HUP0004935A2 - Novel carboxylic acid derivatives, their production and their use as mixed eta/etb endothelin-receptor antagonists - Google Patents
Novel carboxylic acid derivatives, their production and their use as mixed eta/etb endothelin-receptor antagonistsInfo
- Publication number
- HUP0004935A2 HUP0004935A2 HU0004935A HUP0004935A HUP0004935A2 HU P0004935 A2 HUP0004935 A2 HU P0004935A2 HU 0004935 A HU0004935 A HU 0004935A HU P0004935 A HUP0004935 A HU P0004935A HU P0004935 A2 HUP0004935 A2 HU P0004935A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- general formula
- carboxylic acid
- phenyl
- acid derivatives
- Prior art date
Links
- 150000001732 carboxylic acid derivatives Chemical class 0.000 title abstract 2
- 229940118365 Endothelin receptor antagonist Drugs 0.000 title 1
- 239000002308 endothelin receptor antagonist Substances 0.000 title 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000001624 naphthyl group Chemical group 0.000 abstract 2
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 abstract 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 abstract 1
- -1 alkaline earth metal cation Chemical class 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000005217 alkenylheteroaryl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000005213 alkyl heteroaryl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000005025 alkynylaryl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000005215 cycloalkylheteroaryl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
- 125000003831 tetrazolyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/70—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/36—One oxygen atom
- C07D263/38—One oxygen atom attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/44—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/34—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
A találmány tárgyát az (I) általános képletű új karbonsavszármazékok,fiziológiásan elfogadható sóik és enantiomertiszta formáik képezik,ahol R tetrazolilcsoport vagy (a) általános képletű csoport, ahol R1 -OR7 általános képletű csoport, ahol R7 jelentése: hidrogénatom, egyalkálifém kationja, egy alkáliföldfém kationja vagy egy fiziológiásanelfogadható szerves ammóniumion; cikloalkil-, alkilcsoport, olyanbenzil-, fenil-, alkenil- vagy alkinilcsoport, amelyek adott esetbenszubsztituáltak; R4 és R5 olyan fenil- vagy naftilcsoport, amelyekadott esetben szubsztituáltak, vagy amelyeket orto-helyzetben egykémiai kötés vagy egy -CH2-, -CH2-CH2-, -CH=CH-, -O-, -S-, -SO2-, -NH-vagy -N(alkil)- képletű csoport köt egymással össze, adott esetbenszubsztituált cikloalkilcsoport; R6 hidrogénatom, olyan alkil-,alkenil-, alkinil-, cikloalkil-, fenil-, naftil-, 5 vagy 6 tagúheteroarilcsoport, amelyek adott esetben egyszer vagy többszörszubsztituáltak lehetnek; Z kén- vagy oxigénatom; B 2-4 szénatomosalkilénlánc; és Het (Ia) vagy (Ib) általános képletű heterociklusoscsoport. ÓThe subject of the invention is the new carboxylic acid derivatives of the general formula (I), their physiologically acceptable salts and enantiomerically pure forms, where R is a tetrazolyl group or a group of the general formula (a), where R1 -OR7 is a group of the general formula, where R7 means: hydrogen atom, cation of an alkali metal, an alkaline earth metal cation or a physiologically acceptable organic ammonium ion; cycloalkyl, alkyl, benzyl, phenyl, alkenyl or alkynyl which are optionally substituted; R4 and R5 are phenyl or naphthyl groups, which are optionally substituted, or which are in the ortho position a single chemical bond or a -CH2-, -CH2-CH2-, -CH=CH-, -O-, -S-, -SO2-, A group of the formula -NH- or -N(alkyl)- connects to each other, an optionally substituted cycloalkyl group; R6 is a hydrogen atom, an alkyl-, alkenyl-, alkynyl-, cycloalkyl-, phenyl-, naphthyl-, 5- or 6-membered heteroaryl group, which may optionally be mono- or polysubstituted; Z is a sulfur or oxygen atom; B 2-4 alkylene chain; and Het is a heterocyclic group of general formula (Ia) or (Ib). HE
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19738578A DE19738578A1 (en) | 1997-09-04 | 1997-09-04 | Carboxylic acid derivatives useful as endothelin A and B antagonists also active as renin and angiotensin inhibitors |
| DE1998111915 DE19811915A1 (en) | 1998-03-18 | 1998-03-18 | New carboxylic acid derivatives |
| PCT/EP1998/005354 WO1999011629A1 (en) | 1997-09-04 | 1998-08-24 | Novel carboxylic acid derivatives, their production and their use as mixed eta/etb endothelin-receptor antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0004935A2 true HUP0004935A2 (en) | 2001-10-28 |
| HUP0004935A3 HUP0004935A3 (en) | 2001-12-28 |
Family
ID=26039663
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0004935A HUP0004935A3 (en) | 1997-09-04 | 1998-08-24 | Novel carboxylic acid derivatives, their production and their use as mixed eta/etb endothelin-receptor antagonists |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP1009741A1 (en) |
| JP (1) | JP2001514254A (en) |
| KR (1) | KR20010023615A (en) |
| CN (1) | CN1269792A (en) |
| AR (1) | AR017052A1 (en) |
| AU (1) | AU748610B2 (en) |
| BG (1) | BG104222A (en) |
| BR (1) | BR9811631A (en) |
| CA (1) | CA2302350A1 (en) |
| CO (1) | CO4970738A1 (en) |
| HR (1) | HRP980484A2 (en) |
| HU (1) | HUP0004935A3 (en) |
| ID (1) | ID25620A (en) |
| IL (1) | IL134276A0 (en) |
| NO (1) | NO20001077D0 (en) |
| NZ (1) | NZ502660A (en) |
| PL (1) | PL338954A1 (en) |
| SK (1) | SK1522000A3 (en) |
| TR (1) | TR200000602T2 (en) |
| TW (1) | TW546295B (en) |
| WO (1) | WO1999011629A1 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19924892A1 (en) * | 1999-06-01 | 2000-12-07 | Basf Ag | New carboxylic acid derivatives with aryl-substituted nitrogen heterocycles, their production and use as endothelin receptor antagonists |
| CA2652636A1 (en) * | 2006-05-29 | 2007-12-06 | Nicox S.A. | Nitrated heterocyclic compounds as endothelin receptor antagonist |
| PL2268644T3 (en) | 2008-03-05 | 2012-01-31 | Boehringer Ingelheim Int | Tricyclic pyridine derivatives, medicaments containing such compounds, their use and process for their preparation |
| EP2451786B1 (en) * | 2009-07-10 | 2014-01-22 | Cadila Healthcare Limited | Improved process for the preparation of ambrisentan and novel intermediates thereof |
| SG183321A1 (en) | 2010-02-19 | 2012-09-27 | Boehringer Ingelheim Int | Tricyclic pyridine derivatives, medicaments containing such compounds, their use and process for their preparation |
| EP2760868B1 (en) | 2011-08-17 | 2018-04-25 | Boehringer Ingelheim International GmbH | Furo[3,4-c]quinoline derivatives, medicaments containing such compounds, their use and process for their preparation |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4411225A1 (en) * | 1994-03-31 | 1995-10-05 | Basf Ag | Use of carboxylic acid derivatives as a drug |
| DE19533023B4 (en) * | 1994-10-14 | 2007-05-16 | Basf Ag | New carboxylic acid derivatives, their preparation and use |
| JP2000504013A (en) * | 1996-02-01 | 2000-04-04 | スミスクライン・ビーチャム・コーポレイション | Endothelin receptor antagonist |
| DE19614542A1 (en) * | 1996-04-12 | 1997-10-16 | Basf Ag | New carboxylic acid derivatives, their production and use |
| DE19636046A1 (en) * | 1996-09-05 | 1998-03-12 | Basf Ag | New carboxylic acid derivatives, their production and use as mixed ET¶A¶ / ET¶B¶ receptor antagonists |
-
1998
- 1998-08-24 KR KR1020007002264A patent/KR20010023615A/en not_active Application Discontinuation
- 1998-08-24 BR BR9811631-2A patent/BR9811631A/en not_active IP Right Cessation
- 1998-08-24 EP EP98948859A patent/EP1009741A1/en not_active Withdrawn
- 1998-08-24 WO PCT/EP1998/005354 patent/WO1999011629A1/en not_active Application Discontinuation
- 1998-08-24 IL IL13427698A patent/IL134276A0/en unknown
- 1998-08-24 JP JP2000508669A patent/JP2001514254A/en active Pending
- 1998-08-24 CN CN98808862A patent/CN1269792A/en active Pending
- 1998-08-24 HU HU0004935A patent/HUP0004935A3/en unknown
- 1998-08-24 PL PL98338954A patent/PL338954A1/en unknown
- 1998-08-24 NZ NZ502660A patent/NZ502660A/en unknown
- 1998-08-24 CA CA002302350A patent/CA2302350A1/en not_active Abandoned
- 1998-08-24 AU AU95333/98A patent/AU748610B2/en not_active Ceased
- 1998-08-24 TR TR2000/00602T patent/TR200000602T2/en unknown
- 1998-08-24 ID IDW20000386D patent/ID25620A/en unknown
- 1998-08-24 SK SK152-2000A patent/SK1522000A3/en unknown
- 1998-09-02 HR HR19811915.1A patent/HRP980484A2/en not_active Application Discontinuation
- 1998-09-03 CO CO98050561A patent/CO4970738A1/en unknown
- 1998-09-03 TW TW087114595A patent/TW546295B/en active
- 1998-09-03 AR ARP980104402A patent/AR017052A1/en not_active Application Discontinuation
-
2000
- 2000-03-02 NO NO20001077A patent/NO20001077D0/en not_active Application Discontinuation
- 2000-03-06 BG BG104222A patent/BG104222A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL134276A0 (en) | 2001-04-30 |
| BR9811631A (en) | 2000-09-26 |
| TR200000602T2 (en) | 2000-12-21 |
| JP2001514254A (en) | 2001-09-11 |
| SK1522000A3 (en) | 2000-08-14 |
| TW546295B (en) | 2003-08-11 |
| WO1999011629A1 (en) | 1999-03-11 |
| CN1269792A (en) | 2000-10-11 |
| NZ502660A (en) | 2002-02-01 |
| BG104222A (en) | 2001-02-28 |
| PL338954A1 (en) | 2000-12-04 |
| EP1009741A1 (en) | 2000-06-21 |
| HUP0004935A3 (en) | 2001-12-28 |
| HRP980484A2 (en) | 1999-06-30 |
| AR017052A1 (en) | 2001-08-22 |
| CO4970738A1 (en) | 2000-11-07 |
| CA2302350A1 (en) | 1999-03-11 |
| KR20010023615A (en) | 2001-03-26 |
| NO20001077L (en) | 2000-03-02 |
| AU9533398A (en) | 1999-03-22 |
| AU748610B2 (en) | 2002-06-06 |
| ID25620A (en) | 2000-10-19 |
| NO20001077D0 (en) | 2000-03-02 |
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