IE791181L - Tetrahydronaphthaleno and cyclohexeno steroids - Google Patents
Tetrahydronaphthaleno and cyclohexeno steroidsInfo
- Publication number
- IE791181L IE791181L IE791181A IE118179A IE791181L IE 791181 L IE791181 L IE 791181L IE 791181 A IE791181 A IE 791181A IE 118179 A IE118179 A IE 118179A IE 791181 L IE791181 L IE 791181L
- Authority
- IE
- Ireland
- Prior art keywords
- hydrogen
- alkyl
- halogen
- hydroxy
- phenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/002—Carbocyclic rings fused
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Steroids having the formula <IMAGE> and esters thereof, wherein X is hydrogen or halogen; Y is hydrogen, methyl or fluorine; R4 is chlorine, fluorine or hydroxy and R5 is hydrogen or R4 and R5 together are =O; R2 and R3 are each hydrogen, alkyl, phenyl or phenyl substituted with one or more halogen alkyl or alkoxy groups, or R2 and R3 together with the double bond to which they are attached form a benzene ring; R6 and R7 are each hydrogen, alkyl, alkoxy, formyl, <IMAGE> phenyl or cyano and in addition hydroxy, halogen, carboalkoxy and alkylcarbonyl when R2 and R3 are separate, with the proviso that when R6 and R7 are different one of R6 and R7 is hydrogen; R8 is hydrogen or -CH(R9)(R10) wherein R9 and R10 are each hydrogen or alkyl, have anti- inflammatory activity. Preparation (i) from the corresponding 21-ols by oxidation via 20-one-21-als (and/or 21-acetals thereof) and/or 20-hydroxy-21-oic acids (and/or 21-esters thereof); or (ii) from the corresponding ???<16>-21-ols (lacking the fused ring) by oxidation as in process (i) followed by fusing the cyclohexene or tetrahydronaphthalene group into the 16,17-position.
[GB2023608A]
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/919,006 US4160772A (en) | 1978-06-26 | 1978-06-26 | Steroidal[16α,17-d]cyclohexene-21-carboxylic acid esters |
| US05/919,020 US4164504A (en) | 1978-06-26 | 1978-06-26 | Steroidal[16α,17-b]naphthaleno-21-carboxylic acid esters |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE791181L true IE791181L (en) | 1979-12-26 |
| IE49178B1 IE49178B1 (en) | 1985-08-21 |
Family
ID=27129763
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1181/79A IE49178B1 (en) | 1978-06-26 | 1979-08-08 | Steroidal(16a,17a-b)tetrahydronaphthalenes and(16a,17a-d)cyclohexenes |
Country Status (24)
| Country | Link |
|---|---|
| AU (1) | AU524173B2 (en) |
| CA (1) | CA1142916A (en) |
| CH (1) | CH642087A5 (en) |
| CS (2) | CS208160B2 (en) |
| DD (1) | DD144550A5 (en) |
| DE (1) | DE2925552A1 (en) |
| DK (1) | DK267079A (en) |
| ES (2) | ES481875A1 (en) |
| FI (1) | FI791934A (en) |
| FR (1) | FR2429796A1 (en) |
| GB (2) | GB2023608B (en) |
| GR (1) | GR72244B (en) |
| HU (1) | HU180089B (en) |
| IE (1) | IE49178B1 (en) |
| IL (1) | IL57622A (en) |
| IT (1) | IT1162746B (en) |
| LU (1) | LU81420A1 (en) |
| NL (1) | NL7904510A (en) |
| NO (1) | NO792118L (en) |
| NZ (1) | NZ190510A (en) |
| PL (1) | PL216614A1 (en) |
| PT (1) | PT69818A (en) |
| SE (1) | SE7905568L (en) |
| SU (2) | SU946404A3 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4391755A (en) * | 1982-01-18 | 1983-07-05 | E. R. Squibb & Sons, Inc. | Steroid monohydrates, formulations containing same and method |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2924307A (en) * | 1956-09-27 | 1960-02-09 | Gen Motors Corp | Brake adjusting device |
| US3944584A (en) * | 1975-02-03 | 1976-03-16 | E. R. Squibb & Sons, Inc. | Steroidal (16α,17-d)cyclohexenes |
-
1979
- 1979-05-21 NZ NZ190510A patent/NZ190510A/en unknown
- 1979-05-23 CA CA000328182A patent/CA1142916A/en not_active Expired
- 1979-05-25 GB GB7918394A patent/GB2023608B/en not_active Expired
- 1979-05-28 AU AU47481/79A patent/AU524173B2/en not_active Ceased
- 1979-05-29 GR GR59210A patent/GR72244B/el unknown
- 1979-06-07 FR FR7914578A patent/FR2429796A1/en active Granted
- 1979-06-08 NL NL7904510A patent/NL7904510A/en not_active Application Discontinuation
- 1979-06-15 CS CS799420A patent/CS208160B2/en unknown
- 1979-06-15 CS CS794141A patent/CS208159B2/en unknown
- 1979-06-18 FI FI791934A patent/FI791934A/en not_active Application Discontinuation
- 1979-06-22 IL IL57622A patent/IL57622A/en unknown
- 1979-06-25 SU SU792781351A patent/SU946404A3/en active
- 1979-06-25 SE SE7905568A patent/SE7905568L/en not_active Application Discontinuation
- 1979-06-25 NO NO792118A patent/NO792118L/en unknown
- 1979-06-25 IT IT23840/79A patent/IT1162746B/en active
- 1979-06-25 ES ES481875A patent/ES481875A1/en not_active Expired
- 1979-06-25 ES ES481866A patent/ES481866A1/en not_active Expired
- 1979-06-25 HU HU79SU1020A patent/HU180089B/en unknown
- 1979-06-25 LU LU81420A patent/LU81420A1/en unknown
- 1979-06-25 DK DK267079A patent/DK267079A/en not_active Application Discontinuation
- 1979-06-25 CH CH592479A patent/CH642087A5/en not_active IP Right Cessation
- 1979-06-25 DE DE19792925552 patent/DE2925552A1/en not_active Withdrawn
- 1979-06-26 DD DD79213895A patent/DD144550A5/en unknown
- 1979-06-26 PT PT69818A patent/PT69818A/en unknown
- 1979-06-26 PL PL21661479A patent/PL216614A1/xx unknown
- 1979-08-08 IE IE1181/79A patent/IE49178B1/en unknown
-
1980
- 1980-10-23 SU SU802995671A patent/SU1055334A3/en active
-
1982
- 1982-03-19 GB GB08208035A patent/GB2106116B/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CH642087A5 (en) | 1984-03-30 |
| DK267079A (en) | 1979-12-27 |
| GB2023608A (en) | 1980-01-03 |
| PT69818A (en) | 1979-07-01 |
| GB2106116A (en) | 1983-04-07 |
| ES481866A1 (en) | 1980-06-16 |
| IT1162746B (en) | 1987-04-01 |
| IL57622A (en) | 1983-02-23 |
| IT7923840A0 (en) | 1979-06-25 |
| IE49178B1 (en) | 1985-08-21 |
| PL216614A1 (en) | 1980-03-24 |
| CA1142916A (en) | 1983-03-15 |
| HU180089B (en) | 1983-01-28 |
| SU1055334A3 (en) | 1983-11-15 |
| CS208160B2 (en) | 1981-08-31 |
| NL7904510A (en) | 1979-12-28 |
| ES481875A1 (en) | 1980-07-01 |
| CS208159B2 (en) | 1981-08-31 |
| FR2429796A1 (en) | 1980-01-25 |
| DD144550A5 (en) | 1980-10-22 |
| SU946404A3 (en) | 1982-07-23 |
| FI791934A (en) | 1979-12-27 |
| GB2106116B (en) | 1983-08-03 |
| LU81420A1 (en) | 1979-09-12 |
| AU4748179A (en) | 1980-01-03 |
| DE2925552A1 (en) | 1980-01-17 |
| IL57622A0 (en) | 1979-10-31 |
| NO792118L (en) | 1979-12-28 |
| GR72244B (en) | 1983-10-04 |
| NZ190510A (en) | 1982-03-09 |
| GB2023608B (en) | 1983-04-27 |
| SE7905568L (en) | 1979-12-27 |
| AU524173B2 (en) | 1982-09-02 |
| FR2429796B1 (en) | 1983-01-07 |
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