HUP9802447A2 - Piperazinszármazékok, eljárás előállításukra és 5-HT1A antagonistaként történő alkalmazásuk - Google Patents

Piperazinszármazékok, eljárás előállításukra és 5-HT1A antagonistaként történő alkalmazásuk

Info

Publication number
HUP9802447A2
HUP9802447A2 HU9802447A HUP9802447A HUP9802447A2 HU P9802447 A2 HUP9802447 A2 HU P9802447A2 HU 9802447 A HU9802447 A HU 9802447A HU P9802447 A HUP9802447 A HU P9802447A HU P9802447 A2 HUP9802447 A2 HU P9802447A2
Authority
HU
Hungary
Prior art keywords
preparation
piperazine derivatives
derivatives process
ht1a antagonists
above compound
Prior art date
Application number
HU9802447A
Other languages
English (en)
Inventor
Andrew Fensome
Michael Gerard Kelly
Howard Langham Mansell
Original Assignee
American Home Products Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corporation filed Critical American Home Products Corporation
Publication of HUP9802447A2 publication Critical patent/HUP9802447A2/hu
Publication of HUP9802447A3 publication Critical patent/HUP9802447A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A találmány az új (A) képletű R-N-[1-[2-[1-[4-[5-(2,3-dihidrő-[1,4]benző-diőxinil)]-piperazinil]-prőpil]-N-(2-piridil)-ciklőhe-xán-karbőxamidra vagy ennek farmakőlógiailag alkalmazható sóiravőnatkőzik. A találmány kiterjed a fenti vegyületet tartalmazógyógyszerkészítményre, valamint a fenti vegyület előállítására. Avegyületek a közpőnti idegrendszer betegségeinek gyógyításáraalkalmasak. ŕ
HU9802447A 1995-07-20 1996-07-19 Piperazine derivatives process for their preparation and their use as 5-ht1a antagonists HUP9802447A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9514901.9A GB9514901D0 (en) 1995-07-20 1995-07-20 Piperazine derivatives

Publications (2)

Publication Number Publication Date
HUP9802447A2 true HUP9802447A2 (hu) 1999-08-30
HUP9802447A3 HUP9802447A3 (en) 1999-11-29

Family

ID=10778004

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9802447A HUP9802447A3 (en) 1995-07-20 1996-07-19 Piperazine derivatives process for their preparation and their use as 5-ht1a antagonists

Country Status (21)

Country Link
EP (1) EP0839146B1 (hu)
JP (1) JP4166824B2 (hu)
KR (1) KR100447002B1 (hu)
CN (2) CN1077889C (hu)
AR (1) AR003451A1 (hu)
AT (1) ATE196294T1 (hu)
AU (1) AU700546B2 (hu)
BR (1) BR9609694A (hu)
CA (1) CA2227386C (hu)
DE (1) DE69610316T2 (hu)
DK (1) DK0839146T3 (hu)
ES (1) ES2150684T3 (hu)
GB (1) GB9514901D0 (hu)
GR (1) GR3034408T3 (hu)
HU (1) HUP9802447A3 (hu)
IL (1) IL122981A (hu)
MX (1) MX9800483A (hu)
NZ (1) NZ313231A (hu)
PT (1) PT839146E (hu)
WO (1) WO1997003982A1 (hu)
ZA (1) ZA966048B (hu)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6271234B1 (en) * 1997-08-01 2001-08-07 Recordati S.A., Chemical And Pharmaceutical Company 1,4-disubstituted piperazines
IT1293804B1 (it) 1997-08-01 1999-03-10 Recordati Chem Pharm Diarilalchilpiperazine attive sulle basse vie urinarie
US6399614B1 (en) 1997-08-01 2002-06-04 Recordati S.A. Chemical And Pharmaceutical Company 1-(N-phenylaminoalkyl)piperazine derivatives substituted at position 2 of the phenyl ring
US6469007B2 (en) 2000-11-28 2002-10-22 Wyeth Serotonergic agents
US20060223824A1 (en) 2000-11-28 2006-10-05 Wyeth Serotonergic agents
US20060287335A1 (en) 2000-11-28 2006-12-21 Wyeth Serotonergic agents for treating sexual dysfunction
EP1408976B3 (en) 2001-07-20 2010-08-25 Psychogenics Inc. Treatment for attention-deficit hyperactivity disorder
US7361773B2 (en) 2002-03-12 2008-04-22 Wyeth Preparation of N1-(2'-pyridyl)-1,2-propanediamine sulfamic acid and its use in the synthesis of biologically active piperazines
ATE449073T1 (de) * 2002-03-12 2009-12-15 Wyeth Corp Verfahren zur herstellung von n1-(2-pyridyl)-1,2- propandiaminsulfamidsäure und ihre verwendung zur herstellung von biologisch aktiven piperazinen
US7091349B2 (en) 2002-03-12 2006-08-15 Wyeth Process for synthesizing N-aryl piperazines with chiral N′-1-[benzoyl(2-pyridyl)amino]-2-propane substitution
WO2003078417A1 (en) * 2002-03-12 2003-09-25 Wyeth, A Corporation Of The State Of Delaware Process for synthesizing chiral n-aryl piperazines
AU2003220110B2 (en) 2002-03-12 2009-04-09 Wyeth Process for making chiral 1,4-disubstituted piperazines
US20050209245A1 (en) * 2004-03-19 2005-09-22 Wyeth Process for preparing N-aryl-piperazine derivatives
TW200800959A (en) 2005-06-10 2008-01-01 Wyeth Corp Piperazine-piperidine antagonists and agonists of the 5-HT1a receptor
JP2008543867A (ja) 2005-06-17 2008-12-04 ワイス セロトニン阻害剤ならびに５−ｈｔ１ａアゴニストおよびアンタゴニストとして有用な三環系化合物
TW200808741A (en) * 2006-06-09 2008-02-16 Wyeth Corp 6-methoxy-8-[4-(1-(5-fluoro)-quinolin-8-yl-piperidin-4-yl)-piperazin-1-yl]-quinoline hydrochloric acid salts
CL2008000119A1 (es) 2007-01-16 2008-05-16 Wyeth Corp Compuestos derivados de pirazol, antagonistas del receptor nicotinico de acetilcolina; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como demencia senil, alzheimer y esquizofrenia.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL101722A (en) * 1991-05-02 1996-05-14 Wyeth John & Brother Ltd History of piperazine, their preparation and pharmaceutical preparations containing them
ES2180638T3 (es) * 1994-06-03 2003-02-16 Wyeth John & Brother Ltd Nuevos procedimientos e intermediarios para la preparacion de derivados de piperazina.

Also Published As

Publication number Publication date
CN1077889C (zh) 2002-01-16
JP4166824B2 (ja) 2008-10-15
CA2227386C (en) 2006-05-16
KR100447002B1 (ko) 2004-12-04
GB9514901D0 (en) 1995-09-20
HUP9802447A3 (en) 1999-11-29
GR3034408T3 (en) 2000-12-29
PT839146E (pt) 2000-12-29
CN1131861C (zh) 2003-12-24
NZ313231A (en) 2001-03-30
DE69610316D1 (de) 2000-10-19
CN1309127A (zh) 2001-08-22
CN1190968A (zh) 1998-08-19
AU700546B2 (en) 1999-01-07
ZA966048B (en) 1998-01-16
DE69610316T2 (de) 2001-03-29
DK0839146T3 (da) 2000-11-20
AU6524996A (en) 1997-02-18
EP0839146A1 (en) 1998-05-06
ES2150684T3 (es) 2000-12-01
IL122981A0 (en) 1998-08-16
IL122981A (en) 2001-01-28
WO1997003982A1 (en) 1997-02-06
EP0839146B1 (en) 2000-09-13
JPH11509544A (ja) 1999-08-24
ATE196294T1 (de) 2000-09-15
MX9800483A (es) 1998-04-30
CA2227386A1 (en) 1997-02-06
AR003451A1 (es) 1998-08-05
KR19990029067A (ko) 1999-04-15
BR9609694A (pt) 1999-03-23

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees