HUP0401503A2 - Indol, aza-indol és hasonló heterociklikus amido-piperazin-származékok és ezeket tartalmazó gyógyszerkészítmények - Google Patents

Indol, aza-indol és hasonló heterociklikus amido-piperazin-származékok és ezeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP0401503A2
HUP0401503A2 HU0401503A HUP0401503A HUP0401503A2 HU P0401503 A2 HUP0401503 A2 HU P0401503A2 HU 0401503 A HU0401503 A HU 0401503A HU P0401503 A HUP0401503 A HU P0401503A HU P0401503 A2 HUP0401503 A2 HU P0401503A2
Authority
HU
Hungary
Prior art keywords
azaindole
indole
pharmaceutical compositions
compositions containing
group
Prior art date
Application number
HU0401503A
Other languages
English (en)
Inventor
Tao Wang
Owen B. Wallace
Nicholas A. Meanwell
Zhongxing Zhang
John A. Bender
John F. Kadow
Kap-Sun Yeung
Original Assignee
Bristol-Myers Squibb Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Co. filed Critical Bristol-Myers Squibb Co.
Publication of HUP0401503A2 publication Critical patent/HUP0401503A2/hu
Publication of HUP0401503A3 publication Critical patent/HUP0401503A3/hu
Publication of HU230215B1 publication Critical patent/HU230215B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A találmány tárgyát általános képletű vegyületek - amely képletben aszubsztituensek főbb jelentései: Q jelentése ábra szám nélkü!általános képletű csoport << jelenthet egy kötést; A az 1-6 szénatomosalkoxi-, 1-6 szénatomos alkil-, 3-7 szénatomos cikloalkil-, fenil- ésheteroaril-csoport T jelentése R8 és R8' egymástól függetlenülválasztható az alábbiakból álló csoportból: hidrogénatom, hidroxi-, 1-6 szénatomos alkil-, 1-6 szénatomos alkoxi-, cianocsoport ésfluoratom, vagy R8 és R8' együtt =0, =S, =NOR9 vagy =NH csoportotképez; m, n és p értéke egymástól függetlenül 0, 1 vagy 2, azzal afenntartással, hogy m, n és p összege 1 vagy 2 - és az ezekettartalmazó gyógyszerkészítmények képezik, amelyek HIV-fertőzés és AIDSkezelésénél alkalmazhatók. Ó
HU0401503A 2001-04-25 2002-04-23 Indol, aza-indol és hasonló heterociklikus amido-piperazin-származékok HU230215B1 (hu)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28634701P 2001-04-25 2001-04-25
ES60/286,347 2001-04-25
PCT/US2002/012856 WO2002085301A2 (en) 2001-04-25 2002-04-23 Indole, azaindole and related heterocyclic amidopiperazine derivatives

Publications (3)

Publication Number Publication Date
HUP0401503A2 true HUP0401503A2 (hu) 2004-12-28
HUP0401503A3 HUP0401503A3 (en) 2009-06-29
HU230215B1 HU230215B1 (hu) 2015-10-28

Family

ID=23098194

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0401503A HU230215B1 (hu) 2001-04-25 2002-04-23 Indol, aza-indol és hasonló heterociklikus amido-piperazin-származékok

Country Status (15)

Country Link
US (1) US6825201B2 (hu)
EP (1) EP1381366B9 (hu)
JP (1) JP4326221B2 (hu)
CN (1) CN1330307C (hu)
AT (1) ATE429229T1 (hu)
BR (1) BR0209153A (hu)
CA (1) CA2445190C (hu)
CY (1) CY1109219T1 (hu)
DE (1) DE60232065D1 (hu)
DK (1) DK1381366T3 (hu)
ES (1) ES2323859T3 (hu)
HU (1) HU230215B1 (hu)
MX (1) MXPA03009680A (hu)
PT (1) PT1381366E (hu)
WO (1) WO2002085301A2 (hu)

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Also Published As

Publication number Publication date
US6825201B2 (en) 2004-11-30
EP1381366B1 (en) 2009-04-22
ES2323859T3 (es) 2009-07-27
EP1381366A4 (en) 2005-02-16
EP1381366A2 (en) 2004-01-21
WO2002085301A2 (en) 2002-10-31
WO2002085301A3 (en) 2003-02-27
MXPA03009680A (es) 2004-02-12
HU230215B1 (hu) 2015-10-28
JP4326221B2 (ja) 2009-09-02
HUP0401503A3 (en) 2009-06-29
EP1381366B9 (en) 2009-10-21
DK1381366T3 (da) 2009-08-17
CA2445190A1 (en) 2002-10-31
BR0209153A (pt) 2004-07-20
JP2004527538A (ja) 2004-09-09
CN1520295A (zh) 2004-08-11
US20030096825A1 (en) 2003-05-22
DE60232065D1 (de) 2009-06-04
ATE429229T1 (de) 2009-05-15
CA2445190C (en) 2011-08-09
CY1109219T1 (el) 2014-07-02
CN1330307C (zh) 2007-08-08
PT1381366E (pt) 2009-07-21

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