CO4970738A1 - NEW DERIVATIVES OF CARBOXYLIC ACID, ITS PREPARATION AND ITS USE - Google Patents

NEW DERIVATIVES OF CARBOXYLIC ACID, ITS PREPARATION AND ITS USE

Info

Publication number
CO4970738A1
CO4970738A1 CO98050561A CO98050561A CO4970738A1 CO 4970738 A1 CO4970738 A1 CO 4970738A1 CO 98050561 A CO98050561 A CO 98050561A CO 98050561 A CO98050561 A CO 98050561A CO 4970738 A1 CO4970738 A1 CO 4970738A1
Authority
CO
Colombia
Prior art keywords
alkyl
stands
optionally substituted
nitrogen
hydrogen
Prior art date
Application number
CO98050561A
Other languages
Spanish (es)
Inventor
Wilhelm Amberg
Rolf Jansen
Klinge Dagmar
Hartmut Riechers
Stefan Herms
Raschack Manfred
Unger Unger
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19738578A external-priority patent/DE19738578A1/en
Priority claimed from DE1998111915 external-priority patent/DE19811915A1/en
Application filed by Basf Ag filed Critical Basf Ag
Publication of CO4970738A1 publication Critical patent/CO4970738A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/70—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/36—One oxygen atom
    • C07D263/38—One oxygen atom attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/44—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Derivados del ácido carboxílico de fórmula I:en donde R significa tetrazol o un grupo:en donde R1 tiene el siguiente significado:- un resto OR7 , en donde R7 significa:- hidrógeno, el catión de un metal alcalino, el catión de un metal alcalinotérreo o un ión amonio orgánico fisiológicamente tolerable;- cicloalquilo-C3 -C8 , alquilo C1 -C8 , - CH2 -fenilo eventualmente sustituido,- un grupo alquenilo-C3 -C6 o alquinil-C3 -C6 eventualmente sustituido o - fenilo eventualmente sustituido.R2 significa hidrógeno, hidroxi, NH2 , NH(alquilo- C1 -C4 ), N(alquilo-C1 -C4 )2 , halógeno, alquilo-C1 -C4 , alquenilo-C2 -C4 , alquinilo-C2 -C4 , halógenoalquilo-C1 -C4 , alcoxi-C1 -C4 , halógenoalcoxi-C1 -C4 o alquiltio-C1 -C4 , o CR2 está unido con CR10 como se indica más abajo como un anillo de 5 ó 6 miembros;X significa nitrógeno o metino;Y significa nitrógeno o metino;W significa nitrógeno o CR10 , en donde R10 significa hidrógeno o alquilo-C1 -C4 o CR10 junto con CR2 o CR3 forma un anillo alquileno o alquenileno de 5 ó 6 miembros, el cual puede estar eventualmente sustituido, y en donde en cada caso uno o más grupos metileno pueden estar reemplazados por oxígeno, azufre, -NH o N(alquilo-C1 -C4 ); ...Derivatives of the carboxylic acid of formula I: where R means tetrazole or a group: where R1 has the following meaning: - an OR7 residue, where R7 means: - hydrogen, the cation of an alkali metal, the cation of a metal alkaline earth or a physiologically tolerable organic ammonium ion; - C3-C8 cycloalkyl, C1-C8 alkyl, - CH2-optionally substituted phenyl, - an optionally substituted alkenyl-C3-C6 group or - optionally substituted phenyl. R2 stands for hydrogen, hydroxy, NH2, NH (C1-C4-alkyl), N (C1-C4-alkyl) 2, halogen, C1-C4-alkyl, C2-C4-alkenyl, C2-C4-alkynyl, halo-C1-alkyl. -C4, C1-C4-alkoxy, halo-C1-C4-alkoxy or C1-C4-alkylthio, or CR2 is linked with CR10 as indicated below as a 5- or 6-membered ring; X stands for nitrogen or methine; Y stands for nitrogen or methine; W stands for nitrogen or CR10, where R10 stands for hydrogen or C1-C4-alkyl or CR10 together with CR2 or CR3 form to a 5- or 6-membered alkylene or alkenylene ring, which may be optionally substituted, and in which in each case one or more methylene groups may be replaced by oxygen, sulfur, -NH or N (C1-C4-alkyl); ...

CO98050561A 1997-09-04 1998-09-03 NEW DERIVATIVES OF CARBOXYLIC ACID, ITS PREPARATION AND ITS USE CO4970738A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19738578A DE19738578A1 (en) 1997-09-04 1997-09-04 Carboxylic acid derivatives useful as endothelin A and B antagonists also active as renin and angiotensin inhibitors
DE1998111915 DE19811915A1 (en) 1998-03-18 1998-03-18 New carboxylic acid derivatives

Publications (1)

Publication Number Publication Date
CO4970738A1 true CO4970738A1 (en) 2000-11-07

Family

ID=26039663

Family Applications (1)

Application Number Title Priority Date Filing Date
CO98050561A CO4970738A1 (en) 1997-09-04 1998-09-03 NEW DERIVATIVES OF CARBOXYLIC ACID, ITS PREPARATION AND ITS USE

Country Status (21)

Country Link
EP (1) EP1009741A1 (en)
JP (1) JP2001514254A (en)
KR (1) KR20010023615A (en)
CN (1) CN1269792A (en)
AR (1) AR017052A1 (en)
AU (1) AU748610B2 (en)
BG (1) BG104222A (en)
BR (1) BR9811631A (en)
CA (1) CA2302350A1 (en)
CO (1) CO4970738A1 (en)
HR (1) HRP980484A2 (en)
HU (1) HUP0004935A3 (en)
ID (1) ID25620A (en)
IL (1) IL134276A0 (en)
NO (1) NO20001077D0 (en)
NZ (1) NZ502660A (en)
PL (1) PL338954A1 (en)
SK (1) SK1522000A3 (en)
TR (1) TR200000602T2 (en)
TW (1) TW546295B (en)
WO (1) WO1999011629A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19924892A1 (en) * 1999-06-01 2000-12-07 Basf Ag New carboxylic acid derivatives with aryl-substituted nitrogen heterocycles, their production and use as endothelin receptor antagonists
CA2652636A1 (en) * 2006-05-29 2007-12-06 Nicox S.A. Nitrated heterocyclic compounds as endothelin receptor antagonist
PL2268644T3 (en) 2008-03-05 2012-01-31 Boehringer Ingelheim Int Tricyclic pyridine derivatives, medicaments containing such compounds, their use and process for their preparation
EP2451786B1 (en) * 2009-07-10 2014-01-22 Cadila Healthcare Limited Improved process for the preparation of ambrisentan and novel intermediates thereof
SG183321A1 (en) 2010-02-19 2012-09-27 Boehringer Ingelheim Int Tricyclic pyridine derivatives, medicaments containing such compounds, their use and process for their preparation
EP2760868B1 (en) 2011-08-17 2018-04-25 Boehringer Ingelheim International GmbH Furo[3,4-c]quinoline derivatives, medicaments containing such compounds, their use and process for their preparation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4411225A1 (en) * 1994-03-31 1995-10-05 Basf Ag Use of carboxylic acid derivatives as a drug
DE19533023B4 (en) * 1994-10-14 2007-05-16 Basf Ag New carboxylic acid derivatives, their preparation and use
JP2000504013A (en) * 1996-02-01 2000-04-04 スミスクライン・ビーチャム・コーポレイション Endothelin receptor antagonist
DE19614542A1 (en) * 1996-04-12 1997-10-16 Basf Ag New carboxylic acid derivatives, their production and use
DE19636046A1 (en) * 1996-09-05 1998-03-12 Basf Ag New carboxylic acid derivatives, their production and use as mixed ET¶A¶ / ET¶B¶ receptor antagonists

Also Published As

Publication number Publication date
IL134276A0 (en) 2001-04-30
BR9811631A (en) 2000-09-26
TR200000602T2 (en) 2000-12-21
JP2001514254A (en) 2001-09-11
SK1522000A3 (en) 2000-08-14
TW546295B (en) 2003-08-11
HUP0004935A2 (en) 2001-10-28
WO1999011629A1 (en) 1999-03-11
CN1269792A (en) 2000-10-11
NZ502660A (en) 2002-02-01
BG104222A (en) 2001-02-28
PL338954A1 (en) 2000-12-04
EP1009741A1 (en) 2000-06-21
HUP0004935A3 (en) 2001-12-28
HRP980484A2 (en) 1999-06-30
AR017052A1 (en) 2001-08-22
CA2302350A1 (en) 1999-03-11
KR20010023615A (en) 2001-03-26
NO20001077L (en) 2000-03-02
AU9533398A (en) 1999-03-22
AU748610B2 (en) 2002-06-06
ID25620A (en) 2000-10-19
NO20001077D0 (en) 2000-03-02

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