HRP20210212T1 - Triciklični spoj kao antikancerogeni agensi - Google Patents
Triciklični spoj kao antikancerogeni agensi Download PDFInfo
- Publication number
- HRP20210212T1 HRP20210212T1 HRP20210212TT HRP20210212T HRP20210212T1 HR P20210212 T1 HRP20210212 T1 HR P20210212T1 HR P20210212T T HRP20210212T T HR P20210212TT HR P20210212 T HRP20210212 T HR P20210212T HR P20210212 T1 HRP20210212 T1 HR P20210212T1
- Authority
- HR
- Croatia
- Prior art keywords
- cancer
- compound
- pharmaceutically acceptable
- small cell
- cell lung
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims 6
- 239000002246 antineoplastic agent Substances 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 3
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 2
- 208000034578 Multiple myelomas Diseases 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 206010041067 Small cell lung cancer Diseases 0.000 claims 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Peptides Or Proteins (AREA)
- Steroid Compounds (AREA)
Claims (5)
1. Spoj sa formulom
[image]
2. Farmaceutski prihvatljiva sol spoja koje ima strukturu
[image]
3. Farmaceutska kompozicija koja sadrži spoj prema patentnom zahtjevu 1 ili farmaceutski prihvatljivu sol tog spoja i jedan ili više farmaceutski prihvatljivih nosača, razblaživača ili ekscipijenasa.
4. Spoj prema patentnom zahtjevu 1 za primjenu u liječenju raka kod pacijenta gdje je rak sitnostanični rak pluća, nesitnostanični rak pluća, kolorektalni rak, multipli mijelom ili AML.
5. Farmaceutski prihvatljiva sol prema patentnom zahtjevu 2 za primjenu u liječenju rak kod pacijenta gdje je rak sitnostanični rak pluća, nesitnostanični rak pluća, kolorektalni rak, multipli mijelom ili AML.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361920500P | 2013-12-24 | 2013-12-24 | |
EP18192207.1A EP3466949B1 (en) | 2013-12-24 | 2014-12-23 | Tricyclic compound as anticancer agents |
Publications (2)
Publication Number | Publication Date |
---|---|
HRP20210212T1 true HRP20210212T1 (hr) | 2021-07-09 |
HRP20210212T8 HRP20210212T8 (hr) | 2021-08-20 |
Family
ID=52293305
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20181849TT HRP20181849T1 (hr) | 2013-12-24 | 2018-11-07 | Triciklični spojevi kao antikancerogeni agensi |
HRP20210212TT HRP20210212T8 (hr) | 2013-12-24 | 2021-02-08 | Triciklični spoj kao antikancerogeni agensi |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20181849TT HRP20181849T1 (hr) | 2013-12-24 | 2018-11-07 | Triciklični spojevi kao antikancerogeni agensi |
Country Status (33)
Country | Link |
---|---|
US (1) | US20160318928A1 (hr) |
EP (2) | EP3087071B1 (hr) |
JP (2) | JP6466456B2 (hr) |
KR (1) | KR102457145B1 (hr) |
CN (2) | CN108558871B (hr) |
AR (2) | AR099379A1 (hr) |
AU (1) | AU2014369982B2 (hr) |
BR (1) | BR112016013744B1 (hr) |
CA (1) | CA2934953C (hr) |
CL (1) | CL2016001629A1 (hr) |
CY (2) | CY1121076T1 (hr) |
DK (2) | DK3087071T3 (hr) |
EA (2) | EA032469B1 (hr) |
ES (2) | ES2857848T3 (hr) |
HR (2) | HRP20181849T1 (hr) |
HU (2) | HUE041719T2 (hr) |
IL (1) | IL246359B (hr) |
LT (2) | LT3466949T (hr) |
MA (1) | MA39211B1 (hr) |
MX (1) | MX369491B (hr) |
MY (1) | MY176489A (hr) |
NZ (1) | NZ722326A (hr) |
PE (1) | PE20160844A1 (hr) |
PH (1) | PH12016500953A1 (hr) |
PL (2) | PL3466949T3 (hr) |
PT (2) | PT3087071T (hr) |
RS (2) | RS61479B1 (hr) |
SG (1) | SG11201605097SA (hr) |
SI (2) | SI3466949T1 (hr) |
TN (1) | TN2016000238A1 (hr) |
TW (2) | TWI736517B (hr) |
UY (1) | UY35916A (hr) |
WO (1) | WO2015100282A1 (hr) |
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US9458156B2 (en) | 2014-12-23 | 2016-10-04 | Bristol-Myers Squibb Company | Tricyclic compounds as anticancer agents |
PE20160844A1 (es) * | 2013-12-24 | 2016-09-03 | Bristol Myers Squibb Co | Compuestos triciclicos como agentes anticancerigenos |
AU2015222887B2 (en) * | 2014-02-28 | 2019-06-27 | The Regents Of The University Of Michigan | 9H-pyrimido[4,5-b]indoles and related analogs as BET bromodomain inhibitors |
US10174024B2 (en) | 2015-05-12 | 2019-01-08 | Bristol-Myers Squibb Company | 5H-pyrido[3,2-B]indole compounds as anticancer agents |
US9725449B2 (en) | 2015-05-12 | 2017-08-08 | Bristol-Myers Squibb Company | Tricyclic compounds as anticancer agents |
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WO2017124934A1 (zh) * | 2016-01-20 | 2017-07-27 | 宁波文达医药科技有限公司 | 作为布罗莫区结构域抑制剂的含膦咔啉衍生物 |
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UA115576C2 (uk) * | 2012-12-06 | 2017-11-27 | Байєр Фарма Акцієнгезелльшафт | Похідні бензимідазолу як антагоністи ер4 |
US9492460B2 (en) * | 2013-02-27 | 2016-11-15 | Bristol-Myers Squibb Company | Carbazole compounds useful as bromodomain inhibitors |
WO2014134267A1 (en) * | 2013-02-27 | 2014-09-04 | Bristol-Myers Squibb Company | Carbazole compounds useful as bromodomain inhibitors |
CN105377851B (zh) * | 2013-03-11 | 2018-07-20 | 密执安州立大学董事会 | Bet布罗莫结构域抑制剂和使用这些抑制剂的治疗方法 |
PE20160844A1 (es) * | 2013-12-24 | 2016-09-03 | Bristol Myers Squibb Co | Compuestos triciclicos como agentes anticancerigenos |
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