HRP20161271T1 - Učinci metaboličkog utiskivanja specifično dizajnirane lipidne komponente - Google Patents
Učinci metaboličkog utiskivanja specifično dizajnirane lipidne komponente Download PDFInfo
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- 150000002632 lipids Chemical class 0.000 title claims 18
- 230000000694 effects Effects 0.000 title 1
- 230000002503 metabolic effect Effects 0.000 title 1
- 235000016709 nutrition Nutrition 0.000 claims 28
- 239000000203 mixture Substances 0.000 claims 22
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims 12
- 235000014113 dietary fatty acids Nutrition 0.000 claims 10
- 229930195729 fatty acid Natural products 0.000 claims 10
- 239000000194 fatty acid Substances 0.000 claims 10
- 150000004665 fatty acids Chemical group 0.000 claims 10
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 claims 8
- 150000003904 phospholipids Chemical class 0.000 claims 8
- 230000002265 prevention Effects 0.000 claims 8
- 208000008589 Obesity Diseases 0.000 claims 6
- 235000021314 Palmitic acid Nutrition 0.000 claims 6
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims 6
- 235000020824 obesity Nutrition 0.000 claims 6
- 235000020661 alpha-linolenic acid Nutrition 0.000 claims 5
- 235000019197 fats Nutrition 0.000 claims 5
- 229960004488 linolenic acid Drugs 0.000 claims 5
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 4
- 206010022489 Insulin Resistance Diseases 0.000 claims 3
- 239000008346 aqueous phase Substances 0.000 claims 3
- 230000037396 body weight Effects 0.000 claims 3
- 150000001720 carbohydrates Chemical class 0.000 claims 3
- 235000014633 carbohydrates Nutrition 0.000 claims 3
- 235000013350 formula milk Nutrition 0.000 claims 3
- 125000005457 triglyceride group Chemical group 0.000 claims 3
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 2
- 208000029725 Metabolic bone disease Diseases 0.000 claims 2
- 206010049088 Osteopenia Diseases 0.000 claims 2
- 208000001132 Osteoporosis Diseases 0.000 claims 2
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 2
- 235000021342 arachidonic acid Nutrition 0.000 claims 2
- 229940114079 arachidonic acid Drugs 0.000 claims 2
- 210000000988 bone and bone Anatomy 0.000 claims 2
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 claims 2
- 235000020978 long-chain polyunsaturated fatty acids Nutrition 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 230000035764 nutrition Effects 0.000 claims 2
- 239000012071 phase Substances 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 claims 1
- 238000009825 accumulation Methods 0.000 claims 1
- 235000020256 human milk Nutrition 0.000 claims 1
- 210000004251 human milk Anatomy 0.000 claims 1
- 229910052500 inorganic mineral Inorganic materials 0.000 claims 1
- 235000020778 linoleic acid Nutrition 0.000 claims 1
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 claims 1
- 235000013336 milk Nutrition 0.000 claims 1
- 239000008267 milk Substances 0.000 claims 1
- 210000004080 milk Anatomy 0.000 claims 1
- 239000011707 mineral Substances 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
- 239000007764 o/w emulsion Substances 0.000 claims 1
- 229920001542 oligosaccharide Polymers 0.000 claims 1
- 150000002482 oligosaccharides Chemical class 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 230000002028 premature Effects 0.000 claims 1
- 235000020209 toddler milk formula Nutrition 0.000 claims 1
- 150000003626 triacylglycerols Chemical class 0.000 claims 1
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Claims (21)
1. Nutritivni pripravak koji sadrži ugljikohidrate, proteine i lipide, gdje su lipidi prisutni u obliku lipidnih globula, pri čemu
i) sastav masnih kiselina unutar lipida obuhvaća linolensku kiselinu i alfa-linolensku kiselinu u težinskom omjeru od 2 do 10,
ii) sastav masnih kiselina unutar lipida obuhvaća barem 10 tež.% palmitinske kiseline u odnosu na ukupne masne kiseline, i barem 30 tež.% te ukupne palmitinske kiseline je esterificirano na sn-2 položaju triglicerida
iii) lipidne globule su barem djelomično obložene fosfolipidima na površini, količina fosfolipida prisutnih u nutritivnom pripravku je od 0.5 do 20 tež.% fosfolipida u odnosu na ukupne lipide,
gdje nutritivni pripravak nije humano mlijeko.
2. Nutritivni pripravak prema zahtjevu 1 koji sadrži manje od 15 tež.% linolenske kiseline i više od 1 tež.% alfalinolenske kiseline u odnosu na ukupne masne kiseline.
3. Nutritivni pripravak prema bilo kojem od prethodnih zahtjeva koji sadrži barem 0.15 tež.% n-3 LC-PUFA (dugolančane polinezasićene masne kiseline) u odnosu na ukupne masne kiseline, odabrane iz skupine koju čine DHA, EPA i DPA, poželjno DHA.
4. Nutritivni pripravak prema bilo kojem od prethodnih zahtjeva gdje je barem 35 tež.% palmitinske kiseline od ukupne palmitinske kiseline esterificirano na sn-2 položaju triglicerida.
5. Nutritivni pripravak prema bilo kojem od prethodnih zahtjeva gdje lipidne globule imaju volumni modalni promjer od 1.0 µm ili veći.
6. Nutritivni pripravak prema bilo kojem od prethodnih zahtjeva koji sadrži 0.5 do 20 tež.% fosfolipida, u odnosu na ukupne lipide, dobivenih iz mlijeka sisavaca.
7. Nutritivni pripravak prema bilo kojem od prethodnih zahtjeva gdje jezgra lipidnih globula sadrži barem 40 tež.% triglicerida biljnog porijekla.
8. Nutritivni pripravak prema bilo kojem od prethodnih zahtjeva gdje pripravak sadrži 10 do 50 tež.% lipida na temelju suhe težine ukupnog pripravka.
9. Nutritivni pripravak prema bilo kojem od prethodnih zahtjeva gdje lipidi daju 30 do 60 % ukupnih kalorija, proteini daju 5 do 20% ukupnih kalorija i probavljivi ugljikohidrati daju 25 do 75% ukupnih kalorija.
10. Nutritivni pripravak prema bilo kojem od prethodnih zahtjeva koji sadrži barem 0.1 tež.% arahidonske kiseline u odnosu na ukupne masne kiseline i količina arahidonske kiseline ne prelazi 2.0 tež.% u odnosu na ukupne masne kiseline.
11. Nutritivni pripravak prema bilo kojem od prethodnih zahtjeva, gdje proteini daju 5 do 9% ukupnih kalorija.
12. Nutritivni pripravak prema bilo kojem od prethodnih zahtjeva koji dalje sadrži neprobavljive oligosaharide.
13. Nutritivni pripravak prema bilo kojem od prethodnih zahtjeva gdje je pripravak prašak.
14. Nutritivni pripravak prema bilo kojem od prethodnih zahtjeva za uporabu u jednom ili više odabranog između prevencije pretilosti, smanjenja rizika od pretilosti, liječenja pretilosti, prevencije dijabetesa tipa 2, smanjenja rizika od pojave inzulinske rezistencije i poboljšanja osjetljivosti na inzulin, prevencije metaboličkog sindroma, prevencije osteopenije i/ili osteoporoze.
15. Nutritivni pripravak prema bilo kojem od zahtjeva 1-13 za uporabu u poboljšanju tjelesne građe, poboljšanje tjelesne građe se odabire iz skupine koju čine povećanje nemasnog dijela tjelesne težine, smanjenje masne težine u odnosu na ukupnu tjelesnu težinu, smanjenje tkivne masne težine tkiva u odnosu na ukupnu tjelesnu težinu, smanjenje tkivne masne težine tkiva u odnosu na ukupnu masnu težinu, smanjenje nakupljanja masti i povećanje mišićne mase, povećanje koštane mase i povećanje mineralne gustoće kostiju.
16. Nutritivni pripravak za uporabu prema zahtjevu 14 ili 15, gdje je nutritivni pripravak za prehranu ljudskog subjekta u dobi između 0 i 36 mjeseci.
17. Nutritivni pripravak za uporabu prema zahtjevu 16 za prevenciju pretilosti, smanjenje rizika od pretilosti, liječenje pretilosti, poboljšanje tjelesne građe, prevenciju dijabetesa tipa 2, smanjenje rizika od pojave inzulinske rezistencije, prevenciju metaboličkog sindroma, prevenciju osteopenije i/ili osteoporoze u ljudskog subjekta kada taj ljudski subjekt ima dob iznad 36 mjeseci, poželjno kada taj ljudski subjekt ima dob iznad 5 godina.
18. Nutritivni pripravak za uporabu prema bilo kojem od zahtjeva 14-17, gdje je nutritivni pripravak za prehranu nepretilog ljudskog subjekta.
19. Nutritivni pripravak za uporabu prema bilo kojem od zahtjeva 14-18, gdje je nutritivni pripravak formula za nedonoščad, formula za dojenčad, nastavna formula ili mlijeko za odrastanje.
20. Postupak proizvodnje nutritivnog pripravka prema zahtjevima 1 do 13 koji obuhvaća pripremu vodene faze koja sadrži proteine i probavljive ugljikohidrate te pripremu masne faze koja sadrži lipide, gdje su fosfolipidi prisutni u vodenoj i/ili masnoj fazi, gdje sastav masnih kiselina unutar lipida obuhvaća linolensku kiselinu i alfa-linolensku kiselinu u težinskom omjeru od 2 do 10, gdje sastav masnih kiselina unutar lipida obuhvaća barem 10 tež.% palmitinske kiseline u odnosu na ukupne masne kiseline i barem 30 tež.% te ukupne palmitinske kiseline je esterificirano na sn-2 položaju triglicerida, zatim miješanje masne i vodene faze te homogeniziranje smjese masne i vodene faze u emulziju tipa ulje-u-vodi s lipidnim globulama koje su barem djelomično obložene fosfolipidima na površini, količina fosfolipida prisutnih u nutritivnom pripravku je od 0.5 do 20 tež.% fosfolipida u odnosu na ukupne lipide.
21. Proizvod dobiven postupkom prema zahtjevu 20 za uporabu prema bilo kojem od zahtjeva 14 do 19.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/NL2011/050437 WO2012173467A1 (en) | 2011-06-16 | 2011-06-16 | Metabolic imprinting effects of specifically designed lipid component |
| EP12730693.4A EP2720562B2 (en) | 2011-06-16 | 2012-06-18 | Metabolic imprinting effects of specifically designed lipid component |
| PCT/NL2012/050427 WO2012173485A1 (en) | 2011-06-16 | 2012-06-18 | Metabolic imprinting effects of specifically designed lipid component |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20161271T1 true HRP20161271T1 (hr) | 2016-12-16 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20161272TT HRP20161272T4 (hr) | 2011-06-16 | 2012-06-18 | Učinci metaboličkog utiskivanja specifično dizajnirane lipidne komponente |
| HRP20230160TT HRP20230160T1 (hr) | 2011-06-16 | 2012-06-18 | Metabolički učinci utiskivanja posebno dizajnirane lipidne komponente |
| HRP20230159TT HRP20230159T1 (hr) | 2011-06-16 | 2012-06-18 | Metabolički učinci utiskivanja posebno dizajnirane lipidne komponente |
| HRP20161271TT HRP20161271T1 (hr) | 2011-06-16 | 2016-10-04 | Učinci metaboličkog utiskivanja specifično dizajnirane lipidne komponente |
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| HRP20230160TT HRP20230160T1 (hr) | 2011-06-16 | 2012-06-18 | Metabolički učinci utiskivanja posebno dizajnirane lipidne komponente |
| HRP20230159TT HRP20230159T1 (hr) | 2011-06-16 | 2012-06-18 | Metabolički učinci utiskivanja posebno dizajnirane lipidne komponente |
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| WO2011115476A1 (en) | 2010-03-17 | 2011-09-22 | N.V. Nutricia | Infant nutrition for improving fatty acid composition of brain membranes later in life |
| WO2012173467A1 (en) | 2011-06-16 | 2012-12-20 | N.V. Nutricia | Metabolic imprinting effects of specifically designed lipid component |
| AR087158A1 (es) | 2011-06-20 | 2014-02-26 | Gen Biscuit | Masita en capas saludable |
| SE536599C3 (sv) | 2012-04-10 | 2017-01-10 | Hero Ag | Näringssammansättning med lågt kalori- och lågt proteininnehåll |
| WO2013191533A1 (en) | 2012-06-18 | 2013-12-27 | N.V. Nutricia | Metabolic imprinting effects of nutrition with large lipid globules comprising milk fat and vegetable fat |
| WO2014058301A1 (en) * | 2012-10-12 | 2014-04-17 | N.V. Nutricia | Infant nutrition with lipid globules to increase energy expenditure and metabolic flexibility later in life |
| US9661874B2 (en) * | 2013-03-11 | 2017-05-30 | Mead Johnson Nutrition Company | Nutritional compositions containing structured fat globules and uses thereof |
| US9980506B2 (en) | 2013-03-11 | 2018-05-29 | Mead Johnson Nutrition Co. | Nutritional compositions containing structured fat globules and uses thereof |
| US10455854B2 (en) | 2013-03-11 | 2019-10-29 | Mead Johnson Nutrition Company | Nutritional compositions containing structured fat globules and uses thereof |
| US20140255537A1 (en) * | 2013-03-11 | 2014-09-11 | Mead Johnson Nutrition Company | Nutritional Compositions Containing an Enriched Lipid Fraction and Uses Thereof |
| JP2016526907A (ja) * | 2013-07-30 | 2016-09-08 | ベネミルク オーワイＢｅｎｅｍｉｌｋ Ｏｙ | 泌乳反芻動物用飼料 |
| EP2845490A1 (en) * | 2013-09-05 | 2015-03-11 | Loders Croklaan B.V. | Fat composition for improved body fat distribution |
| US20160227810A1 (en) * | 2013-10-17 | 2016-08-11 | University Of Georgia Research Foundation, Inc. | Structured triacylglycerols and methods for making the same |
| US20160263033A1 (en) * | 2013-11-01 | 2016-09-15 | N.V. Nutricia | Lipid composition for improving body composition during catch-up growth |
| WO2015067325A1 (en) * | 2013-11-11 | 2015-05-14 | N.V. Nutricia | Powdered nutritional composition with large lipid globules |
| US20160015068A1 (en) * | 2014-07-16 | 2016-01-21 | Mead Johnson Nutrition Company | Nutritional formulas containing oil blends and uses thereof |
| RU2706963C2 (ru) * | 2014-11-26 | 2019-11-21 | Абботт Лаборэтриз | Молочная смесь, содержащая олигосахариды грудного молока, полиненасыщенные жирные кислоты, нуклеотиды и лютеин |
| ES2964285T3 (es) | 2015-10-15 | 2024-04-05 | Nutricia Nv | Fórmula para lactantes con grasa láctea para promover un crecimiento saludable |
| RU2731641C2 (ru) | 2015-10-15 | 2020-09-07 | Н.В. Нютрисиа | Детская смесь cо специальной структурой липида для стимулирования здорового роста |
| WO2017153998A1 (en) * | 2016-03-10 | 2017-09-14 | Enzymotec Ltd. | Lipid compositions and uses thereof |
| AU2017373837B2 (en) | 2016-12-09 | 2022-07-14 | N.V. Nutricia | Nutritional composition for improving cell membranes |
| CN107049240A (zh) * | 2017-01-18 | 2017-08-18 | 英华达（上海）科技有限公司 | 身体年龄计算方法及体脂测量*** |
| RU2761114C2 (ru) * | 2017-03-29 | 2021-12-06 | Н.В. Нютрисиа | Детская смесь для улучшения пищевого поведения |
| CN109418396A (zh) * | 2017-08-22 | 2019-03-05 | 中国农业大学 | 人工脂滴及其应用 |
| EP3773011A1 (en) * | 2018-04-03 | 2021-02-17 | N.V. Nutricia | Nutritional composition for use in the prevention of dry skin |
| EP4068991B1 (en) | 2019-12-05 | 2024-02-21 | N.V. Nutricia | Infant formula with special lipid architecture for improving postnatal growth of infants born by caesarean section |
| CN114745969A (zh) * | 2019-12-05 | 2022-07-12 | N·V·努特里奇亚 | 用于改善超重和肥胖母亲所生的婴儿出生后生长的具有特殊脂质结构的婴儿配方物 |
| WO2022248599A1 (en) | 2021-05-26 | 2022-12-01 | N.V. Nutricia | Infant formula comprising milk fat for reducing the risk of obesity in at risk infants |
| EP4346447A1 (en) | 2021-05-26 | 2024-04-10 | N.V. Nutricia | Infant formula for improving body composition development |
| WO2023203156A1 (en) | 2022-04-20 | 2023-10-26 | N.V. Nutricia | Infant formula with special lipid architecture for reducing childhood blood pressure |
| WO2024073461A1 (en) * | 2022-09-28 | 2024-04-04 | Cargill, Incorporated | Sunflower oleosome composition |
| WO2024073465A1 (en) * | 2022-09-28 | 2024-04-04 | Cargill, Incorporated | Oleosome composition with bio-actives |
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| US5601860A (en) | 1990-11-30 | 1997-02-11 | American Home Products Corporation | Corandomized fat compositions for infant formulas |
| EP0496456B1 (en) * | 1991-01-23 | 1995-03-15 | Unilever N.V. | Human milk fat substitutes |
| DE69405096T2 (de) | 1993-05-13 | 1998-01-22 | Loders Croklaan Bv | Muttermilch-ersatzstoffe aus umgeestertentriglyceridmischungen |
| IL158554A0 (en) | 2003-10-22 | 2004-05-12 | Enzymotec Ltd | Mimetic lipids as dietary supplements |
| IL158555A0 (en) * | 2003-10-22 | 2004-05-12 | Enzymotec Ltd | Human breast milk lipid mimetic as dietary supplement |
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| US20110136732A1 (en) | 2005-12-23 | 2011-06-09 | N.V. Nutricia | Infant nutritional compositions for preventing obesity |
| DE102007022694A1 (de) * | 2007-05-11 | 2008-11-13 | Humana Milchunion Eg | Milchfett-Milchprotein-Zusammensetzung zur Verbesserung der Calcium-Aufnahme |
| IL184982A0 (en) * | 2007-08-01 | 2008-01-20 | Enzymotec Ltd | Edible fat composition for enhancing bone strength |
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| JP5809053B2 (ja) | 2008-07-03 | 2015-11-10 | スリーエム イノベイティブ プロパティズ カンパニー | 固定研磨粒子及びそれから作製される物品 |
| EP2143340A1 (en) * | 2008-07-07 | 2010-01-13 | Nestec S.A. | A nutritional composition with free amino acids and structured lipids |
| SI2554056T1 (sl) | 2008-09-02 | 2020-02-28 | N.V. Nutricia | Prehranski sestavki z lipidnimi globulami velikega premera z oblogo, ki obsega fosfolipide |
| WO2010068086A1 (en) * | 2008-12-11 | 2010-06-17 | N.V. Nutricia | Nutritional compositions with large lipid globule size |
| WO2011071367A1 (en) | 2009-12-11 | 2011-06-16 | N.V. Nutricia | Metabolic imprinting effects of structured lipids |
| WO2012173467A1 (en) | 2011-06-16 | 2012-12-20 | N.V. Nutricia | Metabolic imprinting effects of specifically designed lipid component |
| WO2013191533A1 (en) | 2012-06-18 | 2013-12-27 | N.V. Nutricia | Metabolic imprinting effects of nutrition with large lipid globules comprising milk fat and vegetable fat |
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