HRP20201088T1 - Anti-cd40 antitijela - Google Patents

Anti-cd40 antitijela Download PDF

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Publication number
HRP20201088T1
HRP20201088T1 HRP20201088TT HRP20201088T HRP20201088T1 HR P20201088 T1 HRP20201088 T1 HR P20201088T1 HR P20201088T T HRP20201088T T HR P20201088TT HR P20201088 T HRP20201088 T HR P20201088T HR P20201088 T1 HRP20201088 T1 HR P20201088T1
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Croatia
Prior art keywords
antibody
humanized anti
disease
seq
amino acid
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HRP20201088TT
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English (en)
Inventor
Rachel Barrett
Scott Brodeur
Keith Canada
Tobias Litzenburger
Sanjaya Singh
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Boehringer Ingelheim International Gmbh
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44169124&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20201088(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim International Gmbh filed Critical Boehringer Ingelheim International Gmbh
Publication of HRP20201088T1 publication Critical patent/HRP20201088T1/hr

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    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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Claims (10)

1. Humanizirano anti-CD40 antitijelo koje ima varijabilan teški lanac i varijabilan laki lanac koji sadrže aminokiselinske sekvence sa SEQ ID NO:53 i SEQ ID NO:52, redom, gdje antitijelo sadrži humanu imunoglobulinski Fc regiju i gdje antitijelo je IgG1 antitijelo.
2. Humanizirano anti-CD40 antitijelo u skladu sa patentnim zahtjevom 1 koje ima laki lanac koji sadrži aminokiselinske sekvence sa SEQ ID NO:31 i težak lanac koji sadrži aminokiselinsku sekvencu sa SEQ ID NO: 32, SEQ ID NO: 33 ili SEQ ID NO: 35.
3. Humanizirano anti-CD40 antitijelo u skladu sa patentnim zahtjevom 1 ili 2, gdje antitijelo ima Leu234Ala i Leu235Ala mutaciju u Fc regiji.
4. Humanizirano anti-CD40 antitijelo iz bilo kojeg od patentnih zahtjeva 1-3 za primjenu u liječenju ili ublažavanju bolesti ili poremećaja kod sisavaca.
5. Humanizirano anti-CD40 antitijelo za primjenu kao u patentnom zahtjevu 4, gdje bolest ili poremećaj je odabran iz grupe koja se sastoji od: bolesti kalem protiv domaćina, autoimune ili inflamatorne bolesti, i CD40-eksprimirajućeg raka.
6. Humanizirano anti-CD40 antitijelo za primjenu kao u patentnom zahtjevu 5, gdje autoimuna ili inflamatorna bolest je odabrana iz grupe koja se sastoji od reumatoidnog artritisa, multiple skleroze, proliferativnog lupus glomerulonefritisa, inflamatorne bolesti crijeva (IBD), psorijaze, idiopatske trombocitopenične purpure (ITP), Kronove bolesti i sistemskog lupusa eritematozusa (SLE), Hashimoto tiroiditisa, primarnog miksoedema, tirotoksikoze/Gravesove bolesti, perniciozne anemije, autoimunog atrofičnog gastritisa, autoimunog karditisa, Adisonove bolesti, preuranjene menopauze, tip 1-dijabetes melitusa, Goodpastureovog sindroma, mijastenije gravis, autoimune hemolitičke anemije, idiopatske leukopenije, primarne bilijarne ciroze, aktivnog kroničnog hepatitisa (HBs Ag negativan), kriptogene ciroze, Sjogrenovog sindroma, dermatomiozitisa, skleroderme, mješovite bolesti vezivnog tkiva, diskoidnog lupus eritematozusa, i sistemskog vaskulitisa.
7. Humanizirano anti-CD40 antitijelo za primjenu kao u bilo kojem od patentnih zahtjeva 4-6, za primjenu sa drugim terapijskim agensom.
8. Humanizirano anti-CD40 antitijelo za primjenu kao u bilo kojem od patentnih zahtjeva 4-7, gdje navedeno antitijelo se administrira putem parenteralnog načina, intravenskog načina ili subkutanog načina administracije.
9. Farmaceutska kompozicija koja sadrži: (i) humanizirano anti-CD40 antitijelo iz bilo kojeg od patentnih zahtjeva 1-3; i (ii) farmaceutski prihvatljiv ekscipijens; i gdje antitijelo je po izboru konjugirano sa drugim agensom.
10. Izolirani polinukleotidi koji sadrže sekvencu koja kodira humanizirano anti-CD40 antitijelo koje ima aminokiselinsku sekvencu varijabilne regije teškog lanca sa SEQ ID NO: 53 i aminokiselinsku sekvencu varijabilne regije lakog lanca sa SEQ ID NO: 52, gdje antitijelo sadrži humani imunoglobulinsku Fc regiju i gdje antitijelo je IgG1 antitijelo.
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