IE34545B1 - Amino-alcohols,their salts and process for preparing the same - Google Patents

Amino-alcohols,their salts and process for preparing the same

Info

Publication number
IE34545B1
IE34545B1 IE1225/70A IE122570A IE34545B1 IE 34545 B1 IE34545 B1 IE 34545B1 IE 1225/70 A IE1225/70 A IE 1225/70A IE 122570 A IE122570 A IE 122570A IE 34545 B1 IE34545 B1 IE 34545B1
Authority
IE
Ireland
Prior art keywords
alkyl
straight
branched chain
same
different
Prior art date
Application number
IE1225/70A
Other versions
IE34545L (en
Original Assignee
Continental Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Continental Pharma filed Critical Continental Pharma
Publication of IE34545L publication Critical patent/IE34545L/en
Publication of IE34545B1 publication Critical patent/IE34545B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/34—Compounds containing oxirane rings with hydrocarbon radicals, substituted by sulphur, selenium or tellurium atoms

Abstract

1-Subst-phenyl-2-amino-ethanols useful as beta adrenergic agents peripheral vasodilators and hypotensive agents M3A. Are new compounds of formula (I):- R7-CHOH.CHR4NR5R6 (I) where R7= and R1=RS, RSO, RSO2, RO, RSe or RSeO2, R=H, straight or branched chain alkyl (pref. 1-8C), alkenyl, alkynyl or acetyl; R2 and R3 are same or different alkyl, halogen, NH2, NO2, COOH, COO Alkyl, alkyl NH, acyl NH or CF3, one of R2 and R3 may be H and R2 and R3 may also be alkoxy or alkylthio in so far as this group is different from R1; R4=H or straight or branched chain alkyl (pref. 1-4C), R5 and R6 are same or different H, straight or branched chain opt. substd. alkyl, cycloalkyl, alkenyl, alkynyl, piperidino, pyridino, or pyrimidino or R5 and R6 together with the adjacent N atom may form an opt. substd. heterocyclic ring), including their salts. They are prepared by (a) reduction of R7COCHR7NR8R6; (b) REACTION OF R7-Z where Z is -CH -CH -R4 or CHOHCHR7x (where X is halogen) with R5R6NH; (c) by reductive amination of R7COCOR4; (d) by alkylin or reductive alkyln of R7CHOH-CHR4.NH2 and (e) by reductive alkyln. of R7COC(R4)=NOH. [FR2070102A1]
IE1225/70A 1969-10-01 1970-09-22 Amino-alcohols,their salts and process for preparing the same IE34545B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
BE79767 1969-10-01
BE93537 1970-09-03

Publications (2)

Publication Number Publication Date
IE34545L IE34545L (en) 1971-04-01
IE34545B1 true IE34545B1 (en) 1975-06-11

Family

ID=25647478

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1225/70A IE34545B1 (en) 1969-10-01 1970-09-22 Amino-alcohols,their salts and process for preparing the same

Country Status (17)

Country Link
JP (1) JPS541693B1 (en)
AR (1) AR194457A1 (en)
AT (1) AT323135B (en)
CA (1) CA953723A (en)
CH (1) CH542177A (en)
CS (1) CS191158B2 (en)
DK (1) DK147853C (en)
FI (1) FI52714C (en)
FR (1) FR2070102A1 (en)
HU (1) HU167354B (en)
IE (1) IE34545B1 (en)
NL (1) NL156688B (en)
NO (1) NO132865C (en)
OA (1) OA03659A (en)
SE (1) SE384855B (en)
SU (1) SU578860A3 (en)
YU (1) YU35580B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1386028A (en) * 1972-03-20 1975-03-05 Smithkline Corp Alpha-aminoalkyl-4-hydroxy-3-alkylsulphonylmethylbenzyl alcohols
DE2862340D1 (en) * 1978-02-01 1983-11-24 Wellcome Found Imidazole derivatives and salts thereof, their synthesis, and pharmaceutical formulations thereof
GB2067187B (en) * 1979-12-07 1983-11-30 Cosmos Enterprise Process for the preparation of 1-(4-hydroxyphenyl)-2-(4-benzylpiperidino)-1-propanol and acid addition salts thereof
FR2503705A1 (en) * 1981-04-14 1982-10-15 Synthelabo PHENETHANOLAMINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
FR2508445A1 (en) * 1981-06-29 1982-12-31 Sori Soc Rech Ind NOVEL BENZOYL-PHENYL-PIPERIDINE DERIVATIVES, PROCESS FOR PREPARING THEM AND THEIR USE, IN PARTICULAR THERAPEUTICS
FR2534580A1 (en) * 1982-10-13 1984-04-20 Synthelabo PHENYL-1 PIPERIDINO-2 PROPANOL DERIVATIVES, THEIR PREPARATION, AND MEDICINES THAT CONTAIN THEM
FR2537132B1 (en) * 1982-12-06 1987-01-09 Lafon Labor NOVEL SULFUR DERIVATIVES OF 2-AMINO-1-PHENYL-1-ETHANOL, USE IN THERAPEUTICS AND METHOD OF PREPARATION
US5101065A (en) * 1991-02-04 1992-03-31 Imperial Chemical Industries Plc Acetophenone intermediates
FR2741067B1 (en) * 1995-11-10 1997-12-26 Rhone Poulenc Chimie PROCESS FOR ACYLATION OF AN AROMATIC THIOETHER
FR2757160B1 (en) * 1996-12-13 1999-03-12 Sanofi Sa 1-PHENYLALKYL-1,2,3,6-TETRAHYDROPYRIDINES
GB201714736D0 (en) * 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714734D0 (en) * 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1503517A (en) * 1965-04-22 1967-12-01 Bayer Ag Manufacturing process of d - (-) - n-alkyl-1-phenyl-2-aminoethanols

Also Published As

Publication number Publication date
NO132865C (en) 1976-01-21
DK147853C (en) 1986-05-20
CS191158B2 (en) 1979-06-29
OA03659A (en) 1971-12-24
FI52714C (en) 1977-11-10
NL156688B (en) 1978-05-16
SE384855B (en) 1976-05-24
FI52714B (en) 1977-08-01
DK147853B (en) 1984-12-24
FR2070102B1 (en) 1974-08-23
IE34545L (en) 1971-04-01
AT323135B (en) 1975-06-25
AR194457A1 (en) 1973-07-23
CH542177A (en) 1973-09-30
NL7014444A (en) 1971-04-05
CA953723A (en) 1974-08-27
JPS541693B1 (en) 1979-01-27
FR2070102A1 (en) 1971-09-10
YU238570A (en) 1980-09-25
HU167354B (en) 1975-09-27
SU578860A3 (en) 1977-10-30
NO132865B (en) 1975-10-13
YU35580B (en) 1981-04-30

Similar Documents

Publication Publication Date Title
IE34545B1 (en) Amino-alcohols,their salts and process for preparing the same
IE44280L (en) 2,3-DIHYDRO-IMIDAZO [2,1-b] THIAZOLES HAVING ANALGESIC AND¹ANTI-INFLAMMATORY ACTIVITY
ATE116964T1 (en) SUBSTITUTED AMINOALKYLBIPHENYL DERIVATIVES, ANTIFUNGAL PREPARATIONS THEREOF AND INTERMEDIATE PRODUCTS FOR THEIR PRODUCTION.
ATE212027T1 (en) CEPHEM DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF
ES387016A1 (en) Isoquinoline derivatives
BG40148A3 (en) Method for preparing heterocyclic compound
DE3867073D1 (en) ALLYLMERCAPTOACETYL SYDNONIMINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE.
IE791655L (en) Protecting crops
DE3870730D1 (en) POLYALKYLENE GLYCOL-NAPHTHYL-3-SULFOPROPYL-DIETHER AND ITS SALTS, METHOD FOR THE PRODUCTION OF THESE COMPOUNDS AND THEIR USE AS A WETTING AGENT IN GALVANOTECHNIK.
AR019661A1 (en) PROCEDURE FOR THE MANUFACTURE OF PIRIDINE-2,3-DICARBOXYLATE COMPOUNDS AND COMPOUND FOR EXCLUSIVE USE IN THIS PROCEDURE
ES419103A1 (en) Tetrasubstituted urea compounds and herbicidal compositions
HU172537B (en) Process for preparing new alkanolamine derivatives
ATE15796T1 (en) BENZHYDRYLSULFINYLETHYLAMINE, PROCESS FOR THEIR PREPARATION AND USE IN THERAPEUTICS.
JPS5253897A (en) Process for preparing, n6-etheno-2-subtituted-thio-adenosine-2', 5'pho sphates
ES419386A1 (en) Indenopyrrole derivatives
JPS549294A (en) 7alpha-methoxycephalosporins and process for their preparation
ES435969A1 (en) Indolobenzazepine derivatives
DE2964836D1 (en) Phthalide-isoquinoline derivatives, their preparation and their use in medicaments
BE810117A (en) N-(2-aroyl-phenyl)-2-alkylamino-imidazoles - as protecting agents for cerebral agents for cerebral anoxia and hypoxia and cerebral blood circulatory activators
JPS51143650A (en) A process for preparing cyclohexanol derivatives
GB1456525A (en) Process for the manufacture of alkanolamine derivatives
ES8101609A1 (en) A 7 alpha -methoxycephalosporin derivative and process for producing the same
ES8306368A1 (en) 1,2,3-Thiadiazole-5-yl-urea derivatives, agents containing these compounds with plant growth regulating and defoliating activity
ES8705433A1 (en) Piperazine derivatives, process for their preparation and their use.
TH797EX (en) Process for preparing Pirimidone derivatives