IL104261A - Azacyclic and azabicyclic compounds, their preparation and pharmaceutical compositions comprising them - Google Patents

Azacyclic and azabicyclic compounds, their preparation and pharmaceutical compositions comprising them

Info

Publication number: IL104261A
Authority: IL; Israel
Prior art keywords: azacyclic; preparation; pharmaceutical compositions; compounds; azabicyclic compounds
Prior art date: 1992-01-13

Application number

IL104261A

Other languages

English (en)

Other versions

IL104261A0 (en

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-01-13

Filing date

1992-12-29

Publication date

1997-11-20

1992-12-29 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

1993-05-13 Publication of IL104261A0 publication Critical patent/IL104261A0/xx

1997-11-20 Publication of IL104261A publication Critical patent/IL104261A/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Ophthalmology & Optometry (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)

IL104261A 1992-01-13 1992-12-29 Azacyclic and azabicyclic compounds, their preparation and pharmaceutical compositions comprising them IL104261A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/DK1992/000009 WO1993014089A1 (en)	1992-01-13	1992-01-13	Heterocyclic compounds and their preparation and use

Publications (2)

Publication Number	Publication Date
IL104261A0 IL104261A0 (en)	1993-05-13
IL104261A true IL104261A (en)	1997-11-20

Family

ID=8153779

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL104261A IL104261A (en)	1992-01-13	1992-12-29	Azacyclic and azabicyclic compounds, their preparation and pharmaceutical compositions comprising them

Country Status (12)

Country	Link
US (2)	US5414009A (ja)
EP (1)	EP0628041B1 (ja)
JP (1)	JP3517234B2 (ja)
AT (1)	ATE194617T1 (ja)
AU (1)	AU672190B2 (ja)
CA (1)	CA2127251A1 (ja)
DE (1)	DE69329018T2 (ja)
FI (1)	FI943313A (ja)
IL (1)	IL104261A (ja)
NO (1)	NO302523B1 (ja)
WO (2)	WO1993014089A1 (ja)
ZA (1)	ZA93218B (ja)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5998404A (en)	1994-10-24	1999-12-07	Eli Lilly And Company	Heterocyclic compounds and their use
US5852037A (en) *	1995-11-13	1998-12-22	Eli Lilly And Company	Method for treating anxiety
WO1997019669A2 (en) *	1995-11-29	1997-06-05	Eli Lilly And Company	Heterocyclic compounds and their use
US5889019A (en) *	1995-11-29	1999-03-30	Eli Lilly And Company	Heterocyclic compounds and their use
WO1997020819A1 (en) *	1995-12-06	1997-06-12	Eli Lilly And Company	Composition for treating pain
AU715645B2 (en) *	1995-12-07	2000-02-10	Eli Lilly And Company	Method for treating pain
JP2000509045A (ja) *	1996-04-23	2000-07-18	イーライ・リリー・アンド・カンパニー	複素環式化合物
JP2000509046A (ja) *	1996-04-23	2000-07-18	イーライ・リリー・アンド・カンパニー	ヘテロサイクリック化合物群
CA2251974A1 (en) *	1996-04-23	1997-10-30	Lone Jeppesen	Heterocyclic compounds
US5834458A (en) *	1996-10-09	1998-11-10	Eli Lilly And Company	Heterocyclic compounds and their use
US5733912A (en) *	1997-02-19	1998-03-31	Abbott Laboratories	7A-heterocycle substituted hexahydro-1H-pyrrolizine compounds useful in controlling chemical synaptic transmission
US6528529B1 (en)	1998-03-31	2003-03-04	Acadia Pharmaceuticals Inc.	Compounds with activity on muscarinic receptors
AU3700999A (en) *	1998-05-15	1999-12-06	Novo Nordisk A/S	Heterocyclic compounds and their preparation and use
US6211204B1 (en)	1999-01-22	2001-04-03	University Of Toledo	Muscarinic receptor agonists
US6376675B2 (en)	1999-01-22	2002-04-23	The University Of Toledo	Muscarinic receptor agonists
US6096767A (en)	1999-01-22	2000-08-01	The University Of Toledo	Muscarinic receptor agonists
EP2258358A3 (en)	2005-08-26	2011-09-07	Braincells, Inc.	Neurogenesis with acetylcholinesterase inhibitor
WO2007025177A2 (en)	2005-08-26	2007-03-01	Braincells, Inc.	Neurogenesis by muscarinic receptor modulation
CN101374836A (zh) *	2005-12-27	2009-02-25	托莱多大学	毒蕈碱激动剂及其使用方法
WO2009140483A1 (en)	2008-05-15	2009-11-19	University Of Toledo	Muscarinic agonists as cognitive enhancers
WO2009152392A2 (en) *	2008-06-11	2009-12-17	University Of Toledo	Muscarinic agonists for neurological disorders and methods of making the same
US9549928B2 (en)	2011-04-29	2017-01-24	The University Of Toledo	Muscarinic agonists as enhancers of cognitive flexibility

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ219646A (en) *	1986-03-27	1990-10-26	Merck Sharp & Dohme	Oxadiazole derivatives of azacyclics for treating cns disorders
GB8610432D0 (en) *	1986-04-29	1986-06-04	Akzo Nv	Amino-thiazole & oxazole derivatives
GB8714789D0 (en) *	1987-06-24	1987-07-29	Lundbeck & Co As H	Heterocyclic compounds
GB8717446D0 (en) *	1987-07-23	1987-08-26	Merck Sharp & Dohme	Chemical compounds
NZ225999A (en) *	1987-09-10	1992-04-28	Merck Sharp & Dohme	Azacyclic- or azabicyclic-substituted thiadiazole derivatives and pharmaceutical compositions
IE63906B1 (en) *	1987-11-13	1995-06-14	Novo Nordisk As	Azabicyclic compounds and their preparation and use
EP0322182A3 (en) *	1987-12-22	1992-01-02	Beecham Group Plc	Azabicyclic compounds, process for their preparation and pharmaceutical compositions containing them
NZ227841A (en) *	1988-02-12	1991-08-27	Merck Sharp & Dohme	Heterocyclic compounds with at least two non-condensed five membered rings and pharmaceutical compositions
DK162892C (da) *	1988-07-04	1992-05-11	Novo Nordisk As	1,2,5,6-tetrahydropyridinforbindelser, deres fremstilling og farmaceutiske praeparater indeholdende disse
US5043345A (en) *	1989-02-22	1991-08-27	Novo Nordisk A/S	Piperidine compounds and their preparation and use
EP0459568A3 (en) *	1990-05-31	1992-09-30	Merck Sharp & Dohme Ltd.	Substituted oxadiazoles and thiadiazoles for use in the treatment of glaucoma and novel compounds having such use
DK198590D0 (da) *	1990-08-21	1990-08-21	Novo Nordisk As	Heterocykliske forbindelser, deres fremstilling og anvendelse

1992
- 1992-01-13 WO PCT/DK1992/000009 patent/WO1993014089A1/en active Application Filing
- 1992-12-29 IL IL104261A patent/IL104261A/xx not_active IP Right Cessation
1993
- 1993-01-04 US US08/000,055 patent/US5414009A/en not_active Expired - Fee Related
- 1993-01-07 DE DE69329018T patent/DE69329018T2/de not_active Expired - Fee Related
- 1993-01-07 WO PCT/DK1993/000007 patent/WO1993014090A1/en active IP Right Grant
- 1993-01-07 JP JP51208593A patent/JP3517234B2/ja not_active Expired - Fee Related
- 1993-01-07 CA CA002127251A patent/CA2127251A1/en not_active Abandoned
- 1993-01-07 EP EP93903177A patent/EP0628041B1/en not_active Expired - Lifetime
- 1993-01-07 AT AT93903177T patent/ATE194617T1/de not_active IP Right Cessation
- 1993-01-07 AU AU34485/93A patent/AU672190B2/en not_active Ceased
- 1993-01-13 ZA ZA93218A patent/ZA93218B/xx unknown
1994
- 1994-07-12 NO NO942610A patent/NO302523B1/no not_active IP Right Cessation
- 1994-07-12 FI FI943313A patent/FI943313A/fi unknown
1995
- 1995-05-03 US US08/999,973 patent/US5977129A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE69329018T2 (de)	2001-03-22
JPH07502737A (ja)	1995-03-23
FI943313A0 (fi)	1994-07-12
IL104261A0 (en)	1993-05-13
ZA93218B (en)	1993-08-17
US5977129A (en)	1999-11-02
FI943313A (fi)	1994-07-12
DE69329018D1 (de)	2000-08-17
CA2127251A1 (en)	1993-07-22
AU672190B2 (en)	1996-09-26
WO1993014090A1 (en)	1993-07-22
ATE194617T1 (de)	2000-07-15
JP3517234B2 (ja)	2004-04-12
NO302523B1 (no)	1998-03-16
US5414009A (en)	1995-05-09
WO1993014089A1 (en)	1993-07-22
AU3448593A (en)	1993-08-03
NO942610D0 (no)	1994-07-12
EP0628041B1 (en)	2000-07-12
EP0628041A1 (en)	1994-12-14
NO942610L (no)	1994-09-12

Legal Events

Date	Code	Title
1998-04-05	FF	Patent granted
1998-09-24	KB	Patent renewed
1999-06-20	KB	Patent renewed
2003-09-17	RH1	Patent not in force

Publication	Publication Date	Title
IL104261A (en)	1997-11-20	Azacyclic and azabicyclic compounds, their preparation and pharmaceutical compositions comprising them
ZA941542B (en)	1995-09-04	Heterocyclic compounds their use and preparation
FI954131A (fi)	1995-09-04	Heterosykliset yhdisteet ja niiden valmistus ja käyttö
IL99165A0 (en)	1992-07-15	Heterocyclic compounds and their preparation and pharmaceutical compositions containing them
IL99145A0 (en)	1992-07-15	Heterocyclic compounds,their preparation and pharmaceutical compositions containing them
IL99146A0 (en)	1992-07-15	Heterocyclic compounds,their preparation and pharmaceutical compositions containing them
GR3017434T3 (en)	1995-12-31	Azacyclic or azabicyclic compounds, their preparation and use.
CA2157579A1 (en)	1994-09-15	Heterocyclic compounds, their use and preparation