MX9702941A - Compuestos de di-ter - butilfenol que tiene una porcion heterociclica, utiles como agentes anti-inflamatorios. - Google Patents

Compuestos de di-ter - butilfenol que tiene una porcion heterociclica, utiles como agentes anti-inflamatorios.

Info

Publication number
MX9702941A
MX9702941A MX9702941A MX9702941A MX9702941A MX 9702941 A MX9702941 A MX 9702941A MX 9702941 A MX9702941 A MX 9702941A MX 9702941 A MX9702941 A MX 9702941A MX 9702941 A MX9702941 A MX 9702941A
Authority
MX
Mexico
Prior art keywords
tert
useful
inflammatory agents
heterocyclic moiety
butylphenol compounds
Prior art date
Application number
MX9702941A
Other languages
English (en)
Other versions
MXPA97002941A (es
Inventor
Michael Wiard Scherz
Stanislaw Pikul
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of MX9702941A publication Critical patent/MX9702941A/es
Publication of MXPA97002941A publication Critical patent/MXPA97002941A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D231/08—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with oxygen or sulfur atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

El sujeto de la invencion se refiere a compuestos que tiene la estructura (I), en donde: a) cada R es independientemente alquilo que tiene de 1 a 7 átomos de carbono; b) Z es 0 o N-X; c) X se selecciona de hidrogeno, alquilo que tiene de 1 a aproximadamente 7 átomos de carbono, C(O)Y, C(S)Y, y SO2Y; d) Y se selecciona de R', OR' y NR'2; e) R' se selecciona de hidrogeno, alquilo que tiene de 1 a aproximadamente 7 átomos de carbono, y fenilo; la presente invencion también se refiere a composiciones farmacéuticas que comprenden los compuestos anteriores, y métodos para tratar la inflamacion o dolor usando los compuestos. (Ver Formula).
MXPA/A/1997/002941A 1994-10-20 1995-10-18 Compuestos de di-ter-butilfenol que tiene unaporcion heterociclica, utiles como agentesanti-inflamatorios MXPA97002941A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08326619 1994-10-20
US08/326,619 US5510361A (en) 1994-10-20 1994-10-20 Di-tert-butylphenol compounds with heterocyclic moiety, useful as anti-inflammatory agents
PCT/US1995/012878 WO1996012710A1 (en) 1994-10-20 1995-10-18 Di-tert-butylphenol compounds with heterocyclic moiety, useful as anti-inflammatory agents

Publications (2)

Publication Number Publication Date
MX9702941A true MX9702941A (es) 1997-07-31
MXPA97002941A MXPA97002941A (es) 1997-12-01

Family

ID=

Also Published As

Publication number Publication date
AU705645B2 (en) 1999-05-27
KR970707108A (ko) 1997-12-01
KR100226509B1 (ko) 1999-10-15
FI971674A (fi) 1997-04-18
NO971789L (no) 1997-06-19
JPH10507754A (ja) 1998-07-28
EP0787130A1 (en) 1997-08-06
AU3859895A (en) 1996-05-15
FI971674A0 (fi) 1997-04-18
WO1996012710A1 (en) 1996-05-02
US5510361A (en) 1996-04-23
NO971789D0 (no) 1997-04-18

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Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees