HUP0200992A2 - Progreszteron antagonista indolinszármazékok és ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk - Google Patents

Progreszteron antagonista indolinszármazékok és ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk

Info

Publication number
HUP0200992A2
HUP0200992A2 HU0200992A HUP0200992A HUP0200992A2 HU P0200992 A2 HUP0200992 A2 HU P0200992A2 HU 0200992 A HU0200992 A HU 0200992A HU P0200992 A HUP0200992 A HU P0200992A HU P0200992 A2 HUP0200992 A2 HU P0200992A2
Authority
HU
Hungary
Prior art keywords
pharmaceutical compositions
compositions containing
indoline derivatives
progesterone antagonists
progesterone
Prior art date
Application number
HU0200992A
Other languages
English (en)
Inventor
Reinhold H. W. Bender
Andrew Fensome
Todd K. Jones
Keith B. Marschke
Lori L. Miller
Christopher M. Tegley
John W. Ullrich
Jay E. Wrobel
Puwen Zhang
Lin Zhi
Original Assignee
Ligand Pharmaceuticals Inc.
Wyeth
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ligand Pharmaceuticals Inc., Wyeth filed Critical Ligand Pharmaceuticals Inc.
Publication of HUP0200992A2 publication Critical patent/HUP0200992A2/hu
Publication of HUP0200992A3 publication Critical patent/HUP0200992A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/96—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
HU0200992A 1999-05-04 2000-05-01 Indoline derivatives as progesterone antagonists and pharmaceutical compositions containing them and their use HUP0200992A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18305899P 1999-05-04 1999-05-04
US09/552,632 US6391907B1 (en) 1999-05-04 2000-04-19 Indoline derivatives

Publications (2)

Publication Number Publication Date
HUP0200992A2 true HUP0200992A2 (hu) 2002-07-29
HUP0200992A3 HUP0200992A3 (en) 2004-12-28

Family

ID=26878706

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0200992A HUP0200992A3 (en) 1999-05-04 2000-05-01 Indoline derivatives as progesterone antagonists and pharmaceutical compositions containing them and their use

Country Status (21)

Country Link
US (5) US6391907B1 (hu)
EP (1) EP1175398B1 (hu)
JP (1) JP2002543183A (hu)
KR (1) KR20010114252A (hu)
CN (1) CN1141295C (hu)
AT (1) ATE366721T1 (hu)
AU (1) AU4814100A (hu)
BR (1) BR0010215A (hu)
CA (1) CA2371638A1 (hu)
CZ (1) CZ20013953A3 (hu)
DE (1) DE60035496T2 (hu)
DK (1) DK1175398T3 (hu)
EA (1) EA200101177A1 (hu)
ES (1) ES2290035T3 (hu)
HU (1) HUP0200992A3 (hu)
IL (1) IL146281A0 (hu)
MX (1) MXPA01011298A (hu)
NO (1) NO20015379L (hu)
PL (1) PL351954A1 (hu)
WO (1) WO2000066556A1 (hu)
ZA (1) ZA200107631B (hu)

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US6391907B1 (en) 2002-05-21
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AU4814100A (en) 2000-11-17
US20030220388A1 (en) 2003-11-27
IL146281A0 (en) 2002-07-25
US20060160882A1 (en) 2006-07-20
ATE366721T1 (de) 2007-08-15
CN1350523A (zh) 2002-05-22
NO20015379L (no) 2002-01-03
US6608068B2 (en) 2003-08-19
ZA200107631B (en) 2002-05-14
DE60035496D1 (de) 2007-08-23
BR0010215A (pt) 2002-02-13
WO2000066556A1 (en) 2000-11-09
JP2002543183A (ja) 2002-12-17
HUP0200992A3 (en) 2004-12-28
ES2290035T3 (es) 2008-02-16
DE60035496T2 (de) 2008-03-13
CN1141295C (zh) 2004-03-10
EP1175398A1 (en) 2002-01-30
PL351954A1 (en) 2003-07-14
CA2371638A1 (en) 2000-11-09
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US20020086874A1 (en) 2002-07-04
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US20070259944A1 (en) 2007-11-08
US7253203B2 (en) 2007-08-07
US7084168B2 (en) 2006-08-01
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US7645761B2 (en) 2010-01-12
MXPA01011298A (es) 2003-07-14

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