IL107292A0 - Substituted benzylaminoquinuclidines - Google Patents

Substituted benzylaminoquinuclidines

Info

Publication number: IL107292A0
Authority: IL; Israel
Prior art keywords: carbon atoms; alkyl; hydrogen; disorders; alkynyl
Prior art date: 1992-10-21

Application number

IL107292A

Other languages

English (en)

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-10-21

Filing date

1993-10-14

Publication date

1994-01-25

1993-10-14 Application filed by Pfizer filed Critical Pfizer

1994-01-25 Publication of IL107292A0 publication Critical patent/IL107292A0/xx

Links

DTJXCCUWIKIZEX-UHFFFAOYSA-N n-benzyl-1-azabicyclo[2.2.2]octan-2-amine Chemical class C1C(CC2)CCN2C1NCC1=CC=CC=C1 DTJXCCUWIKIZEX-UHFFFAOYSA-N 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 9
125000000217 alkyl group Chemical group 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000003342 alkenyl group Chemical group 0.000 abstract 2
125000000304 alkynyl group Chemical group 0.000 abstract 2
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
208000015114 central nervous system disease Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
208000027866 inflammatory disease Diseases 0.000 abstract 1
125000004043 oxo group Chemical group O=* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
125000003107 substituted aryl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Molecular Biology (AREA)
Pulmonology (AREA)
Biochemistry (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

IL107292A 1992-10-21 1993-10-14 Substituted benzylaminoquinuclidines IL107292A0 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP4283135A JP2656699B2 (ja)	1992-10-21	1992-10-21	置換ベンジルアミノキヌクリジン

Publications (1)

Publication Number	Publication Date
IL107292A0 true IL107292A0 (en)	1994-01-25

Family

ID=17661684

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL107292A IL107292A0 (en)	1992-10-21	1993-10-14	Substituted benzylaminoquinuclidines

Country Status (16)

Country	Link
EP (1)	EP0665844B1 (fi)
JP (1)	JP2656699B2 (fi)
AT (1)	ATE196140T1 (fi)
AU (1)	AU5165393A (fi)
CA (1)	CA2146259C (fi)
DE (1)	DE69329386T2 (fi)
DK (1)	DK0665844T3 (fi)
ES (1)	ES2149215T3 (fi)
FI (1)	FI114636B (fi)
GR (1)	GR3034498T3 (fi)
HU (1)	HUT65133A (fi)
IL (1)	IL107292A0 (fi)
MX (1)	MX9306527A (fi)
PT (1)	PT665844E (fi)
WO (1)	WO1994008997A1 (fi)
ZA (1)	ZA937780B (fi)

Families Citing this family (42)

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CA2205016A1 (en) *	1994-11-10	1996-05-23	Hans-Jurgen Ernst Hess	Nk-1 receptor antagonists for the treatment of eye disorders
FR2728166A1 (fr)	1994-12-19	1996-06-21	Oreal	Composition topique contenant un antagoniste de substance p
TW458774B (en)	1995-10-20	2001-10-11	Pfizer	Antiemetic pharmaceutical compositions
FR2741262B1 (fr)	1995-11-20	1999-03-05	Oreal	Utilisation d'un antagoniste de tnf-alpha pour le traitement des rougeurs cutanees d'origine neurogene
US6861526B2 (en)	2002-10-16	2005-03-01	Pfizer Inc.	Process for the preparation of (S,S)-cis-2-benzhydryl-3-benzylaminoquinuclidine
RU2388751C2 (ru)	2004-07-15	2010-05-10	Амр Текнолоджи, Инк.	Арил- и гетероарилзамещенные тетрагидроизохинолины и их применение для блокирования обратного захвата норэпинефрина, допамина и серотонина
ES2382814T3 (es)	2005-05-17	2012-06-13	Merck Sharp & Dohme Ltd.	Ácido cis-4-[(4-clorofenil)sulfonil]-4-(2,5-difluorofenil)ciclohexanopropanoico para el tratamiento del cáncer
KR20080044840A (ko)	2005-07-15	2008-05-21	에이엠알 테크놀로지, 인크.	아릴- 및 헤테로아릴-치환된 테트라히드로벤자제핀, 및노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기위한 용도
BRPI0616463A2 (pt)	2005-09-29	2011-06-21	Merck & Co Inc	composto, composição farmacêutica, e, uso de um composto
GB0603041D0 (en)	2006-02-15	2006-03-29	Angeletti P Ist Richerche Bio	Therapeutic compounds
WO2008039327A2 (en)	2006-09-22	2008-04-03	Merck & Co., Inc.	Method of treatment using fatty acid synthesis inhibitors
US20110218176A1 (en)	2006-11-01	2011-09-08	Barbara Brooke Jennings-Spring	Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
KR101591656B1 (ko)	2007-01-10	2016-02-19	엠에스디 이탈리아 에스.알.엘.	폴리(ａｄｐ-리보오스) 폴리머라아제(ｐａｒｐ) 억제제로서의 아미드 치환된 인다졸
CA2682727C (en)	2007-04-02	2016-03-22	Banyu Pharmaceutical Co., Ltd.	Indoledione derivative
CA2690191C (en)	2007-06-27	2015-07-28	Merck Sharp & Dohme Corp.	4-carboxybenzylamino derivatives as histone deacetylase inhibitors
EP2247185B1 (en)	2008-03-03	2014-04-16	Tiger Pharmatech	Tyrosine kinase inhibitors
US9156812B2 (en)	2008-06-04	2015-10-13	Bristol-Myers Squibb Company	Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
UA105182C2 (ru)	2008-07-03	2014-04-25	Ньюрексон, Інк.	Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность
WO2010114780A1 (en)	2009-04-01	2010-10-07	Merck Sharp & Dohme Corp.	Inhibitors of akt activity
PE20120373A1 (es)	2009-05-12	2012-05-17	Albany Molecular Res Inc	7-([1,2,4]triazolo[1,5-a]piridin-6-il)-4-(3,4-diclorofenil)-1,2,3,4-tetrahidroisoquinolina
AU2010247735B2 (en)	2009-05-12	2015-07-16	Albany Molecular Research, Inc.	Crystalline forms of (S)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)- 1,2,3,4-tetrahydroisoquinoline and use thereof
AU2010247849B2 (en)	2009-05-12	2015-11-19	Albany Molecular Research, Inc.	Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof
CN102638981B (zh)	2009-10-14	2015-07-22	默沙东公司	提高p53活性的取代的哌啶和其用途
WO2011163330A1 (en)	2010-06-24	2011-12-29	Merck Sharp & Dohme Corp.	Novel heterocyclic compounds as erk inhibitors
CN107090456B (zh)	2010-08-02	2022-01-18	瑟纳治疗公司	使用短干扰核酸的RNA干扰介导的联蛋白（钙粘蛋白关联蛋白质），β1基因表达的抑制
HUE044815T2 (hu)	2010-08-17	2019-11-28	Sirna Therapeutics Inc	Hepatitisz B vírus (HBV) génexpressziójának RNS-interferencia közvetített gátlása, rövid interferáló nukleinsav (SINS) alkalmazásával
US8883801B2 (en)	2010-08-23	2014-11-11	Merck Sharp & Dohme Corp.	Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors
EP2613782B1 (en)	2010-09-01	2016-11-02	Merck Sharp & Dohme Corp.	Indazole derivatives useful as erk inhibitors
EP2615916B1 (en)	2010-09-16	2017-01-04	Merck Sharp & Dohme Corp.	Fused pyrazole derivatives as novel erk inhibitors
EP3766975A1 (en)	2010-10-29	2021-01-20	Sirna Therapeutics, Inc.	Rna interference mediated inhibition of gene expression using short interfering nucleic acid (sina)
US9351965B2 (en)	2010-12-21	2016-05-31	Merck Sharp & Dohme Corp.	Indazole derivatives useful as ERK inhibitors
US20140045847A1 (en)	2011-04-21	2014-02-13	Piramal Enterprises Limited	Crystalline form of a salt of a morpholino sulfonyl indole derivative and a process for its preparation
EP2770987B1 (en)	2011-10-27	2018-04-04	Merck Sharp & Dohme Corp.	Novel compounds that are erk inhibitors
WO2013165816A2 (en)	2012-05-02	2013-11-07	Merck Sharp & Dohme Corp.	SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS
RU2660429C2 (ru)	2012-09-28	2018-07-06	Мерк Шарп И Доум Корп.	Новые соединения, которые являются ингибиторами erk
US9655899B2 (en)	2012-11-28	2017-05-23	Merck Sharp & Dohme Corp.	Compositions and methods for treating cancer
TW201429969A (zh)	2012-12-20	2014-08-01	Merck Sharp & Dohme	作爲ｈｄｍ２抑制劑之經取代咪唑吡啶
EP2951180B1 (en)	2013-01-30	2018-05-02	Merck Sharp & Dohme Corp.	2,6,7,8 substituted purines as hdm2 inhibitors
WO2015034925A1 (en)	2013-09-03	2015-03-12	Moderna Therapeutics, Inc.	Circular polynucleotides
US10947234B2 (en)	2017-11-08	2021-03-16	Merck Sharp & Dohme Corp.	PRMT5 inhibitors
WO2020033284A1 (en)	2018-08-07	2020-02-13	Merck Sharp & Dohme Corp.	Prmt5 inhibitors
EP3833668A4 (en)	2018-08-07	2022-05-11	Merck Sharp & Dohme Corp.	PRMT5 INHIBITORS

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MX18467A (es) *	1988-11-23	1993-07-01	Pfizer	Agentes terapeuticos de quinuclidinas
WO1992020676A1 (en) *	1991-05-22	1992-11-26	Pfizer Inc.	Substituted 3-aminoquinuclidines

1992
- 1992-10-21 JP JP4283135A patent/JP2656699B2/ja not_active Expired - Fee Related
1993
- 1993-09-30 DE DE69329386T patent/DE69329386T2/de not_active Expired - Fee Related
- 1993-09-30 AU AU51653/93A patent/AU5165393A/en not_active Abandoned
- 1993-09-30 WO PCT/US1993/009168 patent/WO1994008997A1/en active IP Right Grant
- 1993-09-30 EP EP93922754A patent/EP0665844B1/en not_active Expired - Lifetime
- 1993-09-30 DK DK93922754T patent/DK0665844T3/da active
- 1993-09-30 AT AT93922754T patent/ATE196140T1/de not_active IP Right Cessation
- 1993-09-30 CA CA002146259A patent/CA2146259C/en not_active Expired - Fee Related
- 1993-09-30 PT PT93922754T patent/PT665844E/pt unknown
- 1993-09-30 ES ES93922754T patent/ES2149215T3/es not_active Expired - Lifetime
- 1993-10-14 IL IL107292A patent/IL107292A0/xx not_active IP Right Cessation
- 1993-10-20 MX MX9306527A patent/MX9306527A/es unknown
- 1993-10-20 ZA ZA937780A patent/ZA937780B/xx unknown
- 1993-10-20 FI FI934626A patent/FI114636B/fi active IP Right Grant
- 1993-10-20 HU HU9302965A patent/HUT65133A/hu unknown
2000
- 2000-09-28 GR GR20000402187T patent/GR3034498T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
WO1994008997A1 (en)	1994-04-28
HU9302965D0 (en)	1993-12-28
ES2149215T3 (es)	2000-11-01
ZA937780B (en)	1995-04-20
CA2146259A1 (en)	1994-04-28
FI934626A (fi)	1994-04-22
JP2656699B2 (ja)	1997-09-24
FI114636B (fi)	2004-11-30
DE69329386D1 (de)	2000-10-12
FI934626A0 (fi)	1993-10-20
ATE196140T1 (de)	2000-09-15
JPH06135963A (ja)	1994-05-17
EP0665844A1 (en)	1995-08-09
PT665844E (pt)	2001-01-31
AU5165393A (en)	1994-05-09
GR3034498T3 (en)	2000-12-29
EP0665844B1 (en)	2000-09-06
MX9306527A (es)	1994-07-29
DK0665844T3 (da)	2000-10-16
HUT65133A (en)	1994-04-28
CA2146259C (en)	1998-04-07
DE69329386T2 (de)	2001-01-04

Legal Events

Date	Code	Title	Description
2004-06-20	RH1	Patent not in force

Publication	Publication Date	Title
IL107292A0 (en)	1994-01-25	Substituted benzylaminoquinuclidines
AU565898B2 (en)	1987-10-01	1,8-naphthyridine derivatives
CA2119363A1 (en)	1993-04-01	10-desacetoxytaxol derivatives
CA2212326A1 (en)	1996-08-15	O-carbamoyl-(d)-phenylalanilol compounds and process for preparing the same
HU9301155D0 (en)	1993-07-28	Methods for producing steroide derivatives and for their application in medical treatment
MY104335A (en)	1994-03-31	4-aminophridine deravatives
GR3004493T3 (fi)	1993-03-31
MY117086A (en)	2004-05-31	3''-aziridino-anthracycline derivatives.
ES8506304A1 (es)	1985-07-16	Proceso de produccion de los derivados de la piperacina
AU8460791A (en)	1992-05-14	Compound, preparation and use
ES8801811A1 (es)	1988-02-16	Procedimiento para preparar acidos hexenoicos
EP0626369A4 (en)	1994-08-29	BENZENE SULPHONAMIDE DERIVATIVES.
IL138373A0 (en)	2001-10-31	New compounds
ES8602031A1 (es)	1985-12-01	Procedimiento de preparacion de derivados de nitrosoureas
ES2023760A6 (es)	1992-02-01	Procedimiento para la preparacion de derivados benzotiazinicos.
BG102081A (en)	1998-11-30	New derivatives of 2-azabicyclo [2.2.1] heptane, their preparation and application
HU9500710D0 (en)	1995-04-28	Ureido-acetamide derivatives, preparation thereof and drugs containing same
MX9702941A (es)	1997-07-31	Compuestos de di-ter - butilfenol que tiene una porcion heterociclica, utiles como agentes anti-inflamatorios.