IE32639B1 - Indole derivatives and a process for the production thereof - Google Patents
Indole derivatives and a process for the production thereofInfo
- Publication number
- IE32639B1 IE32639B1 IE156/69A IE15669A IE32639B1 IE 32639 B1 IE32639 B1 IE 32639B1 IE 156/69 A IE156/69 A IE 156/69A IE 15669 A IE15669 A IE 15669A IE 32639 B1 IE32639 B1 IE 32639B1
- Authority
- IE
- Ireland
- Prior art keywords
- compounds
- laevorotatory
- possibly
- substituted
- methyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1,251,716. Indole-derived hydroxyamines. SANDOZ Ltd. 13 Jan., 1969 [9 Feb., 1968], No. 1853/69. Addition to 1,138,968. Heading C2C. The invention comprises laevorotatory compounds of formula wherein one of R 1 , R 2 is H or CH 3 and the other is CH 3 , and their acid addition salts. These compounds are prepared by reacting 4-hydroxyindole (possibly 2- or 3-methyl-substituted), in an alkaline medium and in absence of O 2 , with laevorotatory epichlorohydrin or bromohydrin, heating the reaction product [presumably optically active 4:-glycidyloxyindole (possibly 2- or 3-methyl-substituted)] with (CH 3 ) 2 CR 2 NHR 3 (R 3 being H or benzyl), splitting off any benzyl radical which may be present, and optionally converting the product to an acid addition salt by reaction with an inorganic or organic acid. Therapeutic compositions comprise compounds of the above formula, which are #-receptor blockers, and may be used in the form of tablets, dragees, suppositories or injectable solutions.
[GB1251716A]
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IE1664/71A IE32640B1 (en) | 1968-02-09 | 1969-02-06 | An indole derivative and a process for the production thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH198768A CH495983A (en) | 1968-02-09 | 1968-02-09 | Process for the preparation of levorotatory 4- (2-hydroxy-3-isopropylaminopropoxy) indole |
Publications (1)
Publication Number | Publication Date |
---|---|
IE32639B1 true IE32639B1 (en) | 1973-10-17 |
Family
ID=4223253
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IE156/69A IE32639B1 (en) | 1968-02-09 | 1969-02-06 | Indole derivatives and a process for the production thereof |
Country Status (14)
Country | Link |
---|---|
AT (1) | AT299188B (en) |
BE (1) | BE728142A (en) |
BR (1) | BR6906200D0 (en) |
CH (1) | CH495983A (en) |
DE (1) | DE1905881C2 (en) |
DK (1) | DK119110B (en) |
FI (1) | FI50972C (en) |
FR (2) | FR1598040A (en) |
GB (2) | GB1251716A (en) |
IE (1) | IE32639B1 (en) |
IL (1) | IL31570A (en) |
NL (1) | NL6900797A (en) |
NO (1) | NO125590B (en) |
SE (1) | SE340621B (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4182911A (en) | 1973-11-09 | 1980-01-08 | Imperial Chemical Industries Limited | Optically-active 1-aryloxy-2-propanol intermediates of (S)-absolute configuration |
DE2454198C2 (en) * | 1974-11-15 | 1986-08-07 | Knoll Ag, 6700 Ludwigshafen | Isoquinoline derivatives, processes for their preparation and medicines |
CA1116598A (en) * | 1977-07-13 | 1982-01-19 | William T. Comer | 3-indolyl-tertiary butylaminopropanols |
DE2905053A1 (en) * | 1979-02-08 | 1980-08-14 | Schering Ag | 1-Methyl:indolyl:oxy-2,3-epoxy-propane prodn. - from 4-hydroxy-2-methyl:indole and epichlorohydrin in protic solvent |
DE3030047A1 (en) * | 1980-08-08 | 1982-03-11 | Boehringer Mannheim Gmbh, 6800 Mannheim | NEW AMINOPROPANOL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
DE3029980A1 (en) * | 1980-08-08 | 1982-03-11 | Boehringer Mannheim Gmbh, 6800 Mannheim | INDOLDER DERIVATIVES AND METHOD FOR THEIR PRODUCTION |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1129072A (en) * | 1966-02-01 | 1968-10-02 | Ici Ltd | Benzofuran and indole derivatives |
NL131726C (en) * | 1965-02-01 |
-
1968
- 1968-02-09 CH CH198768A patent/CH495983A/en not_active IP Right Cessation
- 1968-12-23 FR FR1598040D patent/FR1598040A/fr not_active Expired
-
1969
- 1969-01-13 GB GB1251716D patent/GB1251716A/en not_active Expired
- 1969-01-13 GB GB1252399D patent/GB1252399A/en not_active Expired
- 1969-01-17 SE SE00616/69A patent/SE340621B/xx unknown
- 1969-01-17 NL NL6900797A patent/NL6900797A/xx unknown
- 1969-01-17 DK DK26869AA patent/DK119110B/en unknown
- 1969-01-20 FI FI690158A patent/FI50972C/en active
- 1969-01-20 NO NO0209/69A patent/NO125590B/no unknown
- 1969-02-06 IE IE156/69A patent/IE32639B1/en unknown
- 1969-02-06 DE DE1905881A patent/DE1905881C2/en not_active Expired
- 1969-02-07 BR BR206200/69A patent/BR6906200D0/en unknown
- 1969-02-07 BE BE728142D patent/BE728142A/xx not_active IP Right Cessation
- 1969-02-07 IL IL31570A patent/IL31570A/en unknown
- 1969-02-07 AT AT128169A patent/AT299188B/en not_active IP Right Cessation
- 1969-03-18 FR FR183290A patent/FR8067M/fr not_active Expired
Also Published As
Publication number | Publication date |
---|---|
IL31570A (en) | 1972-03-28 |
NL6900797A (en) | 1969-08-12 |
BR6906200D0 (en) | 1973-02-27 |
FI50972C (en) | 1976-09-10 |
GB1252399A (en) | 1971-11-03 |
FR1598040A (en) | 1970-06-29 |
CH495983A (en) | 1970-09-15 |
SE340621B (en) | 1971-11-29 |
FR8067M (en) | 1970-07-06 |
BE728142A (en) | 1969-08-07 |
DE1905881A1 (en) | 1969-09-25 |
FI50972B (en) | 1976-05-31 |
GB1251716A (en) | 1971-10-27 |
NO125590B (en) | 1972-10-02 |
AT299188B (en) | 1972-06-12 |
DE1905881C2 (en) | 1984-03-08 |
DK119110B (en) | 1970-11-16 |
IL31570A0 (en) | 1969-11-12 |
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