HUP9904616A2 - Meiózist befolyásoló holesztánszármazékok - Google Patents

Meiózist befolyásoló holesztánszármazékok

Info

Publication number
HUP9904616A2
HUP9904616A2 HU9904616A HUP9904616A HUP9904616A2 HU P9904616 A2 HUP9904616 A2 HU P9904616A2 HU 9904616 A HU9904616 A HU 9904616A HU P9904616 A HUP9904616 A HU P9904616A HU P9904616 A2 HUP9904616 A2 HU P9904616A2
Authority
HU
Hungary
Prior art keywords
cholestane
derivatives
meiosis regulating
meiosis
regulating
Prior art date
Application number
HU9904616A
Other languages
English (en)
Inventor
Peter Faarup
Christian Grondahl
Frederik Christian Gronvald
Anthony Murray
Jan Lund Ottesen
Original Assignee
Novo Nordisk A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk A/S filed Critical Novo Nordisk A/S
Publication of HUP9904616A2 publication Critical patent/HUP9904616A2/hu
Publication of HUP9904616A3 publication Critical patent/HUP9904616A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Reproductive Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • General Induction Heating (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Oscillators With Electromechanical Resonators (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)

Abstract

Bizőnyős (I) általánős képletű vegyületek, melyek szerkezetilegrőkőnők, példáűl a bikaheréből vagy hűmán tüszőnedvből extrahálhatótermészetes vegyületekkel, felhasználhatók őőciták és hímivarúcsírasejtek meiózisának befőlyásőlására. ŕ
HU9904616A 1996-12-20 1997-12-19 Meiosis regulating cholestane-derivatives HUP9904616A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK147896 1996-12-20
US4148897P 1997-02-11 1997-02-11
PCT/DK1997/000584 WO1998028323A1 (en) 1996-12-20 1997-12-19 Meiosis regulating compounds

Publications (2)

Publication Number Publication Date
HUP9904616A2 true HUP9904616A2 (hu) 2000-06-28
HUP9904616A3 HUP9904616A3 (en) 2001-02-28

Family

ID=26065809

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9904616A HUP9904616A3 (en) 1996-12-20 1997-12-19 Meiosis regulating cholestane-derivatives

Country Status (12)

Country Link
US (3) US6486145B2 (hu)
EP (1) EP0946584B1 (hu)
JP (1) JP2001506656A (hu)
KR (1) KR20000069616A (hu)
AT (1) ATE238339T1 (hu)
AU (1) AU746878B2 (hu)
CA (1) CA2275683A1 (hu)
DE (1) DE69721304T2 (hu)
HU (1) HUP9904616A3 (hu)
IL (1) IL130249A0 (hu)
NO (1) NO313144B1 (hu)
WO (1) WO1998028323A1 (hu)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030004148A1 (en) * 1994-06-23 2003-01-02 Byskov Anne G. Regulation of meiosis
EP1077992B1 (en) * 1998-05-13 2003-12-10 Novo Nordisk A/S Use of meiosis regulating compounds
IL139241A0 (en) * 1998-05-13 2001-11-25 Novo Nordisk As Meiosis regulating compounds
EP1087988A1 (en) * 1998-06-19 2001-04-04 Novo Nordisk A/S Meiosis regulating compounds
EP1137660B1 (en) 1998-12-11 2002-10-02 Akzo Nobel N.V. 22s-hydroxycholesta-8,14-diene derivatives with meiosis regulating activity
BR0008065A (pt) * 1999-02-10 2001-11-06 Schering Aktiengellschaft Derivados de colestano insaturados e seu uso para a preparação de medicamentos que regulam meiose
DE60034662T2 (de) * 1999-02-24 2008-01-03 Novo Nordisk A/S Behandlung von unfruchtbarkeit
HUP0200157A3 (en) * 1999-02-24 2002-06-28 Novo Nordisk As Treatment of infertility
ATE392899T1 (de) * 1999-03-02 2008-05-15 Organon Nv (androst-5-en-17beta-yl)alkyl sulfoxide und sulfone und deren verwendung zur kontrolle der fruchtbarkeit
DE60000978T2 (de) * 1999-03-09 2003-07-17 Akzo Nobel N.V., Arnheim/Arnhem 22r-hydroxycholesta-8,14-diene derivate zur hemmung der meiose
US6902528B1 (en) * 1999-04-14 2005-06-07 Stereotaxis, Inc. Method and apparatus for magnetically controlling endoscopes in body lumens and cavities
WO2001019354A2 (en) 1999-09-16 2001-03-22 Novo Nordisk A/S Composition for ivf
EP1127890A1 (en) 2000-02-22 2001-08-29 Schering Aktiengesellschaft Steroid derivatives with an additional ring annulated to ring A and use of these derivatives for the preparation of meiosis regulating medicaments
WO2001062258A2 (en) * 2000-02-25 2001-08-30 Schering Aktiengesellschaft Improvement of implantation rate using ff-mas
WO2001076360A2 (en) * 2000-04-06 2001-10-18 Novo Nordisk A/S Synchronization of the cytoplasmatic and the nuclear maturation of oocytes in vitro
US6988613B2 (en) 2001-02-06 2006-01-24 Novo Nordisk A/S Composition for IVF
ATE386495T1 (de) * 2001-02-06 2008-03-15 Novo Nordisk As Behältnis mit niedrigem sauerstoffgehalt, das ff- mas enthält
EP1245572A1 (en) 2001-03-26 2002-10-02 Schering Aktiengesellschaft Aminosterol compounds, their use in the preparation of meiosis-regulating medicaments and method for their preparation
US8969543B2 (en) * 2003-04-03 2015-03-03 Bioneer Corporation SiRNA-hydrophilic polymer conjugates for intracellular delivery of siRNA and method thereof
US20080312673A1 (en) * 2007-06-05 2008-12-18 Viswanathan Raju R Method and apparatus for CTO crossing
WO2011127465A2 (en) 2010-04-09 2011-10-13 The Research Foundation Of The State University Of New York Ship inhibitors and uses thereof

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1224738B (de) 1960-12-29 1966-09-15 Takeda Chemical Industries Ltd Verfahren zur Herstellung von Cholestan-3, 5, 6-triol-3-estern oder -3, 6-diestern soowie von deren Salzen
DE1183079B (de) 1961-11-27 1964-12-10 Vismara Francesco Spa Verfahren zur Herstellung von gesaettigten 4-Hydroxy-3-keto-5alpha-steroiden
CH470374A (de) 1965-09-24 1969-03-31 Hoffmann La Roche Verfahren zur Herstellung von Steroiden
DE1593492A1 (de) 1966-01-29 1970-07-16 Schering Ag 6-Ketosteroide aus 20-Formyl-6-keto-Steroide
IL38540A0 (en) 1971-01-18 1972-03-28 Dauten Sa Method for the extraction of insect moulting steroid hormones
ZA725157B (en) 1971-07-29 1973-04-25 Dauten Sa New steroid of insecticide action and process for its production
US4670190A (en) 1973-01-10 1987-06-02 Hesse Robert H 1-α-hydroxy vitamin D compounds and process for preparing same
FR2219943B1 (hu) 1973-03-02 1976-04-30 Eisai Co Ltd
IL41923A (en) 1973-04-01 1978-08-31 Yeda Res & Dev Preparation of hydroxylated derivatives of cholestanol and some such compounds
US3931403A (en) 1973-05-25 1976-01-06 Intellectual Property Development Corporation Antimicrobial compositions
US3887545A (en) 1973-11-12 1975-06-03 Hoffmann La Roche Synthesis of 1{60 -hydroxylated cholesterol derivatives
JPS5119752A (en) 1974-08-07 1976-02-17 Masayuki Ishikawa 1 arufua* 2 arufuaa jihidorokishikorekarushifuerooruno seiho
IL45897A (en) 1974-10-22 1978-12-17 Yeda Res & Dev Process for the preparation of 1 hydroxy-provitamin d3
JPS6039278B2 (ja) 1977-05-23 1985-09-05 中外製薬株式会社 ステロイド誘導体
DE3064789D1 (en) 1979-02-15 1983-10-20 Teijin Ltd New 25-hydroxy-24-oxocholestane derivatives and preparation thereof
US4230626A (en) 1979-07-30 1980-10-28 G. D. Searle & Co. 25-Halocholest-5-ene-3β,22-diols and esters thereof
US4254045A (en) 1980-04-21 1981-03-03 Wisconsin Alumni Research Foundation 1α-Hydroxy-2β-fluorocholecalciferol
GB2089811B (en) 1980-09-22 1984-09-26 Wisconsin Alumni Res Found 23,25-dihydroxyvitamin d3
ATE15050T1 (de) 1981-04-29 1985-09-15 Hoffmann La Roche Verfahren zur herstellung von cholesterinderivaten und zwischenprodukte dafuer.
US4329295A (en) 1981-06-29 1982-05-11 G. D. Searle & Co. 24-Cyclopropylcholene-3β, 22-diols and esters thereof
US4348328A (en) 1981-11-09 1982-09-07 G.D. Searle & Co. 25-Substituted-5α-cholestane-3β,22S-diol
US4871727A (en) 1987-12-21 1989-10-03 Merck & Co, Inc. Anti-inflammatory and antidegenerative compounds isolated from L-681,512
JPH0749435B2 (ja) 1988-07-04 1995-05-31 帝人株式会社 １α，３β，２４−トリヒドロキシ−△▲上５▼−ステロイド類の製造方法
US5716777A (en) * 1994-06-23 1998-02-10 Novo Nordisk A/S Regulation of meiosis using sterols
HUP9800731A3 (en) * 1995-03-06 2000-03-28 Novo Nordisk As Stimulation of meiosis

Also Published As

Publication number Publication date
EP0946584A1 (en) 1999-10-06
AU7878998A (en) 1998-07-17
CA2275683A1 (en) 1998-07-02
KR20000069616A (ko) 2000-11-25
IL130249A0 (en) 2000-06-01
US20050004382A1 (en) 2005-01-06
NO993009D0 (no) 1999-06-18
US20030032824A1 (en) 2003-02-13
NO313144B1 (no) 2002-08-19
EP0946584B1 (en) 2003-04-23
US6759400B2 (en) 2004-07-06
WO1998028323A1 (en) 1998-07-02
DE69721304T2 (de) 2004-03-04
US6486145B2 (en) 2002-11-26
DE69721304D1 (de) 2003-05-28
ATE238339T1 (de) 2003-05-15
AU746878B2 (en) 2002-05-02
JP2001506656A (ja) 2001-05-22
NO993009L (no) 1999-08-19
HUP9904616A3 (en) 2001-02-28
US20010005757A1 (en) 2001-06-28

Similar Documents

Publication Publication Date Title
HUP9904616A2 (hu) Meiózist befolyásoló holesztánszármazékok
MX9700174A (es) Derivados de esterol usados para la regulacion de la meiosis.
AR003441A1 (es) Compuestos para regular la meiosis y el uso de los mismos para preparar medicamentos.
DE69734605D1 (de) Abgeschwächter salmonellenstamm, gebraucht als vehikel zur oralen immunisierung
ATE305448T1 (de) Phenylalaninderivate als herbizide
NO930615L (no) Hypoglykemiske hydroksyurinstoffderivater
TR199801603T2 (xx) �ki par�a yivli k�l�f.
ES2128984B1 (es) Herbicidas a base de heteroariloxi-acetamidas para el empleo en el cultivo de arroz.
MX9704050A (es) P-amidinobencilamidas de dipeptido novedosas con radicales sulfonilo o aminosulfonilo en terminal n.
NO20005667D0 (no) Meioseregulerende forbindelser
KR970064396A (ko) 스트레스 완화용 사료
TR199901386T2 (en) �midazopiridazinler.
DK1343369T3 (da) Konservering af celler
ATE163402T1 (de) Substituierte ortho- ethenylphenylessigsäurederivate
UA42797C2 (uk) Похідні хінолон- і нафтиридонкарбонової кислоти та похідні ізоіндолу для їх одержання
ATE227122T1 (de) Stabilisierte tablettenformulierung
BR9713762A (pt) Composto, uso dos mesmos, e, processo para regular a meiose em uma célula germinativa de mamìfero.
ATE148105T1 (de) Succinoylaminohydroxyäthylaminosulfamidsäureder vate und ihre verwendung als retrovirale proteasehemmer
TR199701011A2 (xx) 1-karba-(detia)-sefalosforin t�revleri.
ATE130596T1 (de) Cyclohexenonderivate als herbizide.
NO954316L (no) Benzo(f)kinoksalidinonderivater, deres fremstilling og anvendelse i legemidler
MX9800053A (es) Herbicidas de cis-2,3-expoxicicloalcanol bencilado.
DK1194158T3 (da) Anvendelse af UK 114-proteiner til hæmning af organtransplantatafstödning
ITMI932171A1 (it) Procedimento per l'estrazione di colori naturali mediante bentonite
MD639G2 (ro) Mediu crioprotector pentru sperma de cocoş