HUP0302746A2 - Szubsztituált propán,1,3-diamin-származékok eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények - Google Patents
Szubsztituált propán,1,3-diamin-származékok eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0302746A2 HUP0302746A2 HU0302746A HUP0302746A HUP0302746A2 HU P0302746 A2 HUP0302746 A2 HU P0302746A2 HU 0302746 A HU0302746 A HU 0302746A HU P0302746 A HUP0302746 A HU P0302746A HU P0302746 A2 HUP0302746 A2 HU P0302746A2
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- cycloalkyl
- aryl
- group
- heterocyclyl
- Prior art date
Links
- XFNJVJPLKCPIBV-UHFFFAOYSA-N trimethylenediamine Chemical class NCCCN XFNJVJPLKCPIBV-UHFFFAOYSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000003118 aryl group Chemical group 0.000 abstract 10
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 8
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 7
- 125000000623 heterocyclic group Chemical group 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 125000004434 sulfur atom Chemical group 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- -1 aryl-(C1-6 alkyl) Chemical group 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
- C07C211/40—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing only non-condensed rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/78—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Anesthesiology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
A találmány (1) általános képletű szubsztituált 1,3-propán-diamin-származékokra és azok gyógyászatilag alkalmazható sóira vonatkozik - aképletben R1 1-12 szénatomos alkil-, 3-8 szénatomos cikloalkil-, (3-8szénatomos cikloalkil)-(1-6 szénatomos alkil)- vagy arilcsoportotjelent; R2 1-12 szénatomos alkil-, 3-8 szénatomos cikloalkil-, (3-8szénatomos cikloalkil)-(1-6 szénatomos alkil)-, aril-, aril-(1-6szénatomos alkil)-, heterociklil- vagy heterociklil-(1-6 szénatomosalkil)-csoportot jelent; R1 és R2 együtt -(CH2)m- általános képletűcsoportot alkot, amelyben m értéke 2, 3, 4, 5 vagy 6, és az ígykialakult gyűrű szubsztituálatlan vagy 1-6 szénatomos alkil-, aril-,1-6 szénatomos alkoxi- és/vagy aril-(1-6 szénatomos alkoxi)-csoportokkal egyszeresen vagy többszörösen szubsztituált vagybenzolgyűrűvel kondenzált lehet; R3 hidrogénatomot vagy 1-12szénatomos alkil-, 3-8 szénatomos cikloalkil-, (3-8 szénatomoscikloalkil)-(1-6 szénatomos alkil)-, aril-, aril-(1-6 szénatomosalkil)-, heterociklil- vagy heterociklil-(1-6 szénatomos alkil)-csoportot vagy C(=O)R7 általános képletű csoportot jelent; R4hidrogénatomot vagy 1-12 szénatomos alkil-, 3-8 szénatomoscikloalkil-, (3-8 szénatomos cikloalkil)-(1-6 szénatomos alkil)-,aril-, aril-(1-6 szénatomos alkil)-, heterociklil- vagy heterociklil-(1-6 szénatomos alkil)-csoportot jelent; vagy R3 és R4 együtt egy -(CH2)n- vagy -(CH2)2-X-(CH2)2- általános képletű csoportot alkot,amelyekben n értéke 2, 3, 4, 5, 6 vagy 7, és X oxigénatomot, kénatomotvagy -NR8- általános képletű csoportot jelent, és az így kialakultgyűrű szubsztituálatlan lehet vagy 1-6 szénatomos alkil-szubsztituensthordozhat; R4 és R5 egymástól függetlenül 1-12 szénatomos alkil-, 3-8szénatomos cikloalkil-, (3-8 szénatomos cikloalkil)-(1-6 szénatomosalkil)-, aril- vagy aril-(1-6 szénatomos alkil)-csoportot jelent, vagyegyütt egy -(CH2)o vagy -(CH2)2-Y-(CH2)2- általános képletű csoportotalkotnak, amelyekben o értéke 3, 4, 5, 6 vagy 7, és Y oxigénatomot,kénatomot vagy -NR9- általános képletű csoportot jelent, és az ígykialakult gyűrű szubsztituálatlan lehet vagy 1-6 szénatomos alkil-szubsztituenst hordozhat; és A aril-, heteroaril- vagy 2-propil-csoportot vagy C(=O)OR10 általános képletű csoportot jelent; és azáltalános képletekkel jelölt csoportokban R7 1-6 szénatomos alkil-, 3-8 szénatomos cikloalkil-, (3-8 szénatomos cikloalkil)-(1-6 szénatomosalkil)-; aril-, aril-(1-6 szénatomos alkil)-, heterociklil- vagyheterociklil-(1-6 szénatomos alkil)-csoportot jelent; R8 és R9egymástól függetlenül hidrogénatomot vagy 1-6 szénatomos alkil-, 3-8szénatomos cikloalkil-, (3-8 szénatomos cikloalkil)-(1-6 szénatomosalkil)-, aril-, aril-(1-6 szénatomos alkil)- vagy heterociklil-csoportot jelent, és R10 1-6 szénatomos alkil-, 3-8 szénatomoscikloalkil-, (3-8 szénatomos cikloalkil)-(1-6 szénatom
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10108307A DE10108307A1 (de) | 2001-02-21 | 2001-02-21 | Substituierte Propan-1,3-diamin-Derivate |
| PCT/EP2002/001765 WO2002066432A1 (de) | 2001-02-21 | 2002-02-20 | Substituierte propan- 1,3-diamin-derivate und ihre pharmazeutische verwendung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0302746A2 true HUP0302746A2 (hu) | 2003-12-29 |
| HUP0302746A3 HUP0302746A3 (en) | 2008-03-28 |
Family
ID=7674965
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0302746A HUP0302746A3 (en) | 2001-02-21 | 2002-02-20 | Substituted propane-1,3-diamine derivatives, process for their preparation and the pharmaceutical compositions containing them |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US7230018B2 (hu) |
| EP (1) | EP1363885B1 (hu) |
| JP (1) | JP4447837B2 (hu) |
| KR (1) | KR20030091995A (hu) |
| CN (1) | CN100434421C (hu) |
| AR (1) | AR035752A1 (hu) |
| AT (1) | ATE362916T1 (hu) |
| AU (1) | AU2002246095B2 (hu) |
| CA (1) | CA2438704C (hu) |
| CY (1) | CY1106711T1 (hu) |
| CZ (1) | CZ20031968A3 (hu) |
| DE (2) | DE10108307A1 (hu) |
| DK (1) | DK1363885T3 (hu) |
| EC (1) | ECSP034739A (hu) |
| ES (1) | ES2286240T3 (hu) |
| HK (1) | HK1060730A1 (hu) |
| HU (1) | HUP0302746A3 (hu) |
| IL (2) | IL157494A0 (hu) |
| MX (1) | MXPA03006744A (hu) |
| NO (1) | NO20033697L (hu) |
| PE (1) | PE20021007A1 (hu) |
| PL (1) | PL372089A1 (hu) |
| PT (1) | PT1363885E (hu) |
| RU (1) | RU2003127397A (hu) |
| SI (1) | SI1363885T1 (hu) |
| SK (1) | SK286980B6 (hu) |
| WO (1) | WO2002066432A1 (hu) |
| ZA (1) | ZA200307321B (hu) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102005061428A1 (de) * | 2005-12-22 | 2007-08-16 | Grünenthal GmbH | Substituierte Cyclohexylmethyl-Derivate |
| ITMI20120536A1 (it) * | 2012-04-02 | 2013-10-03 | Carlo Angelo Ghisalberti | Composizioni per il trattamento dell¿incontinenza urinaria da stress in soggetti femminili |
| GB201601301D0 (en) * | 2016-01-25 | 2016-03-09 | Takeda Pharmaceutical | Novel compounds |
| CN110021156A (zh) * | 2018-01-10 | 2019-07-16 | 金宝电子工业股份有限公司 | 遥控***以及遥控方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4017637A (en) * | 1973-03-26 | 1977-04-12 | American Home Products Corporation | Benzylamine analgesics |
| DE19915602A1 (de) * | 1999-04-07 | 2000-10-19 | Gruenenthal Gmbh | 3-Amino-4-arylpropan-1-ol-Derivate, deren Herstellung und Verwendung |
| DE19915601A1 (de) * | 1999-04-07 | 2000-10-19 | Gruenenthal Gmbh | 3-Amino-3-arylpropan-1-ol-Derivate, deren Herstellung und Verwendung |
-
2001
- 2001-02-21 DE DE10108307A patent/DE10108307A1/de not_active Withdrawn
-
2002
- 2002-02-19 AR ARP020100567A patent/AR035752A1/es not_active Application Discontinuation
- 2002-02-20 HU HU0302746A patent/HUP0302746A3/hu unknown
- 2002-02-20 SK SK1030-2003A patent/SK286980B6/sk not_active IP Right Cessation
- 2002-02-20 SI SI200230563T patent/SI1363885T1/sl unknown
- 2002-02-20 JP JP2002565949A patent/JP4447837B2/ja not_active Expired - Fee Related
- 2002-02-20 AU AU2002246095A patent/AU2002246095B2/en not_active Ceased
- 2002-02-20 IL IL15749402A patent/IL157494A0/xx unknown
- 2002-02-20 RU RU2003127397/04A patent/RU2003127397A/ru not_active Application Discontinuation
- 2002-02-20 CA CA2438704A patent/CA2438704C/en not_active Expired - Fee Related
- 2002-02-20 KR KR10-2003-7011008A patent/KR20030091995A/ko not_active Application Discontinuation
- 2002-02-20 ES ES02714169T patent/ES2286240T3/es not_active Expired - Lifetime
- 2002-02-20 PT PT02714169T patent/PT1363885E/pt unknown
- 2002-02-20 AT AT02714169T patent/ATE362916T1/de active
- 2002-02-20 CN CNB028052463A patent/CN100434421C/zh not_active Expired - Fee Related
- 2002-02-20 PL PL02372089A patent/PL372089A1/xx not_active Application Discontinuation
- 2002-02-20 MX MXPA03006744A patent/MXPA03006744A/es active IP Right Grant
- 2002-02-20 EP EP02714169A patent/EP1363885B1/de not_active Expired - Lifetime
- 2002-02-20 WO PCT/EP2002/001765 patent/WO2002066432A1/de active IP Right Grant
- 2002-02-20 PE PE2002000142A patent/PE20021007A1/es not_active Application Discontinuation
- 2002-02-20 DK DK02714169T patent/DK1363885T3/da active
- 2002-02-20 DE DE50210197T patent/DE50210197D1/de not_active Expired - Lifetime
- 2002-02-20 CZ CZ20031968A patent/CZ20031968A3/cs unknown
-
2003
- 2003-08-20 NO NO20033697A patent/NO20033697L/no not_active Application Discontinuation
- 2003-08-20 EC EC2003004739A patent/ECSP034739A/es unknown
- 2003-08-20 IL IL157494A patent/IL157494A/en not_active IP Right Cessation
- 2003-08-21 US US10/644,981 patent/US7230018B2/en not_active Expired - Fee Related
- 2003-09-18 ZA ZA200307321A patent/ZA200307321B/en unknown
-
2004
- 2004-05-20 HK HK04103603A patent/HK1060730A1/xx not_active IP Right Cessation
-
2007
- 2007-07-09 CY CY20071100903T patent/CY1106711T1/el unknown
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