IE35817B1 - Novel biologically active imidazoles - Google Patents
Novel biologically active imidazolesInfo
- Publication number
- IE35817B1 IE35817B1 IE1448/71A IE144871A IE35817B1 IE 35817 B1 IE35817 B1 IE 35817B1 IE 1448/71 A IE1448/71 A IE 1448/71A IE 144871 A IE144871 A IE 144871A IE 35817 B1 IE35817 B1 IE 35817B1
- Authority
- IE
- Ireland
- Prior art keywords
- group
- optionally substituted
- general formula
- amino
- acid addition
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/52—Nitrogen atoms not forming part of a nitro radical with hetero atoms directly attached to said nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1373346 Imidazoles BEECHAM GROUP Ltd 6 Dec 1971 [9 Dec 1970] 58385/70 Heading C2C Novel imidazoles of the general formula and tautomers thereof, wherein R 1 is a carbocyclic or heterocyclic aromatic group optionally substituted by one or two halogen atoms, optionally substituted hydroxyl, amino, thiol, sulphonic or carboxylic groups, or cyano, nitro, acyl, alkyl, aryl or haloalkyl groups; R 2 is an amino or hydroxyl group or an alkoxy, aryloxy or aralkoxy group optionally substituted by a halogen atom or optionally substituted hydroxyl or amino groups; R 4 is a hydrogen atom or a methyl group; R 5 is a methyl or #-haloethyl group and R 6 is a hydrogen atom or a hydrocarbon group optionally substituted by a halogen atom or an optionally substituted hydroxyl or tertiary amino group; and acid addition salts, solvates and solvated acid addition salts thereof are prepared by reaction of the corresponding diazonium salt of the general formula wherein R<SP>1</SP> 4 is a negative charge or a methyl group (an external anion being present) with an amine of the general formula HNR 5 R 6 ; followed optionally by modification or replacement of substituents R 1 and R 2 to form other substituents R 1 and R 2 by means known per se and/or by salification and/or solvation of the product. Diazonium salts of the second general formula above are prepared by diazotization of the corresponding amine with nitrous acid. 5-Amino-4-carbethoxy-2-phenylimidazole (hydrochloride) is prepared by reaction of α-iminobenzylbenzyl thioetherhydrocyloride with ethyl aminocyanoacetate. Pharmaceutical compositions having bactericidal, antifungal and anti-tumour activity comprise, as active ingredient, an imidazole of the first general formula above or an acid addition salt, solvate or solvated acid addition salt thereof, together with at least one pharmaceutically acceptable carrier, diluent or excipient.
[GB1373346A]
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB5838570A GB1373346A (en) | 1970-12-09 | 1970-12-09 | Biologically active imidazoles |
Publications (2)
Publication Number | Publication Date |
---|---|
IE35817L IE35817L (en) | 1972-06-09 |
IE35817B1 true IE35817B1 (en) | 1976-05-26 |
Family
ID=10481482
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IE1448/71A IE35817B1 (en) | 1970-12-09 | 1971-11-17 | Novel biologically active imidazoles |
Country Status (13)
Country | Link |
---|---|
AT (1) | AT310740B (en) |
BE (1) | BE776422A (en) |
CA (1) | CA979428A (en) |
DE (1) | DE2161209A1 (en) |
ES (1) | ES397573A1 (en) |
FR (1) | FR2117939B1 (en) |
GB (1) | GB1373346A (en) |
HU (1) | HU163484B (en) |
IE (1) | IE35817B1 (en) |
IL (1) | IL38174A0 (en) |
NL (1) | NL7116331A (en) |
SE (1) | SE7412430L (en) |
ZA (1) | ZA717873B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2019113227A1 (en) * | 2017-12-06 | 2019-06-13 | Yale University | Prodrugs activated by reduction in the cytosol |
-
1970
- 1970-12-09 GB GB5838570A patent/GB1373346A/en not_active Expired
-
1971
- 1971-11-17 IE IE1448/71A patent/IE35817B1/en unknown
- 1971-11-18 IL IL38174A patent/IL38174A0/en unknown
- 1971-11-23 ZA ZA717873A patent/ZA717873B/en unknown
- 1971-11-26 CA CA128,705A patent/CA979428A/en not_active Expired
- 1971-11-26 NL NL7116331A patent/NL7116331A/xx unknown
- 1971-12-01 ES ES397573A patent/ES397573A1/en not_active Expired
- 1971-12-03 AT AT1042171A patent/AT310740B/en not_active IP Right Cessation
- 1971-12-08 FR FR7144014A patent/FR2117939B1/fr not_active Expired
- 1971-12-08 BE BE776422A patent/BE776422A/en unknown
- 1971-12-09 DE DE19712161209 patent/DE2161209A1/en active Pending
- 1971-12-09 HU HUBE1108A patent/HU163484B/hu unknown
-
1974
- 1974-10-02 SE SE7412430A patent/SE7412430L/xx not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
GB1373346A (en) | 1974-11-13 |
ES397573A1 (en) | 1975-10-01 |
AU3658871A (en) | 1973-06-14 |
AT310740B (en) | 1973-10-10 |
IE35817L (en) | 1972-06-09 |
FR2117939B1 (en) | 1975-06-13 |
ZA717873B (en) | 1972-08-30 |
SE7412430L (en) | 1974-10-02 |
BE776422A (en) | 1972-06-08 |
IL38174A0 (en) | 1972-01-27 |
HU163484B (en) | 1973-09-27 |
DE2161209A1 (en) | 1972-06-22 |
CA979428A (en) | 1975-12-09 |
FR2117939A1 (en) | 1972-07-28 |
NL7116331A (en) | 1972-06-13 |
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