MX9603520A - Derivados del acido hidroxamico y acido carboxilico, procesos para su preparacion y su uso. - Google Patents

Derivados del acido hidroxamico y acido carboxilico, procesos para su preparacion y su uso.

Info

Publication number
MX9603520A
MX9603520A MX9603520A MX9603520A MX9603520A MX 9603520 A MX9603520 A MX 9603520A MX 9603520 A MX9603520 A MX 9603520A MX 9603520 A MX9603520 A MX 9603520A MX 9603520 A MX9603520 A MX 9603520A
Authority
MX
Mexico
Prior art keywords
carboxylic acid
preparation
hydroxamic
acid derivatives
compounds
Prior art date
Application number
MX9603520A
Other languages
English (en)
Other versions
MXPA96003520A (es
Inventor
Madhusudhan Reddy Gowravaram
Jeffrey Johnson
Ewell R Cook
Robert C Wahl
Alan M Mathiowetz
Ashis K Saha
Bruce E Tomczuk
Original Assignee
Sanofi Winthrop Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Winthrop Inc filed Critical Sanofi Winthrop Inc
Publication of MXPA96003520A publication Critical patent/MXPA96003520A/es
Publication of MX9603520A publication Critical patent/MX9603520A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Esta descripcion se relaciona con una clase nueva de ácido hidroxámico yácido carboxílico a base de derivados inhibidores de la matriz de la metaloproteinasa. La descripcion se relaciona además con composiciones farmacéuticas que contienen tales compuestos y con el uso de tales compuestos y composiciones en el tratamiento de enfermedades inducidas por la matriz de la metaloproteinasa.
MX9603520A 1994-02-25 1996-08-20 Derivados del acido hidroxamico y acido carboxilico, procesos para su preparacion y su uso. MX9603520A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08201837 1994-02-25
US08/201,837 US5514716A (en) 1994-02-25 1994-02-25 Hydroxamic acid and carboxylic acid derivatives, process for their preparation and use thereof

Publications (2)

Publication Number Publication Date
MXPA96003520A MXPA96003520A (es) 1998-01-01
MX9603520A true MX9603520A (es) 1998-01-31

Family

ID=22747514

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9603520A MX9603520A (es) 1994-02-25 1996-08-20 Derivados del acido hidroxamico y acido carboxilico, procesos para su preparacion y su uso.

Country Status (11)

Country Link
US (2) US5514716A (es)
EP (1) EP0749302A4 (es)
JP (1) JPH09509662A (es)
AU (1) AU1881795A (es)
CA (1) CA2184093A1 (es)
FI (1) FI963298A (es)
HU (1) HUT75054A (es)
MX (1) MX9603520A (es)
NO (1) NO963499L (es)
NZ (1) NZ281856A (es)
WO (1) WO1995022966A1 (es)

Families Citing this family (49)

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US6037472A (en) * 1993-11-04 2000-03-14 Syntex (U.S.A.) Inc. Matrix metalloprotease inhibitors
GB9405076D0 (en) 1994-03-16 1994-04-27 Inst Of Ophtalmology A medical use of matrix metalloproteinase inhibitors
GB9601042D0 (en) * 1996-01-17 1996-03-20 Smithkline Beecham Plc Medical use
US5651766A (en) * 1995-06-07 1997-07-29 Transfusion Technologies Corporation Blood collection and separation system
WO1996033968A1 (fr) * 1995-04-25 1996-10-31 Fuji Yakuhin Kogyo Kabushiki Kaisha Inhibiteur des metalloproteinases, tres soluble dans l'eau
BR9611487A (pt) 1995-11-17 1999-01-19 Warner Lambert Co Inibidores de sulfonamida de metaloproteinases de matriz
ES2164264T3 (es) 1995-11-23 2002-02-16 British Biotech Pharm Inhibidores de metaloproteinasas.
CZ292942B6 (cs) * 1995-12-08 2004-01-14 Agouron Pharmaceuticals, Inc. Derivát (N-hydroxykarbamoyl)-1-(4-fenoxy)benzensulfonylu
US6500948B1 (en) 1995-12-08 2002-12-31 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors-compositions, uses preparation and intermediates thereof
HUP9903916A3 (en) * 1996-08-28 2001-06-28 Procter And Gamble Co Cincinna Phosphinic acid amides and pharmaceutical compositions containing the same
CA2265666C (en) 1996-09-10 2008-01-15 British Biotech Pharmaceuticals Limited Cytostatic hydroxamic acid derivatives
US6462023B1 (en) 1996-09-10 2002-10-08 British Biotech Pharmaceuticals, Ltd. Cytostatic agents
US6008243A (en) * 1996-10-24 1999-12-28 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use
US6174915B1 (en) 1997-03-25 2001-01-16 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
JPH10130217A (ja) * 1996-11-01 1998-05-19 Kotobuki Seiyaku Kk カルボン酸及びその誘導体及びその製造法並びにこれを含有する医薬組成物
US5952320A (en) * 1997-01-07 1999-09-14 Abbott Laboratories Macrocyclic inhibitors of matrix metalloproteinases and TNFα secretion
US5985911A (en) * 1997-01-07 1999-11-16 Abbott Laboratories C-terminal ketone inhibitors of matrix metalloproteinases and TNFα secretion
US5985900A (en) * 1997-04-01 1999-11-16 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
US20020031513A1 (en) * 1997-11-24 2002-03-14 Shamir Leibovitz Method and pharmaceutical composition for inhibiting premature rapture of fetal membranes, ripening of uterine cervix and preterm labor in mammals
GB9803005D0 (en) 1998-02-12 1998-04-08 British Biotech Pharm Anti-inflammatory agents
AU745921B2 (en) * 1998-02-13 2002-04-11 British Biotech Pharmaceuticals Limited Cytostatic agents
US6329418B1 (en) 1998-04-14 2001-12-11 The Procter & Gamble Company Substituted pyrrolidine hydroxamate metalloprotease inhibitors
NZ525513A (en) 1998-08-07 2004-09-24 Pont Pharmaceuticals Du Succinoylamino lactams as inhibitors of Abeta protein production
HRP990246A2 (en) 1998-08-07 2000-06-30 Du Pont Pharm Co Succinoylamino benzodiazepines as inhibitors of a beta protein production
US6329400B1 (en) 1998-08-26 2001-12-11 Glaxo Wellcome Inc. Formamide compounds as therapeutic agents
US6172064B1 (en) 1998-08-26 2001-01-09 Glaxo Wellcome Inc. Formamides as therapeutic agents
GB9818605D0 (en) 1998-08-26 1998-10-21 Glaxo Group Ltd Formamide compounds as therepeutic agents
AU1618000A (en) * 1998-11-12 2000-05-29 Du Pont Pharmaceuticals Company Use of radioligands to screen inhibitors of amyloid-beta peptide production
US6737038B1 (en) 1998-11-12 2004-05-18 Bristol-Myers Squibb Company Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging
US6288261B1 (en) 1998-12-18 2001-09-11 Abbott Laboratories Inhibitors of matrix metalloproteinases
WO2000037433A1 (en) * 1998-12-18 2000-06-29 Abbott Laboratories Inhibitors of matrix metalloproteinases
GB9901444D0 (en) * 1999-01-23 1999-03-10 British Biotech Pharm Anti-inflammatory agents
AR035478A1 (es) * 1999-01-27 2004-06-02 Wyeth Corp Acido amida-hidroxamico, acido acetilenico, beta-sulfonamido y fosfinico como inhibidores de la tace, uso de los mismos para la manufactura de un medicamento y composicion farmaceutica que los contiene
US6326516B1 (en) 1999-01-27 2001-12-04 American Cyanamid Company Acetylenic β-sulfonamido and phosphinic acid amide hydroxamic acid TACE inhibitors
RU2001133740A (ru) * 1999-05-17 2003-09-27 Дайити Файн Кемикал Ко., Лтд. (Jp) Новые производные гидроксамовой кислоты
JP2001031637A (ja) * 1999-05-17 2001-02-06 Fuji Chemical Industries Ltd 新規なヒドロキサム酸誘導体
US6696456B1 (en) 1999-10-14 2004-02-24 The Procter & Gamble Company Beta disubstituted metalloprotease inhibitors
MXPA02009311A (es) * 2000-03-21 2003-03-12 Procter & Gamble Inhibidores de las metaloproteasas n-sustituidas que contienen cadenas laterales heterociclicas.
IL151126A0 (en) * 2000-03-21 2003-04-10 Procter & Gamble Carbocyclic side chain containing metalloprotease inhibitors
JP2003528082A (ja) * 2000-03-21 2003-09-24 ザ プロクター アンド ギャンブル カンパニー ニフッ化酪酸メタロプロテアーゼ阻害物質
AU2001253090A1 (en) 2000-04-03 2001-10-15 Bristol-Myers Squibb Pharma Company Cyclic lactams as inhibitors of abeta protein production
CA2404273A1 (en) 2000-04-11 2001-10-18 Bristol-Myers Squibb Pharma Company Substituted lactams as inhibitors of a.beta. protein production
CA2379445C (en) 2000-06-01 2007-08-21 Bristol-Myers Squibb Pharma Company Lactams substituted by cyclic succinates as inhibitors of a.beta. protein production
WO2003033018A1 (en) * 2001-10-18 2003-04-24 Warner-Lambert Company Llc Method for preparing purified matrix metalloproteinase
PE20030701A1 (es) 2001-12-20 2003-08-21 Schering Corp Compuestos para el tratamiento de trastornos inflamatorios
EP1465869B1 (en) 2001-12-21 2013-05-15 Exelixis Patent Company LLC Modulators of lxr
US7482366B2 (en) 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
BR0317715A (pt) * 2002-12-27 2005-11-22 Angiotech Int Ag Composições e processos de uso de collajolie
EP1594459B1 (en) 2002-12-30 2010-02-17 Angiotech International Ag Drug delivery from rapid gelling polymer composition

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Publication number Priority date Publication date Assignee Title
US4091024A (en) * 1976-12-03 1978-05-23 E. R. Squibb & Sons, Inc. Pyrrolidine and piperidine-2-carboxylic acid derivatives
AU652596B2 (en) * 1990-12-03 1994-09-01 Celltech Limited Peptidyl derivatives
CA2058797A1 (en) * 1991-02-01 1992-08-02 Michael John Broadhurst Amino acid derivatives
ATE150452T1 (de) * 1992-04-07 1997-04-15 British Biotech Pharm Hydroxamsäure enthaltende collagenase-inhibitoren und cytokinaktivitätsinhibitoren
AU666727B2 (en) * 1992-06-25 1996-02-22 F. Hoffmann-La Roche Ag Hydroxamic acid derivatives

Also Published As

Publication number Publication date
CA2184093A1 (en) 1995-08-31
NZ281856A (en) 1997-12-19
EP0749302A1 (en) 1996-12-27
HUT75054A (en) 1997-03-28
US5514716A (en) 1996-05-07
JPH09509662A (ja) 1997-09-30
US5618844A (en) 1997-04-08
WO1995022966A1 (en) 1995-08-31
FI963298A0 (fi) 1996-08-23
FI963298A (fi) 1996-10-23
HU9602339D0 (en) 1996-10-28
NO963499D0 (no) 1996-08-22
NO963499L (no) 1996-10-14
EP0749302A4 (en) 1999-08-25
AU1881795A (en) 1995-09-11

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Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees