IE38886L - Quinoline-3-carboxamidotetrazole derivatives - Google Patents
Quinoline-3-carboxamidotetrazole derivativesInfo
- Publication number
- IE38886L IE38886L IE740249A IE24974A IE38886L IE 38886 L IE38886 L IE 38886L IE 740249 A IE740249 A IE 740249A IE 24974 A IE24974 A IE 24974A IE 38886 L IE38886 L IE 38886L
- Authority
- IE
- Ireland
- Prior art keywords
- alkyl group
- hydrogen atom
- group
- compounds
- hydroxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
1433774 Tetrazole-derived amides ALLEN & HANBURYS 6 Feb 1974 [26 Feb 1973] 9249/73 Heading C2C The invention comprises compounds of formula their 4-oxyquinoline tautomers (when R 4 =H) and pharmaceutically acceptable salts and esters thereof, in which : R 1 and R 2 which may be the same or different represent a hydrogen atom, a halogen atom, or an alkyl, trifluoromethyl or nitro group, or a group OR 3 in which R 3 represents a hydrogen atom, or an alkenyl or alkyl group, which alkyl group may be substituted by alkoxy, aryl, amino, alkylamino, dialkylamino, hydroxy or acyloxy groups; or a group NR 6 R 7 in which R 6 and R 7 which may be the same or different represent a hydrogen atom or an alkyl group, which alkyl group may be substituted with a hydroxy or acyloxy group, or in which R 6 and R 7 together with the nitrogen atom form a 5- or 6-membered ring which may contain additional hetero atoms; R 4 represents a hydrogen atom, an alkenyl or alkyl group, which alkyl group may be substituted with hydroxy, acyloxy, alkoxy, aryl, amino, alkylamino, dialkylamino or alkylaralkylamino groups; and R 5 represents a hydrogen atom or an alkyl group. In examples, these compounds are prepared by reacting the corresponding quinolonecarboxylic acid (A) (or a functional derivative thereof such as the acid chloride or the mixed anhydride with EtOCO 2 H) with 5-aminotetrazole and by the interconversion of functional groups in compounds thus prepared; the acids (A) are made by hydrolysing the corresponding esters. Therapeutic compositions for treating conditions primarily caused by antigen/reaginic antibody combination comprise compounds of the above formula, and may be administered orally or by inhalation.
[GB1433774A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB924973A GB1433774A (en) | 1973-02-26 | 1973-02-26 | Heterocyclic compounds apparatus for conveying articles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE38886L true IE38886L (en) | 1974-08-26 |
| IE38886B1 IE38886B1 (en) | 1978-06-21 |
Family
ID=9868317
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE00249/74A IE38886B1 (en) | 1973-02-26 | 1974-02-08 | Heterocyclic compounds |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS5029574A (en) |
| AT (1) | AT329562B (en) |
| AU (1) | AU474797B2 (en) |
| BE (1) | BE811246A (en) |
| CA (1) | CA1025856A (en) |
| CH (1) | CH602707A5 (en) |
| DE (1) | DE2407744A1 (en) |
| FR (1) | FR2218896B1 (en) |
| GB (1) | GB1433774A (en) |
| IE (1) | IE38886B1 (en) |
| LU (1) | LU69479A1 (en) |
| NL (1) | NL7402613A (en) |
| SE (1) | SE7401984L (en) |
| ZA (1) | ZA74883B (en) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2324304A2 (en) * | 1975-09-22 | 1977-04-15 | Roussel Uclaf | Analgesic (4)-hydroxy-quinoline-(3)-amides - prepd. from a quinoline-(3)-carboxyl chloride and an amine |
| US4186201A (en) | 1977-02-07 | 1980-01-29 | Riker Laboratories, Inc. | Methods of using 8(tetrazol-5-ylcarbamoyl)isoquinoline compounds |
| US4390541A (en) | 1980-12-19 | 1983-06-28 | Lilly Industries Limited | Quinolone derivatives and their use in a method of controlling an immediate hypersensitivity disease |
| FR2509728A1 (en) * | 1981-07-17 | 1983-01-21 | Roussel Uclaf | NOVEL QUINOLINE DERIVATIVES, THEIR SALTS, PREPARATION METHOD, MEDICAMENT APPLICATION AND COMPOSITIONS COMPRISING THE SAME |
| US4377579A (en) | 1981-12-03 | 1983-03-22 | Minnesota Mining And Manufacturing Company | N-(Tetrazol-5-yl)phenazine-1-carboxamides |
| FR2537140B1 (en) * | 1982-12-07 | 1986-07-18 | Roussel Uclaf | NOVEL 4-HYDROXY-3-QUINOLEINE CARBOXAMIDE DERIVATIVES, SALTS THEREOF, PROCESS FOR THEIR PREPARATION, APPLICATION AS MEDICAMENTS, AND COMPOSITIONS CONTAINING THEM |
| US4965266A (en) * | 1987-01-20 | 1990-10-23 | Dainippon Pharmaceutical Co., Ltd. | Heteroarylcarboxamide derivatives, process for preparing the same and pharmaceutical composition containing the same |
| US4959363A (en) * | 1989-06-23 | 1990-09-25 | Sterling Drug Inc. | Quinolonecarboxamide compounds, their preparation and use as antivirals. |
| US6034100A (en) * | 1993-03-10 | 2000-03-07 | Otsuka Pharmaceutical Co., Ltd. | Method for inhibiting cytokine secretion |
| US6143760A (en) * | 1997-08-25 | 2000-11-07 | Neurogen Corporation | Substituted 4-oxo-napthyridine-3-carboxamides: GABA brain receptor ligands |
| HUP0003258A3 (en) * | 1997-08-25 | 2001-05-28 | Neurogen Corp Branford | Substituted 4-oxo-napthyridine-3-carboxamides as gaba brain receptor ligands |
| US6194427B1 (en) | 1998-02-26 | 2001-02-27 | Neurogen Corporation | Substituted cycloalkyl-4-Oxonicotinic carboxamides; gaba brain receptor ligands |
| US20100074949A1 (en) | 2008-08-13 | 2010-03-25 | William Rowe | Pharmaceutical composition and administration thereof |
| WO2003097564A2 (en) * | 2002-05-14 | 2003-11-27 | The Regents Of The University Of California | Substituted quinolone carboxylic acids, their derivatives, site of action, and uses thereof |
| EP1650192A4 (en) | 2003-07-24 | 2007-03-21 | Astellas Pharma Inc | Quinolone derivative or salt thereof |
| NZ587551A (en) | 2004-06-24 | 2012-01-12 | Vertex Pharma | 5-Amino-phenol derivatives such as 5-amino-2,4-di-tert-butyl-phenol |
| RU2556984C2 (en) * | 2004-06-24 | 2015-07-20 | Вертекс Фармасьютикалз Инкорпорейтед | Modulators of atp-binding cassette transporters |
| SI2502911T1 (en) * | 2004-06-24 | 2017-07-31 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
| US8354427B2 (en) | 2004-06-24 | 2013-01-15 | Vertex Pharmaceutical Incorporated | Modulators of ATP-binding cassette transporters |
| SI3219705T1 (en) | 2005-12-28 | 2020-08-31 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions of the amorphous form of n-(2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl)-1,4-dihydro-4-oxoquinoline-3-carboxamide |
| RU2543714C2 (en) | 2009-03-20 | 2015-03-10 | Вертекс Фармасьютикалз Инкорпорейтед | Method of obtaining modulators of cystic fibrousis transmembrane conductance regulator |
| US8802700B2 (en) | 2010-12-10 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-Binding Cassette transporters |
| BR112014021090B1 (en) | 2012-02-27 | 2023-01-24 | Vertex Pharmaceuticals Incorporated | PHARMACEUTICAL COMPOSITION AND USE OF N-[2,4-BIS(1,1-DIMETHYLethyl)-5-HYDROXYPHENYL]-1,4-DIHYDRO-4-OXOQUINOLINE3-CARBOXAMIDE IN THE PREPARATION OF THE SAME |
| JP6211509B2 (en) | 2012-03-02 | 2017-10-11 | 武田薬品工業株式会社 | Heterocyclic compounds and uses thereof |
| JP6211530B2 (en) | 2012-11-19 | 2017-10-11 | 武田薬品工業株式会社 | Nitrogen-containing heterocyclic compounds |
| RU2749213C2 (en) | 2014-10-07 | 2021-06-07 | Вертекс Фармасьютикалз Инкорпорейтед | Co-crystals of transmembrane conduction regulator modulators in cystic fibrosis |
| CN105330602B (en) * | 2015-12-07 | 2018-02-09 | 江南大学 | A kind of deccox analog and its application |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1383088A (en) * | 1972-07-03 | 1975-02-05 | Allen & Hanburys Ltd | Pharmacologically active quinaldamide derivatives |
-
1973
- 1973-02-26 GB GB924973A patent/GB1433774A/en not_active Expired
-
1974
- 1974-02-08 IE IE00249/74A patent/IE38886B1/en unknown
- 1974-02-11 ZA ZA740883A patent/ZA74883B/en unknown
- 1974-02-14 AU AU65592/74A patent/AU474797B2/en not_active Expired
- 1974-02-14 SE SE7401984A patent/SE7401984L/xx unknown
- 1974-02-18 DE DE19742407744 patent/DE2407744A1/en active Pending
- 1974-02-18 CH CH224374A patent/CH602707A5/xx not_active IP Right Cessation
- 1974-02-19 BE BE141102A patent/BE811246A/en unknown
- 1974-02-22 LU LU69479A patent/LU69479A1/xx unknown
- 1974-02-25 AT AT149974A patent/AT329562B/en not_active IP Right Cessation
- 1974-02-25 JP JP49022232A patent/JPS5029574A/ja active Pending
- 1974-02-25 FR FR7406327A patent/FR2218896B1/fr not_active Expired
- 1974-02-26 CA CA193,476A patent/CA1025856A/en not_active Expired
- 1974-02-26 NL NL7402613A patent/NL7402613A/xx not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ZA74883B (en) | 1974-12-24 |
| DE2407744A1 (en) | 1974-08-29 |
| CA1025856A (en) | 1978-02-07 |
| CH602707A5 (en) | 1978-07-31 |
| FR2218896A1 (en) | 1974-09-20 |
| SE7401984L (en) | 1974-08-27 |
| AU474797B2 (en) | 1976-08-05 |
| BE811246A (en) | 1974-08-19 |
| IE38886B1 (en) | 1978-06-21 |
| AU6559274A (en) | 1975-08-14 |
| ATA149974A (en) | 1975-08-15 |
| GB1433774A (en) | 1976-04-28 |
| AT329562B (en) | 1976-05-25 |
| NL7402613A (en) | 1974-08-28 |
| FR2218896B1 (en) | 1977-09-09 |
| LU69479A1 (en) | 1975-05-21 |
| JPS5029574A (en) | 1975-03-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IE38886L (en) | Quinoline-3-carboxamidotetrazole derivatives | |
| IE37519B1 (en) | Novel amino derivatives of quinoxaline and quinazoline | |
| NO163956C (en) | ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE (4-PIPERIDINYLMETHYL-HETERO) PURINES. | |
| DE3777505D1 (en) | 4-AMINOQUINOLINE DERIVATIVES AND THEIR USE AS MEDICINAL PRODUCTS. | |
| NO903438L (en) | PROCEDURE FOR THE PREPARATION OF TIAZOLD DERIVATIVES. | |
| FI900085A (en) | Process for Preparing Therapeutically Useful N- (Pyrimidine and Condensed Pyrimidin-4-One) Ethyl-Piperidine and Piperinated Zine Derivatives | |
| DE69428142D1 (en) | Quinoline or quinazoline derivatives, their preparation and use | |
| IE37795L (en) | Quinaldamide derivatives | |
| IE812683L (en) | Thieno-pyridine derivatives | |
| IE33850L (en) | Pyridoindole derivatives. | |
| GB1312391A (en) | Basically substituted 4 3h- quinazolinone derivatives and process for their manufacture | |
| GB1530413A (en) | 5,8-dihydro-5-oxopyrido(2,3-d)pyrimidines | |
| GB1398687A (en) | Substituted oxazolidinones and pharmaceutical uses thereof | |
| GB1254270A (en) | Benzoxazepine derivatives | |
| GB1469197A (en) | Preparation of 1-aminoalkyl triazolobenzodiazepines | |
| HUT45059A (en) | Process for producing abeoergoline derivatives | |
| JPS55129268A (en) | Carbostyril derivative | |
| GB1413407A (en) | Dihydropyrido-pyrimidine derivatives their preparation and therapeutical use | |
| AU564739B2 (en) | Acridanone derivatives | |
| GB1422831A (en) | Acylaminobenzimidazole derivatives | |
| JPS5273875A (en) | Synthesis of carbostyril-carboxylic acid derivatives | |
| GB1453427A (en) | 4-oxo-1,2,3,4-tetrahydropyrido-2,3-d-pyrimidines |