DE69734605D1 - Abgeschwächter salmonellenstamm, gebraucht als vehikel zur oralen immunisierung - Google Patents
Abgeschwächter salmonellenstamm, gebraucht als vehikel zur oralen immunisierungInfo
- Publication number
- DE69734605D1 DE69734605D1 DE69734605T DE69734605T DE69734605D1 DE 69734605 D1 DE69734605 D1 DE 69734605D1 DE 69734605 T DE69734605 T DE 69734605T DE 69734605 T DE69734605 T DE 69734605T DE 69734605 D1 DE69734605 D1 DE 69734605D1
- Authority
- DE
- Germany
- Prior art keywords
- salmonella
- vechicle
- weakened
- oral immunization
- eukaryotic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP97106503 | 1997-04-18 | ||
EP97106503 | 1997-04-18 | ||
PCT/EP1997/006933 WO1998048026A1 (en) | 1997-04-18 | 1997-12-11 | Attenuated salmonella strain used as a vehicle for oral immunization |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69734605D1 true DE69734605D1 (de) | 2005-12-15 |
DE69734605T2 DE69734605T2 (de) | 2006-08-03 |
Family
ID=8226707
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69734605T Expired - Lifetime DE69734605T2 (de) | 1997-04-18 | 1997-12-11 | Abgeschwächter salmonellenstamm, gebraucht als vehikel zur oralen immunisierung |
Country Status (10)
Country | Link |
---|---|
US (1) | US7115269B2 (de) |
EP (1) | EP0977874B1 (de) |
JP (1) | JP2002513287A (de) |
AT (1) | ATE309378T1 (de) |
AU (1) | AU5756298A (de) |
CA (1) | CA2286210A1 (de) |
DE (1) | DE69734605T2 (de) |
DK (1) | DK0977874T3 (de) |
ES (1) | ES2253789T3 (de) |
WO (1) | WO1998048026A1 (de) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7794729B2 (en) | 1994-11-08 | 2010-09-14 | The Trustees Of The University Of Pennsylvania | Methods and compositions for immunotherapy of cancer |
US7662396B2 (en) | 2001-03-26 | 2010-02-16 | The Trustees Of The University Of Pennsylvania | Compositions and methods for enhancing the immunogenicity of antigens |
US8956621B2 (en) | 1994-11-08 | 2015-02-17 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treatment of cervical dysplasia |
US8791237B2 (en) | 1994-11-08 | 2014-07-29 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treatment of non-hodgkins lymphoma |
US8114414B2 (en) | 1994-11-08 | 2012-02-14 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treatment of cervical cancer |
US7820180B2 (en) | 2004-09-24 | 2010-10-26 | The Trustees Of The University Of Pennsylvania | Listeria-based and LLO-based vaccines |
US6682729B1 (en) | 1995-05-03 | 2004-01-27 | University Of Maryland, Baltimore | Method for introducing and expressing genes in animal cells, and live invasive bacterial vectors for use in the same |
WO1997044446A1 (en) * | 1996-05-24 | 1997-11-27 | University Of Maryland At Baltimore | Dna vaccines for eliciting a mucosal immune response |
DE19754938B4 (de) * | 1997-12-11 | 2006-04-20 | Christoph von Dr. Eichel-Streiber | TGC-Verfahren zur Induktion einer zielgerichteten, somatischen Transgenität |
NZ512730A (en) * | 1998-12-04 | 2003-12-19 | Univ Manitoba | A immunization procedure against chlamydia infection using an attenuated bacteria comprsing a plasmid with a major outer membrane protein (MOMP) from chlamydial |
US6977245B2 (en) | 1999-04-12 | 2005-12-20 | The United States Of America As Represented By The Department Of Health And Human Services | Oligodeoxynucleotide and its use to induce an immune response |
US9012141B2 (en) | 2000-03-27 | 2015-04-21 | Advaxis, Inc. | Compositions and methods comprising KLK3 of FOLH1 antigen |
CA2404164A1 (en) | 2000-03-29 | 2001-10-04 | The Trustees Of The University Of Pennsylvania | Compositions and methods for enhancing immunogenicity of antigens |
AU2001292035A1 (en) * | 2000-09-29 | 2002-04-08 | Microscience Limited | Attenuated salmonella microorganisms comprising a mutation in the sifa gene |
US7700344B2 (en) * | 2001-03-26 | 2010-04-20 | The Trustees Of The University Of Pennsylvania | Compositions and methods for enhancing the immunogenicity of antigens |
US8771702B2 (en) | 2001-03-26 | 2014-07-08 | The Trustees Of The University Of Pennsylvania | Non-hemolytic LLO fusion proteins and methods of utilizing same |
US7666674B2 (en) | 2001-07-27 | 2010-02-23 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of sterically stabilized cationic liposomes to efficiently deliver CPG oligonucleotides in vivo |
US7354909B2 (en) | 2001-08-14 | 2008-04-08 | The United States Of America As Represented By Secretary Of The Department Of Health And Human Services | Method for rapid generation of mature dendritic cells |
WO2003054161A2 (en) | 2001-12-20 | 2003-07-03 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | USE OF CpG OLIGODEOXYNUCLEOTIDES TO INDUCE ANGIOGENESIS |
US8466116B2 (en) | 2001-12-20 | 2013-06-18 | The Unites States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of CpG oligodeoxynucleotides to induce epithelial cell growth |
US8263091B2 (en) | 2002-09-18 | 2012-09-11 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method of treating and preventing infections in immunocompromised subjects with immunostimulatory CpG oligonucleotides |
DE10326189A1 (de) * | 2003-06-06 | 2005-01-05 | MedInnova Gesellschaft für medizinische Innovationen aus akademischer Forschung mbH | Bakterielle Träger für Nukleotidsequenzen kodierend für Wirkstoffe |
EP1670505B1 (de) | 2003-09-18 | 2012-11-14 | GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Dna-promotor und anthrax-vakzine |
ES2555544T3 (es) | 2006-03-07 | 2016-01-04 | Vaxinnate Corporation | Composiciones que incluyen hemaglutinina, métodos de preparación y métodos de uso de las mismas |
EP2061800B1 (de) | 2006-08-15 | 2015-07-29 | The Trustees of the University of Pennsylvania | Zusammensetzungen mit hmw-maa und fragmenten davon sowie verfahren zu ihrer verwendung |
US8268326B2 (en) | 2006-08-15 | 2012-09-18 | The Trustees Of The University Of Pennsylvania | Compositions comprising HMW-MAA and fragments thereof, and methods of use thereof |
WO2009128949A2 (en) | 2008-04-18 | 2009-10-22 | Vaxinnate Corporation | Compositions of dengue viral proteins and methods of use |
US9650639B2 (en) | 2008-05-19 | 2017-05-16 | Advaxis, Inc. | Dual delivery system for heterologous antigens |
EP2288379A4 (de) | 2008-05-19 | 2012-08-08 | Advaxis | Doppeltes freisetzungssystem für heterologe antigene |
US9017660B2 (en) | 2009-11-11 | 2015-04-28 | Advaxis, Inc. | Compositions and methods for prevention of escape mutation in the treatment of Her2/neu over-expressing tumors |
EP2403935B1 (de) | 2009-03-04 | 2017-05-10 | The Trustees Of The University Of Pennsylvania | Zusammensetzungen mit angiogenen faktoren und verwendungsverfahren dafür |
US10016617B2 (en) | 2009-11-11 | 2018-07-10 | The Trustees Of The University Of Pennsylvania | Combination immuno therapy and radiotherapy for the treatment of Her-2-positive cancers |
US9226958B2 (en) | 2010-10-01 | 2016-01-05 | University Of Georgia Research Foundation, Inc. | Use of Listeria vaccine vectors to reverse vaccine unresponsiveness in parasitically infected individuals |
AU2012229218B2 (en) | 2011-03-11 | 2017-03-02 | Advaxis, Inc. | Listeria-based adjuvants |
BR112014022662A2 (pt) | 2012-03-12 | 2017-10-03 | Advaxis Inc | Inibição da função de célula supressora seguindo tratamento de vacina de listeria |
US8932598B2 (en) | 2012-08-28 | 2015-01-13 | Vaxinnate Corporation | Fusion proteins and methods of use |
SI2988762T1 (sl) | 2013-04-25 | 2018-10-30 | Vaximm Ag | Vektorji na osnovi salmonele za imunoterapijo raka, usmerjeno v Wilmsov tumorski gen WT1 |
EP3652318A1 (de) | 2017-07-11 | 2020-05-20 | Actym Therapeutics, Inc. | Manipulierte immunstimulierende bakterienstämme und verwendungen davon |
CN118147029A (zh) * | 2018-07-11 | 2024-06-07 | 阿克蒂姆治疗有限公司 | 工程化的免疫刺激性细菌菌株及其用途 |
EP3844276A2 (de) | 2018-08-28 | 2021-07-07 | Actym Therapeutics, Inc. | Manipulierte immunstimulierende bakterienstämme und verwendungen davon |
US10973908B1 (en) | 2020-05-14 | 2021-04-13 | David Gordon Bermudes | Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5231176A (en) * | 1984-08-27 | 1993-07-27 | Genentech, Inc. | Distinct family DNA encoding of human leukocyte interferons |
JP3055687B2 (ja) * | 1987-08-10 | 2000-06-26 | ザ ユニバーシティー オブ メルボルン | Vp7をコードするヒトロタウイルス血清型4遺伝子9の分子クローニング、糖タンパク質特異的主要外部カプシド中和及びワクチンに使用するためのvp7及びそのフラグメントの発現 |
US5986061A (en) * | 1988-10-28 | 1999-11-16 | Pbl Biomedical Laboratories | Phosphorylated fusion proteins |
ES2133311T3 (es) * | 1990-11-21 | 1999-09-16 | Univ Washington | Vacunas antifertilidad de salmonella avirulenta recombinante. |
US5736388A (en) * | 1994-12-30 | 1998-04-07 | Chada; Sunil | Bacteriophage-mediated gene transfer systems capable of transfecting eukaryotic cells |
US6682729B1 (en) | 1995-05-03 | 2004-01-27 | University Of Maryland, Baltimore | Method for introducing and expressing genes in animal cells, and live invasive bacterial vectors for use in the same |
US6150170A (en) | 1998-05-03 | 2000-11-21 | University Of Maryland At Baltimore | Method for introducing and expressing genes in animal cells, and live invasive bacterial vectors for use in the same |
US5877159A (en) | 1995-05-03 | 1999-03-02 | University Of Maryland At Baltimore | Method for introducing and expressing genes in animal cells and live invasive bacterial vectors for use in the same |
US5869057A (en) * | 1995-06-07 | 1999-02-09 | Rock; Edwin P. | Recombinant vaccines to break self-tolerance |
EP0881884A4 (de) * | 1995-09-06 | 2004-07-14 | Dept Of The Army Us Government | System zur verabreichung von bakterien |
US5824538A (en) * | 1995-09-06 | 1998-10-20 | The United States Of America As Represented By The Secretary Of The Army | Shigella vector for delivering DNA to a mammalian cell |
US5866340A (en) * | 1996-03-22 | 1999-02-02 | Johns Hopkins University | Selective expression of desired genes in cells expressing oncoproteins |
US6099848A (en) * | 1997-11-18 | 2000-08-08 | The Trustees Of The University Of Pennsylvania | Immunogenic compositions comprising DAL/DAT double-mutant, auxotrophic, attenuated strains of Listeria and their methods of use |
US6365576B1 (en) * | 1999-06-24 | 2002-04-02 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Method for inhibiting herpes infection |
-
1997
- 1997-12-11 DE DE69734605T patent/DE69734605T2/de not_active Expired - Lifetime
- 1997-12-11 ES ES97953786T patent/ES2253789T3/es not_active Expired - Lifetime
- 1997-12-11 CA CA002286210A patent/CA2286210A1/en not_active Abandoned
- 1997-12-11 AT AT97953786T patent/ATE309378T1/de active
- 1997-12-11 AU AU57562/98A patent/AU5756298A/en not_active Abandoned
- 1997-12-11 JP JP54477598A patent/JP2002513287A/ja active Pending
- 1997-12-11 DK DK97953786T patent/DK0977874T3/da active
- 1997-12-11 WO PCT/EP1997/006933 patent/WO1998048026A1/en active IP Right Grant
- 1997-12-11 EP EP97953786A patent/EP0977874B1/de not_active Revoked
-
1999
- 1999-10-18 US US09/419,545 patent/US7115269B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP2002513287A (ja) | 2002-05-08 |
AU5756298A (en) | 1998-11-13 |
WO1998048026A1 (en) | 1998-10-29 |
DE69734605T2 (de) | 2006-08-03 |
CA2286210A1 (en) | 1998-10-29 |
DK0977874T3 (da) | 2006-03-20 |
US7115269B2 (en) | 2006-10-03 |
EP0977874B1 (de) | 2005-11-09 |
ES2253789T3 (es) | 2006-06-01 |
ATE309378T1 (de) | 2005-11-15 |
US20030180320A1 (en) | 2003-09-25 |
EP0977874A1 (de) | 2000-02-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8363 | Opposition against the patent |