IE31935L - Dihydro-benzdiaz [1, 4] epines - Google Patents

Dihydro-benzdiaz [1, 4] epines

Info

Publication number
IE31935L
IE31935L IE13868A IE13868A IE31935L IE 31935 L IE31935 L IE 31935L IE 13868 A IE13868 A IE 13868A IE 13868 A IE13868 A IE 13868A IE 31935 L IE31935 L IE 31935L
Authority
IE
Ireland
Prior art keywords
formula
feb
alkyl
compound
base
Prior art date
Application number
IE13868A
Other versions
IE31935B1 (en
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Priority to IE1012/70A priority Critical patent/IE31937B1/en
Priority to IE1011/70A priority patent/IE31936B1/en
Publication of IE31935L publication Critical patent/IE31935L/en
Publication of IE31935B1 publication Critical patent/IE31935B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1,199,862. Benzodiazepine derivatives preparation. F. HOFFMANN-LA ROCHE & CO. A.G. 5 Feb., 1968 [6 Feb., 1967], No. 5706/68. Heading C2C. Compounds of the general Formula (I) (A = phenyl, pyridyl, halophenyl; B=CO, CH 2 ; R, R<SP>1</SP> = halogen, CF 3 , NO 2 ; R<SP>2</SP> = C 1-7 alkyl, C 2-7 alkenyl; R<SP>3</SP> = C 1-7 alkyl; broken lines denote optional substituents) and their acid addition salts are prepared by treating a compound of the Formula (II) with a base (X = arylsulphonyl, C 1-7 alkanesulphonyl) or alkali metal C 1-7 alkoxide or hydride (X = C 1-7 alkanoyl) in the presence of an inert organic solvent, optionally followed by salt formation. When B=CO a compound of the Formula (III): may be obtained as an intermediate and can be converted, with or without isolation, to (I) by treatment with a base. The preparation of starting materials of Formula (II) is described. [GB1199862A]
IE13868A 1967-02-06 1968-02-05 Process for the manufacture of benzodiazepine derivatives IE31935B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IE1012/70A IE31937B1 (en) 1967-02-06 1968-02-05 Benzdiaz (1,4)epinone-(2) derivatives
IE1011/70A IE31936B1 (en) 1967-02-06 1968-02-05 Tetrahydro-benzdiaz(1,4)epine derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US61400967A 1967-02-06 1967-02-06

Publications (2)

Publication Number Publication Date
IE31935L true IE31935L (en) 1968-08-06
IE31935B1 IE31935B1 (en) 1973-02-21

Family

ID=24459538

Family Applications (1)

Application Number Title Priority Date Filing Date
IE13868A IE31935B1 (en) 1967-02-06 1968-02-05 Process for the manufacture of benzodiazepine derivatives

Country Status (13)

Country Link
BE (1) BE710301A (en)
CH (1) CH492723A (en)
DE (1) DE1695223A1 (en)
DK (1) DK137494B (en)
ES (1) ES350159A1 (en)
FI (1) FI48469C (en)
FR (1) FR1553404A (en)
GB (3) GB1199864A (en)
IE (1) IE31935B1 (en)
NL (2) NL143567B (en)
NO (1) NO121545B (en)
SE (1) SE341190B (en)
YU (1) YU34128B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4002611A (en) * 1968-02-13 1977-01-11 Sumitomo Chemical Company, Limited Preparation of benzodiazepines
JPS515395B1 (en) * 1971-04-12 1976-02-19

Also Published As

Publication number Publication date
NO121545B (en) 1971-03-15
GB1199863A (en) 1970-07-22
NL143567C (en)
NL6801612A (en) 1968-08-07
DK137494C (en) 1978-08-28
GB1199862A (en) 1970-07-22
GB1199864A (en) 1970-07-22
CH492723A (en) 1970-06-30
YU34128B (en) 1978-12-31
NL143567B (en) 1974-10-15
ES350159A1 (en) 1969-04-16
BE710301A (en) 1968-08-05
DE1695223A1 (en) 1972-02-03
SE341190B (en) 1971-12-20
FI48469B (en) 1974-07-01
DK137494B (en) 1978-03-13
FR1553404A (en) 1969-01-10
YU25768A (en) 1978-05-15
FI48469C (en) 1974-10-10
IE31935B1 (en) 1973-02-21

Similar Documents

Publication Publication Date Title
GB1132082A (en) The manufacture of pyrimidine derivatives
SE7409654L (en)
GB1489394A (en) Halogen-containing metal phthalocyanines and a process for their manufacture
GB1055056A (en) Benzo-cyclohepta-thiophene derivatives and method of producing them
GB1456627A (en) Pyridobenzodiazepinones
ES457993A1 (en) Isothiazolo-pyridines
ES454063A1 (en) Novel benzylalcohol derivatives and processes for preparing the same
IE31935L (en) Dihydro-benzdiaz [1, 4] epines
GB1208195A (en) Process for producing benzodiazepine derivatives
GB1325770A (en) Pyrimidopyridazine derivatives
GB1224530A (en) Indolyltetrahydropyridines
GB1116308A (en) Novels-triazolo[3,4-a]isoquinolines and the preparation thereof
GB1276168A (en) Benzodiazepine derivatives preparation
GB1441637A (en) Preparation of morphanthridin-6-5h-ones
GB1253368A (en) Benzodiazepine derivatives and process for preparing them
GB1497723A (en) Octahydrobenzo-(c)(1,6)-naphthyridine derivative
JPS51133243A (en) Process for preparing phthalamic acid ester derivatives
JPS5427573A (en) 3,4-dihydrocarbostyril derivatives
GB1321296A (en) Process for the preparation of heterocyclic substituted benzopyrans and such compounds
ES341311A1 (en) Dehydration process for forming benzodiazepines
JPS5262295A (en) Preparation of n1-oxy-2-thioadenosines
JPS5412384A (en) Carbostyril derivative
GB1197138A (en) Method for Producing Benzodiazephine Derivatives
ES454104A1 (en) Synthesis of novel penicillin derivatives
GB1306478A (en) Process for preparing -substituted benzodiazepine derivatives