IE37271B1 - Phenoxypropylamine derivatives and the preparation thereo - Google Patents
Phenoxypropylamine derivatives and the preparation thereoInfo
- Publication number
- IE37271B1 IE37271B1 IE198/73A IE19873A IE37271B1 IE 37271 B1 IE37271 B1 IE 37271B1 IE 198/73 A IE198/73 A IE 198/73A IE 19873 A IE19873 A IE 19873A IE 37271 B1 IE37271 B1 IE 37271B1
- Authority
- IE
- Ireland
- Prior art keywords
- alkyl
- urea
- compounds
- formula
- hydroxyalkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
1397663 Urea derivatives CHEMIE LINZ AG 5 Feb 1973 [28 Feb 1972] 5681/73 Heading C2C The invention comprises urea derivatives of the formula wherein X is C 1-4 alkylene; R 1 is H or C 1-6 alkyl; R 2 is H, C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 1-6 hydroxyalkyl, alkoxy-C 1-6 alkyl, C 1-6 aminoalkyl, aliphatic carboxylic acylamino- C 1-6 alkyl, cyano-C 1-6 alkyl, C 1-6 alkylamino- C 1-6 alkyl, di-(C 1-6 alkyl)amino-C 1-6 alkyl aryl or aralkyl; R 3 C 1-6 alkyl, C 2-6 alkenyl, C 1-6 alkoxy, C 2-6 alkenyloxy, halogen, aliphatic carboxylic acyl, benzoyl, CN, NO 2 , NH 2 or aliphatic carboxylic acylamino ; R 4 is a branched chain alkyl, a hydroxalkyl or cycloalkyl group containing up to 6 carbon atoms and n is 0 or 1 and pharmaceutically acceptable acid addition salts thereof and their preparation. The compounds are prepared by reacting compounds of the formula wherein Y is oxiranyl or -CH(OH)CH 2 -Hal, in which Hal is Cl, Br or I or mixtures of such compounds with ammonia or amines of the formula H 2 N-R 5 wherein R 5 is H or the group R 4 , and when R 5 is H reacting the resulting products with carbonyl compound of the formula O = CR 6 R 7 in which R 6 is H and R 7 is C 1-4 hydroxyalkyl or R 6 is CH 3 or CH 3 CH 2 and R 7 is C 1-4 alkyl or C 1-4 hydroxyalkyl, the sum of the number of carbon atoms in R 6 and R 7 not exceeding 5, or R 6 and R 7 taken together may form C 1-5 alkylene and reducing the resulting products. N - {4 - [(2,3 - epoxy)propoxy]benzyl}urea and N - {3 - methoxy - 4 - [(3 - chloro - 2 - hydroxypropoxy]benzyl}-urea are obtained by reacting epichlorohydrin with the sodium salt of N-[3- hydroxybenzyl]urea and N-[3-methoxy-4-hydroxybenzyl]urea respectively. Pharmaceutical compositions suitable for oral or parenteral administration, contain the above novel compounds or pharmaceutically acceptable acid addition salts thereof in admixture with excipients. The compounds possess #- receptor-blocking properties.
[GB1397663A]
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT157372A AT321315B (en) | 1972-02-28 | 1972-02-28 | Process for the preparation of new ureidophenoxypropylamine derivatives and their salts |
Publications (2)
Publication Number | Publication Date |
---|---|
IE37271L IE37271L (en) | 1973-08-28 |
IE37271B1 true IE37271B1 (en) | 1977-06-08 |
Family
ID=3516334
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IE198/73A IE37271B1 (en) | 1972-02-28 | 1973-02-08 | Phenoxypropylamine derivatives and the preparation thereo |
Country Status (21)
Country | Link |
---|---|
JP (1) | JPS5626654B2 (en) |
AT (1) | AT321315B (en) |
BE (1) | BE796029A (en) |
CH (1) | CH577956A5 (en) |
CS (1) | CS168625B2 (en) |
DD (1) | DD105214A1 (en) |
DE (1) | DE2264182C3 (en) |
DK (1) | DK136185B (en) |
ES (1) | ES412061A1 (en) |
FI (1) | FI59582C (en) |
FR (1) | FR2173990B1 (en) |
GB (1) | GB1397663A (en) |
HU (1) | HU165235B (en) |
IE (1) | IE37271B1 (en) |
LU (1) | LU66869A1 (en) |
NL (1) | NL7300688A (en) |
PL (1) | PL82613B1 (en) |
RO (1) | RO62862A (en) |
SU (1) | SU530639A3 (en) |
YU (1) | YU36158B (en) |
ZA (1) | ZA73949B (en) |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1149819A (en) * | 1970-01-08 | 1983-07-12 | Max Wilhelm | Process for the manufacture of new amines |
-
1972
- 1972-02-28 AT AT157372A patent/AT321315B/en not_active IP Right Cessation
- 1972-12-29 PL PL1972159973A patent/PL82613B1/pl unknown
- 1972-12-29 DE DE2264182A patent/DE2264182C3/en not_active Expired
-
1973
- 1973-01-10 FI FI60/73A patent/FI59582C/en active
- 1973-01-17 NL NL7300688A patent/NL7300688A/xx not_active Application Discontinuation
- 1973-01-17 RO RO7300073527A patent/RO62862A/en unknown
- 1973-01-17 CS CS388A patent/CS168625B2/cs unknown
- 1973-01-19 LU LU66869A patent/LU66869A1/xx unknown
- 1973-02-02 YU YU260/73A patent/YU36158B/en unknown
- 1973-02-05 GB GB568173A patent/GB1397663A/en not_active Expired
- 1973-02-05 SU SU1879539A patent/SU530639A3/en active
- 1973-02-05 FR FR7303913A patent/FR2173990B1/fr not_active Expired
- 1973-02-06 DK DK60373AA patent/DK136185B/en unknown
- 1973-02-08 IE IE198/73A patent/IE37271B1/en unknown
- 1973-02-09 ZA ZA730949A patent/ZA73949B/en unknown
- 1973-02-13 HU HUOE189A patent/HU165235B/hu unknown
- 1973-02-26 DD DD169049A patent/DD105214A1/xx unknown
- 1973-02-26 CH CH275373A patent/CH577956A5/xx not_active IP Right Cessation
- 1973-02-26 JP JP2229773A patent/JPS5626654B2/ja not_active Expired
- 1973-02-26 ES ES73412061A patent/ES412061A1/en not_active Expired
- 1973-02-27 BE BE128160A patent/BE796029A/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
YU26073A (en) | 1981-06-30 |
JPS4897838A (en) | 1973-12-13 |
PL82613B1 (en) | 1975-10-31 |
JPS5626654B2 (en) | 1981-06-19 |
CS168625B2 (en) | 1976-06-29 |
FR2173990B1 (en) | 1976-09-03 |
BE796029A (en) | 1973-08-27 |
YU36158B (en) | 1982-02-25 |
ZA73949B (en) | 1973-11-28 |
DK136185B (en) | 1977-08-29 |
DE2264182B2 (en) | 1981-06-25 |
ES412061A1 (en) | 1976-01-01 |
FR2173990A1 (en) | 1973-10-12 |
RO62862A (en) | 1978-02-15 |
FI59582C (en) | 1981-09-10 |
GB1397663A (en) | 1975-06-18 |
FI59582B (en) | 1981-05-29 |
IE37271L (en) | 1973-08-28 |
LU66869A1 (en) | 1973-03-19 |
DK136185C (en) | 1978-02-13 |
SU530639A3 (en) | 1976-09-30 |
DE2264182A1 (en) | 1973-12-20 |
AU5205273A (en) | 1974-08-15 |
NL7300688A (en) | 1973-08-30 |
AT321315B (en) | 1975-03-25 |
HU165235B (en) | 1974-07-27 |
DD105214A1 (en) | 1974-04-12 |
CH577956A5 (en) | 1976-07-30 |
DE2264182C3 (en) | 1982-03-18 |
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