AU5827296A - (-)-(3R0-3-methyl-4-(4-(4-(4-pyridyl)piperazin-1-yl)phenoxy) butyric acid as cellular adhesion inhibitor - Google Patents

(-)-(3R0-3-methyl-4-(4-(4-(4-pyridyl)piperazin-1-yl)phenoxy) butyric acid as cellular adhesion inhibitor

Info

Publication number
AU5827296A
AU5827296A AU58272/96A AU5827296A AU5827296A AU 5827296 A AU5827296 A AU 5827296A AU 58272/96 A AU58272/96 A AU 58272/96A AU 5827296 A AU5827296 A AU 5827296A AU 5827296 A AU5827296 A AU 5827296A
Authority
AU
Australia
Prior art keywords
piperazin
phenoxy
pyridyl
methyl
butyric acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU58272/96A
Other versions
AU710105B2 (en
Inventor
Stuart Dennett Mills
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syngenta Ltd
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/457,538 external-priority patent/US5652242A/en
Priority claimed from GBGB9518188.9A external-priority patent/GB9518188D0/en
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of AU5827296A publication Critical patent/AU5827296A/en
Application granted granted Critical
Publication of AU710105B2 publication Critical patent/AU710105B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
AU58272/96A 1995-06-01 1996-05-28 (-)-(3R0-3-methyl-4-(4-(4-(4-pyridyl)piperazin-1-yl)phenoxy) butyric acid as cellular adhesion inhibitor Ceased AU710105B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/457,538 US5652242A (en) 1993-03-29 1995-06-01 Heterocyclic derivatives
US08/457538 1995-06-01
GB9518188 1995-09-07
GBGB9518188.9A GB9518188D0 (en) 1995-09-07 1995-09-07 Optically active derivative
PCT/GB1996/001260 WO1996038416A1 (en) 1995-06-01 1996-05-28 (-)-(3r)-3-methyl-4-{4-[4-(4-pyridyl)piperazin-1-yl]phenoxy} butyric acid as cellular adhesion inhibitor

Publications (2)

Publication Number Publication Date
AU5827296A true AU5827296A (en) 1996-12-18
AU710105B2 AU710105B2 (en) 1999-09-16

Family

ID=26307696

Family Applications (1)

Application Number Title Priority Date Filing Date
AU58272/96A Ceased AU710105B2 (en) 1995-06-01 1996-05-28 (-)-(3R0-3-methyl-4-(4-(4-(4-pyridyl)piperazin-1-yl)phenoxy) butyric acid as cellular adhesion inhibitor

Country Status (31)

Country Link
EP (1) EP0796247A1 (en)
JP (1) JP2885941B2 (en)
KR (1) KR100245957B1 (en)
AT (1) AT406675B (en)
AU (1) AU710105B2 (en)
BE (1) BE1009520A5 (en)
BR (1) BR9606409A (en)
CA (1) CA2194397A1 (en)
CH (1) CH691808A5 (en)
CZ (1) CZ26997A3 (en)
DE (1) DE19680509T1 (en)
DK (1) DK10697A (en)
ES (1) ES2137886B1 (en)
FI (1) FI970393A (en)
GB (1) GB2304340B (en)
GR (1) GR1002702B (en)
HU (1) HUP9700274A3 (en)
IE (1) IE960405A1 (en)
IL (1) IL118477A0 (en)
IT (1) IT1290839B1 (en)
LU (1) LU90008B1 (en)
MC (1) MC2418A1 (en)
MX (1) MX9700379A (en)
NL (1) NL1003243C2 (en)
NO (1) NO307460B1 (en)
NZ (1) NZ308597A (en)
PL (1) PL318440A1 (en)
SE (1) SE510812C2 (en)
SK (1) SK13097A3 (en)
TR (1) TR199700020T1 (en)
WO (1) WO1996038416A1 (en)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0100158A3 (en) * 1982-07-28 1985-03-27 The Upjohn Company (3-pyridinyl)heteroalkarylalkanols, alkanoic acids and esters
GB8609630D0 (en) * 1986-04-19 1986-05-21 Pfizer Ltd Anti-arrhythmia agents
DK0825184T3 (en) * 1993-03-29 2001-09-10 Astrazeneca Ab Heterocyclic derivatives such as platelet aggregation inhibitors
IL109145A0 (en) * 1993-03-29 1994-06-24 Zeneca Ltd Heterocyclic compounds

Also Published As

Publication number Publication date
GB2304340B (en) 1998-07-29
WO1996038416A1 (en) 1996-12-05
AU710105B2 (en) 1999-09-16
KR970704689A (en) 1997-09-06
FI970393A0 (en) 1997-01-30
HUP9700274A3 (en) 2000-02-28
PL318440A1 (en) 1997-06-09
IE960405A1 (en) 1996-12-11
ITMI961113A1 (en) 1997-12-01
BR9606409A (en) 1997-09-30
KR100245957B1 (en) 2000-04-01
ATA900596A (en) 1999-12-15
HUP9700274A2 (en) 1999-06-28
SE9700203L (en) 1997-01-24
HU9700274D0 (en) 1997-04-28
BE1009520A5 (en) 1997-04-01
AT406675B (en) 2000-07-25
EP0796247A1 (en) 1997-09-24
ITMI961113A0 (en) 1996-05-31
SE510812C2 (en) 1999-06-28
IL118477A0 (en) 1996-09-12
GR1002702B (en) 1997-05-22
CZ26997A3 (en) 1997-08-13
MX9700379A (en) 1997-04-30
JP2885941B2 (en) 1999-04-26
TR199700020T1 (en) 1997-04-22
FI970393A (en) 1997-01-30
SE9700203D0 (en) 1997-01-24
CA2194397A1 (en) 1996-12-05
DE19680509T1 (en) 1997-12-04
NO970437D0 (en) 1997-01-31
LU90008B1 (en) 1997-04-16
NO307460B1 (en) 2000-04-10
NZ308597A (en) 1998-11-25
JPH09512836A (en) 1997-12-22
NL1003243C2 (en) 1996-12-04
CH691808A5 (en) 2001-10-31
ES2137886B1 (en) 2000-08-16
IT1290839B1 (en) 1998-12-14
SK13097A3 (en) 1997-08-06
DK10697A (en) 1997-04-01
ES2137886A1 (en) 1999-12-16
GB9627127D0 (en) 1997-02-19
MC2418A1 (en) 1997-05-23
GB2304340A (en) 1997-03-19
NO970437L (en) 1997-02-20

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired