DK645689A - Nye piperazinderivater - Google Patents

Nye piperazinderivater Download PDF

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Publication number
DK645689A
DK645689A DK645689A DK645689A DK645689A DK 645689 A DK645689 A DK 645689A DK 645689 A DK645689 A DK 645689A DK 645689 A DK645689 A DK 645689A DK 645689 A DK645689 A DK 645689A
Authority
DK
Denmark
Prior art keywords
compounds
piperazine derivatives
new piperazine
sterotonin
isomeres
Prior art date
Application number
DK645689A
Other languages
English (en)
Other versions
DK645689D0 (da
DK169266B1 (da
Inventor
Jens Perregaard
John Willie Stenberg
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of DK645689D0 publication Critical patent/DK645689D0/da
Publication of DK645689A publication Critical patent/DK645689A/da
Application granted granted Critical
Publication of DK169266B1 publication Critical patent/DK169266B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, ***e
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK645689A 1988-12-28 1989-12-19 1,4-disubstituerede piperazinforbindelser, farmaceutiske præparater, der indeholder dem, og fremgangsmåder til deres fremstilling DK169266B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB888830312A GB8830312D0 (en) 1988-12-28 1988-12-28 Heterocyclic compounds
GB8830312 1988-12-28

Publications (3)

Publication Number Publication Date
DK645689D0 DK645689D0 (da) 1989-12-19
DK645689A true DK645689A (da) 1990-06-29
DK169266B1 DK169266B1 (da) 1994-09-26

Family

ID=10649223

Family Applications (1)

Application Number Title Priority Date Filing Date
DK645689A DK169266B1 (da) 1988-12-28 1989-12-19 1,4-disubstituerede piperazinforbindelser, farmaceutiske præparater, der indeholder dem, og fremgangsmåder til deres fremstilling

Country Status (17)

Country Link
US (1) US5002948A (da)
EP (1) EP0376607B1 (da)
JP (1) JP2895121B2 (da)
AT (1) ATE102184T1 (da)
AU (1) AU637991B2 (da)
CA (1) CA2006356C (da)
DE (1) DE68913487T2 (da)
DK (1) DK169266B1 (da)
ES (1) ES2062050T3 (da)
FI (1) FI93005C (da)
GB (1) GB8830312D0 (da)
IE (1) IE62668B1 (da)
IL (1) IL92990A (da)
NO (1) NO174772C (da)
NZ (1) NZ231855A (da)
PT (1) PT92728B (da)
ZA (1) ZA899960B (da)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
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DE3923045A1 (de) * 1989-07-13 1991-01-17 Merck Patent Gmbh Indolderivate
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US5643784A (en) * 1990-12-04 1997-07-01 H, Lundbeck A/S Indan derivatives
FR2670491B1 (fr) * 1990-12-14 1993-02-05 Adir Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les renfermant.
DE4101686A1 (de) * 1991-01-22 1992-07-23 Merck Patent Gmbh Indolderivate
NZ243065A (en) 1991-06-13 1995-07-26 Lundbeck & Co As H Piperidine derivatives and pharmaceutical compositions
DE4127849A1 (de) * 1991-08-22 1993-02-25 Merck Patent Gmbh Benzodioxanderivate
CA2084531A1 (en) * 1991-12-19 1993-06-20 David W. Smith Antimigraine 4-pyrimidinyl and pyridinyl derivatives of indol-3yl-alkyl piperazines
DK55192D0 (da) * 1992-04-28 1992-04-28 Lundbeck & Co As H 1-piperazino-1,2-dihydroindenderivater
FR2692264B1 (fr) * 1992-06-12 1994-08-05 Adir Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant.
DK78692D0 (da) * 1992-06-12 1992-06-12 Lundbeck & Co As H Dimere piperidin- og piperazinderivater
ES2050623B1 (es) * 1992-11-06 1994-12-16 Merck Patent Gmbh Derivados de 1,4-benzodioxano.
DK148392D0 (da) * 1992-12-09 1992-12-09 Lundbeck & Co As H Heterocykliske forbindelser
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WO1996038420A1 (fr) * 1995-05-31 1996-12-05 Nisshin Flour Milling Co., Ltd. Derives de l'indazole a groupe amino monocyclique
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WO1998008816A1 (fr) * 1996-08-26 1998-03-05 Meiji Seika Kaisha, Ltd. Derives d'indoxyle et psychotropes
ES2206963T3 (es) * 1997-07-25 2004-05-16 H. Lundbeck A/S Derivados de indol y de 2,3-dihidroindol, su preparacion y uso.
AR013206A1 (es) * 1997-07-25 2000-12-13 Lundbeck & Co As H Derivados indol y 2,3-dihidroindol, composiciones farmaceuticas que contienen estos compuestos y el uso de dichos compuestos para la preparacion de un medicamento para el tratamiento de desordenes sensibles a la inhibicion de la reabsorcion de serotonina y antagonismo de receptores 5-ht1a.
CN1160332C (zh) * 1998-04-08 2004-08-04 惠氏公司 用于治疗抑郁症的n-芳氧基乙基胺衍生物
AR022303A1 (es) 1999-01-22 2002-09-04 Lundbeck & Co As H Derivados de piperidina, tetrahidropiridina y piperazina, su preparacion y utilizacion
JP4919565B2 (ja) * 1999-08-23 2012-04-18 アボツト・ヘルスケア・プロダクツ・ベー・ブイ 新規なフェニルピペラジン
AR027134A1 (es) * 1999-12-30 2003-03-12 Lundbeck & Co As H Derivados de indol.
WO2001049678A1 (en) * 1999-12-30 2001-07-12 H. Lundbeck A/S Substituted phenyl-piperazine derivatives, their preparation and use
TR200201684T2 (tr) * 1999-12-30 2002-10-21 H. Lundbeck A/S Fenilpiperazinil türevleri
US7211594B2 (en) * 2000-07-31 2007-05-01 Signal Pharmaceuticals, Llc Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith
US6897231B2 (en) * 2000-07-31 2005-05-24 Signal Pharmaceuticals, Inc. Indazole derivatives as JNK inhibitors and compositions and methods related thereto
AR035521A1 (es) * 2000-12-22 2004-06-02 Lundbeck & Co As H Derivados de 3-indolina y composicion farmaceutica que los comprende
AR032712A1 (es) 2001-02-21 2003-11-19 Solvay Pharm Bv Un mesilato de derivados de fenilpiperazina y composiciones farmaceuticas que lo contienen
US6559169B2 (en) 2001-04-24 2003-05-06 Wyeth Antidepressant azaheterocyclymethyl derivatives of 2,3-dihydro-1,4-benzodioxan
US7041683B2 (en) 2001-04-24 2006-05-09 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1, 4-benzodiozan
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US7276603B2 (en) * 2003-05-02 2007-10-02 Wyeth Benzofuranyl-and benzothienyl-piperazinyl quinolines and methods of their use
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MXPA06013065A (es) * 2004-05-11 2007-05-04 Egis Gyogyszergyar Nyrt Derivados de indol-2-ona para el tratamiento de trastornos del sistema nervioso central, trastornos gastrointestinales y trastornos cardiovasculares.
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JP2009536176A (ja) * 2006-05-09 2009-10-08 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 閉経後の性的欲求障害の治療のためのフリバンセリンの使用
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CL2008002693A1 (es) 2007-09-12 2009-10-16 Boehringer Ingelheim Int Uso de flibanserina para el tratamiento de sintomas vasomotores seleccionados de sofocos, sudores nocturnos, cambios de estado de animo e irritabilidad
SG177628A1 (en) * 2009-07-30 2012-03-29 Univ Singapore Small molecule inhibitors of isoprenylcysteine carboxyl methyltransferase with potential anticancer activity
EP2464227A4 (en) * 2009-08-10 2013-02-20 Galenea Corp COMPOUNDS AND METHODS OF USE
CN102993186B (zh) * 2012-12-20 2015-11-18 北京海步国际医药科技发展有限公司 一种新型的哌嗪衍生物
CN104337812B (zh) 2013-07-29 2018-09-14 广东东阳光药业有限公司 取代的杂芳基化合物及其使用方法和用途
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CN106065018B (zh) * 2015-04-23 2020-04-21 广东东阳光药业有限公司 取代的吲哚化合物及其使用方法和用途
CN106243088B (zh) 2015-06-03 2019-01-04 广东东阳光药业有限公司 取代的哌嗪化合物及其使用方法和用途

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Also Published As

Publication number Publication date
PT92728B (pt) 1995-12-29
CA2006356C (en) 1999-09-14
NZ231855A (en) 1992-02-25
NO174772C (no) 1994-07-06
GB8830312D0 (en) 1989-02-22
NO895281D0 (no) 1989-12-27
IE62668B1 (en) 1995-02-22
US5002948A (en) 1991-03-26
FI896300A0 (fi) 1989-12-28
NO895281L (no) 1990-06-29
FI93005B (fi) 1994-10-31
CA2006356A1 (en) 1990-06-28
IL92990A (en) 1995-01-24
FI93005C (fi) 1995-02-10
ES2062050T3 (es) 1994-12-16
ATE102184T1 (de) 1994-03-15
EP0376607B1 (en) 1994-03-02
JP2895121B2 (ja) 1999-05-24
DK645689D0 (da) 1989-12-19
AU4719889A (en) 1990-07-05
DE68913487T2 (de) 1994-08-04
DE68913487D1 (de) 1994-04-07
PT92728A (pt) 1990-06-29
JPH02225460A (ja) 1990-09-07
IE893976L (en) 1990-06-13
ZA899960B (en) 1990-11-28
NO174772B (no) 1994-03-28
AU637991B2 (en) 1993-06-17
DK169266B1 (da) 1994-09-26
EP0376607A1 (en) 1990-07-04
IL92990A0 (en) 1990-09-17

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