ES424238A1 - N-substituted acetamides processes for their preparation and pharmaceutical compositions containing them apparatus for processing photograp - Google Patents

N-substituted acetamides processes for their preparation and pharmaceutical compositions containing them apparatus for processing photograp

Info

Publication number
ES424238A1
ES424238A1 ES424238A ES424238A ES424238A1 ES 424238 A1 ES424238 A1 ES 424238A1 ES 424238 A ES424238 A ES 424238A ES 424238 A ES424238 A ES 424238A ES 424238 A1 ES424238 A1 ES 424238A1
Authority
ES
Spain
Prior art keywords
radical
lower alcohol
organic acid
general formula
represents hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES424238A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Science Union et Cie
Original Assignee
Science Union et Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Science Union et Cie filed Critical Science Union et Cie
Publication of ES424238A1 publication Critical patent/ES424238A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/08—Preparation of carboxylic acids or their salts, halides or anhydrides from nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/38—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Procedure for obtaining new nitrogen-substituted acetamides, which respond to general formula I: ** (See formula) ** where R1 represents hydrogen or a lower alcohol radical, R2 and R3 represent simultaneously or separately a lower alcohol radical, a cycloalkoxy radical or an aryl radical, R6 represents hydrogen or a lower alcohol radical, R4 represents hydrogen, a lower alcohol radical, a lower alkenyl radical or a benzyl radical, R5 represents a lower alcohol radical, a lower alkenyl radical, a lower alkynyl radical or a lower alcohol aryl radical, or R4 and R5 together form with the adjacent nitrogen atom a heterocyclic radical having from 5 to 7 rings and may further include another heteroatom and/or be substituted by one or more lower alcohol radicals, and R'represents hydrogen or the acyl residue of an organic acid of 1 to 18 carbon atoms, characterized in that a diamino propanol-2 of general formula IV is condensed: ** (See formula) ** wherein the substitutes R4, R5, R6 and R'are defined as above, with a di- or tri-R acetic acid of general formula III: ** (See formula) ** wherein the substitutes R1, R2, and R3 are defined as above, or with one of their functional derivatives, to obtain an acetamide of general formula I that, if desired, can: a) salify by adding a mineral or organic acid, b) split by combination with an optically active organic acid, c) acylate when R'is hydrogen, with the help of a functional derivative of an organic acid of 1 to 18 carbon atoms, d) they must be cyclized by acidolysis or hydrogenolysis when R4 is a benzyl radical. (Machine-translation by Google Translate, not legally binding)
ES424238A 1973-03-15 1974-03-13 N-substituted acetamides processes for their preparation and pharmaceutical compositions containing them apparatus for processing photograp Expired ES424238A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1243073A GB1436593A (en) 1973-03-15 1973-03-15 N-substituted acetamides processes for their preparation and pharmaceutical compositions containing them apparatus for processing photograp

Publications (1)

Publication Number Publication Date
ES424238A1 true ES424238A1 (en) 1976-05-16

Family

ID=10004460

Family Applications (1)

Application Number Title Priority Date Filing Date
ES424238A Expired ES424238A1 (en) 1973-03-15 1974-03-13 N-substituted acetamides processes for their preparation and pharmaceutical compositions containing them apparatus for processing photograp

Country Status (16)

Country Link
JP (1) JPS537406B2 (en)
AR (1) AR213712A1 (en)
AT (1) AT336579B (en)
AU (1) AU503812B2 (en)
BE (1) BE812339A (en)
CA (1) CA1052788A (en)
CH (1) CH583688A5 (en)
DE (1) DE2411885A1 (en)
ES (1) ES424238A1 (en)
FR (1) FR2221144B1 (en)
GB (1) GB1436593A (en)
HU (1) HU168559B (en)
IE (1) IE39166B1 (en)
NL (1) NL154496B (en)
SU (1) SU625600A3 (en)
ZA (1) ZA741711B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES469020A1 (en) * 1977-05-10 1979-09-01 Kali Chemie Pharma Gmbh N1-acyl-N2-phenyldiaminopropanols and pharmaceutical compositions thereof
DE2720915C2 (en) * 1977-05-10 1986-04-17 Kali-Chemie Pharma Gmbh, 3000 Hannover N? 1? -Acyl-2-hydroxy-1,3-diaminopropanes and drugs containing these compounds as an active ingredient
EP1640359A3 (en) * 1997-12-10 2006-04-05 Nps Pharmaceuticals, Inc. Anticonvulsant and central nervous system-active bis(fluorophenyl)alkylamides
WO2004094793A1 (en) 2003-04-24 2004-11-04 Byd Company Limited Muffler and catalytic converter devices

Also Published As

Publication number Publication date
AU503812B2 (en) 1979-09-20
AR213712A1 (en) 1979-03-15
NL7403543A (en) 1974-09-17
IE39166B1 (en) 1978-08-16
NL154496B (en) 1977-09-15
GB1436593A (en) 1976-05-19
SU625600A3 (en) 1978-09-25
FR2221144A1 (en) 1974-10-11
IE39166L (en) 1974-09-15
JPS49134619A (en) 1974-12-25
AT336579B (en) 1977-05-10
ZA741711B (en) 1975-04-30
ATA217874A (en) 1976-09-15
JPS537406B2 (en) 1978-03-17
CH583688A5 (en) 1977-01-14
AU6645874A (en) 1975-09-11
CA1052788A (en) 1979-04-17
FR2221144B1 (en) 1978-07-21
BE812339A (en) 1974-09-16
DE2411885A1 (en) 1974-09-26
HU168559B (en) 1976-05-28

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