HU9401073D0 - Novel bioprocesses for preparing 7-acaand 7-adac - Google Patents

Novel bioprocesses for preparing 7-acaand 7-adac

Info

Publication number
HU9401073D0
HU9401073D0 HU9401073A HU9401073A HU9401073D0 HU 9401073 D0 HU9401073 D0 HU 9401073D0 HU 9401073 A HU9401073 A HU 9401073A HU 9401073 A HU9401073 A HU 9401073A HU 9401073 D0 HU9401073 D0 HU 9401073D0
Authority
HU
Hungary
Prior art keywords
adipoyl
side chain
adac
aca
acid
Prior art date
Application number
HU9401073A
Other languages
English (en)
Other versions
HUT69783A (en
HU219370B (en
Inventor
Michael J Conder
Lorilee Crawford
Anthony Michael Stepan
Phyllis C Mcada
Christopher D Reeves
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of HU9401073D0 publication Critical patent/HU9401073D0/hu
Publication of HUT69783A publication Critical patent/HUT69783A/hu
Publication of HU219370B publication Critical patent/HU219370B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y10S435/933—Penicillium
    • Y10S435/935—Penicillium chrysogenum

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
HU9401073A 1991-10-15 1992-10-08 Novel bioprocesses for preparing 7-aca and 7-adac HU219370B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US77783391A 1991-10-15 1991-10-15
US95349292A 1992-10-06 1992-10-06
PCT/US1992/008585 WO1993008287A1 (en) 1991-10-15 1992-10-08 Novel bioprocesses for preparing 7-aca and 7-adac

Publications (3)

Publication Number Publication Date
HU9401073D0 true HU9401073D0 (en) 1994-07-28
HUT69783A HUT69783A (en) 1995-09-28
HU219370B HU219370B (en) 2001-03-28

Family

ID=27119363

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9401073A HU219370B (en) 1991-10-15 1992-10-08 Novel bioprocesses for preparing 7-aca and 7-adac

Country Status (27)

Country Link
US (4) US5559005A (hu)
EP (2) EP0856516B1 (hu)
JP (1) JP2655790B2 (hu)
KR (1) KR100227711B1 (hu)
CN (1) CN1074484A (hu)
AT (2) ATE174057T1 (hu)
AU (1) AU657800B2 (hu)
BG (1) BG62261B1 (hu)
CA (1) CA2080573C (hu)
CZ (1) CZ288721B6 (hu)
DE (2) DE69232581T2 (hu)
DK (2) DK0856516T3 (hu)
ES (2) ES2127205T3 (hu)
FI (1) FI106965B (hu)
GR (1) GR3029343T3 (hu)
HU (1) HU219370B (hu)
IL (3) IL103419A (hu)
MX (1) MX9205902A (hu)
NO (1) NO315802B1 (hu)
NZ (1) NZ244714A (hu)
RO (1) RO116648B1 (hu)
RU (1) RU2002130702A (hu)
SK (1) SK280569B6 (hu)
TW (1) TW272233B (hu)
UA (1) UA47385C2 (hu)
WO (1) WO1993008287A1 (hu)
YU (1) YU48930B (hu)

Families Citing this family (34)

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EP0233715B1 (en) * 1986-01-31 1994-05-25 BEECHAM GROUP plc Isolation and expression of genes involved in the biosynthesis of beta-lactams
US6709859B1 (en) * 1986-01-31 2004-03-23 Beecham Group P.L.C. Chromosomal DNA Fragments Encoding Enzymes for Encoding B-Lactam Biosynthesis Enzymes, and Vector and Transformants for Their Expression
KR0171897B1 (ko) * 1989-12-27 1999-02-01 후지사와 도모끼찌로 7-아미노세펨 화합물 또는 그 염류의 제조 방법
US5318896A (en) * 1991-09-11 1994-06-07 Merck & Co., Inc. Recombinant expandase bioprocess for preparing 7-aminodesacetoxy cephalosporanic acid (7-ADCA)
KR100327881B1 (ko) * 1993-07-30 2002-07-02 한스 발터 라벤 3-(카르복시에틸티오)프로피오닐-7-adca를경유하여7-adca를제조하는효율적인방법
HU219259B (en) * 1993-07-30 2001-03-28 Gist Brocades Bv Process for the efficient production of 7-adca via 2-(carboxyethylthio)acetyl-7-adca and 3-(carboxymethylthio)propionyl-7-adca, recombinant dna vectrors and transformed host cells
DE69535126D1 (de) * 1994-09-28 2006-09-07 Novozymes As Verfahren zur herstellung von sekundären metaboliten
DE4437420A1 (de) * 1994-10-19 1996-04-25 Hoechst Ag Verbessertes, induktionsfreies Verfahren zur gentechnischen Herstellung von Glutarylamidase
US5731165A (en) * 1995-06-02 1998-03-24 Gist-Brocades, B.V. Process for the production of 7-ADCA via expandase activity on penicillin G
BR9608954A (pt) * 1995-06-02 1999-03-02 Gist Brocades Bv Processo para a produção de 7-adca via atividade de expandase na penicilina g
AU2508897A (en) * 1996-04-04 1997-10-29 Gist-Brocades B.V. An enzyme with high adipoyl-coenzyme a synthetase activity and uses thereof
EP0914463A2 (en) 1996-07-16 1999-05-12 Gist-Brocades B.V. NOVEL PROCESS FOR THE PREPARATION OF CEPHALOSPORINS USING $i(ACREMONIUM CHRYSOGENUM)
EP0915988B1 (en) * 1997-04-22 2003-01-29 Dsm N.V. Process for the fermentative production of deacylated cephalosporins
WO1998048034A1 (en) * 1997-04-22 1998-10-29 Gist-Brocades B.V. Process for the fermentative production of deacylated cephalosporins
ES2237840T3 (es) 1997-04-22 2005-08-01 Dsm Ip Assets B.V. Proceso mejorado para la produccion fermentativa de cefalosporina.
ZA983396B (en) * 1997-04-22 1998-10-27 Gist Brocades Bv A method for controlling the solubility of a beta-lactam nucleus
WO1999010499A1 (en) * 1997-08-22 1999-03-04 Dsm N.V. Statin production by fermentation
ID26888A (id) 1998-03-27 2001-02-15 Dsm Nv Proses produksi fermentasi cephalosporin
US6383773B2 (en) 1998-04-23 2002-05-07 Massachusetts Institute Of Technology Penicillin conversion
WO2000037671A2 (en) * 1998-12-22 2000-06-29 Dsm N.V. Improved in vivo production of cephalosporins
ES2165276B1 (es) * 1999-06-18 2003-03-01 Antibioticos Sau Procedimiento biotecnologico para la produccion de acido 7-aminocefal osporanico (7-adca) y compuestos de sintesis intermedios particularmente penicilina n y desacetoxicefalosporina c (daoc)
ATE273982T1 (de) 2000-05-13 2004-09-15 Smithkline Beecham Plc Verfahren zur reinigung eines salzes der clavulansäure
US6699699B2 (en) * 2002-03-26 2004-03-02 Synmax Biochemical Co., Ltd. Mutated penicillin expandases
ES2400562T3 (es) 2003-05-28 2013-04-10 Dsm Sinochem Pharmaceuticals Netherlands B.V. Compuesto de cefem
EP1987041B1 (en) * 2006-02-23 2013-05-22 DSM Sinochem Pharmaceuticals Netherlands B.V. Improved cephalosporin production
KR101569832B1 (ko) * 2008-11-19 2015-11-18 삼성전자주식회사 시료 중의 게놈 ｄｎａ 및 플라스미드 ｄｎａ를 서로 분리하는 방법 및 그를 위한 키트
CN101429538B (zh) * 2008-12-12 2011-05-25 河北九派制药有限公司 7-α-甲氧基-3-去乙酰基头孢噻吩苄星盐的制备方法
CN102369290A (zh) 2009-04-03 2012-03-07 帝斯曼知识产权资产管理有限公司 发酵工艺
US8863444B2 (en) 2010-05-31 2014-10-21 Feature Walters Assembly system for modular building units
WO2011161004A1 (en) 2010-06-22 2011-12-29 Dsm Ip Assets B.V. Air bubble fermentation process
CN103108879B (zh) 2010-09-07 2016-08-17 中化帝斯曼制药有限公司荷兰公司 用于生产头孢菌素类的方法
CN102702229A (zh) * 2011-08-04 2012-10-03 重庆天地药业有限责任公司 一种头孢唑肟钠关键中间体的制备及高含量头孢唑肟钠的制备
WO2015091455A1 (en) 2013-12-17 2015-06-25 Dpx Holdings B.V. Bioreactor
KR101808192B1 (ko) * 2016-08-26 2018-01-18 아미코젠주식회사 7-아미노세팔로스포란산의 고농도 생산 재조합 아크레모니움 크리소제눔 균주의 제조방법 및 이 방법으로 제조된 균주

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US5318896A (en) * 1991-09-11 1994-06-07 Merck & Co., Inc. Recombinant expandase bioprocess for preparing 7-aminodesacetoxy cephalosporanic acid (7-ADCA)

Also Published As

Publication number Publication date
EP0856516B1 (en) 2002-04-24
MX9205902A (es) 1994-06-30
JPH06113884A (ja) 1994-04-26
EP0540210A1 (en) 1993-05-05
IL103419A (en) 2003-06-24
YU92592A (sh) 1995-10-03
IL133734A0 (en) 2001-04-30
DE69232581D1 (de) 2002-05-29
US5629171A (en) 1997-05-13
BG62261B1 (bg) 1999-06-30
EP0856516A1 (en) 1998-08-05
WO1993008287A1 (en) 1993-04-29
IL133733A0 (en) 2001-04-30
HUT69783A (en) 1995-09-28
NZ244714A (en) 1994-03-25
HU219370B (en) 2001-03-28
RU2002130702A (ru) 2004-05-20
US6071713A (en) 2000-06-06
SK43194A3 (en) 1996-11-06
YU48930B (sh) 2002-12-10
US5559005A (en) 1996-09-24
UA47385C2 (uk) 2002-07-15
SK280569B6 (sk) 2000-03-13
GR3029343T3 (en) 1999-05-28
DE69232581T2 (de) 2002-11-14
CN1074484A (zh) 1993-07-21
DE69227750T2 (de) 1999-04-22
DE69227750D1 (de) 1999-01-14
CA2080573C (en) 2004-01-06
CZ88494A3 (en) 1995-03-15
TW272233B (hu) 1996-03-11
ES2176613T3 (es) 2002-12-01
FI106965B (fi) 2001-05-15
NO315802B1 (no) 2003-10-27
BG98714A (bg) 1995-02-28
CZ288721B6 (cs) 2001-08-15
DK0856516T3 (da) 2002-07-29
KR100227711B1 (ko) 1999-12-01
FI941730A (fi) 1994-04-14
IL103419A0 (en) 1993-03-15
NO941345L (no) 1994-06-15
NO941345D0 (no) 1994-04-14
CA2080573A1 (en) 1993-04-16
ES2127205T3 (es) 1999-04-16
JP2655790B2 (ja) 1997-09-24
FI941730A0 (fi) 1994-04-14
AU657800B2 (en) 1995-03-23
AU2701692A (en) 1993-04-22
ATE216700T1 (de) 2002-05-15
ATE174057T1 (de) 1998-12-15
US6017726A (en) 2000-01-25
RO116648B1 (ro) 2001-04-30
DK0540210T3 (da) 1999-06-23
EP0540210B1 (en) 1998-12-02

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Owner name: GIST-BROCADES B.V., NL

MM4A Lapse of definitive patent protection due to non-payment of fees