HUP0204515A2 - 4-Aminopiperidin-származékok, eljárás előállításukra, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk - Google Patents
4-Aminopiperidin-származékok, eljárás előállításukra, ezeket tartalmazó gyógyszerkészítmények és alkalmazásukInfo
- Publication number
- HUP0204515A2 HUP0204515A2 HU0204515A HUP0204515A HUP0204515A2 HU P0204515 A2 HUP0204515 A2 HU P0204515A2 HU 0204515 A HU0204515 A HU 0204515A HU P0204515 A HUP0204515 A HU P0204515A HU P0204515 A2 HUP0204515 A2 HU P0204515A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- alkenyl
- alkyl
- optionally substituted
- formula
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- BCIIMDOZSUCSEN-UHFFFAOYSA-N piperidin-4-amine Chemical class NC1CCNCC1 BCIIMDOZSUCSEN-UHFFFAOYSA-N 0.000 title 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 6
- 125000000304 alkynyl group Chemical group 0.000 abstract 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 3
- 208000007913 Pituitary Neoplasms Diseases 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 125000004434 sulfur atom Chemical group 0.000 abstract 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 1
- 206010000599 Acromegaly Diseases 0.000 abstract 1
- 101150039148 NHX1 gene Proteins 0.000 abstract 1
- 201000005746 Pituitary adenoma Diseases 0.000 abstract 1
- 206010061538 Pituitary tumour benign Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 235000005985 organic acids Nutrition 0.000 abstract 1
- 208000021310 pituitary gland adenoma Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
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- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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Abstract
A találmány tárgya (I) általános képletű vegyületek, racém, enantiomerformában, vagy ezek bármilyen kombinációjában, ahol a képletben R1jelentése lineáris vagy elágazó láncú 1-16 szénatomos alkil-,alkenil-, alkinil-, -(CH2)m-Y-Z11 vagy -(CH2)m-Z12 csoport, R2jelentése -C(Y)NHX1, -C(O)X2 vagy SO2X3 képletű csoport; R3 jelentésehidrogénatom, adott esetben szubsztituált alkil-, alkenil-, alkinil-,aralkilcsoport, adott esetben szubsztituált heteroarilalkilcsoportvagy -C(Y)-NHX11, -(CH2)n-C(O)X2, SO2X3 képletű csoport; X1 jelentéselineáris vagy elágazó láncú 1-15 szénatomos alkil-, alkenil-,alkinil-, -(CH2)m-Y-Z21, vagy -C(H2)pZ22 képletű csoport, X2 jelentéselineáris vagy elágazó láncú 1-10 szénatomos alkilcsoport,alkenilcsoport, amely adott esetben fenilcsoporttal van helyettesítve,ahol a fenilcsoport adott esetben önmagában is helyettesített lehet,alkinilcsoport vagy -(CH2)m,-W-(CH2)q-Z23 vagy -(CH2)p-U-Z24 képletűcsoport, X3 jelentése lineáris vagy elágazó láncú 1-10 szénatomosalkilcsoport, alkenilcsoport, amely adott esetben fenilcsoporttal vanhelyettesítve, ahol a fenilcsoport adott esetben önmagában ishelyettesített lehet, CF3 vagy -(CH2)pZ25 képletű csoport, Y jelentéseoxigénatom vagy kénatom; W jelentése oxigénatom vagy kénatom vagy SO2csoport; U jelentése kovalens kötés vagy oxigénatom; n értéke 0-4 egészszám; m értéke 1-6 egész szám; p jelentése 0-6 egész szám; q jelentése0-2 egész szám; vagy ezek gyógyászatilag elfogadható ásványi vagyszerves savakkal alkotott savaddíciós sói, azzal a megkötéssel, hogyaz (I) általános képletű vegyületekben R1 jelentése alkilcsoporttól,alkenilcsoporttól vagy benzilcsoporttól különböző; R2 csoportjelentése adott esetben szubsztituált benziloxicsoporttól különböző ésR3 jelentése aralkilcsoporttól különböző. A találmány tárgyát képezimég az (1) általános képletű vegyületek gyógyászati alkalmazása,elsősorban acromegalia, hipofízises adenoma vagy daganatok kezelésére. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9915724A FR2802206B1 (fr) | 1999-12-14 | 1999-12-14 | Derives de 4-aminopiperidine et leur utilisation en tant que medicament |
| PCT/FR2000/003497 WO2001044191A1 (fr) | 1999-12-14 | 2000-12-13 | Derives de 4-aminopiperidine et leur utilisation en tant que medicament |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HUP0204515A2 true HUP0204515A2 (hu) | 2003-04-28 |
| HUP0204515A3 HUP0204515A3 (en) | 2005-04-28 |
| HU227838B1 HU227838B1 (en) | 2012-05-02 |
Family
ID=9553215
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0204515A HU227838B1 (en) | 1999-12-14 | 2000-12-13 | 4-aminopiperidine derivatives, process for their preparation, pharmaceutical compositions containing them and their use |
Country Status (23)
| Country | Link |
|---|---|
| US (4) | US7115634B2 (hu) |
| EP (1) | EP1286966B1 (hu) |
| JP (2) | JP4838474B2 (hu) |
| KR (2) | KR20070014235A (hu) |
| CN (1) | CN1207283C (hu) |
| AR (1) | AR034244A1 (hu) |
| AT (1) | ATE401308T1 (hu) |
| AU (1) | AU779341B2 (hu) |
| CA (1) | CA2394086C (hu) |
| CY (1) | CY1108415T1 (hu) |
| CZ (1) | CZ305360B6 (hu) |
| DE (1) | DE60039539D1 (hu) |
| DK (1) | DK1286966T3 (hu) |
| ES (1) | ES2310529T3 (hu) |
| FR (1) | FR2802206B1 (hu) |
| HK (1) | HK1054029A1 (hu) |
| HU (1) | HU227838B1 (hu) |
| MY (1) | MY126973A (hu) |
| NZ (1) | NZ520071A (hu) |
| PL (1) | PL204864B1 (hu) |
| PT (1) | PT1286966E (hu) |
| RU (1) | RU2266282C2 (hu) |
| WO (1) | WO2001044191A1 (hu) |
Families Citing this family (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2802206B1 (fr) * | 1999-12-14 | 2005-04-22 | Sod Conseils Rech Applic | Derives de 4-aminopiperidine et leur utilisation en tant que medicament |
| RU2398765C1 (ru) | 2000-03-06 | 2010-09-10 | Акадиа Фармасьютикалз, Инк. | Азациклические соединения для применения при лечении опосредованных серотонином заболеваний |
| EP1311502A1 (en) * | 2000-08-17 | 2003-05-21 | Celltech R&D Limited | Bicyclic heteroaromatic derivatives for the treatment of immune and inflammatory disorders |
| US7208497B2 (en) | 2001-07-02 | 2007-04-24 | Novo Nordisk A/S | Substituted piperazines and diazepanes |
| CN1780621A (zh) * | 2001-08-03 | 2006-05-31 | 先灵公司 | 作为γ分泌酶抑制剂的磺酰胺衍生物 |
| ATE450508T1 (de) * | 2001-09-14 | 2009-12-15 | High Point Pharmaceuticals Llc | Substituierte piperidinen mit selektiver bindungsfähigkeit zu histamin h3-rezeptoren |
| US20030186963A1 (en) | 2001-09-14 | 2003-10-02 | Dorwald Florencio Zaragoza | Substituted piperidines |
| DE60237528D1 (de) | 2001-09-14 | 2010-10-14 | High Point Pharmaceuticals Llc | Neue aminoazetidin-, aminopyrrolidin- und aminopiperidinderivative |
| US6673829B2 (en) | 2001-09-14 | 2004-01-06 | Novo Nordisk A/S | Aminoazetidine,-pyrrolidine and -piperidine derivatives |
| CN100462359C (zh) * | 2001-11-28 | 2009-02-18 | 科学研究和应用咨询公司 | 5-硫烷基-4h-1,2,4-***衍生物及其作为药物的应用 |
| FR2832710B1 (fr) * | 2001-11-28 | 2004-09-03 | Sod Conseils Rech Applic | Derives de 5-sulfanyl-4h-1,2,4-triazoles et leur utilisation en tant que medicaments |
| NZ533567A (en) | 2001-12-28 | 2007-06-29 | Acadia Pharm Inc | Spiroazacyclic compounds as monoamine receptor for modulating 5-HT2A receptor-mediated events |
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| GB1425354A (en) * | 1973-10-10 | 1976-02-18 | Wyeth John & Brother Ltd | Indole derivatives |
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| RU2398765C1 (ru) * | 2000-03-06 | 2010-09-10 | Акадиа Фармасьютикалз, Инк. | Азациклические соединения для применения при лечении опосредованных серотонином заболеваний |
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- 2000-12-13 KR KR1020077001118A patent/KR20070014235A/ko not_active Application Discontinuation
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