HUT69170A - 2-debenzoyl-2-acyl-taxol derivatives and methods for making same, and parmaceutical preparations kontaining them - Google Patents
2-debenzoyl-2-acyl-taxol derivatives and methods for making same, and parmaceutical preparations kontaining themInfo
- Publication number
- HUT69170A HUT69170A HU9400710A HU9400710A HUT69170A HU T69170 A HUT69170 A HU T69170A HU 9400710 A HU9400710 A HU 9400710A HU 9400710 A HU9400710 A HU 9400710A HU T69170 A HUT69170 A HU T69170A
- Authority
- HU
- Hungary
- Prior art keywords
- kontaining
- parmaceutical
- debenzoyl
- acyl
- preparations
- Prior art date
Links
- 238000000034 method Methods 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3061293A | 1993-03-11 | 1993-03-11 | |
US2975993A | 1993-03-11 | 1993-03-11 |
Publications (2)
Publication Number | Publication Date |
---|---|
HU9400710D0 HU9400710D0 (en) | 1994-06-28 |
HUT69170A true HUT69170A (en) | 1995-08-28 |
Family
ID=26705310
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9400710A HUT69170A (en) | 1993-03-11 | 1994-03-10 | 2-debenzoyl-2-acyl-taxol derivatives and methods for making same, and parmaceutical preparations kontaining them |
Country Status (12)
Country | Link |
---|---|
US (3) | US5703247A (hu) |
EP (1) | EP0617034A1 (hu) |
JP (1) | JPH06329650A (hu) |
KR (1) | KR940021543A (hu) |
CN (1) | CN1108653A (hu) |
AU (1) | AU678423B2 (hu) |
CA (1) | CA2118867A1 (hu) |
FI (1) | FI941137A (hu) |
HU (1) | HUT69170A (hu) |
IL (1) | IL108873A0 (hu) |
NO (1) | NO940825L (hu) |
NZ (1) | NZ250998A (hu) |
Families Citing this family (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5710287A (en) * | 1991-09-23 | 1998-01-20 | Florida State University | Taxanes having an amino substituted side-chain and pharmaceutical compositions containing them |
US5998656A (en) * | 1991-09-23 | 1999-12-07 | Florida State University | C10 tricyclic taxanes |
US6018073A (en) * | 1991-09-23 | 2000-01-25 | Florida State University | Tricyclic taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them |
US6794523B2 (en) | 1991-09-23 | 2004-09-21 | Florida State University | Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them |
US6339164B1 (en) | 1993-01-29 | 2002-01-15 | Florida State University | C2 substituted phenyl taxane derivatives and pharmaceutical compositions containing them |
GB9405400D0 (en) * | 1994-03-18 | 1994-05-04 | Erba Carlo Spa | Taxane derivatives |
AU728057B2 (en) * | 1995-09-13 | 2001-01-04 | Florida State University | Radiosensitizing taxanes and their pharmaceutical preparations |
AU724499B2 (en) * | 1996-05-06 | 2000-09-21 | Florida State University | 1-deoxy baccatin III, 1-deoxy taxol and 1-deoxy taxol analogs and method for the preparation thereof |
US5635531A (en) * | 1996-07-08 | 1997-06-03 | Bristol-Myers Squibb Company | 3'-aminocarbonyloxy paclitaxels |
US5773464A (en) * | 1996-09-30 | 1998-06-30 | Bristol-Myers Squibb Company | C-10 epoxy taxanes |
US5977386A (en) * | 1996-12-24 | 1999-11-02 | Bristol-Myers Squibb Company | 6-thio-substituted paclitaxels |
US5739359A (en) * | 1997-01-24 | 1998-04-14 | Virginia Tech Intellectual Properties, Inc. | Methods for preparing 1-deoxy paclitaxels |
US5902822A (en) * | 1997-02-28 | 1999-05-11 | Bristol-Myers Squibb Company | 7-methylthiooxomethyl and 7-methylthiodioxomethyl paclitaxels |
US7288665B1 (en) | 1997-08-18 | 2007-10-30 | Florida State University | Process for selective derivatization of taxanes |
DE69812395T2 (de) | 1997-08-21 | 2004-02-05 | Florida State University, Tallahassee | Verfahren zur synthese von taxanen |
US5917062A (en) * | 1997-11-21 | 1999-06-29 | Indena S.P.A | Intermediates and methods useful in the semisynthesis of paclitaxel and analogs |
US6410757B1 (en) * | 1999-02-16 | 2002-06-25 | Bio Research Corporation Of Yokohama | Baccatin derivatives and a process for producing the same |
JP4502338B2 (ja) * | 1999-09-17 | 2010-07-14 | 株式会社横浜国際バイオ研究所 | タキソイド化合物の製造法 |
AU775373B2 (en) | 1999-10-01 | 2004-07-29 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
MXPA01009922A (es) * | 2000-02-02 | 2003-07-14 | Univ Florida State Res Found | Taxanos de acetato heterosustituido en c7 como agentes antitumorales. |
CO5280224A1 (es) * | 2000-02-02 | 2003-05-30 | Univ Florida State Res Found | Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen |
ATE381328T1 (de) * | 2000-02-02 | 2008-01-15 | Univ Florida State Res Found | Heterosubstituierte taxan-c10-acetate als antitumormittel |
US6649632B2 (en) * | 2000-02-02 | 2003-11-18 | Fsu Research Foundation, Inc. | C10 ester substituted taxanes |
IL145637A0 (en) * | 2000-02-02 | 2002-06-30 | Univ Florida State Res Found | C7 carbonate substituted taxanes as antitumor agents |
HUP0200759A3 (en) | 2000-02-02 | 2002-10-28 | Univ Florida State Res Found | C10 carbonate substituted taxanes as antitumor agents and pharmaceutical compositions containing them and their use |
US6452024B1 (en) | 2000-02-22 | 2002-09-17 | Chaichem Pharmaceuticals International | Process for extraction and purification of paclitaxel from natural sources |
US6624317B1 (en) | 2000-09-25 | 2003-09-23 | The University Of North Carolina At Chapel Hill | Taxoid conjugates as antimitotic and antitumor agents |
ATE481097T1 (de) | 2001-01-16 | 2010-10-15 | Vascular Therapies Llc | Implantierbare vorrichtung enthaltend resorbierbares matrixmaterial und antiproliferative wirkstoffe zur vorbeugung oder behandlung von versagen vaskulärer hämodialysezugänge und anderer vaskulärer transplantate |
WO2004013093A2 (en) * | 2002-08-02 | 2004-02-12 | Immunogen, Inc. | Cytotoxic agents containing novel potent taxanes and their therapeutic use |
US7390898B2 (en) | 2002-08-02 | 2008-06-24 | Immunogen Inc. | Cytotoxic agents containing novel potent taxanes and their therapeutic use |
US20080220074A1 (en) * | 2002-10-04 | 2008-09-11 | Elan Corporation Plc | Gamma radiation sterilized nanoparticulate docetaxel compositions and methods of making same |
WO2004033442A2 (en) * | 2002-10-09 | 2004-04-22 | Chatham Biotec Ltd. | Novel taxanes and methods related to use and preparation thereof |
US6759539B1 (en) | 2003-02-27 | 2004-07-06 | Chaichem Pharmaceuticals International | Process for isolation and purification of paclitaxel from natural sources |
US7064980B2 (en) * | 2003-09-17 | 2006-06-20 | Sandisk Corporation | Non-volatile memory and method with bit line coupled compensation |
US7202370B2 (en) * | 2003-10-27 | 2007-04-10 | Conor Medsystems, Inc. | Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III |
HN2005000054A (es) * | 2004-02-13 | 2009-02-18 | Florida State University Foundation Inc | Taxanos sustituidos con esteres de ciclopentilo en c10 |
EP1737444A4 (en) | 2004-03-05 | 2008-05-21 | Univ Florida State Res Found | C7-LACTYLOXA-SUBSTITUTED TAXANE |
WO2005105767A1 (en) * | 2004-04-23 | 2005-11-10 | Chatham Biotec Ltd. | Semi-synthesis and isolation of taxane intermediates from a mixture of taxanes |
US7893283B2 (en) * | 2004-06-04 | 2011-02-22 | Chatham Biotec, Limited | Semi-synthesis of taxane intermediates and their conversion to paclitaxel and docetaxel |
US20050288520A1 (en) | 2004-06-25 | 2005-12-29 | Phytogen Life Sciences Inc. | One pot synthesis of taxane derivatives and their conversion to paclitaxel and docetaxel |
US20050288521A1 (en) * | 2004-06-29 | 2005-12-29 | Phytogen Life Sciences Inc. | Semi-synthetic conversion of paclitaxel to docetaxel |
CA2486285C (en) * | 2004-08-30 | 2017-03-07 | Viktor S. Goldmakher | Immunoconjugates targeting syndecan-1 expressing cells and use thereof |
EP1669358A1 (en) * | 2004-12-07 | 2006-06-14 | Aventis Pharma S.A. | Cytotoxic agents comprising new taxanes |
EP1688415A1 (en) | 2004-12-07 | 2006-08-09 | Aventis Pharma S.A. | Cytotoxic agents comprising new C-2 modified taxanes |
CA2597682A1 (en) * | 2005-02-14 | 2006-08-24 | Florida State University Research Foundation, Inc. | C10 cyclopropyl ester substituted taxane compositions |
BRPI0611954A2 (pt) | 2005-06-10 | 2009-04-28 | Univ Florida State Res Found | processos para a produÇço de compostos de anel fundido policÍclico |
CA2610908A1 (en) * | 2005-06-10 | 2006-12-21 | Florida State University Research Foundation, Inc. | Processes for the preparation of paclitaxel |
JP5990365B2 (ja) | 2007-12-26 | 2016-09-14 | バイオテスト・アクチエンゲゼルシヤフト | Cd138を標的とする剤及びその使用 |
MX2010007101A (es) * | 2007-12-26 | 2011-07-01 | Biotest Ag | Metodos y agentes para mejorar el reconocimiento de celulas de tumor que expresan cd138. |
JP5817034B2 (ja) * | 2007-12-26 | 2015-11-18 | バイオテスト・アクチエンゲゼルシヤフト | Cd138を標的とする免疫複合体及びその使用 |
WO2009080831A1 (en) * | 2007-12-26 | 2009-07-02 | Biotest Ag | Method of decreasing cytotoxic side-effects and improving efficacy of immunoconjugates |
EP2276755A4 (en) * | 2008-03-31 | 2011-05-04 | Univ Florida State Res Found | C (10) -ETHYESTER- AND C (10) -CYCLOPROPYLESTER-SUBSTITUTED TAXANES |
MX358680B (es) | 2011-12-08 | 2018-08-31 | Biotest Ag | Usos de inmunoconjugados dirigidos a cd138. |
WO2019164891A1 (en) | 2018-02-21 | 2019-08-29 | Celgene Corporation | Bcma-binding antibodies and uses thereof |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2601675B1 (fr) * | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent |
FR2601676B1 (fr) * | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | Procede de preparation du taxol et du desacetyl-10 taxol |
US4960790A (en) * | 1989-03-09 | 1990-10-02 | University Of Kansas | Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof |
US5015744A (en) * | 1989-11-14 | 1991-05-14 | Florida State University | Method for preparation of taxol using an oxazinone |
FR2679230B1 (fr) * | 1991-07-16 | 1993-11-19 | Rhone Poulenc Rorer Sa | Nouveaux derives d'analogues du taxol, leur preparation et les compositions qui les contiennent. |
CA2119363C (en) * | 1991-09-23 | 2001-07-17 | Robert A. Holton | 10-desacetoxytaxol derivatives |
US5283253A (en) * | 1991-09-23 | 1994-02-01 | Florida State University | Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them |
US5399726A (en) * | 1993-01-29 | 1995-03-21 | Florida State University | Process for the preparation of baccatin III analogs bearing new C2 and C4 functional groups |
EP0639186B1 (en) * | 1992-04-17 | 1999-06-23 | Abbott Laboratories | Taxol derivatives |
WO1994005282A1 (en) * | 1992-09-04 | 1994-03-17 | The Scripps Research Institute | Water soluble taxol derivatives |
FR2697019B1 (fr) * | 1992-10-15 | 1994-11-25 | Rhone Poulenc Rorer Sa | Nouveaux dérivés du taxane, leur préparation et les compositions pharmaceutiques qui les contiennent. |
US5356928A (en) * | 1992-11-06 | 1994-10-18 | Hauser Chemical Research, Inc. | Cytotoxic agents |
-
1994
- 1994-02-25 US US08/202,108 patent/US5703247A/en not_active Expired - Fee Related
- 1994-03-01 NZ NZ250998A patent/NZ250998A/en unknown
- 1994-03-01 AU AU56474/94A patent/AU678423B2/en not_active Ceased
- 1994-03-06 IL IL10887394A patent/IL108873A0/xx unknown
- 1994-03-09 EP EP94103622A patent/EP0617034A1/en not_active Withdrawn
- 1994-03-09 NO NO940825A patent/NO940825L/no unknown
- 1994-03-10 KR KR1019940004696A patent/KR940021543A/ko not_active Application Discontinuation
- 1994-03-10 FI FI941137A patent/FI941137A/fi not_active Application Discontinuation
- 1994-03-10 HU HU9400710A patent/HUT69170A/hu unknown
- 1994-03-10 JP JP6076259A patent/JPH06329650A/ja active Pending
- 1994-03-11 CN CN94102870A patent/CN1108653A/zh active Pending
- 1994-03-11 CA CA002118867A patent/CA2118867A1/en not_active Abandoned
-
1995
- 1995-06-07 US US08/471,886 patent/US5614645A/en not_active Expired - Fee Related
-
1997
- 1997-10-15 US US08/950,590 patent/US6002023A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
NZ250998A (en) | 1996-02-27 |
US6002023A (en) | 1999-12-14 |
NO940825D0 (no) | 1994-03-09 |
FI941137A (fi) | 1994-09-12 |
CA2118867A1 (en) | 1994-09-12 |
HU9400710D0 (en) | 1994-06-28 |
IL108873A0 (en) | 1994-06-24 |
EP0617034A1 (en) | 1994-09-28 |
AU678423B2 (en) | 1997-05-29 |
KR940021543A (ko) | 1994-10-19 |
US5614645A (en) | 1997-03-25 |
JPH06329650A (ja) | 1994-11-29 |
FI941137A0 (fi) | 1994-03-10 |
CN1108653A (zh) | 1995-09-20 |
NO940825L (no) | 1994-09-12 |
AU5647494A (en) | 1994-09-15 |
US5703247A (en) | 1997-12-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
DFD9 | Temporary protection cancelled due to non-payment of fee |