HUE038637T2 - Eljárás a diaril-tiohidantoin és a diaril-hidantoin vegyületek szintetizálására - Google Patents

Eljárás a diaril-tiohidantoin és a diaril-hidantoin vegyületek szintetizálására

Info

Publication number
HUE038637T2
HUE038637T2 HUE11748095A HUE11748095A HUE038637T2 HU E038637 T2 HUE038637 T2 HU E038637T2 HU E11748095 A HUE11748095 A HU E11748095A HU E11748095 A HUE11748095 A HU E11748095A HU E038637 T2 HUE038637 T2 HU E038637T2
Authority
HU
Hungary
Prior art keywords
diarylthiohydantoin
synthesis
processes
diarylhydantoin compounds
diarylhydantoin
Prior art date
Application number
HUE11748095A
Other languages
English (en)
Inventor
Andrew Thompson
Carol Lamberson
Scott Greenfield
Rajendra Jain
Remy Angelaud
Original Assignee
Medivation Prostate Therapeutics Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medivation Prostate Therapeutics Llc filed Critical Medivation Prostate Therapeutics Llc
Publication of HUE038637T2 publication Critical patent/HUE038637T2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/74—Two oxygen atoms, e.g. hydantoin with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to other ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/86—Oxygen and sulfur atoms, e.g. thiohydantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
HUE11748095A 2010-02-24 2011-02-24 Eljárás a diaril-tiohidantoin és a diaril-hidantoin vegyületek szintetizálására HUE038637T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US30779610P 2010-02-24 2010-02-24

Publications (1)

Publication Number Publication Date
HUE038637T2 true HUE038637T2 (hu) 2018-12-28

Family

ID=44507217

Family Applications (2)

Application Number Title Priority Date Filing Date
HUE11748095A HUE038637T2 (hu) 2010-02-24 2011-02-24 Eljárás a diaril-tiohidantoin és a diaril-hidantoin vegyületek szintetizálására
HUE18153287A HUE055051T2 (hu) 2010-02-24 2011-02-24 Eljárás diaril-tiohidantoin és diaril-hidantoin vegyületek szintézisére

Family Applications After (1)

Application Number Title Priority Date Filing Date
HUE18153287A HUE055051T2 (hu) 2010-02-24 2011-02-24 Eljárás diaril-tiohidantoin és diaril-hidantoin vegyületek szintézisére

Country Status (17)

Country Link
US (1) US9174943B2 (hu)
EP (2) EP3329775B1 (hu)
JP (1) JP5718372B2 (hu)
KR (1) KR101514659B1 (hu)
CN (1) CN103108549B (hu)
BR (1) BR112012021406B1 (hu)
CA (1) CA2790924C (hu)
CY (2) CY1120207T1 (hu)
DK (2) DK2538785T3 (hu)
ES (2) ES2880354T3 (hu)
HU (2) HUE038637T2 (hu)
MX (1) MX2012009782A (hu)
PL (2) PL3329775T3 (hu)
PT (2) PT3329775T (hu)
RU (1) RU2554081C2 (hu)
SI (2) SI3329775T1 (hu)
WO (1) WO2011106570A1 (hu)

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CA2966280A1 (en) 2007-10-26 2009-04-30 The Regents Of The University Of California Diarylhydantoin compounds
CN106983749A (zh) * 2010-02-16 2017-07-28 亚拉冈制药公司 雄激素受体调节剂及其用途
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WO2013067151A1 (en) * 2011-11-02 2013-05-10 Medivation Prostate Therapeutics, Inc. Treatment methods using diarylthiohydantoin derivatives
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JOP20200097A1 (ar) 2013-01-15 2017-06-16 Aragon Pharmaceuticals Inc معدل مستقبل أندروجين واستخداماته
RU2520134C1 (ru) * 2013-02-27 2014-06-20 Общество с ограниченной ответственностью "Авионко" (ООО "Авионко") Замещенные (r)-3-(4-метилкарбамоил-3-фторфениламино)-тетрагидро-фуран-3-енкарбоновые кислоты и их эфиры, способ их получения и применения
WO2014167428A2 (en) * 2013-04-10 2014-10-16 Shilpa Medicare Limited Amorphous 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-n-methylbenzamide
CA2921156A1 (en) * 2013-09-19 2015-03-26 Glaxosmithkline Llc Combination drug therapy
CN105188699B (zh) * 2013-10-14 2017-04-26 杭州普晒医药科技有限公司 恩杂鲁胺的固态形式及其制备方法和用途
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US20160318875A1 (en) 2013-12-16 2016-11-03 Sun Pharmaceutical Industries Limited Processes and intermediates for the preparation of enzalutamide
CN104803918B (zh) * 2014-01-26 2017-11-10 上海医药工业研究院 恩杂鲁胺的制备方法
CN104803919A (zh) * 2014-01-26 2015-07-29 上海医药工业研究院 用于制备恩杂鲁胺中间体的方法
US9611225B2 (en) * 2014-01-27 2017-04-04 Cadila Healthcare Limited Process for preparation of androgen receptor antagonist
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CN104844521B (zh) * 2014-02-13 2017-08-15 成都伊诺达博医药科技有限公司 抗***癌药物恩杂鲁胺的合成方法
CN104844520B (zh) * 2014-02-13 2017-09-05 成都伊诺达博医药科技有限公司 一种合成恩杂鲁胺的方法
CZ2014232A3 (cs) * 2014-04-07 2015-10-14 Zentiva, K.S. Způsob výroby enzalutamidu
CN103910679B (zh) * 2014-04-23 2016-05-25 杭州新博思生物医药有限公司 一种恩杂鲁胺的制备方法
CN103980141A (zh) * 2014-04-25 2014-08-13 山东大学 恩泽特鲁的合成方法
CN104016924B (zh) * 2014-06-16 2016-04-13 上海鼎雅药物化学科技有限公司 一种“一锅法”合成恩杂鲁胺的方法
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CN105461633A (zh) * 2014-07-31 2016-04-06 江苏豪森药业集团有限公司 恩杂鲁胺的制备方法
CN105367441B (zh) * 2014-08-18 2018-11-06 上海医药工业研究院 用于合成恩杂鲁胺的新化合物
CN105461634A (zh) * 2014-08-19 2016-04-06 江苏豪森药业集团有限公司 恩杂鲁胺的制备方法
US10131636B2 (en) * 2014-10-01 2018-11-20 Laurus Labs Limited Process for the preparation of Enzalutamide
CN104356068A (zh) * 2014-10-30 2015-02-18 杭州新博思生物医药有限公司 恩杂鲁胺新晶型及其制备方法
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ITUB20151256A1 (it) 2015-05-28 2016-11-28 Olon Spa Processo industriale per la preparazione di enzalutamide
ES2942618T3 (es) 2015-05-29 2023-06-05 Astellas Pharma Inc Procedimiento para la fabricación de una forma cristalina de enzalutamida
TWI613194B (zh) * 2015-06-10 2018-02-01 台灣神隆股份有限公司 用於製備恩雜魯胺的新穎方法
CN105330560A (zh) * 2015-10-13 2016-02-17 福格森（武汉）生物科技股份有限公司 一种恩杂鲁胺中间体的制备方法
TWI726969B (zh) 2016-01-11 2021-05-11 比利時商健生藥品公司 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物
CN107954936B (zh) * 2016-10-17 2021-03-19 海创药业股份有限公司 一种制备氘代咪唑二酮类化合物的方法
CN108069869B (zh) * 2016-11-09 2022-03-01 上海医药工业研究院 一种Apalutamide的制备方法及其中间体
TW201831461A (zh) * 2017-01-18 2018-09-01 台灣神隆股份有限公司 製備阿帕魯醯胺的方法
CN110573153B (zh) 2017-04-28 2023-04-04 安斯泰来制药有限公司 含有恩杂鲁胺的口服给药用药物组合物
CN107501237B (zh) * 2017-08-17 2022-03-22 上海西浦医药科技有限公司 一种Apalutamide的合成方法
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CN108047200A (zh) * 2017-12-05 2018-05-18 上海丰瑞医药科技有限公司 一种二芳基乙内酰硫脲类化合物的制备方法及其中间体
CN109988077A (zh) * 2017-12-29 2019-07-09 上海法默生物科技有限公司 一种阿帕鲁胺的合成方法及中间体
CN110872258B (zh) * 2018-09-04 2021-05-25 北京凯莱天成医药科技有限公司 一种***癌药物恩杂鲁胺的制备工艺
CN109651256A (zh) * 2018-11-20 2019-04-19 上海健康医学院 一种式（viii）的恩杂鲁胺的制备方法
CN109503416A (zh) * 2018-12-24 2019-03-22 常州智超化学有限公司 一种恩杂鲁胺中间体合成方法
CN112047888A (zh) * 2019-06-05 2020-12-08 安礼特（上海）医药科技有限公司 一种合成恩杂鲁胺的方法
CN111320552B (zh) * 2020-02-28 2023-10-27 江西科睿药业有限公司 一种恩扎卢胺中间体的制备方法
WO2022206742A1 (zh) * 2021-03-30 2022-10-06 苏州开拓药业股份有限公司 一种一步法合成乙内酰硫脲衍生物的方法
EP4112603A1 (en) 2021-06-29 2023-01-04 Química Sintética, S.A. Processes for the preparation of non-steroidal antiandrogens
CN113698310B (zh) * 2021-08-20 2023-03-17 江西金丰药业有限公司 一种恩杂鲁胺双酯中间体的制备方法
CN114591246A (zh) * 2022-03-25 2022-06-07 重庆华邦制药有限公司 一种恩扎卢胺的纯化方法
CN114907439B (zh) * 2022-06-29 2023-07-21 云南中医药大学 一种抗癌化合物及其制药用途
CN115181043B (zh) * 2022-07-27 2024-05-07 爱斯特（成都）生物制药股份有限公司 一种连续流制备4-异硫氰基-2-(三氟甲基)苯甲腈的方法
CN115611765A (zh) * 2022-09-30 2023-01-17 重庆华邦胜凯制药有限公司 一种恩扎卢胺中间体的制备方法
CN115536634B (zh) * 2022-10-17 2024-06-11 上海博悦生物科技有限公司 一种阿帕他胺的合成方法

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Also Published As

Publication number Publication date
US20130190507A1 (en) 2013-07-25
CA2790924A1 (en) 2011-09-01
KR101514659B1 (ko) 2015-04-23
ES2671343T3 (es) 2018-06-06
DK3329775T3 (da) 2021-07-26
PT2538785T (pt) 2018-05-09
BR112012021406B1 (pt) 2021-08-10
ES2880354T3 (es) 2021-11-24
US9174943B2 (en) 2015-11-03
BR112012021406A8 (pt) 2018-07-31
WO2011106570A1 (en) 2011-09-01
EP2538785A4 (en) 2013-10-30
EP3329775B1 (en) 2021-04-21
DK2538785T3 (en) 2018-05-22
PL2538785T3 (pl) 2018-08-31
KR20130027468A (ko) 2013-03-15
EP3329775A1 (en) 2018-06-06
JP5718372B2 (ja) 2015-05-13
EP2538785A1 (en) 2013-01-02
RU2012140454A (ru) 2014-03-27
RU2554081C2 (ru) 2015-06-27
MX2012009782A (es) 2012-11-29
CN103108549A (zh) 2013-05-15
BR112012021406A2 (pt) 2018-06-05
CY1120207T1 (el) 2018-12-12
SI2538785T1 (en) 2018-05-31
CY1124334T1 (el) 2022-07-22
PT3329775T (pt) 2021-07-19
JP2013520519A (ja) 2013-06-06
CN103108549B (zh) 2015-09-09
PL3329775T3 (pl) 2021-11-08
SI3329775T1 (sl) 2021-09-30
HUE055051T2 (hu) 2021-10-28
CA2790924C (en) 2016-08-02
EP2538785B1 (en) 2018-03-21

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