IE39166B1 - N-substituted acetamides processes for their preparation and pharmaceutical compositions containing them - Google Patents
N-substituted acetamides processes for their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IE39166B1 IE39166B1 IE542/74A IE54274A IE39166B1 IE 39166 B1 IE39166 B1 IE 39166B1 IE 542/74 A IE542/74 A IE 542/74A IE 54274 A IE54274 A IE 54274A IE 39166 B1 IE39166 B1 IE 39166B1
- Authority
- IE
- Ireland
- Prior art keywords
- alkyl
- acid
- compounds
- prepared
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/08—Preparation of carboxylic acids or their salts, halides or anhydrides from nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
- C07C57/38—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
- C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
1436593 Substituted acetamides SCIENCE UNION ET CIE SOC FRANCAISE DE REMEDICALE 15 March 1974 [15 March 1973] 12430/73 Heading C2C Novel substituted acetamides of the Formula I in which R 1 is H or C 1 -C 6 alkyl; R 2 and R 3 each are C 1 -C 6 alkyl, cycloalkyl or aryl; R 6 is H or C 1 -C 6 alkyl; R 4 is H, C 1 -C 6 alkyl, C 2 -C 10 alkenyl or benzyl; R 5 is C 1 -C 6 alkyl, C 2 -C 10 alkenyl, C 2 -C 6 alkynyl or aryl-C 1 -C 4 alkyl; or R 4 and R 5 together with the nitrogen atom to which they are attached form a 5 to 8 membered saturated heterocyclic ring which is optionally substituted and may contain a further hetereo atom, and R<SP>1</SP> is H or acyl, and the acid addition salts thereof are prepared by reaction carboxylic acids of the formula or reactive functional derivatives thereof with amines of the formula compounds of the Formula I above in which R 4 is H may also be obtained by the hydrogenolysis or acid hydrolysis of the corresponding compounds in which R 4 is benzyl, and those in which R<SP>1</SP> is acyl by acylating the corresponding compounds in which R<SP>1</SP> is H. (2,2<SP>1</SP>,6,6<SP>1</SP> - Tetramethyldiphenyl)acetyl chloride is prepared by reacting thionyl chloride with the acid, resulting from the hydrolysis of the corresponding nitrile, which is made by reacting silver cyanide with (2,21,6,61-tetramethyldiphenyl)chloromethane. Similarly the following are prepared: (4,41 - difluorodiphenyl)acetyl chloride, (4,4<SP>1</SP> - difluorodiphenyl)acetic acid, and (4,4<SP>1</SP>-difluorodiphenyl)acetonitrile. Dicyclopropylacetyl chloride is prepared by reacting thionyl chloride with dicyclopropylacetic acid, obtained by oxidizing dicyclopropylacetaldehyde. (2,2<SP>1</SP>,3-Trimethoxy-5<SP>1</SP>-methyldiphenyl)acetic acid and (2-methoxy-2<SP>1</SP>-methylthio- 5<SP>1</SP>-methyldiphenyl)acetic acid are also obtained by oxidating the corresponding acetaldehydes. Pharmaceutical compositions, suitable for oral, parenteral, sublingual or rectal administration, contain the above compounds or non- toxic acid addition salts thereof in admixture or conjunction with pharmaceutical carriers. The compounds anti-arhythmic, cardio-depressive, vasodilatory, anti-hypertensive and anti-aggregating properties.
[GB1436593A]
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1243073A GB1436593A (en) | 1973-03-15 | 1973-03-15 | N-substituted acetamides processes for their preparation and pharmaceutical compositions containing them apparatus for processing photograp |
Publications (2)
Publication Number | Publication Date |
---|---|
IE39166L IE39166L (en) | 1974-09-15 |
IE39166B1 true IE39166B1 (en) | 1978-08-16 |
Family
ID=10004460
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IE542/74A IE39166B1 (en) | 1973-03-15 | 1974-03-14 | N-substituted acetamides processes for their preparation and pharmaceutical compositions containing them |
Country Status (16)
Country | Link |
---|---|
JP (1) | JPS537406B2 (en) |
AR (1) | AR213712A1 (en) |
AT (1) | AT336579B (en) |
AU (1) | AU503812B2 (en) |
BE (1) | BE812339A (en) |
CA (1) | CA1052788A (en) |
CH (1) | CH583688A5 (en) |
DE (1) | DE2411885A1 (en) |
ES (1) | ES424238A1 (en) |
FR (1) | FR2221144B1 (en) |
GB (1) | GB1436593A (en) |
HU (1) | HU168559B (en) |
IE (1) | IE39166B1 (en) |
NL (1) | NL154496B (en) |
SU (1) | SU625600A3 (en) |
ZA (1) | ZA741711B (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES469020A1 (en) * | 1977-05-10 | 1979-09-01 | Kali Chemie Pharma Gmbh | N1-acyl-N2-phenyldiaminopropanols and pharmaceutical compositions thereof |
DE2720915C2 (en) * | 1977-05-10 | 1986-04-17 | Kali-Chemie Pharma Gmbh, 3000 Hannover | N? 1? -Acyl-2-hydroxy-1,3-diaminopropanes and drugs containing these compounds as an active ingredient |
EP1640359A3 (en) * | 1997-12-10 | 2006-04-05 | Nps Pharmaceuticals, Inc. | Anticonvulsant and central nervous system-active bis(fluorophenyl)alkylamides |
WO2004094793A1 (en) | 2003-04-24 | 2004-11-04 | Byd Company Limited | Muffler and catalytic converter devices |
-
1973
- 1973-03-15 GB GB1243073A patent/GB1436593A/en not_active Expired
-
1974
- 1974-03-08 CH CH332974A patent/CH583688A5/xx not_active IP Right Cessation
- 1974-03-08 AU AU66458/74A patent/AU503812B2/en not_active Expired
- 1974-03-11 AR AR252719A patent/AR213712A1/en active
- 1974-03-12 HU HUSI1384A patent/HU168559B/hu unknown
- 1974-03-12 DE DE2411885A patent/DE2411885A1/en not_active Withdrawn
- 1974-03-13 CA CA194,875A patent/CA1052788A/en not_active Expired
- 1974-03-13 ES ES424238A patent/ES424238A1/en not_active Expired
- 1974-03-14 BE BE142041A patent/BE812339A/en unknown
- 1974-03-14 IE IE542/74A patent/IE39166B1/en unknown
- 1974-03-14 FR FR7408610A patent/FR2221144B1/fr not_active Expired
- 1974-03-14 JP JP2957974A patent/JPS537406B2/ja not_active Expired
- 1974-03-14 SU SU742005426A patent/SU625600A3/en active
- 1974-03-15 NL NL747403543A patent/NL154496B/en unknown
- 1974-03-15 AT AT217874A patent/AT336579B/en not_active IP Right Cessation
- 1974-03-15 ZA ZA00741711A patent/ZA741711B/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU503812B2 (en) | 1979-09-20 |
AR213712A1 (en) | 1979-03-15 |
NL7403543A (en) | 1974-09-17 |
NL154496B (en) | 1977-09-15 |
GB1436593A (en) | 1976-05-19 |
SU625600A3 (en) | 1978-09-25 |
FR2221144A1 (en) | 1974-10-11 |
IE39166L (en) | 1974-09-15 |
JPS49134619A (en) | 1974-12-25 |
AT336579B (en) | 1977-05-10 |
ZA741711B (en) | 1975-04-30 |
ATA217874A (en) | 1976-09-15 |
JPS537406B2 (en) | 1978-03-17 |
CH583688A5 (en) | 1977-01-14 |
AU6645874A (en) | 1975-09-11 |
CA1052788A (en) | 1979-04-17 |
FR2221144B1 (en) | 1978-07-21 |
BE812339A (en) | 1974-09-16 |
ES424238A1 (en) | 1976-05-16 |
DE2411885A1 (en) | 1974-09-26 |
HU168559B (en) | 1976-05-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
GB1465229A (en) | Cyclic amino acids | |
IE821846L (en) | Carbamimidoyl-1-carbadethiapen-2-em-3 carboxylic acid | |
GB1180749A (en) | A New Polycyclic Amine and Processes for its Production | |
IE41528L (en) | Furfuryl-benzomorphane derivatives. | |
GR77296B (en) | ||
IE40511B1 (en) | N-(1-(-phenylalkyl)-piperidyl-j)-(-(-pyridyl)-carbonic acid amides | |
GB1358624A (en) | Phenylacetic acid derivatives process for their preparation and applications thereof | |
GB1398209A (en) | Chromone derivatives | |
IE39166B1 (en) | N-substituted acetamides processes for their preparation and pharmaceutical compositions containing them | |
GB1314830A (en) | Pharmaceutically useful benzomorphanes and their production | |
IE40825L (en) | Ortho alkoxyanilides,a process for their preparation and pharmaceutical compositions containing them | |
GB1314952A (en) | 3,4,5-trialkoxy-benzoic acid derivatives and their uses | |
US4163786A (en) | Thiazoloisoquinolines with coronary and respiratory effects | |
US3663711A (en) | Methods for producing gastrointestinal antisecretory action | |
IE38377L (en) | Maleopimarimide derivatives | |
JPS5555160A (en) | Preparation of substituted benzamide | |
GB1378419A (en) | Phenylalanine derivatives | |
GB1324687A (en) | 3-amino-delta2-pyrazoline derivatives and process for the preparation thereof | |
GB1425911A (en) | Phenylacetic acid derivatives, process for their preparation and therapeutic composition containing same | |
GB1179262A (en) | New Amides of Aliphatic Carboxylic Acids | |
GB1215812A (en) | Esters of penicillanic acids | |
GB1489724A (en) | Thiazole-5-methanol derivatives | |
GB1139985A (en) | Basically substituted 2-imidazolidone derivatives and their production | |
GB1464962A (en) | Acyl derivatives of antibiotic ws-4545 | |
GB1413255A (en) | Acyloxyalkylpyrrolidine derivatives |