DE69610316T2 - Piperazin-derivate und ihre verwendung als 5-ht1a-antagoniste - Google Patents

Piperazin-derivate und ihre verwendung als 5-ht1a-antagoniste

Info

Publication number
DE69610316T2
DE69610316T2 DE69610316T DE69610316T DE69610316T2 DE 69610316 T2 DE69610316 T2 DE 69610316T2 DE 69610316 T DE69610316 T DE 69610316T DE 69610316 T DE69610316 T DE 69610316T DE 69610316 T2 DE69610316 T2 DE 69610316T2
Authority
DE
Germany
Prior art keywords
piperazine derivatives
ht1a antagonists
ht1a
antagonists
piperazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69610316T
Other languages
English (en)
Other versions
DE69610316D1 (de
Inventor
Andrew Fensome
Gerard Kelly
Langham Mansell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corp filed Critical American Home Products Corp
Publication of DE69610316D1 publication Critical patent/DE69610316D1/de
Application granted granted Critical
Publication of DE69610316T2 publication Critical patent/DE69610316T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69610316T 1995-07-20 1996-07-19 Piperazin-derivate und ihre verwendung als 5-ht1a-antagoniste Expired - Lifetime DE69610316T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9514901.9A GB9514901D0 (en) 1995-07-20 1995-07-20 Piperazine derivatives
PCT/GB1996/001714 WO1997003982A1 (en) 1995-07-20 1996-07-19 Piperazine derivatives and their use as 5-ht1a antagonists

Publications (2)

Publication Number Publication Date
DE69610316D1 DE69610316D1 (de) 2000-10-19
DE69610316T2 true DE69610316T2 (de) 2001-03-29

Family

ID=10778004

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69610316T Expired - Lifetime DE69610316T2 (de) 1995-07-20 1996-07-19 Piperazin-derivate und ihre verwendung als 5-ht1a-antagoniste

Country Status (21)

Country Link
EP (1) EP0839146B1 (de)
JP (1) JP4166824B2 (de)
KR (1) KR100447002B1 (de)
CN (2) CN1077889C (de)
AR (1) AR003451A1 (de)
AT (1) ATE196294T1 (de)
AU (1) AU700546B2 (de)
BR (1) BR9609694A (de)
CA (1) CA2227386C (de)
DE (1) DE69610316T2 (de)
DK (1) DK0839146T3 (de)
ES (1) ES2150684T3 (de)
GB (1) GB9514901D0 (de)
GR (1) GR3034408T3 (de)
HU (1) HUP9802447A3 (de)
IL (1) IL122981A (de)
MX (1) MX9800483A (de)
NZ (1) NZ313231A (de)
PT (1) PT839146E (de)
WO (1) WO1997003982A1 (de)
ZA (1) ZA966048B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1293804B1 (it) 1997-08-01 1999-03-10 Recordati Chem Pharm Diarilalchilpiperazine attive sulle basse vie urinarie
US6399614B1 (en) 1997-08-01 2002-06-04 Recordati S.A. Chemical And Pharmaceutical Company 1-(N-phenylaminoalkyl)piperazine derivatives substituted at position 2 of the phenyl ring
US6271234B1 (en) * 1997-08-01 2001-08-07 Recordati S.A., Chemical And Pharmaceutical Company 1,4-disubstituted piperazines
US6469007B2 (en) * 2000-11-28 2002-10-22 Wyeth Serotonergic agents
US20060287335A1 (en) 2000-11-28 2006-12-21 Wyeth Serotonergic agents for treating sexual dysfunction
US20060223824A1 (en) 2000-11-28 2006-10-05 Wyeth Serotonergic agents
EP1408976B3 (de) 2001-07-20 2010-08-25 Psychogenics Inc. Behandlung von hyperaktivitätsstörungen und aufmerksamkeitsdefiziten
US7361773B2 (en) 2002-03-12 2008-04-22 Wyeth Preparation of N1-(2'-pyridyl)-1,2-propanediamine sulfamic acid and its use in the synthesis of biologically active piperazines
RU2315762C2 (ru) * 2002-03-12 2008-01-27 Уайт Способ синтеза хиральных n-арилпиперазинов
ES2283762T3 (es) * 2002-03-12 2007-11-01 Wyeth Preparacion de acido n1-(2'-piridil)-1,2-propanodiaminosulfamico y su uso en la sintesis de piperazinas biologicamente activas.
AU2003220110B2 (en) 2002-03-12 2009-04-09 Wyeth Process for making chiral 1,4-disubstituted piperazines
US7091349B2 (en) 2002-03-12 2006-08-15 Wyeth Process for synthesizing N-aryl piperazines with chiral N′-1-[benzoyl(2-pyridyl)amino]-2-propane substitution
US20050209245A1 (en) * 2004-03-19 2005-09-22 Wyeth Process for preparing N-aryl-piperazine derivatives
TW200800959A (en) 2005-06-10 2008-01-01 Wyeth Corp Piperazine-piperidine antagonists and agonists of the 5-HT1a receptor
MX2007015772A (es) 2005-06-17 2008-02-22 Wyeth Corp Compuestos utiles como inhibidores de serotonina y agonistas y antagonistas de 5-ht-1a.
TW200808741A (en) * 2006-06-09 2008-02-16 Wyeth Corp 6-methoxy-8-[4-(1-(5-fluoro)-quinolin-8-yl-piperidin-4-yl)-piperazin-1-yl]-quinoline hydrochloric acid salts
TW200901974A (en) 2007-01-16 2009-01-16 Wyeth Corp Compounds, compositions, and methods of making and using them

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU645681B2 (en) * 1991-05-02 1994-01-20 John Wyeth & Brother Limited Piperazine derivatives
PT763024E (pt) * 1994-06-03 2002-11-29 Wyeth John & Brother Ltd Novos processos e intermediarios para a preparacao de derivados de piperazina

Also Published As

Publication number Publication date
AR003451A1 (es) 1998-08-05
CN1077889C (zh) 2002-01-16
DE69610316D1 (de) 2000-10-19
GR3034408T3 (en) 2000-12-29
MX9800483A (es) 1998-04-30
HUP9802447A3 (en) 1999-11-29
CN1190968A (zh) 1998-08-19
CA2227386C (en) 2006-05-16
HUP9802447A2 (hu) 1999-08-30
CN1131861C (zh) 2003-12-24
ZA966048B (en) 1998-01-16
EP0839146A1 (de) 1998-05-06
PT839146E (pt) 2000-12-29
ES2150684T3 (es) 2000-12-01
KR19990029067A (ko) 1999-04-15
JPH11509544A (ja) 1999-08-24
WO1997003982A1 (en) 1997-02-06
CN1309127A (zh) 2001-08-22
CA2227386A1 (en) 1997-02-06
JP4166824B2 (ja) 2008-10-15
KR100447002B1 (ko) 2004-12-04
AU700546B2 (en) 1999-01-07
EP0839146B1 (de) 2000-09-13
AU6524996A (en) 1997-02-18
IL122981A0 (en) 1998-08-16
DK0839146T3 (da) 2000-11-20
BR9609694A (pt) 1999-03-23
GB9514901D0 (en) 1995-09-20
NZ313231A (en) 2001-03-30
IL122981A (en) 2001-01-28
ATE196294T1 (de) 2000-09-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: WYETH (N.D.GES.D. STAATES DELAWARE), MADISON, N.J.