HUP0402257A2 - Eljárás az N-[3-(3-cianopirazolo[1,5-a]pirimidin-7-il)-fenil]-N-etil-acetamid (zaleplon) előállítására - Google Patents

Eljárás az N-[3-(3-cianopirazolo[1,5-a]pirimidin-7-il)-fenil]-N-etil-acetamid (zaleplon) előállítására

Info

Publication number
HUP0402257A2
HUP0402257A2 HU0402257A HUP0402257A HUP0402257A2 HU P0402257 A2 HUP0402257 A2 HU P0402257A2 HU 0402257 A HU0402257 A HU 0402257A HU P0402257 A HUP0402257 A HU P0402257A HU P0402257 A2 HUP0402257 A2 HU P0402257A2
Authority
HU
Hungary
Prior art keywords
phenyl
cyanopyrazolo
zaleplon
pyrimidin
acetamide
Prior art date
Application number
HU0402257A
Other languages
English (en)
Inventor
Ferenc Kóródi
Erika Fehér
Erika Magyar
Original Assignee
BIOGAL Gyógyszergyár Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BIOGAL Gyógyszergyár Rt. filed Critical BIOGAL Gyógyszergyár Rt.
Publication of HUP0402257A2 publication Critical patent/HUP0402257A2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

(57) Jelen találmány az N-[3-(3-cianopirazolo[1,5-a]pirimidin-7-il)-fenil]-N-etil-acetamid (zaleplon) javított előállítási eljárásáravonatkozik. Az eljárás során N-[3-[3-(dimetilamino)-1-oxo-2-propenil]-fenil]-N-etil-acetamidot vagy sóját 3-amino-4-cianopirazollal vagysójával reagáltatják savas körülmények között, olyan reakcióközegben,ami víz és vízzel elegyedő szerves vegyület elegyét tartalmazza. Ó
HU0402257A 2001-06-12 2002-06-12 Eljárás az N-[3-(3-cianopirazolo[1,5-a]pirimidin-7-il)-fenil]-N-etil-acetamid (zaleplon) előállítására HUP0402257A2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29763501P 2001-06-12 2001-06-12
PCT/US2002/018567 WO2002100828A2 (en) 2001-06-12 2002-06-12 Process for the production of zaleplon

Publications (1)

Publication Number Publication Date
HUP0402257A2 true HUP0402257A2 (hu) 2005-02-28

Family

ID=23147125

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0402257A HUP0402257A2 (hu) 2001-06-12 2002-06-12 Eljárás az N-[3-(3-cianopirazolo[1,5-a]pirimidin-7-il)-fenil]-N-etil-acetamid (zaleplon) előállítására

Country Status (20)

Country Link
US (2) US6884888B2 (hu)
EP (1) EP1406871A4 (hu)
JP (1) JP2005507858A (hu)
KR (1) KR20040007683A (hu)
CN (1) CN1537113A (hu)
CA (1) CA2450384A1 (hu)
CZ (1) CZ20033544A3 (hu)
DE (1) DE02778962T1 (hu)
ES (1) ES2223311T1 (hu)
HR (1) HRP20040016A2 (hu)
HU (1) HUP0402257A2 (hu)
IL (1) IL159281A0 (hu)
IS (1) IS7069A (hu)
MX (1) MXPA03011485A (hu)
NO (1) NO20035538D0 (hu)
PL (1) PL372942A1 (hu)
SK (1) SK16232003A3 (hu)
TR (1) TR200402588T3 (hu)
WO (1) WO2002100828A2 (hu)
ZA (1) ZA200309677B (hu)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6852858B2 (en) 2001-08-01 2005-02-08 Biogal Gyogyszergyar Rt. Process for purifying N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethylacetamide (zaleplon) and crystalline forms of zaleplon accessible with the process
WO2002100828A2 (en) * 2001-06-12 2002-12-19 Biogal Gyogyszergyar Rt Process for the production of zaleplon
US20050032818A1 (en) * 2001-06-12 2005-02-10 Entire Interest N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-5-yl)phenyl]-N-ethylacetamide and crystalline forms of zaleplon
PL373694A1 (en) * 2002-02-15 2005-09-05 Teva Gyogyszergyar Reszvenytarsasag Powder composition comprising zaleplon of defined particle size distribution and pharmaceutical products made therefrom
PL207322B1 (pl) * 2002-05-14 2010-11-30 Adamed Społka Z Ograniczoną Odpowiedzialnością Sposób wytwarzania zaleplonu
WO2004035585A1 (en) * 2002-10-16 2004-04-29 Sanmar Speciality Chemicals Limited Synthesis of zaleplon
CZ293015B6 (cs) * 2002-10-25 2004-01-14 Léčiva, A.S. Způsob výroby N-ethyl-N-[3-(3-methyl-pyrazolo[1,5-a]pyrimidin-7-yl)-fenyl]-acetamidu (zaleplonu)
WO2005023813A1 (en) * 2003-09-04 2005-03-17 Cipla Limited Zaleplon synthesis
AU2004314335A1 (en) * 2004-01-14 2005-08-04 Mallinckrodt Inc. Two-phase method for the synthesis of selected pyrazolopyrimidines
HUP0400325A3 (en) 2004-02-02 2005-11-28 Richter Gedeon Vegyeszet Pure n-[3-(-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-n-ethyl-acetamide, process for its preparation and intermediates
WO2005099712A2 (en) * 2004-04-19 2005-10-27 Sanmar Speciality Chemicals Limited Process for preparation of n-[3-(3-cyanopyrazolo [1,5-a]pyrimidin-7-yl)phenyl]-n-ethylacetamide
WO2006070244A2 (en) * 2004-11-22 2006-07-06 Bakulesh Mafatlal Khamar A process for the preparation of zaleplon
CN102816163A (zh) * 2012-08-20 2012-12-12 四川禾邦阳光制药股份有限公司 扎来普隆的新晶型及制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4626538A (en) * 1983-06-23 1986-12-02 American Cyanamid Company [7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines
US5714607A (en) * 1995-12-01 1998-02-03 American Cyanamid Company Process improvement in the synthesis of N- 3-(3-cyano-pyrazolo 1,5-a!pyrimidin-7-yl)phenyl!-N-ethylacetamide
US6485746B1 (en) * 2000-08-25 2002-11-26 Neurocrine Biosciences, Inc. Controlled-release sedative-hypnotic compositions and methods related thereto
US6384221B1 (en) * 1999-09-02 2002-05-07 Neurocrine Biosciences, Inc. Polymorphs of N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-α]-pyrimidin-7-yl}phenyl)acetamide and compositions and methods related thereto
BR0113244A (pt) * 2000-08-03 2003-07-08 Wyeth Corp Polimorfos de zaleplon; métodos e processos para a preparação dos mesmos; composição farmacêutica
AR029780A1 (es) * 2000-12-13 2003-07-16 Gador Sa Procedimiento mejorado para la obtencion de n-[3(3-ciano-pirazolo[1,5-a]pirimidin-7-il)fenil]-n-etil-acetamida
WO2002100828A2 (en) * 2001-06-12 2002-12-19 Biogal Gyogyszergyar Rt Process for the production of zaleplon
US6852858B2 (en) * 2001-08-01 2005-02-08 Biogal Gyogyszergyar Rt. Process for purifying N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethylacetamide (zaleplon) and crystalline forms of zaleplon accessible with the process
PL207322B1 (pl) * 2002-05-14 2010-11-30 Adamed Społka Z Ograniczoną Odpowiedzialnością Sposób wytwarzania zaleplonu

Also Published As

Publication number Publication date
CZ20033544A3 (cs) 2004-11-10
SK16232003A3 (sk) 2004-12-01
IL159281A0 (en) 2004-06-01
MXPA03011485A (es) 2004-06-11
TR200402588T3 (tr) 2004-11-22
CA2450384A1 (en) 2002-12-19
PL372942A1 (en) 2005-08-08
IS7069A (is) 2003-12-10
EP1406871A4 (en) 2005-01-26
WO2002100828A3 (en) 2003-05-01
CN1537113A (zh) 2004-10-13
NO20035538D0 (no) 2003-12-11
JP2005507858A (ja) 2005-03-24
KR20040007683A (ko) 2004-01-24
US20030040522A1 (en) 2003-02-27
EP1406871A2 (en) 2004-04-14
HRP20040016A2 (en) 2004-10-31
US6884888B2 (en) 2005-04-26
US20050187225A1 (en) 2005-08-25
DE02778962T1 (de) 2005-02-10
WO2002100828A2 (en) 2002-12-19
ZA200309677B (en) 2004-12-13
ES2223311T1 (es) 2005-03-01

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Legal Events

Date Code Title Description
HC9A Change of name, address

Owner name: TEVA GYOGYSZERGYAR ZARTKOERUEEN MUEKOEDOE RESZ, HU

Free format text: FORMER OWNER(S): BIOGAL GYOGYSZERGYAR RT., HU

FD9A Lapse of provisional protection due to non-payment of fees