HUP1400378A2 - Eljárás apixaban elõállítására - Google Patents
Eljárás apixaban elõállításáraInfo
- Publication number
- HUP1400378A2 HUP1400378A2 HU1400378A HUP1400378A HUP1400378A2 HU P1400378 A2 HUP1400378 A2 HU P1400378A2 HU 1400378 A HU1400378 A HU 1400378A HU P1400378 A HUP1400378 A HU P1400378A HU P1400378 A2 HUP1400378 A2 HU P1400378A2
- Authority
- HU
- Hungary
- Prior art keywords
- apixaban
- preparation
- Prior art date
Links
- QNZCBYKSOIHPEH-UHFFFAOYSA-N Apixaban Chemical compound C1=CC(OC)=CC=C1N1C(C(=O)N(CC2)C=3C=CC(=CC=3)N3C(CCCC3)=O)=C2C(C(N)=O)=N1 QNZCBYKSOIHPEH-UHFFFAOYSA-N 0.000 title 1
- 229960003886 apixaban Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/86—Oxygen atoms
- C07D211/88—Oxygen atoms attached in positions 2 and 6, e.g. glutarimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU1400378A HU231122B1 (hu) | 2014-08-06 | 2014-08-06 | Eljárás apixaban előállítására |
| PCT/HU2015/050004 WO2016020711A1 (en) | 2014-08-06 | 2015-08-03 | Process for the preparation of apixaban |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU1400378A HU231122B1 (hu) | 2014-08-06 | 2014-08-06 | Eljárás apixaban előállítására |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP1400378A2 true HUP1400378A2 (hu) | 2016-02-29 |
| HU231122B1 HU231122B1 (hu) | 2020-11-30 |
Family
ID=89991558
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU1400378A HU231122B1 (hu) | 2014-08-06 | 2014-08-06 | Eljárás apixaban előállítására |
Country Status (2)
| Country | Link |
|---|---|
| HU (1) | HU231122B1 (hu) |
| WO (1) | WO2016020711A1 (hu) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3228619B1 (en) * | 2016-04-04 | 2020-07-29 | Zaklady Farmaceutyczne Polpharma SA | Process for the preparation of apixaban |
| CN107434806A (zh) * | 2016-12-09 | 2017-12-05 | 陕西科技大学 | 一种阿哌沙班羧酸衍生物的γ晶型固体物质及其制备方法与用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2345993C2 (ru) | 2001-09-21 | 2009-02-10 | Бристол-Маерс Сквибб Компани | ЛАКТАМСОДЕРЖАЩЕЕ СОЕДИНЕНИЕ И ЕГО ПРОИЗВОДНЫЕ В КАЧЕСТВЕ ИНГИБИТОРОВ ФАКТОРА Xa |
| TW200303201A (en) | 2001-12-10 | 2003-09-01 | Bristol Myers Squibb Co | Synthesis of 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones |
| US7396932B2 (en) | 2004-09-28 | 2008-07-08 | Bristol-Myers Squibb Company | Process for preparing 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones |
| JP2014516072A (ja) | 2011-06-10 | 2014-07-07 | ディフアルマ フランチス ソシエタ ア レスポンサビリタ リミタータ | アピキサバン製造方法 |
| WO2014111954A1 (en) * | 2013-01-17 | 2014-07-24 | Glenmark Pharmaceuticals Limited; Glenmark Generics Limited | Process for the preparation and purification of apixaban |
| CN103694237B (zh) * | 2014-01-07 | 2016-03-23 | 上海现代制药股份有限公司 | 一种抗凝血药阿哌沙班的制备方法及关键中间体 |
-
2014
- 2014-08-06 HU HU1400378A patent/HU231122B1/hu unknown
-
2015
- 2015-08-03 WO PCT/HU2015/050004 patent/WO2016020711A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| HU231122B1 (hu) | 2020-11-30 |
| WO2016020711A1 (en) | 2016-02-11 |
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