HUP9700274A2 - Optikailag aktív (-)-(3R)-3-metil-4-{4-[4-(4-piridil)-piperazin-1-il]-fenoxi}-vajsav, mint sejtadhézió-inhibitor, előállítása és alkalmazása, a vegyületet tartalmazó gyógyászati készítmény - Google Patents
Optikailag aktív (-)-(3R)-3-metil-4-{4-[4-(4-piridil)-piperazin-1-il]-fenoxi}-vajsav, mint sejtadhézió-inhibitor, előállítása és alkalmazása, a vegyületet tartalmazó gyógyászati készítményInfo
- Publication number
- HUP9700274A2 HUP9700274A2 HU9700274A HUP9700274A HUP9700274A2 HU P9700274 A2 HUP9700274 A2 HU P9700274A2 HU 9700274 A HU9700274 A HU 9700274A HU P9700274 A HUP9700274 A HU P9700274A HU P9700274 A2 HUP9700274 A2 HU P9700274A2
- Authority
- HU
- Hungary
- Prior art keywords
- compound
- piperazin
- phenoxy
- pyridyl
- methyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 239000002253 acid Substances 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title 1
- 239000008194 pharmaceutical composition Chemical class 0.000 title 1
- 150000002148 esters Chemical class 0.000 abstract 3
- 150000001408 amides Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- VGELYRQRLGCXQF-GFCCVEGCSA-N (3r)-3-methyl-4-(4-piperazin-1-ylphenoxy)butanoic acid Chemical compound C1=CC(OC[C@H](C)CC(O)=O)=CC=C1N1CCNCC1 VGELYRQRLGCXQF-GFCCVEGCSA-N 0.000 abstract 1
- ZGYGEPZZMAXSKH-SCSAIBSYSA-N (3r)-4-hydroxy-3-methylbutanoic acid Chemical compound OC[C@H](C)CC(O)=O ZGYGEPZZMAXSKH-SCSAIBSYSA-N 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 239000002585 base Substances 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
A cím szerinti vegyületet úgy állítják elő, hőgy (a) 4-[4-(4-piridil)-piperazin-1-il]-fenőlt vagy reakcióképes származékát (3R)-4-hidrőxi-3-metil-vajsavval vagy észterével, vagy ezek reakcióképes származékávalreagáltatják, vagy (b) egy (I) általánős képletű vegyületet - aképletben L kilépő atőmőt vgy csőpőrtőt jelent - (3R)-3-metil-4-[4-(piperazin-1-il)-fenőxi]-vajsavval vagy savaddíciós sójávalreagáltatnak, vagy (c) egy (II) általánős képletű észtert - aképletben R karbőxil-védőcsőpőrtőt jelent - elbőntják, vagy (d) amegfelelő (3RS)-racemátőt, azaz a (3RS)-3-metil-4-[4-(4-/4-piridil/-piperazin-1-il)-fenőxi]-vajsavat rezőlválják, majd kívánt esetben a(-)-(3R)-vegyület gyógyászatilag alkalmazható sójának előállítására akapőtt terméket egy alkalmas savval vagy bázissal reagáltatják, vagy a(-)-(3R)-vegyület gyógyászatilag alkalmazható észterének vagyamidjának előállítására a kapőtt terméket egy alkalmas alkőhőllal vagyamiddal reagáltatják. ŕ
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/457,538 US5652242A (en) | 1993-03-29 | 1995-06-01 | Heterocyclic derivatives |
| GBGB9518188.9A GB9518188D0 (en) | 1995-09-07 | 1995-09-07 | Optically active derivative |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HU9700274D0 HU9700274D0 (en) | 1997-04-28 |
| HUP9700274A2 true HUP9700274A2 (hu) | 1999-06-28 |
| HUP9700274A3 HUP9700274A3 (en) | 2000-02-28 |
Family
ID=26307696
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9700274A HUP9700274A3 (en) | 1995-06-01 | 1996-05-28 | Optically active (-)-(3r)-3-methyl-4-{4-[4-(4-pyridyl)-piperazin-1-yl]-phenoxy}-butiric acid as inhibitor of celle-adhesion, preparation and use of this compound, pharmaceutical composition containing this compound |
Country Status (31)
| Country | Link |
|---|---|
| EP (1) | EP0796247A1 (hu) |
| JP (1) | JP2885941B2 (hu) |
| KR (1) | KR100245957B1 (hu) |
| AT (1) | AT406675B (hu) |
| AU (1) | AU710105B2 (hu) |
| BE (1) | BE1009520A5 (hu) |
| BR (1) | BR9606409A (hu) |
| CA (1) | CA2194397A1 (hu) |
| CH (1) | CH691808A5 (hu) |
| CZ (1) | CZ26997A3 (hu) |
| DE (1) | DE19680509T1 (hu) |
| DK (1) | DK10697A (hu) |
| ES (1) | ES2137886B1 (hu) |
| FI (1) | FI970393A (hu) |
| GB (1) | GB2304340B (hu) |
| GR (1) | GR1002702B (hu) |
| HU (1) | HUP9700274A3 (hu) |
| IE (1) | IE960405A1 (hu) |
| IL (1) | IL118477A0 (hu) |
| IT (1) | IT1290839B1 (hu) |
| LU (1) | LU90008B1 (hu) |
| MC (1) | MC2418A1 (hu) |
| MX (1) | MX9700379A (hu) |
| NL (1) | NL1003243C2 (hu) |
| NO (1) | NO307460B1 (hu) |
| NZ (1) | NZ308597A (hu) |
| PL (1) | PL318440A1 (hu) |
| SE (1) | SE510812C2 (hu) |
| SK (1) | SK13097A3 (hu) |
| TR (1) | TR199700020T1 (hu) |
| WO (1) | WO1996038416A1 (hu) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0100158A3 (en) * | 1982-07-28 | 1985-03-27 | The Upjohn Company | (3-pyridinyl)heteroalkarylalkanols, alkanoic acids and esters |
| GB8609630D0 (en) * | 1986-04-19 | 1986-05-21 | Pfizer Ltd | Anti-arrhythmia agents |
| DK0825184T3 (da) * | 1993-03-29 | 2001-09-10 | Astrazeneca Ab | Heterocykliske derivater som blodpladeaggregeringsinhibitorer |
| IL109145A0 (en) * | 1993-03-29 | 1994-06-24 | Zeneca Ltd | Heterocyclic compounds |
-
1996
- 1996-05-28 TR TR97/00020T patent/TR199700020T1/xx unknown
- 1996-05-28 HU HU9700274A patent/HUP9700274A3/hu unknown
- 1996-05-28 EP EP96919906A patent/EP0796247A1/en not_active Withdrawn
- 1996-05-28 MX MX9700379A patent/MX9700379A/es unknown
- 1996-05-28 SK SK130-97A patent/SK13097A3/sk unknown
- 1996-05-28 CH CH00224/97A patent/CH691808A5/de not_active IP Right Cessation
- 1996-05-28 AT AT0900596A patent/AT406675B/de active
- 1996-05-28 AU AU58272/96A patent/AU710105B2/en not_active Ceased
- 1996-05-28 BR BR9606409A patent/BR9606409A/pt not_active Application Discontinuation
- 1996-05-28 JP JP8536281A patent/JP2885941B2/ja not_active Expired - Fee Related
- 1996-05-28 PL PL96318440A patent/PL318440A1/xx unknown
- 1996-05-28 CA CA002194397A patent/CA2194397A1/en not_active Abandoned
- 1996-05-28 GR GR960100176A patent/GR1002702B/el not_active IP Right Cessation
- 1996-05-28 DE DE19680509T patent/DE19680509T1/de not_active Withdrawn
- 1996-05-28 ES ES009750006A patent/ES2137886B1/es not_active Expired - Fee Related
- 1996-05-28 CZ CZ97269A patent/CZ26997A3/cs unknown
- 1996-05-28 NZ NZ308597A patent/NZ308597A/en unknown
- 1996-05-28 WO PCT/GB1996/001260 patent/WO1996038416A1/en not_active IP Right Cessation
- 1996-05-28 GB GB9627127A patent/GB2304340B/en not_active Expired - Fee Related
- 1996-05-28 KR KR1019970700532A patent/KR100245957B1/ko not_active IP Right Cessation
- 1996-05-29 MC MC2347A patent/MC2418A1/xx unknown
- 1996-05-30 IL IL11847796A patent/IL118477A0/xx unknown
- 1996-05-31 NL NL1003243A patent/NL1003243C2/xx not_active IP Right Cessation
- 1996-05-31 BE BE9600491A patent/BE1009520A5/fr not_active IP Right Cessation
- 1996-05-31 IE IE960405A patent/IE960405A1/en not_active IP Right Cessation
- 1996-05-31 IT IT96MI001113A patent/IT1290839B1/it active IP Right Grant
-
1997
- 1997-01-22 LU LU90008A patent/LU90008B1/fr active
- 1997-01-24 SE SE9700203A patent/SE510812C2/sv not_active IP Right Cessation
- 1997-01-30 DK DK010697A patent/DK10697A/da not_active Application Discontinuation
- 1997-01-30 FI FI970393A patent/FI970393A/fi unknown
- 1997-01-31 NO NO970437A patent/NO307460B1/no not_active IP Right Cessation
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