HRP20200871T1 - Izmjenjeni rsv f proteini i postupci njihove uporabe - Google Patents
Izmjenjeni rsv f proteini i postupci njihove uporabe Download PDFInfo
- Publication number
- HRP20200871T1 HRP20200871T1 HRP20200871TT HRP20200871T HRP20200871T1 HR P20200871 T1 HRP20200871 T1 HR P20200871T1 HR P20200871T T HRP20200871T T HR P20200871TT HR P20200871 T HRP20200871 T HR P20200871T HR P20200871 T1 HRP20200871 T1 HR P20200871T1
- Authority
- HR
- Croatia
- Prior art keywords
- rsv
- protein
- arginine
- nucleic acid
- pharmaceutically acceptable
- Prior art date
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- 108090000623 proteins and genes Proteins 0.000 title claims 2
- 102000004169 proteins and genes Human genes 0.000 title claims 2
- 241000725643 Respiratory syncytial virus Species 0.000 claims 15
- 108010068327 4-hydroxyphenylpyruvate dioxygenase Proteins 0.000 claims 13
- 239000004475 Arginine Substances 0.000 claims 6
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 6
- 150000001413 amino acids Chemical class 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 239000013638 trimer Substances 0.000 claims 3
- 229960005486 vaccine Drugs 0.000 claims 3
- 102000004961 Furin Human genes 0.000 claims 2
- 108090001126 Furin Proteins 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 239000012752 auxiliary agent Substances 0.000 claims 2
- 238000003776 cleavage reaction Methods 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 230000008105 immune reaction Effects 0.000 claims 2
- 230000007017 scission Effects 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 108020004705 Codon Proteins 0.000 claims 1
- 241000238631 Hexapoda Species 0.000 claims 1
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 1
- 108091034057 RNA (poly(A)) Proteins 0.000 claims 1
- 229940037003 alum Drugs 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 1
- 125000000404 glutamine group Chemical group N[C@@H](CCC(N)=O)C(=O)* 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A61P31/14—Antivirals for RNA viruses
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Claims (11)
1. Respiratorni sincicijski virus (RSV) fuzijski (F) protein koji sadrži:
(i) brisanje jedne ili više aminokiselina koje se podudaraju s aminokiselinama 137-146 divljeg tipa RSV F proteina SEQ ID NO: 2;
(ii) inaktivirano mjesto cijepanja primarnog furina, pri čemu se mjesto cijepanja primarnog furina inaktivira s tri supstitucije aminokiselina uvedene na položajima koji se poravnavaju s argininom 133, argininom 135 i argininom 136 iz SEQ ID NO: 2; i
(iii) supstitucije aminokiselina iz P102A, I379V i M447V.
2. RSV F protein prema zahtjevu 1, naznačen time što su tri aminokiseline usklađene s argininom 133, argininom 135 i argininom 136 divljeg tipa RSV F proteina SEQ ID NO: 2 supstituirane glutaminom.
3. RSV F protein prema bilo kojem od prethodnih zahtjeva, naznačen time što RSV F protein pokazuje porast ekspresije u stanici domaćina u odnosu na divlji tip RSV F proteina SEQ ID NO: 2.
4. Izolirana nukleinska kiselina koja kodira RSV F protein prema bilo kojem od prethodnih zahtjeva.
5. Izolirana nukleinska kiselina prema zahtjevu 4, naznačena time što je sekvenca nukleinske kiseline kodon optimiziran za ekspresiju u stanicama insekata, i pri čemu sekvenca nukleinske kiseline sadrži modifikaciju jednog ili više kriptičnih poli (A) mjesta.
6. Izolirana stanica koja sadrži nukleinsku kiselinu prema zahtjevu 4 ili zahtjevu 5.
7. Farmaceutski prihvatljiv pripravak cjepiva koji sadrži RSV F protein prema bilo kojem od zahtjeva 1-3, i farmaceutski prihvatljiv nosač, pri čemu RSV F protein izaziva imunološku reakciju kod domaćina.
8. RSV F protein prema zahtjevu 1, naznačen time što RSV F proteinu nedostaje N-terminalni signalni peptid.
9. Pročišćeni trimer koji sadrži RSV F protein prema bilo kojem od zahtjeva 1-3 ili 8, naznačen time što svaki RSV F protein sadrži barem jednu disulfidnu vezu između F1 i F2 lanaca.
10. Farmaceutski prihvatljiv pripravak cjepiva koji sadrži pročišćeni trimer prema zahtjevu 9, i farmaceutski prihvatljiv nosač, naznačen time što trimer izaziva imunološku reakciju kod domaćina.
11. Pripravak cjepiva prema zahtjevu 7 ili zahtjevu 10 koji nadalje sadrži pomoćno sredstvo, izborno pri čemu je pomoćno sredstvo alum.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12112608P | 2008-12-09 | 2008-12-09 | |
| US16907709P | 2009-04-14 | 2009-04-14 | |
| US22478709P | 2009-07-10 | 2009-07-10 | |
| EP16166033.7A EP3067064B1 (en) | 2008-12-09 | 2009-12-09 | Modified rsv f proteins and methods of their use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20200871T1 true HRP20200871T1 (hr) | 2020-10-30 |
Family
ID=42310119
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20160859TT HRP20160859T1 (hr) | 2008-12-09 | 2016-07-13 | Modificirani proteini rsv f i postupci njihove upotrebe |
| HRP20200871TT HRP20200871T1 (hr) | 2008-12-09 | 2020-06-02 | Izmjenjeni rsv f proteini i postupci njihove uporabe |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20160859TT HRP20160859T1 (hr) | 2008-12-09 | 2016-07-13 | Modificirani proteini rsv f i postupci njihove upotrebe |
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| Country | Link |
|---|---|
| US (7) | US8715692B2 (hr) |
| EP (3) | EP3067064B1 (hr) |
| JP (4) | JP5813513B2 (hr) |
| KR (2) | KR101691574B1 (hr) |
| CN (2) | CN106146671B (hr) |
| AU (1) | AU2009333484B2 (hr) |
| BR (1) | BRPI0922867B8 (hr) |
| CA (1) | CA2746228C (hr) |
| CY (2) | CY1117757T1 (hr) |
| DK (2) | DK3067064T3 (hr) |
| ES (2) | ES2582005T3 (hr) |
| HK (1) | HK1161690A1 (hr) |
| HR (2) | HRP20160859T1 (hr) |
| HU (2) | HUE051666T2 (hr) |
| IL (2) | IL213450B (hr) |
| LT (1) | LT3067064T (hr) |
| MX (4) | MX358836B (hr) |
| PL (2) | PL3067064T3 (hr) |
| PT (2) | PT3067064T (hr) |
| RU (1) | RU2531510C2 (hr) |
| SG (2) | SG172022A1 (hr) |
| SI (2) | SI3067064T1 (hr) |
| WO (1) | WO2010077717A1 (hr) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20160000902A1 (en) * | 2003-07-11 | 2016-01-07 | Novavax, Inc. | Combination vaccine for respiratory syncytial virus and influenza |
| AU2009316680B2 (en) * | 2008-11-18 | 2016-03-24 | Takeda Vaccines, Inc. | RSV F VLPs and methods of manufacture and use thereof |
| US11446374B2 (en) | 2008-12-09 | 2022-09-20 | Novavax, Inc. | Modified RSV F proteins and methods of their use |
| LT3067064T (lt) | 2008-12-09 | 2020-09-10 | Novavax, Inc. | Modifikuoti rsv f baltymai ir jų panaudojimo būdai |
| PL3178490T3 (pl) * | 2009-07-15 | 2022-08-01 | Glaxosmithkline Biologicals S.A. | Kompozycje białka f rsv i sposoby ich wytwarzania |
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