ATE193647T1 - Di- und trivalente kleine moleküle als selektininhibitoren - Google Patents

Di- und trivalente kleine moleküle als selektininhibitoren

Info

Publication number
ATE193647T1
ATE193647T1 AT96921803T AT96921803T ATE193647T1 AT E193647 T1 ATE193647 T1 AT E193647T1 AT 96921803 T AT96921803 T AT 96921803T AT 96921803 T AT96921803 T AT 96921803T AT E193647 T1 ATE193647 T1 AT E193647T1
Authority
AT
Austria
Prior art keywords
trivalent
small molecules
selectin inhibitors
selectin
inhibitors
Prior art date
Application number
AT96921803T
Other languages
English (en)
Inventor
Timothy P Kogan
Brian Dupre
Ian L Scott
Huong Bui
Kathy L Wheeler
Karin M Keller
Jamal M Kassir
Original Assignee
Texas Biotechnology Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Texas Biotechnology Corp filed Critical Texas Biotechnology Corp
Application granted granted Critical
Publication of ATE193647T1 publication Critical patent/ATE193647T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Cardiology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • External Artificial Organs (AREA)
AT96921803T 1995-06-29 1996-06-26 Di- und trivalente kleine moleküle als selektininhibitoren ATE193647T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US53395P 1995-06-29 1995-06-29
US278495P 1995-06-29 1995-06-29
PCT/US1996/011032 WO1997001335A1 (en) 1995-06-29 1996-06-26 Di- and trivalent small molecule selectin inhibitors

Publications (1)

Publication Number Publication Date
ATE193647T1 true ATE193647T1 (de) 2000-06-15

Family

ID=26667782

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96921803T ATE193647T1 (de) 1995-06-29 1996-06-26 Di- und trivalente kleine moleküle als selektininhibitoren

Country Status (21)

Country Link
EP (1) EP0840606B1 (de)
JP (1) JP4046351B2 (de)
KR (1) KR100438136B1 (de)
CN (1) CN1149082C (de)
AT (1) ATE193647T1 (de)
AU (1) AU704596B2 (de)
BR (1) BR9608873A (de)
CA (1) CA2221991C (de)
CZ (1) CZ290072B6 (de)
DE (1) DE69608804T2 (de)
DK (1) DK0840606T3 (de)
ES (1) ES2146886T3 (de)
FI (1) FI974618A (de)
GR (1) GR3034289T3 (de)
HU (1) HU224590B1 (de)
NO (1) NO310623B1 (de)
PL (1) PL185372B1 (de)
PT (1) PT840606E (de)
RU (1) RU2165931C2 (de)
UA (1) UA52607C2 (de)
WO (1) WO1997001335A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6024998A (en) * 1997-01-15 1998-08-07 Glycomed Incorporated Aryl c-glycoside compounds and sulfated esters thereof
WO1999029706A2 (en) * 1997-12-08 1999-06-17 Glycomed Incorporated DISALICYLATE ANALOG BASED SIALYL LEWISx MIMETICS
JP2003524598A (ja) * 1998-09-04 2003-08-19 アルタナ ファルマ アクチエンゲゼルシャフト 新規ピラノセン
PH12000002657B1 (en) 1999-10-12 2006-02-21 Bristol Myers Squibb Co C-aryl glucoside SGLT2 inhibitors
GB9924990D0 (en) * 1999-10-21 1999-12-22 Glaxo Group Ltd Medicaments
US6683056B2 (en) 2000-03-30 2004-01-27 Bristol-Myers Squibb Company O-aryl glucoside SGLT2 inhibitors and method
US6555519B2 (en) 2000-03-30 2003-04-29 Bristol-Myers Squibb Company O-glucosylated benzamide SGLT2 inhibitors and method
US6936590B2 (en) 2001-03-13 2005-08-30 Bristol Myers Squibb Company C-aryl glucoside SGLT2 inhibitors and method
EP1577289A1 (de) 2004-03-18 2005-09-21 Revotar Biopharmaceuticals AG Nicht-glykosylierte/-glykosidische/-peptidische keine Moleküle als Selektininhibitoren für die Behandlung entzündlicher Erkrankungen.
EP2264043B1 (de) 2005-09-02 2017-11-08 GlycoMimetics, Inc. Heterobifunktionelle Pan-Selektin-Inhibitoren
EP1764095A1 (de) * 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Neue Nitrocatecholderivate mit Selectin-Ligand-Activität
EP1764096A1 (de) 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Neue Phloroglucinolderivate mit Selectin-Ligand-Aktivität
EP1764093A1 (de) 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Neue aromatische Verbindungen und deren medizinische Verwendung
KR100827674B1 (ko) * 2006-05-23 2008-05-07 (주)한빛테크 자동트립 장치와 그 제어방법
EP1903049A1 (de) 2006-09-08 2008-03-26 Revotar Biopharmaceuticals AG Kristalline Formen von 1,6-Bis [3-(3-carboxymethylphenyl)-4-(2-alpha -D-mannopyranosyloxy)-phenyl] hexane
EP1897533A1 (de) * 2006-09-08 2008-03-12 Revotar Biopharmaceuticals AG Verwendung von 1,6-Bis[3-(3-carboxymethylphenyl)-4-(2-alpha-D-mannopyranosyl-oxy)-phenyl]hexan zur Herstellung von kosmetischen Zusammensetzungen
EP1958637A1 (de) * 2007-02-14 2008-08-20 Revotar Biopharmaceuticals AG Pharmazeutische Zusammensetzung zur Behandlung von IL-8-vermittelten Erkrankungen
EP2234954B1 (de) 2007-12-20 2015-02-18 Envivo Pharmaceuticals, Inc. Tetrasubstituierte benzole
WO2009126556A1 (en) 2008-04-08 2009-10-15 Glycomimetics, Inc. Pan-selectin inhibitor with enhanced pharmacokinetic activity
KR20130056238A (ko) * 2010-05-07 2013-05-29 레보타 바이오파마슈티컬스 아게 비모시아모스의 제조 방법
WO2012037034A1 (en) 2010-09-14 2012-03-22 Glycomimetics, Inc. E-selectin antagonists
WO2013096926A1 (en) 2011-12-22 2013-06-27 Glycomimetics, Inc. E-selectin antagonist compounds, compositions, and methods of use
EP2928476B1 (de) 2012-12-07 2018-02-14 GlycoMimetics, Inc. Verbindungen, zusammensetzungen und verfahren mit e-selectin-antagonisten zur mobilisierung blutbildender zellen
ES2754549T3 (es) 2014-12-03 2020-04-20 Glycomimetics Inc Inhibidores heterobifuncionales de E-selectinas y receptores de quimioquinas CXCR4
EP3497131B1 (de) 2016-08-08 2022-03-09 GlycoMimetics, Inc. Kombination von t-zell-checkpoint-inhibitoren mit e-selectin- oder cxcr4-inhibitoren oder mit heterobifunktionellen e-selectin- wie auch cxcr4-inhibitoren
WO2018169853A1 (en) 2017-03-15 2018-09-20 Glycomimetics, Inc. Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993015098A1 (en) * 1992-01-31 1993-08-05 Nippon Shinyaku Co., Ltd. Lewis-type sugar chain derivative
US5444050A (en) * 1994-04-29 1995-08-22 Texas Biotechnology Corporation Binding of E-selectin or P-selectin to sialyl Lewisx or sialyl-Lewisa
US5498775A (en) * 1994-11-07 1996-03-12 American Home Products Corporation Polyanionic benzylglycosides as inhibitors of smooth muscle cell proliferation

Also Published As

Publication number Publication date
CA2221991A1 (en) 1997-01-16
JP4046351B2 (ja) 2008-02-13
UA52607C2 (uk) 2003-01-15
HUP9802602A2 (hu) 1999-02-01
ES2146886T3 (es) 2000-08-16
BR9608873A (pt) 1999-07-06
CA2221991C (en) 2007-09-18
NO976074D0 (no) 1997-12-23
HUP9802602A3 (en) 1999-08-30
PL185372B1 (pl) 2003-04-30
AU6292396A (en) 1997-01-30
NO310623B1 (no) 2001-07-30
CZ407597A3 (cs) 1998-07-15
DE69608804T2 (de) 2000-11-02
CN1196678A (zh) 1998-10-21
WO1997001335A1 (en) 1997-01-16
NO976074L (no) 1998-03-02
DE69608804D1 (de) 2000-07-13
FI974618A0 (fi) 1997-12-23
EP0840606A4 (de) 1998-05-13
EP0840606A1 (de) 1998-05-13
PT840606E (pt) 2000-11-30
KR19990028441A (ko) 1999-04-15
FI974618A (fi) 1997-12-23
GR3034289T3 (en) 2000-12-29
DK0840606T3 (da) 2000-08-07
JPH11508885A (ja) 1999-08-03
RU2165931C2 (ru) 2001-04-27
AU704596B2 (en) 1999-04-29
CN1149082C (zh) 2004-05-12
EP0840606B1 (de) 2000-06-07
HU224590B1 (hu) 2005-11-28
PL324330A1 (en) 1998-05-25
CZ290072B6 (cs) 2002-05-15
KR100438136B1 (ko) 2004-08-25

Similar Documents

Publication Publication Date Title
ATE193647T1 (de) Di- und trivalente kleine moleküle als selektininhibitoren
PT971713E (pt) Utilizacao de inibidores da colinesterase para tratamento de desordens da atencao
ATE148130T1 (de) Typ-iv-dipeptidyl-aminopeptidase-inhibitoren
NO990405L (no) Substituerte N-(indol-2-karbonyl)-glycinamider og derivater som antidiabetiske midler
DK1355889T3 (da) Substituerede triazoldiaminderivater som kinaseinhibitorer
EA199800667A1 (ru) Новые фенантридины
DE69618231D1 (de) TETRAHYDROIMIDAZOPYRIDOINDOLDIONE ALS cGMP SPEZIFISCHE PDE HEMMER
DK1143967T3 (da) Anticonvulsive derivater egnede til behandling af Hortons hovedpine
ES2114487B1 (es) Mezcla estabilizante sinergistica.
DK0705100T3 (da) Terapeutiske substituerede guanidiner
AU2001260880A1 (en) Pharmaceutical compounds for treating copd
DK0700380T3 (da) N-Alkylthiopolyaminderivater som radioprotektive midler
YU48698A (sh) Karboksamidni derivati pirolidina, piperidina i heksahidroazepina za lečenje oboljenja na bazi tromboze
TR199800854T2 (xx) Antis�tma kinolin t�revleri.
ATE228760T1 (de) Thrombininhibitoren
TR200103125T2 (tr) Otizmin iyileştirilmesinde kullanıma yönelik antikonvülsan türevleri.
BG100248A (en) Squalene synthetase inhibitors
MX9709511A (es) Inhibidores de selectina de moleculas pequeñas divalentes y trivalentes.
DE69409961D1 (de) Triarylethylenderivate zur therapeutischen verwendung
DE59608611D1 (de) Topische aciclovir-zubereitung
ATE270113T1 (de) Zusammenstellungen zur verbesserten wundheilung
BG105252A (en) Isoquinolines as urokinase inhibitors
AR005866A1 (es) Composicion farmaceutica antioxidante
TR200103126T2 (tr) Yapısal titremenin iyileştirilmesinde kullanıma yönelik antikonvülsan türevleri
SE9404438D0 (sv) New process

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification