CO4970738A1 - NEW DERIVATIVES OF CARBOXYLIC ACID, ITS PREPARATION AND ITS USE - Google Patents
NEW DERIVATIVES OF CARBOXYLIC ACID, ITS PREPARATION AND ITS USEInfo
- Publication number
- CO4970738A1 CO4970738A1 CO98050561A CO98050561A CO4970738A1 CO 4970738 A1 CO4970738 A1 CO 4970738A1 CO 98050561 A CO98050561 A CO 98050561A CO 98050561 A CO98050561 A CO 98050561A CO 4970738 A1 CO4970738 A1 CO 4970738A1
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- stands
- optionally substituted
- nitrogen
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/70—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/36—One oxygen atom
- C07D263/38—One oxygen atom attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/44—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/34—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Derivados del ácido carboxílico de fórmula I:en donde R significa tetrazol o un grupo:en donde R1 tiene el siguiente significado:- un resto OR7 , en donde R7 significa:- hidrógeno, el catión de un metal alcalino, el catión de un metal alcalinotérreo o un ión amonio orgánico fisiológicamente tolerable;- cicloalquilo-C3 -C8 , alquilo C1 -C8 , - CH2 -fenilo eventualmente sustituido,- un grupo alquenilo-C3 -C6 o alquinil-C3 -C6 eventualmente sustituido o - fenilo eventualmente sustituido.R2 significa hidrógeno, hidroxi, NH2 , NH(alquilo- C1 -C4 ), N(alquilo-C1 -C4 )2 , halógeno, alquilo-C1 -C4 , alquenilo-C2 -C4 , alquinilo-C2 -C4 , halógenoalquilo-C1 -C4 , alcoxi-C1 -C4 , halógenoalcoxi-C1 -C4 o alquiltio-C1 -C4 , o CR2 está unido con CR10 como se indica más abajo como un anillo de 5 ó 6 miembros;X significa nitrógeno o metino;Y significa nitrógeno o metino;W significa nitrógeno o CR10 , en donde R10 significa hidrógeno o alquilo-C1 -C4 o CR10 junto con CR2 o CR3 forma un anillo alquileno o alquenileno de 5 ó 6 miembros, el cual puede estar eventualmente sustituido, y en donde en cada caso uno o más grupos metileno pueden estar reemplazados por oxígeno, azufre, -NH o N(alquilo-C1 -C4 ); ...Derivatives of the carboxylic acid of formula I: where R means tetrazole or a group: where R1 has the following meaning: - an OR7 residue, where R7 means: - hydrogen, the cation of an alkali metal, the cation of a metal alkaline earth or a physiologically tolerable organic ammonium ion; - C3-C8 cycloalkyl, C1-C8 alkyl, - CH2-optionally substituted phenyl, - an optionally substituted alkenyl-C3-C6 group or - optionally substituted phenyl. R2 stands for hydrogen, hydroxy, NH2, NH (C1-C4-alkyl), N (C1-C4-alkyl) 2, halogen, C1-C4-alkyl, C2-C4-alkenyl, C2-C4-alkynyl, halo-C1-alkyl. -C4, C1-C4-alkoxy, halo-C1-C4-alkoxy or C1-C4-alkylthio, or CR2 is linked with CR10 as indicated below as a 5- or 6-membered ring; X stands for nitrogen or methine; Y stands for nitrogen or methine; W stands for nitrogen or CR10, where R10 stands for hydrogen or C1-C4-alkyl or CR10 together with CR2 or CR3 form to a 5- or 6-membered alkylene or alkenylene ring, which may be optionally substituted, and in which in each case one or more methylene groups may be replaced by oxygen, sulfur, -NH or N (C1-C4-alkyl); ...
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19738578A DE19738578A1 (en) | 1997-09-04 | 1997-09-04 | Carboxylic acid derivatives useful as endothelin A and B antagonists also active as renin and angiotensin inhibitors |
DE1998111915 DE19811915A1 (en) | 1998-03-18 | 1998-03-18 | New carboxylic acid derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
CO4970738A1 true CO4970738A1 (en) | 2000-11-07 |
Family
ID=26039663
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO98050561A CO4970738A1 (en) | 1997-09-04 | 1998-09-03 | NEW DERIVATIVES OF CARBOXYLIC ACID, ITS PREPARATION AND ITS USE |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP1009741A1 (en) |
JP (1) | JP2001514254A (en) |
KR (1) | KR20010023615A (en) |
CN (1) | CN1269792A (en) |
AR (1) | AR017052A1 (en) |
AU (1) | AU748610B2 (en) |
BG (1) | BG104222A (en) |
BR (1) | BR9811631A (en) |
CA (1) | CA2302350A1 (en) |
CO (1) | CO4970738A1 (en) |
HR (1) | HRP980484A2 (en) |
HU (1) | HUP0004935A3 (en) |
ID (1) | ID25620A (en) |
IL (1) | IL134276A0 (en) |
NO (1) | NO20001077D0 (en) |
NZ (1) | NZ502660A (en) |
PL (1) | PL338954A1 (en) |
SK (1) | SK1522000A3 (en) |
TR (1) | TR200000602T2 (en) |
TW (1) | TW546295B (en) |
WO (1) | WO1999011629A1 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19924892A1 (en) * | 1999-06-01 | 2000-12-07 | Basf Ag | New carboxylic acid derivatives with aryl-substituted nitrogen heterocycles, their production and use as endothelin receptor antagonists |
CA2652636A1 (en) * | 2006-05-29 | 2007-12-06 | Nicox S.A. | Nitrated heterocyclic compounds as endothelin receptor antagonist |
PL2268644T3 (en) | 2008-03-05 | 2012-01-31 | Boehringer Ingelheim Int | Tricyclic pyridine derivatives, medicaments containing such compounds, their use and process for their preparation |
EP2451786B1 (en) * | 2009-07-10 | 2014-01-22 | Cadila Healthcare Limited | Improved process for the preparation of ambrisentan and novel intermediates thereof |
SG183321A1 (en) | 2010-02-19 | 2012-09-27 | Boehringer Ingelheim Int | Tricyclic pyridine derivatives, medicaments containing such compounds, their use and process for their preparation |
EP2760868B1 (en) | 2011-08-17 | 2018-04-25 | Boehringer Ingelheim International GmbH | Furo[3,4-c]quinoline derivatives, medicaments containing such compounds, their use and process for their preparation |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4411225A1 (en) * | 1994-03-31 | 1995-10-05 | Basf Ag | Use of carboxylic acid derivatives as a drug |
DE19533023B4 (en) * | 1994-10-14 | 2007-05-16 | Basf Ag | New carboxylic acid derivatives, their preparation and use |
JP2000504013A (en) * | 1996-02-01 | 2000-04-04 | スミスクライン・ビーチャム・コーポレイション | Endothelin receptor antagonist |
DE19614542A1 (en) * | 1996-04-12 | 1997-10-16 | Basf Ag | New carboxylic acid derivatives, their production and use |
DE19636046A1 (en) * | 1996-09-05 | 1998-03-12 | Basf Ag | New carboxylic acid derivatives, their production and use as mixed ET¶A¶ / ET¶B¶ receptor antagonists |
-
1998
- 1998-08-24 KR KR1020007002264A patent/KR20010023615A/en not_active Application Discontinuation
- 1998-08-24 BR BR9811631-2A patent/BR9811631A/en not_active IP Right Cessation
- 1998-08-24 EP EP98948859A patent/EP1009741A1/en not_active Withdrawn
- 1998-08-24 WO PCT/EP1998/005354 patent/WO1999011629A1/en not_active Application Discontinuation
- 1998-08-24 IL IL13427698A patent/IL134276A0/en unknown
- 1998-08-24 JP JP2000508669A patent/JP2001514254A/en active Pending
- 1998-08-24 CN CN98808862A patent/CN1269792A/en active Pending
- 1998-08-24 HU HU0004935A patent/HUP0004935A3/en unknown
- 1998-08-24 PL PL98338954A patent/PL338954A1/en unknown
- 1998-08-24 NZ NZ502660A patent/NZ502660A/en unknown
- 1998-08-24 CA CA002302350A patent/CA2302350A1/en not_active Abandoned
- 1998-08-24 AU AU95333/98A patent/AU748610B2/en not_active Ceased
- 1998-08-24 TR TR2000/00602T patent/TR200000602T2/en unknown
- 1998-08-24 ID IDW20000386D patent/ID25620A/en unknown
- 1998-08-24 SK SK152-2000A patent/SK1522000A3/en unknown
- 1998-09-02 HR HR19811915.1A patent/HRP980484A2/en not_active Application Discontinuation
- 1998-09-03 CO CO98050561A patent/CO4970738A1/en unknown
- 1998-09-03 TW TW087114595A patent/TW546295B/en active
- 1998-09-03 AR ARP980104402A patent/AR017052A1/en not_active Application Discontinuation
-
2000
- 2000-03-02 NO NO20001077A patent/NO20001077D0/en not_active Application Discontinuation
- 2000-03-06 BG BG104222A patent/BG104222A/en unknown
Also Published As
Publication number | Publication date |
---|---|
IL134276A0 (en) | 2001-04-30 |
BR9811631A (en) | 2000-09-26 |
TR200000602T2 (en) | 2000-12-21 |
JP2001514254A (en) | 2001-09-11 |
SK1522000A3 (en) | 2000-08-14 |
TW546295B (en) | 2003-08-11 |
HUP0004935A2 (en) | 2001-10-28 |
WO1999011629A1 (en) | 1999-03-11 |
CN1269792A (en) | 2000-10-11 |
NZ502660A (en) | 2002-02-01 |
BG104222A (en) | 2001-02-28 |
PL338954A1 (en) | 2000-12-04 |
EP1009741A1 (en) | 2000-06-21 |
HUP0004935A3 (en) | 2001-12-28 |
HRP980484A2 (en) | 1999-06-30 |
AR017052A1 (en) | 2001-08-22 |
CA2302350A1 (en) | 1999-03-11 |
KR20010023615A (en) | 2001-03-26 |
NO20001077L (en) | 2000-03-02 |
AU9533398A (en) | 1999-03-22 |
AU748610B2 (en) | 2002-06-06 |
ID25620A (en) | 2000-10-19 |
NO20001077D0 (en) | 2000-03-02 |
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