IL101960A - 3 -]) hetero (arylmethylamino [- 2 -) di) hetero (arylmethyl (converted quinuclidines and pharmaceutical preparations containing them - Google Patents

3 -]) hetero (arylmethylamino [- 2 -) di) hetero (arylmethyl (converted quinuclidines and pharmaceutical preparations containing them

Info

Publication number
IL101960A
IL101960A IL10196092A IL10196092A IL101960A IL 101960 A IL101960 A IL 101960A IL 10196092 A IL10196092 A IL 10196092A IL 10196092 A IL10196092 A IL 10196092A IL 101960 A IL101960 A IL 101960A
Authority
IL
Israel
Prior art keywords
disorders
compound according
optionally substituted
substituted
alkyl
Prior art date
Application number
IL10196092A
Other languages
English (en)
Hebrew (he)
Other versions
IL101960A0 (en
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of IL101960A0 publication Critical patent/IL101960A0/xx
Publication of IL101960A publication Critical patent/IL101960A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Medicinal Preparation (AREA)
IL10196092A 1991-05-22 1992-05-21 3 -]) hetero (arylmethylamino [- 2 -) di) hetero (arylmethyl (converted quinuclidines and pharmaceutical preparations containing them IL101960A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14682691 1991-05-22

Publications (2)

Publication Number Publication Date
IL101960A0 IL101960A0 (en) 1994-04-12
IL101960A true IL101960A (en) 1999-03-12

Family

ID=15416402

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10196092A IL101960A (en) 1991-05-22 1992-05-21 3 -]) hetero (arylmethylamino [- 2 -) di) hetero (arylmethyl (converted quinuclidines and pharmaceutical preparations containing them

Country Status (25)

Country Link
EP (1) EP0585328B1 (de)
KR (1) KR100246065B1 (de)
CN (1) CN1041827C (de)
AT (1) ATE211743T1 (de)
AU (1) AU658898B2 (de)
BR (1) BR9206044A (de)
CA (1) CA2109415C (de)
CZ (1) CZ247993A3 (de)
DE (2) DE69232334T2 (de)
DK (1) DK0585328T3 (de)
EG (1) EG20218A (de)
ES (1) ES2168260T3 (de)
FI (1) FI935134A0 (de)
HU (1) HUT65771A (de)
IE (1) IE921662A1 (de)
IL (1) IL101960A (de)
MX (1) MX9202449A (de)
NO (1) NO305173B1 (de)
NZ (2) NZ242880A (de)
PL (4) PL171921B1 (de)
PT (1) PT100514B (de)
RU (1) RU2092486C1 (de)
UA (1) UA26401C2 (de)
WO (1) WO1992020676A1 (de)
ZA (1) ZA923773B (de)

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HU221634B1 (hu) * 1991-06-20 2002-12-28 Pfizer Inc. Nitrogéntartalmú heterociklusos vegyületek fluor-alkoxi-benzilamino-származékai, eljárás előállításukra és az ezeket tartalmazó gyógyszerkészítmények
JP2656702B2 (ja) * 1992-03-23 1997-09-24 ファイザー製薬株式会社 ペプチド性キヌクリジン
US5721255A (en) * 1992-08-19 1998-02-24 Pfizer Inc. Substituted benzylamino nitrogen containing non-aromatic heterocycles
JP2656699B2 (ja) * 1992-10-21 1997-09-24 ファイザー製薬株式会社 置換ベンジルアミノキヌクリジン
US5837711A (en) * 1992-10-28 1998-11-17 Pfizer Inc. Substituted quinuclidines as substance P antagonists
JP2656700B2 (ja) * 1992-10-28 1997-09-24 ファイザー製薬株式会社 置換キヌクリジン誘導体
EP0675886B1 (de) * 1992-12-10 2000-07-05 Pfizer Inc. Aminomethylen substituierte heterocyclische verbindungen und ihre verwendung alssubstanz p antagonisten
JP2822274B2 (ja) * 1993-05-19 1998-11-11 ファイザー製薬株式会社 Ｐ物質拮抗剤としてのヘテロ原子置換アルキルベンジルアミノキヌクリジン類
IL109646A0 (en) * 1993-05-19 1994-08-26 Pfizer Heteroatom substituted alkyl benzylamino-quinuclidines
US5393762A (en) * 1993-06-04 1995-02-28 Pfizer Inc. Pharmaceutical agents for treatment of emesis
US5869499A (en) * 1993-07-15 1999-02-09 Pfizer Inc Benzyloxyquinuclidines as substance P antagonists
ATE265432T1 (de) * 1993-09-17 2004-05-15 Pfizer 3-amino-5-carboxy-substituierte piperidine und 3- amino-4-carboxy-substituierte pyrrolidine als tachykinin-antagonisten
US6083943A (en) * 1993-09-17 2000-07-04 Pfizer Inc Substituted azaheterocyclecarboxylic acid
EP0653208A3 (de) * 1993-11-17 1995-10-11 Pfizer Substanz P Antagonisten zur Behandlung oder Verhütung des sonnenbrandes.
EP0659409A3 (de) * 1993-11-23 1995-08-09 Pfizer Substanz P Antagonisten zur Hemmung der Angiogenese.
EP0655246A1 (de) * 1993-11-30 1995-05-31 Pfizer Inc. Substanz P Antagonisten zur Behandlung von durch Helicobacter Pylori oder andere spirale Urease-positive Gram-negative Bakterien verursachten Krankheiten
FR2728165A1 (fr) 1994-12-19 1996-06-21 Oreal Utilisation d'un antagoniste de substance p pour le traitement des rougeurs cutanees d'origine neurogene
FR2728169A1 (fr) 1994-12-19 1996-06-21 Oreal Utilisation d'un antagoniste de substance p pour le traitement des prurits et des dysesthesies oculaires ou palpebrales
FR2728166A1 (fr) 1994-12-19 1996-06-21 Oreal Composition topique contenant un antagoniste de substance p
PE8798A1 (es) * 1995-07-17 1998-03-02 Pfizer Procedimiento de separacion de los enantiomeros del 1-azabiciclo[2.2.2] octan-3-amina, 2-(difenilmetil) -n- [[2-metoxi-5-(1-metiletil) fenil] metil]
TW458774B (en) 1995-10-20 2001-10-11 Pfizer Antiemetic pharmaceutical compositions
FR2741262B1 (fr) 1995-11-20 1999-03-05 Oreal Utilisation d'un antagoniste de tnf-alpha pour le traitement des rougeurs cutanees d'origine neurogene
MX9706944A (es) * 1996-09-12 1998-08-30 Pfizer Quinuclidinas sustituidas con tetrazolilo como antagonistas de la sustancia p.
NZ329807A (en) * 1997-04-23 2000-07-28 Pfizer NK-1 receptor antagonists and P receptor antagonists 2-Diarylmethyl-3-amino-1-azabicyclo[2.2.2]octane derivatives and amino substituted N-containing rings as agents for treating irritable bowel syndrome
RU2309953C2 (ru) 1999-11-03 2007-11-10 Эймр Текнолоджи, Инк. Арил- и гетероарилзамещенные тетрагидроизохинолины, фармацевтическая композиция и способ лечения на их основе
US7163949B1 (en) 1999-11-03 2007-01-16 Amr Technology, Inc. 4-phenyl substituted tetrahydroisoquinolines and use thereof
US7084152B2 (en) 2000-07-11 2006-08-01 Amr Technology, Inc. 4-phenyl substituted tetrahydroisoquinolines therapeutic use thereof
DOP2002000332A (es) * 2001-02-14 2002-08-30 Warner Lambert Co Inhibidores de piridina de metaloproteinasas de la matriz
US6861526B2 (en) * 2002-10-16 2005-03-01 Pfizer Inc. Process for the preparation of (S,S)-cis-2-benzhydryl-3-benzylaminoquinuclidine
GEP20094640B (en) 2004-07-15 2009-03-10 Bristol Myers Squibb Co Aryl-and heteroaryl-substituted tetrahydro isoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
US8362075B2 (en) 2005-05-17 2013-01-29 Merck Sharp & Dohme Corp. Cyclohexyl sulphones for treatment of cancer
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UA105182C2 (ru) 2008-07-03 2014-04-25 Ньюрексон, Інк. Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность
EP2413932A4 (de) 2009-04-01 2012-09-19 Merck Sharp & Dohme Hemmer der akt-aktivität
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CA2807307C (en) 2010-08-17 2021-02-09 Merck Sharp & Dohme Corp. Rna interference mediated inhibition of hepatitis b virus (hbv) gene expression using short interfering nucleic acid (sina)
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Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990005525A1 (en) * 1988-11-23 1990-05-31 Pfizer Inc. Quinuclidine derivatives as substance p antagonists

Also Published As

Publication number Publication date
NO934195D0 (no) 1993-11-19
CA2109415A1 (en) 1992-11-23
ES2168260T3 (es) 2002-06-16
HUT65771A (en) 1994-07-28
CN1068571A (zh) 1993-02-03
NZ272941A (en) 1997-05-26
PL170513B1 (en) 1996-12-31
FI935134A (fi) 1993-11-19
FI935134A0 (fi) 1993-11-19
UA26401C2 (uk) 1999-08-30
DE9290057U1 (de) 1994-01-05
CN1041827C (zh) 1999-01-27
PT100514A (pt) 1993-09-30
DE69232334D1 (de) 2002-02-14
PL172069B1 (pl) 1997-07-31
AU658898B2 (en) 1995-05-04
HU9303307D0 (en) 1994-03-28
PL171921B1 (pl) 1997-06-30
DK0585328T3 (da) 2002-02-11
NO305173B1 (no) 1999-04-12
ATE211743T1 (de) 2002-01-15
NZ242880A (en) 1995-10-26
MX9202449A (es) 1993-03-01
IE921662A1 (en) 1992-12-02
BR9206044A (pt) 1995-03-01
EP0585328A1 (de) 1994-03-09
AU1927592A (en) 1992-12-30
KR100246065B1 (en) 2000-04-01
PL170525B1 (en) 1996-12-31
NO934195L (no) 1993-11-19
DE69232334T2 (de) 2002-11-14
EG20218A (en) 1997-11-30
CZ247993A3 (en) 1994-07-13
RU2092486C1 (ru) 1997-10-10
WO1992020676A1 (en) 1992-11-26
EP0585328B1 (de) 2002-01-09
CA2109415C (en) 1998-12-29
PT100514B (pt) 1999-06-30
IL101960A0 (en) 1994-04-12
ZA923773B (en) 1993-11-22

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