HUP0302226A3 - Substituted pyrrolopyridinone dervatives useful as phosphodiesterse inhibitors, their intermediates and pharmaceutical compositions containing the compounds - Google Patents

Substituted pyrrolopyridinone dervatives useful as phosphodiesterse inhibitors, their intermediates and pharmaceutical compositions containing the compounds

Info

Publication number: HUP0302226A3
Authority: HU; Hungary
Prior art keywords: phosphodiesterse; dervatives; intermediates; inhibitors; compounds
Prior art date: 2000-05-17

Application number

HU0302226A

Other languages

English (en)

Original Assignee

Ortho Mcneil Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-05-17

Filing date

2001-05-03

Publication date

2012-12-28

2001-05-03 Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc

2003-11-28 Publication of HUP0302226A2 publication Critical patent/HUP0302226A2/hu

2012-12-28 Publication of HUP0302226A3 publication Critical patent/HUP0302226A3/hu

Links

150000001875 compounds Chemical class 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
239000000543 intermediate Substances 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
ORKUYZDMEWAUEZ-UHFFFAOYSA-N pyrrolo[3,2-b]pyridin-2-one Chemical class N1=CC=CC2=NC(=O)C=C21 ORKUYZDMEWAUEZ-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

HU0302226A 2000-05-17 2001-05-03 Substituted pyrrolopyridinone dervatives useful as phosphodiesterse inhibitors, their intermediates and pharmaceutical compositions containing the compounds HUP0302226A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US20464600P	2000-05-17	2000-05-17
PCT/US2001/014391 WO2001087882A2 (en)	2000-05-17	2001-05-03	Substituted pyrrolopyridinone derivatives useful as phosphodiesterase inhibitors

Publications (2)

Publication Number	Publication Date
HUP0302226A2 HUP0302226A2 (hu)	2003-11-28
HUP0302226A3 true HUP0302226A3 (en)	2012-12-28

Family

ID=22758822

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HU0302226A HUP0302226A3 (en)	2000-05-17	2001-05-03	Substituted pyrrolopyridinone dervatives useful as phosphodiesterse inhibitors, their intermediates and pharmaceutical compositions containing the compounds

Country Status (29)

Country	Link
US (3)	US6635638B2 (hu)
EP (1)	EP1296981B1 (hu)
JP (1)	JP5366349B2 (hu)
KR (2)	KR20030031483A (hu)
CN (1)	CN1280291C (hu)
AR (1)	AR028575A1 (hu)
AT (1)	ATE278690T1 (hu)
AU (1)	AU6117801A (hu)
BG (1)	BG65925B1 (hu)
CA (1)	CA2409743C (hu)
CZ (1)	CZ20023945A3 (hu)
DE (1)	DE60106252T2 (hu)
ES (1)	ES2230316T3 (hu)
GE (1)	GEP20053510B (hu)
HK (1)	HK1054034B (hu)
HR (1)	HRP20020911B1 (hu)
HU (1)	HUP0302226A3 (hu)
IL (2)	IL152872A0 (hu)
MX (1)	MXPA02011425A (hu)
MY (1)	MY126917A (hu)
NO (1)	NO324843B1 (hu)
NZ (1)	NZ522732A (hu)
PL (1)	PL363150A1 (hu)
PT (1)	PT1296981E (hu)
RU (1)	RU2267490C2 (hu)
SK (1)	SK286992B6 (hu)
UA (1)	UA72611C2 (hu)
WO (1)	WO2001087882A2 (hu)
ZA (1)	ZA200210114B (hu)

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UA72611C2 (uk) *	2000-05-17	2005-03-15	Орто-Макнейл Фармацевтикал, Інк.	Похідні заміщеного піролопіридинону, корисні як інгібітори фосфодіестерази
JP4223285B2 (ja) *	2001-02-12	2009-02-12	リリーアイコスリミテッドライアビリティカンパニー	化合物
ES2248412T3 (es)	2001-02-12	2006-03-16	Lilly Icos Llc	Derivados de carbolina.
DK1448562T3 (da)	2001-11-14	2007-09-24	Ortho Mcneil Pharmaceutical Co	Substituerede tetracycliske pyrroloquinolonderivater egnede som phosphodiesteraseinhibitorer
PT1534707E (pt) *	2002-06-19	2007-12-19	Janssen Pharmaceutica Nv	Derivados de 2,4-di-hidro-pirrolo(3,4-b)-quinolin-9-ona substituídos, úteis como inibidores da fosfodiesterase
US7045652B2 (en) *	2002-07-03	2006-05-16	Pfizer Inc	Processes for preparing substituted aryl boronic acids
US8076353B2 (en)	2004-03-15	2011-12-13	Ptc Therapeutics, Inc.	Inhibition of VEGF translation
NZ588388A (en)	2004-03-15	2012-05-25	Ptc Therapeutics Inc	Carboline derivatives useful in the inhibition of angiogenesis
US8076352B2 (en)	2004-03-15	2011-12-13	Ptc Therapeutics, Inc.	Administration of carboline derivatives useful in the treatment of cancer and other diseases
US7767689B2 (en)	2004-03-15	2010-08-03	Ptc Therapeutics, Inc.	Carboline derivatives useful in the treatment of cancer
US20070015798A1 (en) *	2005-02-25	2007-01-18	Xun Li	Efficient and stereoselective process for large scale synthesis of (3R)-3-(2,3-dihydrobenzofuran-5-yl)-1,2,3,4-tetrahydropyrrolo[3,4-b]quinolin-9-one derivatives
EP1851227A4 (en) *	2005-02-25	2010-03-10	Janssen Pharmaceutica Nv	EFFICIENT AND STEREOSELECTIVE PROCEDURE FOR THE MASS SYNTHESIS OF 3- (R) -3- (2,3-DIHYDROBENZOFURAN-5-YL) -1,2,3,4-TETRAHYDROPYRROLO {3,4-B} CHINOLIN-9-ON
EP2275095A3 (en)	2005-08-26	2011-08-17	Braincells, Inc.	Neurogenesis by muscarinic receptor modulation
EP2258357A3 (en)	2005-08-26	2011-04-06	Braincells, Inc.	Neurogenesis with acetylcholinesterase inhibitor
EP2377530A3 (en)	2005-10-21	2012-06-20	Braincells, Inc.	Modulation of neurogenesis by PDE inhibition
EP2314289A1 (en)	2005-10-31	2011-04-27	Braincells, Inc.	Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en)	2006-03-08	2010-08-26	Braincells, Inc.	Modulation of neurogenesis by nootropic agents
WO2007134136A2 (en)	2006-05-09	2007-11-22	Braincells, Inc.	Neurogenesis by modulating angiotensin
CA2651862A1 (en)	2006-05-09	2007-11-22	Braincells, Inc.	5 ht receptor mediated neurogenesis
JP2010502722A (ja)	2006-09-08	2010-01-28	ブレインセルス，インコーポレイティド	４−アシルアミノピリジン誘導体を含む組み合わせ
US20100184806A1 (en)	2006-09-19	2010-07-22	Braincells, Inc.	Modulation of neurogenesis by ppar agents
EP2379076B1 (en)	2008-12-23	2014-11-12	The Trustees of Columbia University in the City of New York	Phosphodiesterase inhibitors and uses thereof
WO2010099217A1 (en)	2009-02-25	2010-09-02	Braincells, Inc.	Modulation of neurogenesis using d-cycloserine combinations
RU2451686C1 (ru) *	2010-12-27	2012-05-27	Александр Васильевич Иващенко	ЗАМЕЩЕННЫЕ ГИДРИРОВАННЫЕ ТИЕНО-ПИРРОЛО [3,2-c] ПИРИДИНЫ, ЛИГАНДЫ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И СПОСОБ ИХ ПРИМЕНЕНИЯ
KR101236188B1 (ko) *	2011-03-10	2013-02-22	한국화학연구원	신규한 피롤로피리디논 유도체 및 그의 ｍｃｈ 수용체-1 관련 질환에 대한 치료학적 용도
EP2757887B1 (en)	2011-09-22	2017-04-26	VIIV Healthcare UK Limited	Pyrrolopyridinone compounds and methods for treating hiv
WO2013106547A1 (en)	2012-01-10	2013-07-18	President And Fellows Of Harvard College	Beta-cell replication promoting compounds and methods of their use
JO3407B1 (ar)	2012-05-31	2019-10-20	Eisai R&D Man Co Ltd	مركبات رباعي هيدرو بيرازولو بيريميدين
AU2015279047B2 (en)	2014-06-27	2020-01-02	Nogra Pharma Limited	Aryl receptor modulators and methods of making and using the same
WO2017168174A1 (en)	2016-04-02	2017-10-05	N4 Pharma Uk Limited	New pharmaceutical forms of sildenafil
CN107216327A (zh) *	2017-06-27	2017-09-29	山东大学	5型磷酸二酯酶抑制剂及其制备方法和用途
CN108752340B (zh) *	2018-07-18	2020-09-01	山东中医药大学附属医院	吡咯并喹啉衍生物及其在治疗心律失常中的用途
CN109134463B (zh) *	2018-09-17	2020-05-08	山东大学	β-咔啉类5型磷酸二酯酶抑制剂及其制备方法和用途

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CH625521A5 (hu)	1976-10-15	1981-09-30	Sandoz Ag
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2001
- 2001-03-05 UA UA2002119180A patent/UA72611C2/uk unknown
- 2001-05-02 US US09/847,749 patent/US6635638B2/en not_active Expired - Lifetime
- 2001-05-03 NZ NZ522732A patent/NZ522732A/en not_active IP Right Cessation
- 2001-05-03 DE DE60106252T patent/DE60106252T2/de not_active Expired - Lifetime
- 2001-05-03 WO PCT/US2001/014391 patent/WO2001087882A2/en active Application Filing
- 2001-05-03 CN CNB018128440A patent/CN1280291C/zh not_active Expired - Fee Related
- 2001-05-03 SK SK1713-2002A patent/SK286992B6/sk not_active IP Right Cessation
- 2001-05-03 AU AU6117801A patent/AU6117801A/xx not_active Withdrawn
- 2001-05-03 CZ CZ20023945A patent/CZ20023945A3/cs unknown
- 2001-05-03 MX MXPA02011425A patent/MXPA02011425A/es active IP Right Grant
- 2001-05-03 EP EP01935050A patent/EP1296981B1/en not_active Expired - Lifetime
- 2001-05-03 KR KR1020027015582A patent/KR20030031483A/ko not_active Application Discontinuation
- 2001-05-03 AT AT01935050T patent/ATE278690T1/de active
- 2001-05-03 ES ES01935050T patent/ES2230316T3/es not_active Expired - Lifetime
- 2001-05-03 CA CA2409743A patent/CA2409743C/en not_active Expired - Fee Related
- 2001-05-03 GE GE5004A patent/GEP20053510B/en unknown
- 2001-05-03 PL PL01363150A patent/PL363150A1/xx not_active IP Right Cessation
- 2001-05-03 IL IL15287201A patent/IL152872A0/xx unknown
- 2001-05-03 KR KR1020027015580A patent/KR100854050B1/ko not_active IP Right Cessation
- 2001-05-03 HU HU0302226A patent/HUP0302226A3/hu unknown
- 2001-05-03 JP JP2001584276A patent/JP5366349B2/ja not_active Expired - Fee Related
- 2001-05-03 RU RU2002133863/04A patent/RU2267490C2/ru not_active IP Right Cessation
- 2001-05-03 PT PT01935050T patent/PT1296981E/pt unknown
- 2001-05-16 MY MYPI20012295 patent/MY126917A/en unknown
- 2001-05-16 AR ARP010102325A patent/AR028575A1/es active IP Right Grant
2002
- 2002-11-15 IL IL152872A patent/IL152872A/en not_active IP Right Cessation
- 2002-11-15 HR HR20020911A patent/HRP20020911B1/xx not_active IP Right Cessation
- 2002-11-18 BG BG107284A patent/BG65925B1/bg unknown
- 2002-11-18 NO NO20025525A patent/NO324843B1/no not_active IP Right Cessation
- 2002-12-12 ZA ZA200210114A patent/ZA200210114B/en unknown
2003
- 2003-08-11 US US10/638,901 patent/US6818646B2/en not_active Expired - Lifetime
- 2003-09-08 HK HK03106376.8A patent/HK1054034B/zh not_active IP Right Cessation
2004
- 2004-10-22 US US10/971,476 patent/US20050113402A1/en not_active Abandoned

Also Published As

Publication number	Publication date
DE60106252T2 (de)	2006-03-02
CZ20023945A3 (cs)	2003-10-15
CA2409743C (en)	2010-10-19
CN1280291C (zh)	2006-10-18
AU6117801A (en)	2001-11-26
BG107284A (bg)	2003-07-31
NZ522732A (en)	2004-10-29
ZA200210114B (en)	2004-03-12
WO2001087882A3 (en)	2002-05-23
US6635638B2 (en)	2003-10-21
JP2003533524A (ja)	2003-11-11
HRP20020911A2 (en)	2004-12-31
SK17132002A3 (sk)	2003-12-02
ES2230316T3 (es)	2005-05-01
KR20020094063A (ko)	2002-12-16
HUP0302226A2 (hu)	2003-11-28
KR20030031483A (ko)	2003-04-21
SK286992B6 (sk)	2009-09-07
MY126917A (en)	2006-10-31
PT1296981E (pt)	2004-12-31
EP1296981B1 (en)	2004-10-06
IL152872A0 (en)	2003-06-24
US20020010183A1 (en)	2002-01-24
JP5366349B2 (ja)	2013-12-11
US20050113402A1 (en)	2005-05-26
NO20025525L (no)	2003-01-03
NO324843B1 (no)	2007-12-17
IL152872A (en)	2010-11-30
HK1054034B (zh)	2005-04-29
HK1054034A1 (en)	2003-11-14
US6818646B2 (en)	2004-11-16
UA72611C2 (uk)	2005-03-15
BG65925B1 (bg)	2010-05-31
CA2409743A1 (en)	2001-11-22
HRP20020911B1 (en)	2009-01-31
CN1441801A (zh)	2003-09-10
KR100854050B1 (ko)	2008-08-26
WO2001087882A2 (en)	2001-11-22
ATE278690T1 (de)	2004-10-15
RU2267490C2 (ru)	2006-01-10
PL363150A1 (en)	2004-11-15
MXPA02011425A (es)	2004-09-06
EP1296981A2 (en)	2003-04-02
AR028575A1 (es)	2003-05-14
DE60106252D1 (de)	2004-11-11
GEP20053510B (en)	2005-05-10
US20040044021A1 (en)	2004-03-04
NO20025525D0 (no)	2002-11-18

Legal Events

Date	Code	Title	Description
2013-11-28	FA9A	Lapse of provisional patent protection due to relinquishment or protection considered relinquished

Publication	Publication Date	Title
HUP0302226A3 (en)	2012-12-28	Substituted pyrrolopyridinone dervatives useful as phosphodiesterse inhibitors, their intermediates and pharmaceutical compositions containing the compounds
HUP0600592A2 (en)	2006-11-28	Substituted imidazopyridines, pharmaceutical compositions containing them and intermediates
HUP0402338A3 (en)	2008-10-28	Spiro-hydantoin compounds, their use as anti-inflammatory agents, pharmaceutical compositions containing them and intermediates for preparing them
IL159022A0 (en)	2004-05-12	Hv protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis
EG24357A (en)	2009-03-04	New Pharmaceutical composition
HUP0301745A3 (en)	2010-03-29	Cyclopentanoindoles, compositions containing such compounds and their use
IL154981A0 (en)	2003-10-31	Substituted indoles, pharmaceutical compositions containing such indoles and their use as ppay-y-binding agents
EP1450824A4 (en)	2005-09-28	PHARMACEUTICAL COMPOSITION
IL158898A0 (en)	2004-05-12	PHARMACEUTICAL COMPOSITIONS CONTAINING APOMORPHINE, 6aR-(-)-N-PROPYL-NORAPOMORPHINE AND DERIVATIVES THEREOF
HUP0303163A3 (en)	2008-03-28	Tramadol-based pharmaceutical composition
GB0117057D0 (en)	2001-09-05	Pharmaceutical composition
EP1408896A4 (en)	2010-02-24	PHARMACEUTICAL COMPOSITION
GB0129117D0 (en)	2002-01-23	Pharmaceutical composition
GB0116107D0 (en)	2001-08-22	Pharmaceutical composition
IL152243A0 (en)	2003-05-29	Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis
GB0127805D0 (en)	2002-01-09	Pharmaceutical composition
PL370037A1 (en)	2005-05-16	Pharmaceutical composition
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