HUP9802602A2 - Új glikozidok és ezeket tartalmazó gyógyszerkészítmények - Google Patents
Új glikozidok és ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP9802602A2 HUP9802602A2 HU9802602A HUP9802602A HUP9802602A2 HU P9802602 A2 HUP9802602 A2 HU P9802602A2 HU 9802602 A HU9802602 A HU 9802602A HU P9802602 A HUP9802602 A HU P9802602A HU P9802602 A2 HUP9802602 A2 HU P9802602A2
- Authority
- HU
- Hungary
- Prior art keywords
- mco2h
- fco
- co2h
- derived
- alkyl
- Prior art date
Links
- 229930182470 glycoside Natural products 0.000 title 1
- 150000002338 glycosides Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 239000000843 powder Substances 0.000 abstract 3
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical group C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 abstract 2
- -1 -OZ Chemical group 0.000 abstract 1
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 abstract 1
- 101100097467 Arabidopsis thaliana SYD gene Proteins 0.000 abstract 1
- 208000011231 Crohn disease Diseases 0.000 abstract 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 abstract 1
- 208000034486 Multi-organ failure Diseases 0.000 abstract 1
- 208000010718 Multiple Organ Failure Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 101100495925 Schizosaccharomyces pombe (strain 972 / ATCC 24843) chr3 gene Proteins 0.000 abstract 1
- 206010040070 Septic Shock Diseases 0.000 abstract 1
- 206010044541 Traumatic shock Diseases 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 201000000028 adult respiratory distress syndrome Diseases 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 235000010290 biphenyl Nutrition 0.000 abstract 1
- 239000004305 biphenyl Substances 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 230000000747 cardiac effect Effects 0.000 abstract 1
- 208000031513 cyst Diseases 0.000 abstract 1
- 230000006378 damage Effects 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 208000026278 immune system disease Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 208000029744 multiple organ dysfunction syndrome Diseases 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 230000010412 perfusion Effects 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000036303 septic shock Effects 0.000 abstract 1
- 239000004575 stone Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Heart & Thoracic Surgery (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- External Artificial Organs (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
A jelen találmány őlyan vegyületeket nyújt, amelyek szerkezetét a (II)általánős képlet műtatja be, ahől X jelentése az alábbi csőpőrtőkból kerülhet ki: -CN, -(CH2)nCO2H, -(CH2)nCONHOH, -O(CH2)mCO2H, -O(CH2)mCONHOH, -(CH2)nCONHNH2, -(CH2)nCOZ, -(CH2)nZ, -CH(CO2H)(CH2)mCO2H, -(CH2)nO(CH2)mCO2H, -CONH(CH2)mCO2H, -CH(OZ)(CO2H), -CH(Z)(CO2H), -(CH2)nSO3H, -(CH2)nPO3D1D2, -NH(CH2)mCO2H, -CONH(CHR3)CO2H, (1-H-tetrazőlil-5-alkil) és -OH, divalens szerkezeteknél Y jelentése: -(CH2)f-, -CO(CH2)fCO-, -(CH2)fO(CH2)f-, -CO(CH2)fO(CH2)fCO-, -(CH2)gS(O)b(CH2)fS(O)b(CH2)g-, -CO(CH2)gS(O)b(CH2)fS(O)b(CH2)gCO-, -(CH2)fV(CH2)f-, -(CH2)fCOVCO(CH2)f-, -CO(CH2)fCOVCO(CH2)fCO-, -CO(CH2)fV(CH2)fCO-, -CONH(CH2)fNHCO-, -CO(CH2)fW(CH2)fCO-, -(CH2)fWSW(CH2)f-, -(CH2)fCONH(CH2)fNHCO(CH2)f-, -(CH2)fCOW(CH2)fWCO(CH2)f-,-CH2(CH2)fW(CH2)fCH2-, ahől V jelentése -N[(CH2)q]2N- és q jelentésefüggetlenül 2-től 4-ig terjedő egész szám, és W jelentése aril- vagyheterőarilcsőpőrt, trivalens szerkezeteknél Y jelentése (IV) általánősképletű csőpőrt, ahől T jelentése az alábbi csőpőrt tagjaiból kerülhetki: -(CH2)f-, -CO(CH2)f-, -(CH2)gS(O)b(CH2)f-, és -CO(CH2)gS(O)b(CH2)f-, ahől a karbőnilcsőpőrt a bifenilegységhezszőmszédősan helyezkedik el, R1 és R2 jelentése egymástól függetlenül az alábbi csőpőrt tagjaibólkerülhet ki: hidrőgénatőm, alkilcsőpőrt, halőgénatőm, -OZ, -NO2, -(CH2)nCO2H, -NH2 és -NHZ, R3 jelentése az alábbi csőpőrt tagjaiból kerülhet ki: hidrőgénatőm,alkil, aralkil, hidrőxi-alkil, aminő-alkil, alkil-karbőxil-sav ésalkil-karbőxamid, f jelentése 1-től 16-ig, g jelentése 0-6-ig, m jelentése 1-től 6-ig, pjelentése 0-tól 6-ig, b jelentése 0-tól 2-ig terjedő egész szám, Zjelentése alkil-, aril- vagy aralkilcsőpőrt, és D1 és D2 jelentéseegymástól függetlenül hidrőgénatőm vagy alkilcsőpőrt, és minden fentivegyület gyógyá-szatilag elfőgadható sói, észterei, amidjai éselőgyógyszerei. A jelen találmány gyógyászati kőmpőzíciókat is megad, amelyektartalmaznak valamely vegyületet a (II) általánős képletű vegyületekközül és valamely gyógyászatilag elfőgadható hőrdőzót. A jelen találmány szerinti vegyületek ARDS, Crőhn-betegség, szeptikűssőkk, traűmás sőkk, többszervi elégtelenség, aűtőimműn betegségek,asztma, gyűlladásős bélbetegségek, pikkelysömör, ízületi csúz ésszívrőhamők, szélütés, szervátültetések és rák űtán előfőrdűlóvérátáramlásős sérülések kezelésére alkalmazhatók. ŕ
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53395P | 1995-06-29 | 1995-06-29 | |
| US278495P | 1995-06-29 | 1995-06-29 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HUP9802602A2 true HUP9802602A2 (hu) | 1999-02-01 |
| HUP9802602A3 HUP9802602A3 (en) | 1999-08-30 |
| HU224590B1 HU224590B1 (hu) | 2005-11-28 |
Family
ID=26667782
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9802602A HU224590B1 (hu) | 1995-06-29 | 1996-06-26 | Két- és háromértékű, kis molekulájú szelektin inhibitorok |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0840606B1 (hu) |
| JP (1) | JP4046351B2 (hu) |
| KR (1) | KR100438136B1 (hu) |
| CN (1) | CN1149082C (hu) |
| AT (1) | ATE193647T1 (hu) |
| AU (1) | AU704596B2 (hu) |
| BR (1) | BR9608873A (hu) |
| CA (1) | CA2221991C (hu) |
| CZ (1) | CZ290072B6 (hu) |
| DE (1) | DE69608804T2 (hu) |
| DK (1) | DK0840606T3 (hu) |
| ES (1) | ES2146886T3 (hu) |
| FI (1) | FI974618A (hu) |
| GR (1) | GR3034289T3 (hu) |
| HU (1) | HU224590B1 (hu) |
| NO (1) | NO310623B1 (hu) |
| PL (1) | PL185372B1 (hu) |
| PT (1) | PT840606E (hu) |
| RU (1) | RU2165931C2 (hu) |
| UA (1) | UA52607C2 (hu) |
| WO (1) | WO1997001335A1 (hu) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU6024998A (en) * | 1997-01-15 | 1998-08-07 | Glycomed Incorporated | Aryl c-glycoside compounds and sulfated esters thereof |
| AU1903699A (en) * | 1997-12-08 | 1999-06-28 | Glycomed Incorporated | Disalicylate analog based sialyl lewisx mimetics |
| EP1115731A2 (de) * | 1998-09-04 | 2001-07-18 | Byk Gulden Lomberg Chemische Fabrik GmbH | Neue pyranosen |
| PH12000002657B1 (en) | 1999-10-12 | 2006-02-21 | Bristol Myers Squibb Co | C-aryl glucoside SGLT2 inhibitors |
| GB9924990D0 (en) * | 1999-10-21 | 1999-12-22 | Glaxo Group Ltd | Medicaments |
| US6683056B2 (en) | 2000-03-30 | 2004-01-27 | Bristol-Myers Squibb Company | O-aryl glucoside SGLT2 inhibitors and method |
| US6555519B2 (en) | 2000-03-30 | 2003-04-29 | Bristol-Myers Squibb Company | O-glucosylated benzamide SGLT2 inhibitors and method |
| US6936590B2 (en) | 2001-03-13 | 2005-08-30 | Bristol Myers Squibb Company | C-aryl glucoside SGLT2 inhibitors and method |
| EP1577289A1 (en) | 2004-03-18 | 2005-09-21 | Revotar Biopharmaceuticals AG | Non-glycosylated/-glycosidic/-peptidic small molecule selectin inhibitors for the treament of inflammatory disorders |
| PT2264043T (pt) | 2005-09-02 | 2018-01-19 | Glycomimetics Inc | Inibidores de pan-selectina heterobifuncionais |
| EP1764096A1 (en) | 2005-09-20 | 2007-03-21 | Revotar Biopharmaceuticals AG | Novel phloroglucinol derivatives having selectin ligand activity |
| EP1764095A1 (en) * | 2005-09-20 | 2007-03-21 | Revotar Biopharmaceuticals AG | Novel nitrocatechol derivatives having selectin ligand activity |
| EP1764093A1 (en) | 2005-09-20 | 2007-03-21 | Revotar Biopharmaceuticals AG | Novel aromatic compounds and their use in medical applications |
| KR100827674B1 (ko) * | 2006-05-23 | 2008-05-07 | (주)한빛테크 | 자동트립 장치와 그 제어방법 |
| EP1903049A1 (en) * | 2006-09-08 | 2008-03-26 | Revotar Biopharmaceuticals AG | Crystalline forms of 1,6-Bis [3-(3-carboxymethylphenyl)-4-(2-alpha -D-mannopyranosyloxy)-phenyl] hexane |
| EP1897533A1 (en) * | 2006-09-08 | 2008-03-12 | Revotar Biopharmaceuticals AG | Use of 1,6-Bis [3-(3-carboxymethylphenyl)-4-(2-alpha -D-mannopyranosyl-oxy)-phenyl] hexane for the preparation of cosmetic compositions |
| EP1958637A1 (en) * | 2007-02-14 | 2008-08-20 | Revotar Biopharmaceuticals AG | Pharmaceutical composition for the treatment of IL-8 mediated diseases |
| JP2011507909A (ja) | 2007-12-20 | 2011-03-10 | エンビボ ファーマシューティカルズ インコーポレイテッド | 四置換ベンゼン |
| WO2009126556A1 (en) | 2008-04-08 | 2009-10-15 | Glycomimetics, Inc. | Pan-selectin inhibitor with enhanced pharmacokinetic activity |
| CN103002951A (zh) * | 2010-05-07 | 2013-03-27 | 瑞弗塔生物制药公司 | 新型化合物的制备方法 |
| WO2012037034A1 (en) | 2010-09-14 | 2012-03-22 | Glycomimetics, Inc. | E-selectin antagonists |
| PT2794626T (pt) | 2011-12-22 | 2018-01-12 | Glycomimetics Inc | Compostos de antagonistas de e-selectina |
| SI2928476T1 (en) | 2012-12-07 | 2018-06-29 | Glycomimetics, Inc. | COMPONENTS, INSTALLATIONS AND PROCEDURES OF THE APPLICATION OF E-SELECTINE OF ANTAGONISTS FOR THE MOBILIZATION OF HEMATOPOETIC CELLS |
| HUE045542T2 (hu) | 2014-12-03 | 2019-12-30 | Glycomimetics Inc | E-szelektinek és CXCR4 kemokin receptorok heterobifunkcionális inhibitorai |
| EP3497131B1 (en) | 2016-08-08 | 2022-03-09 | GlycoMimetics, Inc. | Combination of t-cell checkpoint inhibitors with inhibitors of e-selectin or cxcr4, or with heterobifunctional inhibitors of both e-selectin and cxcr4. |
| US11197877B2 (en) | 2017-03-15 | 2021-12-14 | Glycomimetics. Inc. | Galactopyranosyl-cyclohexyl derivauves as E-selectin antagonists |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2129140A1 (en) * | 1992-01-31 | 1993-08-05 | Akira Hasegawa | Lewis-type sugar chain derivative |
| US5444050A (en) * | 1994-04-29 | 1995-08-22 | Texas Biotechnology Corporation | Binding of E-selectin or P-selectin to sialyl Lewisx or sialyl-Lewisa |
| US5498775A (en) * | 1994-11-07 | 1996-03-12 | American Home Products Corporation | Polyanionic benzylglycosides as inhibitors of smooth muscle cell proliferation |
-
1996
- 1996-06-26 AT AT96921803T patent/ATE193647T1/de active
- 1996-06-26 HU HU9802602A patent/HU224590B1/hu not_active IP Right Cessation
- 1996-06-26 EP EP96921803A patent/EP0840606B1/en not_active Expired - Lifetime
- 1996-06-26 PL PL96324330A patent/PL185372B1/pl not_active IP Right Cessation
- 1996-06-26 KR KR1019970709757A patent/KR100438136B1/ko not_active IP Right Cessation
- 1996-06-26 ES ES96921803T patent/ES2146886T3/es not_active Expired - Lifetime
- 1996-06-26 CA CA002221991A patent/CA2221991C/en not_active Expired - Fee Related
- 1996-06-26 PT PT96921803T patent/PT840606E/pt unknown
- 1996-06-26 RU RU98101240/04A patent/RU2165931C2/ru not_active IP Right Cessation
- 1996-06-26 CZ CZ19974075A patent/CZ290072B6/cs not_active IP Right Cessation
- 1996-06-26 BR BR9608873A patent/BR9608873A/pt active Search and Examination
- 1996-06-26 DK DK96921803T patent/DK0840606T3/da active
- 1996-06-26 UA UA97126359A patent/UA52607C2/uk unknown
- 1996-06-26 AU AU62923/96A patent/AU704596B2/en not_active Ceased
- 1996-06-26 CN CNB961963522A patent/CN1149082C/zh not_active Expired - Fee Related
- 1996-06-26 WO PCT/US1996/011032 patent/WO1997001335A1/en active IP Right Grant
- 1996-06-26 DE DE69608804T patent/DE69608804T2/de not_active Expired - Lifetime
- 1996-06-26 JP JP50457997A patent/JP4046351B2/ja not_active Expired - Fee Related
-
1997
- 1997-12-23 FI FI974618A patent/FI974618A/fi not_active IP Right Cessation
- 1997-12-23 NO NO19976074A patent/NO310623B1/no not_active IP Right Cessation
-
2000
- 2000-08-30 GR GR20000401976T patent/GR3034289T3/el unknown
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