims abstract description 43
- 102000007072 Nerve Growth Factors Human genes 0.000 claims abstract description 24
- 239000003900 neurotrophic factor Substances 0.000 claims abstract description 24
- 102000015336 Nerve Growth Factor Human genes 0.000 claims abstract description 19
- 230000000508 neurotrophic effect Effects 0.000 claims abstract description 12
- 210000002569 neuron Anatomy 0.000 claims abstract description 6
- 125000000217 alkyl group Chemical group 0.000 claims description 105
- -1 1,3,5- trithianyl Chemical group 0.000 claims description 95
- 125000003342 alkenyl group Chemical group 0.000 claims description 92
- 125000000304 alkynyl group Chemical group 0.000 claims description 61
- 239000001257 hydrogen Substances 0.000 claims description 52
- 229910052739 hydrogen Inorganic materials 0.000 claims description 52
- 150000002431 hydrogen Chemical class 0.000 claims description 28
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 27
- 239000001301 oxygen Substances 0.000 claims description 27
- 229910052760 oxygen Inorganic materials 0.000 claims description 27
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 22
- 125000006705 (C5-C7) cycloalkyl group Chemical group 0.000 claims description 21
- 125000001424 substituent group Chemical group 0.000 claims description 21
- 229910052799 carbon Inorganic materials 0.000 claims description 17
- 239000003814 drug Substances 0.000 claims description 17
- 229940053128 nerve growth factor Drugs 0.000 claims description 17
- 229910052757 nitrogen Inorganic materials 0.000 claims description 16
- 125000006709 (C5-C7) cycloalkenyl group Chemical group 0.000 claims description 15
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims description 15
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 claims description 15
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims description 15
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims description 15
- 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 claims description 14
- 150000003857 carboxamides Chemical class 0.000 claims description 14
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 14
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 13
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 13
- 125000001041 indolyl group Chemical group 0.000 claims description 13
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 claims description 12
- 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 claims description 12
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 claims description 12
- 125000003682 3-furyl group Chemical group O1C([H])=C([*])C([H])=C1[H] 0.000 claims description 12
- 125000005842 heteroatom Chemical group 0.000 claims description 12
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 11
- 125000000335 thiazolyl group Chemical group 0.000 claims description 11
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 10
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 10
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 10
- YBYIRNPNPLQARY-UHFFFAOYSA-N 1H-indene Natural products C1=CC=C2CC=CC2=C1 YBYIRNPNPLQARY-UHFFFAOYSA-N 0.000 claims description 9
- 125000002178 anthracenyl group Chemical group C1(=CC=CC2=CC3=CC=CC=C3C=C12)* 0.000 claims description 9
- 125000003983 fluorenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3CC12)* 0.000 claims description 9
- 229910052736 halogen Inorganic materials 0.000 claims description 9
- 150000002367 halogens Chemical class 0.000 claims description 9
- 125000003454 indenyl group Chemical group C1(C=CC2=CC=CC=C12)* 0.000 claims description 9
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims description 9
- IIBOGKHTXBPGEI-UHFFFAOYSA-N N-benzylformamide Chemical compound O=CNCC1=CC=CC=C1 IIBOGKHTXBPGEI-UHFFFAOYSA-N 0.000 claims description 8
- 125000003828 azulenyl group Chemical group 0.000 claims description 8
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims description 8
- NOQAFHBELOIHBE-UHFFFAOYSA-N n-formylpyridine-2-carboxamide Chemical compound O=CNC(=O)C1=CC=CC=N1 NOQAFHBELOIHBE-UHFFFAOYSA-N 0.000 claims description 8
- HTHDQCIQHNPBNB-UHFFFAOYSA-N n-thiomorpholin-4-ylformamide Chemical compound O=CNN1CCSCC1 HTHDQCIQHNPBNB-UHFFFAOYSA-N 0.000 claims description 8
- 125000000714 pyrimidinyl group Chemical group 0.000 claims description 8
- 239000003102 growth factor Substances 0.000 claims description 7
- ZPQHRYDGTIMVKO-UHFFFAOYSA-N n-morpholin-4-ylformamide Chemical compound O=CNN1CCOCC1 ZPQHRYDGTIMVKO-UHFFFAOYSA-N 0.000 claims description 7
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 7
- 125000006729 (C2-C5) alkenyl group Chemical group 0.000 claims description 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 6
- 102000004219 Brain-derived neurotrophic factor Human genes 0.000 claims description 6
- 108090000715 Brain-derived neurotrophic factor Proteins 0.000 claims description 6
- 108090000386 Fibroblast Growth Factor 1 Proteins 0.000 claims description 6
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims description 6
- 102000034615 Glial cell line-derived neurotrophic factor Human genes 0.000 claims description 6
- 108091010837 Glial cell line-derived neurotrophic factor Proteins 0.000 claims description 6
- 108090000742 Neurotrophin 3 Proteins 0.000 claims description 6
- 108090000099 Neurotrophin-4 Proteins 0.000 claims description 6
- 102100033857 Neurotrophin-4 Human genes 0.000 claims description 6
- 208000006011 Stroke Diseases 0.000 claims description 6
- 229940077737 brain-derived neurotrophic factor Drugs 0.000 claims description 6
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 6
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 6
- 230000001537 neural effect Effects 0.000 claims description 6
- 125000005936 piperidyl group Chemical group 0.000 claims description 6
- 125000004502 1,2,3-oxadiazolyl group Chemical group 0.000 claims description 5
- 125000001399 1,2,3-triazolyl group Chemical group N1N=NC(=C1)* 0.000 claims description 5
- 125000003363 1,3,5-triazinyl group Chemical group N1=C(N=CN=C1)* 0.000 claims description 5
- 125000002471 4H-quinolizinyl group Chemical group C=1(C=CCN2C=CC=CC12)* 0.000 claims description 5
- 102000003971 Fibroblast Growth Factor 1 Human genes 0.000 claims description 5
- 102000003974 Fibroblast growth factor 2 Human genes 0.000 claims description 5
- 125000000641 acridinyl group Chemical group C1(=CC=CC2=NC3=CC=CC=C3C=C12)* 0.000 claims description 5
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims description 5
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims description 5
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims description 5
- 125000000609 carbazolyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3NC12)* 0.000 claims description 5
- 125000000259 cinnolinyl group Chemical group N1=NC(=CC2=CC=CC=C12)* 0.000 claims description 5
- 125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 5
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Zoology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pyridine Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Steroid Compounds (AREA)
- Saccharide Compounds (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL13611896A IL136118A (en) | 1995-06-08 | 1996-06-06 | Compositions for stimulating neurite growth |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US48600495A | 1995-06-08 | 1995-06-08 | |
PCT/US1996/010123 WO1996041609A2 (en) | 1995-06-08 | 1996-06-06 | Methods and compositions for stimulating neurite growth |
Publications (2)
Publication Number | Publication Date |
---|---|
IL122346A0 IL122346A0 (en) | 1998-04-05 |
IL122346A true IL122346A (he) | 2002-05-23 |
Family
ID=23930232
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL12234696A IL122346A (he) | 1995-06-08 | 1996-06-06 | תכשירים להמרצת גידול של ניורית |
Country Status (17)
Country | Link |
---|---|
US (3) | US6037370A (he) |
EP (2) | EP1666037A3 (he) |
JP (1) | JP2007308517A (he) |
KR (1) | KR100480662B1 (he) |
CN (1) | CN1202104A (he) |
AT (1) | ATE311875T1 (he) |
BR (1) | BR9609333A (he) |
CA (1) | CA2222430A1 (he) |
DE (1) | DE69635550T2 (he) |
DK (1) | DK0831812T3 (he) |
ES (1) | ES2255077T3 (he) |
IL (1) | IL122346A (he) |
NZ (1) | NZ310339A (he) |
PL (1) | PL185798B1 (he) |
RU (1) | RU2197240C2 (he) |
WO (1) | WO1996041609A2 (he) |
ZA (1) | ZA964852B (he) |
Families Citing this family (73)
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US5846981A (en) * | 1993-05-28 | 1998-12-08 | Gpi Nil Holdings Inc. | Inhibitors of rotamase enzyme activity |
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US5801197A (en) * | 1995-10-31 | 1998-09-01 | Gpi Nil Holdings, Inc. | Rotamase enzyme activity inhibitors |
US6218424B1 (en) * | 1996-09-25 | 2001-04-17 | Gpi Nil Holdings, Inc. | Heterocyclic ketone and thioester compounds and uses |
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US5780484A (en) * | 1996-11-13 | 1998-07-14 | Vertex Pharmaceuticals Incorporated | Methods for stimulating neurite growth with piperidine compounds |
US5811434A (en) * | 1996-11-13 | 1998-09-22 | Vertex Pharmacueticals Incorporated | Methods and compositions for stimulating neurite growth |
US5840736A (en) * | 1996-11-13 | 1998-11-24 | Vertex Pharmaceuticals Incorporated | Methods and compositions for stimulating neurite growth |
JP2002515051A (ja) | 1996-12-31 | 2002-05-21 | ジーピーアイ エヌアイエル ホールディングス インコーポレイテッド | ヘテロ環式チオエステルのn−結合スルホンアミド |
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NZ336386A (en) | 1996-12-31 | 2001-09-28 | Guilford Pharm Inc | An urea or carbamate derivative of heterocyclic thioester useful for effecting neuronal activity |
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US6242468B1 (en) | 1997-02-27 | 2001-06-05 | Jia-He Li | Carbamate and urea compositions and neurotrophic uses |
ZA98825B (en) * | 1997-02-27 | 1998-10-19 | Guilford Pharm Inc | Method of using neurotrophic carbamates and ureas |
US5846979A (en) * | 1997-02-28 | 1998-12-08 | Gpi Nil Holdings, Inc. | N-oxides of heterocyclic esters, amides, thioesters, and ketones |
US5945441A (en) | 1997-06-04 | 1999-08-31 | Gpi Nil Holdings, Inc. | Pyrrolidine carboxylate hair revitalizing agents |
US6852496B1 (en) * | 1997-08-12 | 2005-02-08 | Oregon Health And Science University | Methods of screening for agents that promote nerve cell growth |
US5968921A (en) * | 1997-10-24 | 1999-10-19 | Orgegon Health Sciences University | Compositions and methods for promoting nerve regeneration |
AU3193399A (en) | 1998-03-23 | 1999-10-18 | Genentech Inc. | Method of selection for genes encoding secreted and transmembrane proteins |
WO1999062511A1 (en) | 1998-06-02 | 1999-12-09 | Bristol-Myers Squibb Company | Neurotrophic difluoroamide agents |
KR20010071920A (ko) | 1998-07-17 | 2001-07-31 | 개리 이. 프라이드만 | 뉴우런 성장 및 연장을 자극하는 화합물, 조성물 및 방법 |
US6218423B1 (en) * | 1998-08-14 | 2001-04-17 | Gpi Nil Holdings, Inc. | Pyrrolidine derivatives for vision and memory disorders |
US6335348B1 (en) * | 1998-08-14 | 2002-01-01 | Gpi Nil Holdings, Inc. | Nitrogen-containing linear and azepinyl/ compositions and uses for vision and memory disorders |
US6376517B1 (en) * | 1998-08-14 | 2002-04-23 | Gpi Nil Holdings, Inc. | Pipecolic acid derivatives for vision and memory disorders |
AU5555699A (en) * | 1998-08-14 | 2000-03-06 | Gpi Nil Holdings, Inc. | Compositions and uses for vision and memory disorders |
US6384056B1 (en) * | 1998-08-14 | 2002-05-07 | Gpi Nil Holdings, Inc. | Heterocyclic thioesters or ketones for vision and memory disorders |
US7338976B1 (en) * | 1998-08-14 | 2008-03-04 | Gpi Nil Holdings, Inc. | Heterocyclic esters or amides for vision and memory disorders |
US6462072B1 (en) | 1998-09-21 | 2002-10-08 | Gpi Nil Holdings, Inc. | Cyclic ester or amide derivatives |
US6228872B1 (en) | 1998-11-12 | 2001-05-08 | Bristol-Myers Squibb Company | Neurotrophic diamide and carbamate agents |
DE19905254A1 (de) * | 1999-02-03 | 2000-08-10 | Schering Ag | Piperidin- und Pyrrolidin-Derivate |
WO2000046181A1 (en) * | 1999-02-03 | 2000-08-10 | Schering Aktiengesellschaft | Carboxylic acid derivatives, process for their preparation and their use as rotamase enzyme activity inhibitors |
DE19905256A1 (de) * | 1999-02-03 | 2000-08-10 | Schering Ag | Piperidin- und Pyrrolidin-Derivate |
US6284779B1 (en) | 1999-02-03 | 2001-09-04 | Schering Aktiiengesellschaft | Heteroaromatic compounds |
AU3587300A (en) * | 1999-02-03 | 2000-08-25 | Schering Aktiengesellschaft | Ether derivatives |
DE19905255A1 (de) * | 1999-02-03 | 2000-08-10 | Schering Ag | Piperidin- und Pyrrolidin-Derivate |
EP1196387A1 (en) | 1999-07-06 | 2002-04-17 | Vertex Pharmaceuticals Incorporated | Azo amino acid derivatives for the treatment of neurological diseases |
WO2001002368A1 (en) | 1999-07-06 | 2001-01-11 | Vertex Pharmaceuticals Incorporated | N-heterocyclic derivatives with neuronal activity |
AU5912800A (en) * | 1999-07-06 | 2001-01-22 | Vertex Pharmaceuticals Incorporated | Beta-amino acid derivatives for the treatment of neurological diseases |
JP2003503479A (ja) * | 1999-07-06 | 2003-01-28 | バーテックス ファーマシューティカルズ インコーポレイテッド | N置換化グリシン誘導体 |
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AU5606400A (en) * | 1999-07-09 | 2001-01-30 | Ortho-Mcneil Pharmaceutical, Inc. | Neurotrophic tetrahydroisoquinolines and tetrahydrothienopyridines, and related compositions and methods |
US6734211B1 (en) | 1999-07-09 | 2004-05-11 | Oregon Health & Sciences University | Compositions and methods for promoting nerve regeneration |
AU6497200A (en) * | 1999-07-30 | 2001-02-19 | Vertex Pharmaceuticals Incorporated | Acyclic and cyclic amine derivatives |
WO2001009097A1 (en) * | 1999-07-30 | 2001-02-08 | Vertex Pharmaceuticals Incorporated | Cyclic amine derivatives for the treatment of neurological diseases |
US6417189B1 (en) | 1999-11-12 | 2002-07-09 | Gpi Nil Holdings, Inc. | AZA compounds, pharmaceutical compositions and methods of use |
US7253169B2 (en) | 1999-11-12 | 2007-08-07 | Gliamed, Inc. | Aza compounds, pharmaceutical compositions and methods of use |
DOP2000000107A (es) | 1999-12-01 | 2002-09-16 | Agouron Pharmaceutical Inc | Compuestos, composiciones y metodos para estimular el crecimiento y alongamiento de las neuronas |
US6818643B1 (en) | 1999-12-08 | 2004-11-16 | Bristol-Myers Squibb Company | Neurotrophic bicyclic diamides |
US7060676B2 (en) * | 1999-12-20 | 2006-06-13 | Trustees Of Tufts College | T. cruzi-derived neurotrophic agents and methods of use therefor |
ATE319712T1 (de) | 1999-12-21 | 2006-03-15 | Mgi Gp Inc | Hydantoin derivate, pharmazeutische zusammensetzungen und verfahren zu ihrer verwendung |
EP1404325A2 (en) * | 2001-05-29 | 2004-04-07 | Guilford Pharmaceuticals Inc. | Method for treating nerve injury caused by surgery |
CN1240691C (zh) | 2001-12-06 | 2006-02-08 | 中国人民解放军军事医学科学院毒物药物研究所 | 取代五元氮杂环类化合物及其预防和治疗神经退行性疾病的用途 |
KR20040011237A (ko) * | 2002-07-29 | 2004-02-05 | 김윤희 | Pdgf, 그의 유도체 및 약학적으로 허용되는 그의 염을함유하는 신경세포 보호 및 재생용 조성물 |
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CN1882338A (zh) | 2003-09-18 | 2006-12-20 | 马库赛特公司 | 经巩膜递送 |
US8663639B2 (en) | 2005-02-09 | 2014-03-04 | Santen Pharmaceutical Co., Ltd. | Formulations for treating ocular diseases and conditions |
US20060258698A1 (en) | 2005-02-09 | 2006-11-16 | Sreenivasu Mudumba | Liquid formulations for treatment of diseases or conditions |
US8492400B2 (en) | 2006-02-09 | 2013-07-23 | Santen Pharmaceutical Co., Ltd. | Stable formulations, and methods of their preparation and use |
JP5506378B2 (ja) | 2006-03-23 | 2014-05-28 | 参天製薬株式会社 | 血管透過性に関連する疾患または病気のための製剤および方法 |
KR101846136B1 (ko) | 2010-03-12 | 2018-04-05 | 오메로스 코포레이션 | Pde10 억제제 및 관련 조성물 및 방법 |
US10052362B2 (en) | 2011-05-05 | 2018-08-21 | Emory University | Glial cell line derived neurotrophic factor, obesity, and obesity-related diseases and conditions |
US20140038887A1 (en) * | 2011-05-05 | 2014-02-06 | Us Government Represented By The Us Department Of Veterans Affairs | Glial cell line derived neurotrophic factor, obesity, and obesity-related diseases and conditions |
NZ716494A (en) | 2014-04-28 | 2017-07-28 | Omeros Corp | Processes and intermediates for the preparation of a pde10 inhibitor |
NZ630803A (en) | 2014-04-28 | 2016-03-31 | Omeros Corp | Optically active pde10 inhibitor |
US9879002B2 (en) | 2015-04-24 | 2018-01-30 | Omeros Corporation | PDE10 inhibitors and related compositions and methods |
US9920045B2 (en) | 2015-11-04 | 2018-03-20 | Omeros Corporation | Solid state forms of a PDE10 inhibitor |
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US5192773A (en) | 1990-07-02 | 1993-03-09 | Vertex Pharmaceuticals, Inc. | Immunosuppressive compounds |
ES2137186T3 (es) * | 1991-05-09 | 1999-12-16 | Vertex Pharma | Nuevos compuestos inmunosupresores. |
WO1993000427A2 (en) * | 1991-06-24 | 1993-01-07 | Erziehungsdirektion Of The Canton Zurich | Neurite growth regulatory factors |
NZ314207A (en) * | 1992-09-28 | 2000-12-22 | Vertex Pharma | 1-(2-Oxoacetyl)-piperidine-2-carboxylic acid derivatives as multi drug resistant cancer cell sensitizers |
US5543423A (en) | 1994-11-16 | 1996-08-06 | Vertex Pharmaceuticals, Incorporated | Amino acid derivatives with improved multi-drug resistance activity |
KR19990022569A (ko) * | 1995-06-07 | 1999-03-25 | 다비 엑스. 맥파레인 | 색에 영향을 미치는 상태를 검지·측정하기 위한 방법 및 장치 |
US5859031A (en) * | 1995-06-07 | 1999-01-12 | Gpi Nil Holdings, Inc. | Small molecule inhibitors of rotamase enzyme activity |
US5614547A (en) * | 1995-06-07 | 1997-03-25 | Guilford Pharmaceuticals Inc. | Small molecule inhibitors of rotamase enzyme |
US5696135A (en) * | 1995-06-07 | 1997-12-09 | Gpi Nil Holdings, Inc. | Inhibitors of rotamase enzyme activity effective at stimulating neuronal growth |
US5801197A (en) * | 1995-10-31 | 1998-09-01 | Gpi Nil Holdings, Inc. | Rotamase enzyme activity inhibitors |
-
1995
- 1995-06-08 US US08/486,004 patent/US6037370A/en not_active Expired - Lifetime
-
1996
- 1996-06-06 AT AT96918469T patent/ATE311875T1/de not_active IP Right Cessation
- 1996-06-06 ES ES96918469T patent/ES2255077T3/es not_active Expired - Lifetime
- 1996-06-06 PL PL96328723A patent/PL185798B1/pl not_active IP Right Cessation
- 1996-06-06 IL IL12234696A patent/IL122346A/he not_active IP Right Cessation
- 1996-06-06 NZ NZ310339A patent/NZ310339A/xx unknown
- 1996-06-06 WO PCT/US1996/010123 patent/WO1996041609A2/en active IP Right Grant
- 1996-06-06 CN CN96195690A patent/CN1202104A/zh active Pending
- 1996-06-06 CA CA002222430A patent/CA2222430A1/en not_active Abandoned
- 1996-06-06 EP EP05026521A patent/EP1666037A3/en not_active Withdrawn
- 1996-06-06 DK DK96918469T patent/DK0831812T3/da active
- 1996-06-06 RU RU98100456/14A patent/RU2197240C2/ru not_active IP Right Cessation
- 1996-06-06 KR KR1019970709288A patent/KR100480662B1/ko not_active IP Right Cessation
- 1996-06-06 BR BR9609333-1A patent/BR9609333A/pt not_active IP Right Cessation
- 1996-06-06 EP EP96918469A patent/EP0831812B1/en not_active Expired - Lifetime
- 1996-06-06 DE DE69635550T patent/DE69635550T2/de not_active Expired - Lifetime
- 1996-06-07 ZA ZA964852A patent/ZA964852B/xx unknown
-
1997
- 1997-02-28 US US08/795,956 patent/US6124328A/en not_active Expired - Lifetime
-
2000
- 2000-07-14 US US09/616,539 patent/US6326387B1/en not_active Expired - Lifetime
-
2007
- 2007-09-03 JP JP2007227995A patent/JP2007308517A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
RU2197240C2 (ru) | 2003-01-27 |
NZ310339A (en) | 2000-03-27 |
BR9609333A (pt) | 1999-10-13 |
EP0831812A2 (en) | 1998-04-01 |
ATE311875T1 (de) | 2005-12-15 |
IL122346A0 (en) | 1998-04-05 |
CA2222430A1 (en) | 1996-12-27 |
EP1666037A3 (en) | 2006-06-21 |
DK0831812T3 (da) | 2006-07-17 |
CN1202104A (zh) | 1998-12-16 |
JP2007308517A (ja) | 2007-11-29 |
US6124328A (en) | 2000-09-26 |
US6037370A (en) | 2000-03-14 |
DE69635550T2 (de) | 2006-08-24 |
DE69635550D1 (de) | 2006-01-12 |
WO1996041609A2 (en) | 1996-12-27 |
US6326387B1 (en) | 2001-12-04 |
KR100480662B1 (ko) | 2005-09-12 |
KR19990022819A (ko) | 1999-03-25 |
PL185798B1 (pl) | 2003-07-31 |
EP0831812B1 (en) | 2005-12-07 |
PL328723A1 (en) | 1999-02-15 |
EP1666037A2 (en) | 2006-06-07 |
ES2255077T3 (es) | 2006-06-16 |
ZA964852B (en) | 1996-07-29 |
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Legal Events
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KB | Patent renewed | ||
MM9K | Patent not in force due to non-payment of renewal fees |