HUE039419T2 - Eljárás ramipril elõállítására - Google Patents
Eljárás ramipril elõállításáraInfo
- Publication number
- HUE039419T2 HUE039419T2 HUE15727647A HUE15727647A HUE039419T2 HU E039419 T2 HUE039419 T2 HU E039419T2 HU E15727647 A HUE15727647 A HU E15727647A HU E15727647 A HUE15727647 A HU E15727647A HU E039419 T2 HUE039419 T2 HU E039419T2
- Authority
- HU
- Hungary
- Prior art keywords
- ramipril
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C249/02—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of compounds containing imino groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
- C07C251/20—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups being part of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C255/46—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of non-condensed rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14171915 | 2014-06-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
HUE039419T2 true HUE039419T2 (hu) | 2018-12-28 |
Family
ID=50896197
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HUE15727647A HUE039419T2 (hu) | 2014-06-11 | 2015-06-08 | Eljárás ramipril elõállítására |
Country Status (6)
Country | Link |
---|---|
US (1) | US10112973B2 (hu) |
EP (1) | EP3154940B1 (hu) |
CN (1) | CN106536541B (hu) |
HU (1) | HUE039419T2 (hu) |
TW (1) | TWI675023B (hu) |
WO (1) | WO2015189108A1 (hu) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109721524A (zh) * | 2017-10-31 | 2019-05-07 | 鲁南制药集团股份有限公司 | 一种雷米普利的精制方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3226768A1 (de) | 1981-11-05 | 1983-05-26 | Hoechst Ag, 6230 Frankfurt | Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung |
DE3333455A1 (de) | 1983-09-16 | 1985-04-11 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung n-alkylierter dipeptide und deren estern |
FR2563216B1 (fr) | 1984-04-24 | 1986-05-30 | Centre Nat Rech Scient | Composes imines de synthese contenant un atome de carbone quaternaire chiral, leur preparation et leur utilisation |
WO2005049568A1 (en) | 2003-11-24 | 2005-06-02 | Potluri Ramesh Babu | A process for industrially viable preparation of (s,s,s) phenylmethyl-2-azabicyclo-[3.3.0]-octane-3-carboxylate tosylate |
EP1692106A1 (en) * | 2003-11-24 | 2006-08-23 | Potluri Ramesh Babu | A novel synthesis of 2-azabicyclic-3-carboxylic acids, useful as important drug intermediates |
DE102005012771A1 (de) * | 2005-03-19 | 2006-09-21 | Degussa Ag | Verfahren zur Herstellung von 2-Azabicyclo(3.3.0)octan-3-carbonsäurederivaten |
DE102005061756B4 (de) | 2005-12-21 | 2008-01-03 | Sanofi-Aventis Deutschland Gmbh | Verbessertes Verfahren zur Herstellung von Ramipril |
US20070232680A1 (en) | 2006-04-04 | 2007-10-04 | Vijayabhaskar Bolugoddu | Preparation of ramipril and stable pharmaceutical compositions |
WO2009098251A1 (en) | 2008-02-07 | 2009-08-13 | Dsm Ip Assets B.V. | NOVEL CYCLOALKANONE β-SUBSTITUTED ALANINE DERIVATIVES |
EP2560493B1 (en) * | 2010-04-20 | 2018-06-06 | Chiral Quest, Inc. | An enantioselective process for cycloalkenyl b-substituted alanines |
WO2012063252A2 (en) * | 2010-11-11 | 2012-05-18 | Aarti Healthcare Limited | A method for preparing ramipril |
-
2015
- 2015-06-08 CN CN201580041231.XA patent/CN106536541B/zh active Active
- 2015-06-08 EP EP15727647.8A patent/EP3154940B1/en active Active
- 2015-06-08 WO PCT/EP2015/062632 patent/WO2015189108A1/en active Application Filing
- 2015-06-08 HU HUE15727647A patent/HUE039419T2/hu unknown
- 2015-06-08 US US15/317,362 patent/US10112973B2/en active Active
- 2015-06-09 TW TW104118563A patent/TWI675023B/zh active
Also Published As
Publication number | Publication date |
---|---|
EP3154940B1 (en) | 2018-04-18 |
WO2015189108A1 (en) | 2015-12-17 |
US10112973B2 (en) | 2018-10-30 |
TWI675023B (zh) | 2019-10-21 |
CN106536541A (zh) | 2017-03-22 |
EP3154940A1 (en) | 2017-04-19 |
CN106536541B (zh) | 2021-01-08 |
US20170158733A1 (en) | 2017-06-08 |
TW201613857A (en) | 2016-04-16 |
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