HUE039419T2 - Eljárás ramipril elõállítására - Google Patents

Eljárás ramipril elõállítására

Info

Publication number
HUE039419T2
HUE039419T2 HUE15727647A HUE15727647A HUE039419T2 HU E039419 T2 HUE039419 T2 HU E039419T2 HU E15727647 A HUE15727647 A HU E15727647A HU E15727647 A HUE15727647 A HU E15727647A HU E039419 T2 HUE039419 T2 HU E039419T2
Authority
HU
Hungary
Prior art keywords
ramipril
preparation
Prior art date
Application number
HUE15727647A
Other languages
English (en)
Inventor
Gerhard Kretzschmar
Jan Oehme
Kai Rossen
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of HUE039419T2 publication Critical patent/HUE039419T2/hu

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06017Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00Carboxylic acid amides
    • C07C233/01Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/47Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C249/00Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C249/02Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of compounds containing imino groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/02Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
    • C07C251/20Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups being part of rings other than six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • C07C255/45Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C255/46Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of non-condensed rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/06Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/06Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/10Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
HUE15727647A 2014-06-11 2015-06-08 Eljárás ramipril elõállítására HUE039419T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP14171915 2014-06-11

Publications (1)

Publication Number Publication Date
HUE039419T2 true HUE039419T2 (hu) 2018-12-28

Family

ID=50896197

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE15727647A HUE039419T2 (hu) 2014-06-11 2015-06-08 Eljárás ramipril elõállítására

Country Status (6)

Country Link
US (1) US10112973B2 (hu)
EP (1) EP3154940B1 (hu)
CN (1) CN106536541B (hu)
HU (1) HUE039419T2 (hu)
TW (1) TWI675023B (hu)
WO (1) WO2015189108A1 (hu)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109721524A (zh) * 2017-10-31 2019-05-07 鲁南制药集团股份有限公司 一种雷米普利的精制方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3226768A1 (de) 1981-11-05 1983-05-26 Hoechst Ag, 6230 Frankfurt Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
DE3333455A1 (de) 1983-09-16 1985-04-11 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung n-alkylierter dipeptide und deren estern
FR2563216B1 (fr) 1984-04-24 1986-05-30 Centre Nat Rech Scient Composes imines de synthese contenant un atome de carbone quaternaire chiral, leur preparation et leur utilisation
WO2005049568A1 (en) 2003-11-24 2005-06-02 Potluri Ramesh Babu A process for industrially viable preparation of (s,s,s) phenylmethyl-2-azabicyclo-[3.3.0]-octane-3-carboxylate tosylate
EP1692106A1 (en) * 2003-11-24 2006-08-23 Potluri Ramesh Babu A novel synthesis of 2-azabicyclic-3-carboxylic acids, useful as important drug intermediates
DE102005012771A1 (de) * 2005-03-19 2006-09-21 Degussa Ag Verfahren zur Herstellung von 2-Azabicyclo(3.3.0)octan-3-carbonsäurederivaten
DE102005061756B4 (de) 2005-12-21 2008-01-03 Sanofi-Aventis Deutschland Gmbh Verbessertes Verfahren zur Herstellung von Ramipril
US20070232680A1 (en) 2006-04-04 2007-10-04 Vijayabhaskar Bolugoddu Preparation of ramipril and stable pharmaceutical compositions
WO2009098251A1 (en) 2008-02-07 2009-08-13 Dsm Ip Assets B.V. NOVEL CYCLOALKANONE β-SUBSTITUTED ALANINE DERIVATIVES
EP2560493B1 (en) * 2010-04-20 2018-06-06 Chiral Quest, Inc. An enantioselective process for cycloalkenyl b-substituted alanines
WO2012063252A2 (en) * 2010-11-11 2012-05-18 Aarti Healthcare Limited A method for preparing ramipril

Also Published As

Publication number Publication date
EP3154940B1 (en) 2018-04-18
WO2015189108A1 (en) 2015-12-17
US10112973B2 (en) 2018-10-30
TWI675023B (zh) 2019-10-21
CN106536541A (zh) 2017-03-22
EP3154940A1 (en) 2017-04-19
CN106536541B (zh) 2021-01-08
US20170158733A1 (en) 2017-06-08
TW201613857A (en) 2016-04-16

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