HUP0104878A2 - 5-HT újbóli felvétel inhibitorként és 5HT1B/D-ligandumként ható amid- és karbamidszármazékok, eljárás az előállításukra és a vegyületeket tartalmazó gyógyszerkészítmények - Google Patents
5-HT újbóli felvétel inhibitorként és 5HT1B/D-ligandumként ható amid- és karbamidszármazékok, eljárás az előállításukra és a vegyületeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0104878A2 HUP0104878A2 HU0104878A HUP0104878A HUP0104878A2 HU P0104878 A2 HUP0104878 A2 HU P0104878A2 HU 0104878 A HU0104878 A HU 0104878A HU P0104878 A HUP0104878 A HU P0104878A HU P0104878 A2 HUP0104878 A2 HU P0104878A2
- Authority
- HU
- Hungary
- Prior art keywords
- ring
- group
- value
- formula
- atom
- Prior art date
Links
- 150000001408 amides Chemical class 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 150000003672 ureas Chemical class 0.000 title 1
- -1 CH2OA Chemical compound 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004955 1,4-cyclohexylene group Chemical group [H]C1([H])C([H])([H])C([H])([*:1])C([H])([H])C([H])([H])C1([H])[*:2] 0.000 abstract 1
- XXJGBENTLXFVFI-UHFFFAOYSA-N 1-amino-methylene Chemical compound N[CH2] XXJGBENTLXFVFI-UHFFFAOYSA-N 0.000 abstract 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Gynecology & Obstetrics (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Anesthesiology (AREA)
- Psychology (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Electric Double-Layer Capacitors Or The Like (AREA)
- Secondary Cells (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Catalysts (AREA)
Abstract
A tal lm ny szerinti vegyületek (I) ltal nos képletében R1 jelentéseszubsztitu latlan vagy egy vagy kettő A, AO, OH, Hal, CN, NO2, NH2,NHA, NA2, COA, CONH2, CONHA, CONA2, CH2OH, CH2OA, CH2NH2, CH2NHA,CH2NA2, COOH és/vagy COOA csoporttal szubsztitu lt 3-indolilcsoport,R2 jelentése (Ia), Ib), (Ic) vagy (Id) ltal nos képletű csoport, mértéke 1 vagy 2, n értéke 0, 1, 2, 3 vagy 4, Y jelentése 1,4-ciklohexiléngyűrű, 1,3-pirrolidiniléngyűrű, 1,4-piperaziniléngyűrűvagy 1,4-piperidiniléngyűrű, amelyek adott esetben részbendehidrogénezett form ban lehetnek, Z jelentése -(CH2)n- vagy -(CH2)nNH- képletű csoport, q értéke 0 vagy 1, r értéke 0 vagy 1, R3jelentése A, R4 jelentése AO, Hal jelentése fluoratom, klóratom,brómatom vagy jódatom, A jelentése 1-6 szénatomos egyenes vagy el gazószénl ncú alkilcsoport, azzal a megszorít ssal, hogy q és r k"züllegal bb az egyik értéke 0-tól eltérő. A tal lm ny kiterjed a fentivegyületek elő llít s ra és ezeket tartalmazó gyógyszerkészítményekre. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19756036A DE19756036A1 (de) | 1997-12-17 | 1997-12-17 | Amid- und Harnstoffderivate |
| PCT/EP1998/008457 WO2000037456A1 (de) | 1997-12-17 | 1998-12-22 | Amid- und harnstoffderivate als 5-ht-reuptake-inhibitoren und als 5-ht1b/1d-liganden |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0104878A2 true HUP0104878A2 (hu) | 2002-04-29 |
| HUP0104878A3 HUP0104878A3 (en) | 2003-01-28 |
Family
ID=26042517
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0104878A HUP0104878A3 (en) | 1997-12-17 | 1998-12-22 | Amide and urea derivatives as 5-ht reuptake inhibitors and as 5-ht1b/d ligands, process for their preparation and medicaments containing them |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6509340B1 (hu) |
| EP (1) | EP1140898B1 (hu) |
| JP (1) | JP2002533333A (hu) |
| CN (1) | CN1336924A (hu) |
| AT (1) | ATE222903T1 (hu) |
| AU (1) | AU753335B2 (hu) |
| BR (1) | BR9816121A (hu) |
| CA (1) | CA2355861A1 (hu) |
| CZ (1) | CZ20012270A3 (hu) |
| DE (2) | DE19756036A1 (hu) |
| DK (1) | DK1140898T3 (hu) |
| ES (1) | ES2182401T3 (hu) |
| HU (1) | HUP0104878A3 (hu) |
| NO (1) | NO20013086L (hu) |
| PT (1) | PT1140898E (hu) |
| SI (1) | SI1140898T1 (hu) |
| SK (1) | SK9232001A3 (hu) |
| WO (1) | WO2000037456A1 (hu) |
| ZA (1) | ZA9811467B (hu) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10252650A1 (de) | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Cyclohexyl-Harnstoff-Derivate |
| DE10337184A1 (de) * | 2003-08-13 | 2005-03-10 | Gruenenthal Gmbh | Substituierte 3-Pyrrolidin-Indol-Derivate |
| PL1701940T3 (pl) * | 2003-12-23 | 2008-11-28 | H Lundbeck As | Pochodne 2-(1H-indolilosulfanylo)benzyloaminy jako SSRI |
| GB0400895D0 (en) * | 2004-01-15 | 2004-02-18 | Smithkline Beecham Corp | Chemical compounds |
| TW200616967A (en) | 2004-06-24 | 2006-06-01 | Smithkline Beecham Corp | Novel indazole carboxamides and their use |
| AR052308A1 (es) * | 2004-07-16 | 2007-03-14 | Lundbeck & Co As H | Derivados de 2-(1h-indolilsulfanil)-arilamina y una composicion farmaceutica que contiene al compuesto |
| US7629473B2 (en) * | 2005-06-17 | 2009-12-08 | H. Lundbeck A/S | 2-(1H-indolylsulfanyl)-aryl amine derivatives |
| AR054393A1 (es) * | 2005-06-17 | 2007-06-20 | Lundbeck & Co As H | Derivados de benzo(b)furano y benzo(b)tiofeno, composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por la inhibicion de la reabsorcion de neurotransmisores de amina biogenicos. |
| US8063071B2 (en) | 2007-10-31 | 2011-11-22 | GlaxoSmithKline, LLC | Chemical compounds |
| CN100448849C (zh) * | 2006-02-02 | 2009-01-07 | 深圳市天和医药科技开发有限公司 | 一种4位-酰基取代-2-甲基哌嗪化合物的制备方法 |
| PE20081889A1 (es) | 2007-03-23 | 2009-03-05 | Smithkline Beecham Corp | Indol carboxamidas como inhibidores de ikk2 |
| WO2009049030A1 (en) * | 2007-10-09 | 2009-04-16 | Triton Biopharma, Llc | Method to use compositions having antidepressant anxiolytic and other neurological activity and compositions of matter |
| EP2406249A1 (en) | 2009-03-10 | 2012-01-18 | Glaxo Group Limited | Indole derivatives as ikk2 inhibitors |
| EP2518064A1 (en) * | 2009-12-25 | 2012-10-31 | Mochida Pharmaceutical Co., Ltd. | Novel aryl urea derivative |
| WO2013085954A1 (en) * | 2011-12-06 | 2013-06-13 | Janssen Pharmaceutica Nv | Substituted piperidinyl-carboxamide derivatives useful as scd 1 inhibitors |
| US9102669B2 (en) | 2011-12-06 | 2015-08-11 | Janssen Pharmaceutica Nv | Substituted piperidinyl-pyridazinyl derivatives useful as SCD 1 inhibitors |
| EA201790806A1 (ru) | 2014-11-05 | 2017-11-30 | Флексус Байосайенсиз, Инк. | Иммунорегулирующие средства |
| UY36390A (es) * | 2014-11-05 | 2016-06-01 | Flexus Biosciences Inc | Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen |
| EP3820567A1 (en) * | 2018-07-12 | 2021-05-19 | UCB Biopharma SRL | Spirocyclic indane analogues as il-17 modulators |
| WO2020183011A1 (en) | 2019-03-14 | 2020-09-17 | Institut Curie | Htr1d inhibitors and uses thereof in the treatment of cancer |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2084531A1 (en) | 1991-12-19 | 1993-06-20 | David W. Smith | Antimigraine 4-pyrimidinyl and pyridinyl derivatives of indol-3yl-alkyl piperazines |
| FR2740134B1 (fr) * | 1995-10-18 | 1998-01-09 | Pf Medicament | Derives d'amines cycliques d'aryl-piperazines, leur preparation et les compositions pharmaceutiques les contenant |
| DE19615232A1 (de) * | 1996-04-18 | 1997-10-23 | Merck Patent Gmbh | Neue Carbamoylderivate und deren Verwendung als 5-HT ¶1¶¶A¶-Antagonisten |
-
1997
- 1997-12-17 DE DE19756036A patent/DE19756036A1/de not_active Withdrawn
-
1998
- 1998-12-14 ZA ZA9811467A patent/ZA9811467B/xx unknown
- 1998-12-22 WO PCT/EP1998/008457 patent/WO2000037456A1/de not_active Application Discontinuation
- 1998-12-22 CA CA002355861A patent/CA2355861A1/en not_active Abandoned
- 1998-12-22 SI SI9830281T patent/SI1140898T1/xx unknown
- 1998-12-22 HU HU0104878A patent/HUP0104878A3/hu unknown
- 1998-12-22 ES ES98966851T patent/ES2182401T3/es not_active Expired - Lifetime
- 1998-12-22 JP JP2000589528A patent/JP2002533333A/ja active Pending
- 1998-12-22 EP EP98966851A patent/EP1140898B1/de not_active Expired - Lifetime
- 1998-12-22 AU AU25140/99A patent/AU753335B2/en not_active Ceased
- 1998-12-22 PT PT98966851T patent/PT1140898E/pt unknown
- 1998-12-22 US US09/868,840 patent/US6509340B1/en not_active Expired - Fee Related
- 1998-12-22 DE DE59805363T patent/DE59805363D1/de not_active Expired - Fee Related
- 1998-12-22 DK DK98966851T patent/DK1140898T3/da active
- 1998-12-22 BR BR9816121-0A patent/BR9816121A/pt not_active IP Right Cessation
- 1998-12-22 CN CN98814399A patent/CN1336924A/zh active Pending
- 1998-12-22 CZ CZ20012270A patent/CZ20012270A3/cs unknown
- 1998-12-22 AT AT98966851T patent/ATE222903T1/de not_active IP Right Cessation
- 1998-12-22 SK SK923-2001A patent/SK9232001A3/sk unknown
-
2001
- 2001-06-21 NO NO20013086A patent/NO20013086L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DE59805363D1 (de) | 2002-10-02 |
| AU753335B2 (en) | 2002-10-17 |
| CZ20012270A3 (cs) | 2001-12-12 |
| SK9232001A3 (en) | 2001-12-03 |
| DK1140898T3 (da) | 2002-11-25 |
| EP1140898B1 (de) | 2002-08-28 |
| ES2182401T3 (es) | 2003-03-01 |
| HUP0104878A3 (en) | 2003-01-28 |
| EP1140898A1 (de) | 2001-10-10 |
| PT1140898E (pt) | 2003-01-31 |
| CA2355861A1 (en) | 2000-06-29 |
| ATE222903T1 (de) | 2002-09-15 |
| ZA9811467B (en) | 1999-06-14 |
| BR9816121A (pt) | 2001-11-13 |
| DE19756036A1 (de) | 1999-06-24 |
| AU2514099A (en) | 2000-07-12 |
| JP2002533333A (ja) | 2002-10-08 |
| NO20013086D0 (no) | 2001-06-21 |
| WO2000037456A1 (de) | 2000-06-29 |
| CN1336924A (zh) | 2002-02-20 |
| SI1140898T1 (en) | 2003-02-28 |
| NO20013086L (no) | 2001-08-21 |
| US6509340B1 (en) | 2003-01-21 |
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