AR017052A1 - DERIVATIVES OF CARBOXYL ACID AND ITS USE TO PREPARE MEDICINES. - Google Patents
DERIVATIVES OF CARBOXYL ACID AND ITS USE TO PREPARE MEDICINES.Info
- Publication number
- AR017052A1 AR017052A1 ARP980104402A ARP980104402A AR017052A1 AR 017052 A1 AR017052 A1 AR 017052A1 AR P980104402 A ARP980104402 A AR P980104402A AR P980104402 A ARP980104402 A AR P980104402A AR 017052 A1 AR017052 A1 AR 017052A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- optionally substituted
- phenyl
- sulfur
- oxygen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/70—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/36—One oxygen atom
- C07D263/38—One oxygen atom attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/44—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/34—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Derivados del ácido carboxílico de formula I caracterizados porque R significa tetrazol o un grupo II en donde R1 tiene el siguiente significado: unresto OR7, en donde R7 significa: hidrogeno, el cation de un metal alcalino, el cation de un metal alcalinotérreo o un ion amonio orgánico fisiologicamentetolerable; cicloalquilo C3-8, alquilo C1-8, CH2-fenilo eventualmente sustituido, un grupo alquenilo C3-6 o alquinilo C3-6 eventualmente sustituido o feniloeventualmente sustituido. R2 significa hidrogeno, hidroxi, NH2, NH(alquilo C1-4), N(alquilo C1-4)2, halogeno, alquilo C1-4, alquenilo C2-4, alquinilo C2-4,halogenoalquilo C1-4, alcoxi C1-4, halogenoalcoxi C1-4 o alquiltio C1-4, o CR2 está unido con CR10 como se indica más abajo como un anillo de 5 o 6 miembros, Xsignifica nitrogeno o metino; Y significa nitrogeno o metino; W significa nitrogeno o CR10 en donde R10 significa H o alquilo C1-4, o CR10 junto con CR2 o CR3forma un anillo alquileno o alquenileno de 5 o 6 miembros,el cual puede estar eventualmente sustituido,y en donde en cada caso uno o más grupos metileno puedenestar reemplazados por oxígeno, azufre,-NH o -N(alquilo C1-4); R3 significa H, hidroxi, NH2, NH(alquilo C1-4), N(alquilo C1-4)2, halogeno, alquilo C1-4,alqueniloC2-4, alquinilo C2-4, halogenoalquilo C1-4, alcoxi C1-4, halogenoalcoxi C1-4, alquiltio C1-4, o CR2 está unido con CR10 como se indica más arribacomo un anillo de 5 o 6 miembros; R4 y R5 (que pueden ser iguales o diferentes) significan: fenilo o naftilo, eventualmente sustituido, o fenilo o naftilo, quepueden estar unidos entre sí en posicion orto a través de una ligadura directa, un grupo metileno, etileno o etenileno, un átomo de oxígeno o azufre o un grupoSO2, NH o N-alquilo, cicloalquilo C3-8 eventualmente sustituido; R6 significa cicloalquilo C3-8 eventualmente sustituido; fenilo o naftilo, eventualmentesustituido, un compuesto heteroaromático de 5 o 6 miembros que contienen uno a 3 átomos de nitrogeno y/o un átomo de azufre u oxígenoy el cual puede estareventualmente sustituido; Z significa azufre u oxígeno; B significa alquileno C2-4; Het significa un resto heterocíclico de la formula general Ia o Ib con T=OCarboxylic acid derivatives of formula I characterized in that R means tetrazole or a group II where R1 has the following meaning: an OR7 residue, wherein R7 means: hydrogen, the cation of an alkali metal, the cation of an alkaline earth metal or an ion physiologically tolerable organic ammonium; C3-8 cycloalkyl, C1-8 alkyl, CH2-optionally substituted phenyl, a C3-6 alkenyl group or C3-6 alkynyl optionally substituted or optionally substituted phenyl. R2 means hydrogen, hydroxy, NH2, NH (C1-4 alkyl), N (C1-4 alkyl) 2, halogen, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-4 halogenoalkyl, C1- alkoxy 4, C1-4 halogenoalkoxy or C1-4 alkylthio, or CR2 is linked with CR10 as indicated below as a 5 or 6 membered ring, X means nitrogen or methine; And it means nitrogen or methine; W means nitrogen or CR10 where R10 means H or C1-4 alkyl, or CR10 together with CR2 or CR3 forms a 5 or 6 membered alkylene or alkenylene ring, which may eventually be substituted, and where in each case one or more methylene groups may be replaced by oxygen, sulfur, -NH or -N (C1-4 alkyl); R3 means H, hydroxy, NH2, NH (C1-4 alkyl), N (C1-4 alkyl) 2, halogen, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-4 halogenoalkyl, C1-4 alkoxy , C1-4 halogenoalkoxy, C1-4 alkylthio, or CR2 is linked to CR10 as indicated above as a 5 or 6 membered ring; R4 and R5 (which may be the same or different) mean: phenyl or naphthyl, optionally substituted, or phenyl or naphthyl, which may be linked to each other in ortho position through a direct ligation, a methylene, ethylene or ethenylene group, an atom of oxygen or sulfur or a group SO2, NH or N-alkyl, C3-8 cycloalkyl optionally substituted; R6 means C3-8 cycloalkyl optionally substituted; phenyl or naphthyl, optionally substituted, a 5 or 6 membered heteroaromatic compound containing one to 3 nitrogen atoms and / or a sulfur or oxygen atom and which may be eventually substituted; Z means sulfur or oxygen; B means C2-4 alkylene; Het means a heterocyclic moiety of the general formula Ia or Ib with T = O
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19738578A DE19738578A1 (en) | 1997-09-04 | 1997-09-04 | Carboxylic acid derivatives useful as endothelin A and B antagonists also active as renin and angiotensin inhibitors |
| DE1998111915 DE19811915A1 (en) | 1998-03-18 | 1998-03-18 | New carboxylic acid derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR017052A1 true AR017052A1 (en) | 2001-08-22 |
Family
ID=26039663
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980104402A AR017052A1 (en) | 1997-09-04 | 1998-09-03 | DERIVATIVES OF CARBOXYL ACID AND ITS USE TO PREPARE MEDICINES. |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP1009741A1 (en) |
| JP (1) | JP2001514254A (en) |
| KR (1) | KR20010023615A (en) |
| CN (1) | CN1269792A (en) |
| AR (1) | AR017052A1 (en) |
| AU (1) | AU748610B2 (en) |
| BG (1) | BG104222A (en) |
| BR (1) | BR9811631A (en) |
| CA (1) | CA2302350A1 (en) |
| CO (1) | CO4970738A1 (en) |
| HR (1) | HRP980484A2 (en) |
| HU (1) | HUP0004935A3 (en) |
| ID (1) | ID25620A (en) |
| IL (1) | IL134276A0 (en) |
| NO (1) | NO20001077D0 (en) |
| NZ (1) | NZ502660A (en) |
| PL (1) | PL338954A1 (en) |
| SK (1) | SK1522000A3 (en) |
| TR (1) | TR200000602T2 (en) |
| TW (1) | TW546295B (en) |
| WO (1) | WO1999011629A1 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19924892A1 (en) * | 1999-06-01 | 2000-12-07 | Basf Ag | New carboxylic acid derivatives with aryl-substituted nitrogen heterocycles, their production and use as endothelin receptor antagonists |
| CA2652636A1 (en) * | 2006-05-29 | 2007-12-06 | Nicox S.A. | Nitrated heterocyclic compounds as endothelin receptor antagonist |
| PL2268644T3 (en) | 2008-03-05 | 2012-01-31 | Boehringer Ingelheim Int | Tricyclic pyridine derivatives, medicaments containing such compounds, their use and process for their preparation |
| EP2451786B1 (en) * | 2009-07-10 | 2014-01-22 | Cadila Healthcare Limited | Improved process for the preparation of ambrisentan and novel intermediates thereof |
| SG183321A1 (en) | 2010-02-19 | 2012-09-27 | Boehringer Ingelheim Int | Tricyclic pyridine derivatives, medicaments containing such compounds, their use and process for their preparation |
| EP2760868B1 (en) | 2011-08-17 | 2018-04-25 | Boehringer Ingelheim International GmbH | Furo[3,4-c]quinoline derivatives, medicaments containing such compounds, their use and process for their preparation |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4411225A1 (en) * | 1994-03-31 | 1995-10-05 | Basf Ag | Use of carboxylic acid derivatives as a drug |
| DE19533023B4 (en) * | 1994-10-14 | 2007-05-16 | Basf Ag | New carboxylic acid derivatives, their preparation and use |
| JP2000504013A (en) * | 1996-02-01 | 2000-04-04 | スミスクライン・ビーチャム・コーポレイション | Endothelin receptor antagonist |
| DE19614542A1 (en) * | 1996-04-12 | 1997-10-16 | Basf Ag | New carboxylic acid derivatives, their production and use |
| DE19636046A1 (en) * | 1996-09-05 | 1998-03-12 | Basf Ag | New carboxylic acid derivatives, their production and use as mixed ET¶A¶ / ET¶B¶ receptor antagonists |
-
1998
- 1998-08-24 KR KR1020007002264A patent/KR20010023615A/en not_active Application Discontinuation
- 1998-08-24 BR BR9811631-2A patent/BR9811631A/en not_active IP Right Cessation
- 1998-08-24 EP EP98948859A patent/EP1009741A1/en not_active Withdrawn
- 1998-08-24 WO PCT/EP1998/005354 patent/WO1999011629A1/en not_active Application Discontinuation
- 1998-08-24 IL IL13427698A patent/IL134276A0/en unknown
- 1998-08-24 JP JP2000508669A patent/JP2001514254A/en active Pending
- 1998-08-24 CN CN98808862A patent/CN1269792A/en active Pending
- 1998-08-24 HU HU0004935A patent/HUP0004935A3/en unknown
- 1998-08-24 PL PL98338954A patent/PL338954A1/en unknown
- 1998-08-24 NZ NZ502660A patent/NZ502660A/en unknown
- 1998-08-24 CA CA002302350A patent/CA2302350A1/en not_active Abandoned
- 1998-08-24 AU AU95333/98A patent/AU748610B2/en not_active Ceased
- 1998-08-24 TR TR2000/00602T patent/TR200000602T2/en unknown
- 1998-08-24 ID IDW20000386D patent/ID25620A/en unknown
- 1998-08-24 SK SK152-2000A patent/SK1522000A3/en unknown
- 1998-09-02 HR HR19811915.1A patent/HRP980484A2/en not_active Application Discontinuation
- 1998-09-03 CO CO98050561A patent/CO4970738A1/en unknown
- 1998-09-03 TW TW087114595A patent/TW546295B/en active
- 1998-09-03 AR ARP980104402A patent/AR017052A1/en not_active Application Discontinuation
-
2000
- 2000-03-02 NO NO20001077A patent/NO20001077D0/en not_active Application Discontinuation
- 2000-03-06 BG BG104222A patent/BG104222A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL134276A0 (en) | 2001-04-30 |
| BR9811631A (en) | 2000-09-26 |
| TR200000602T2 (en) | 2000-12-21 |
| JP2001514254A (en) | 2001-09-11 |
| SK1522000A3 (en) | 2000-08-14 |
| TW546295B (en) | 2003-08-11 |
| HUP0004935A2 (en) | 2001-10-28 |
| WO1999011629A1 (en) | 1999-03-11 |
| CN1269792A (en) | 2000-10-11 |
| NZ502660A (en) | 2002-02-01 |
| BG104222A (en) | 2001-02-28 |
| PL338954A1 (en) | 2000-12-04 |
| EP1009741A1 (en) | 2000-06-21 |
| HUP0004935A3 (en) | 2001-12-28 |
| HRP980484A2 (en) | 1999-06-30 |
| CO4970738A1 (en) | 2000-11-07 |
| CA2302350A1 (en) | 1999-03-11 |
| KR20010023615A (en) | 2001-03-26 |
| NO20001077L (en) | 2000-03-02 |
| AU9533398A (en) | 1999-03-22 |
| AU748610B2 (en) | 2002-06-06 |
| ID25620A (en) | 2000-10-19 |
| NO20001077D0 (en) | 2000-03-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |