HRP20160923T1 - Oslobađanje amlikona višestrukom (multiplex) lančanom reakcijom polimeraze za umnožavanje više ciljeva - Google Patents
Oslobađanje amlikona višestrukom (multiplex) lančanom reakcijom polimeraze za umnožavanje više ciljeva Download PDFInfo
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- HRP20160923T1 HRP20160923T1 HRP20160923TT HRP20160923T HRP20160923T1 HR P20160923 T1 HRP20160923 T1 HR P20160923T1 HR P20160923T T HRP20160923T T HR P20160923TT HR P20160923 T HRP20160923 T HR P20160923T HR P20160923 T1 HRP20160923 T1 HR P20160923T1
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- Prior art keywords
- seq
- amplification
- nucleic acids
- target
- target nucleic
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Links
- 108091093088 Amplicon Proteins 0.000 title claims 8
- 238000007403 mPCR Methods 0.000 title claims 2
- 230000003321 amplification Effects 0.000 claims 9
- 238000003199 nucleic acid amplification method Methods 0.000 claims 9
- 108020004707 nucleic acids Proteins 0.000 claims 8
- 150000007523 nucleic acids Chemical class 0.000 claims 8
- 102000039446 nucleic acids Human genes 0.000 claims 8
- 238000000034 method Methods 0.000 claims 7
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 230000002538 fungal effect Effects 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 238000003752 polymerase chain reaction Methods 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Claims (7)
1. Postupak višestruke (multiplex) lančane reakcije polimeraze (PCR) koji obuhvaća:
umnožavanje više ciljnih nukleinskih kiselina pomoću ciljno-specifičnih ugniježdenih (engl. nested) parova početnica koji obuhvaćaju nizvodnu (engl. forward) vanjsku, nizvodnu unutarnju, reverznu unutarnju i reverznu vanjsku početnicu za svaki cilj u prvoj reakciji umnožavanja, gdje je koncentracija ugniježdene početnice 100-1000nM, i gdje barem jedna od navedenih unutarnjih početnica ima dodatne nukleotide koji omogućavaju dodatnu sekvencu koja nije specifična za ciljne nukleinske kiseline tako da će umnožavanje ciljnih nukleinskih kiselina takvom početnicom također u dobiveni amplikon uključiti vezno mjesto za zajedničku početnicu koja se, za razliku od ciljno-specifičnih početnica, može koristiti za daljnje umnožavanje nesrodnih amplikona ciljnih nukleinskih kiselina, čime se dobiva barem jedan amplikon nukleinske kiseline koji sadrži barem jedno vezno mjesto zajedničke početnice;
odvajanje barem jednog amplikona nukleinske kiseline od barem dijela početnica iz prvog umnožavanja; i
umnožavanje barem jednog amplikona nukleinske kiseline u drugoj reakciji umnožavanja pomoću barem jedne zajedničke početnice koja se veže za barem jedno vezno mjesto zajedničke početnice.
2. Postupak prema zahtjevu 1 gdje se jedna ili više ciljnih nukleinskih kiselina odabire iz skupine koju čine virusne, bakterijske i gljivične nukleinske kiseline.
3. Postupak prema zahtjevu 1 ili zahtjevu 2 gdje se jedna ili više ciljnih nukleinskih kiselina dobiva iz ljudskog kliničkog uzorka.
4. Postupak prema zahtjevu 1 ili zahtjevu 2 gdje se jedna ili više ciljnih nukleinskih kiselina dobiva iz životinjskog kliničkog uzorka.
5. Postupak prema bilo kojem od zahtjeva 1 do 4 gdje se barem jedna zajednička početnica odabire iz skupine koju čine SEQ ID NO: 1 (identifikacijski broj sekvence), SEQ ID NO: 2 i njihove kombinacije.
6. Postupak prema bilo kojem od zahtjeva 1 do 5 gdje korak odvajanja barem jednog amplikona nukleinske kiseline od barem dijela početnica iz prvog umnožavana dalje obuhvaća uzimanje malog uzorka iz dovršenog umnožavanja u prvom reakcijskom sustavu da se dobiju amplikoni za drugo umnožavanje u drugom reakcijskom sustavu.
7. Postupak prema bilo kojem od zahtjeva 1 do 6 gdje se ciljno-specifične početnice odabiru iz skupine koju čine SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 8, SEQ ID NO: 9, SEQ ID NO: 10, SEQ ID NO: 11, SEQ ID NO: 13, SEQ ID NO: 14, SEQ ID NO: 15, SEQ ID NO: 16, SEQ ID NO:18, SEQ ID NO: 19, SEQ ID NO: 20, SEQ ID NO: 21, SEQ ID NO: 23, SEQ ID NO: 24, SEQ ID NO: 25, SEQ ID NO: 26, SEQ ID NO: 28, SEQ ID NO: 29, SEQ ID NO: 30, SEQ ID NO: 31, SEQ ID NO: 33, SEQ ID NO: 34, SEQ ID NO: 35, SEQ ID NO: 36, SEQ ID NO: 38, SEQ ID NO: 39, SEQ ID NO: 40, SEQ ID NO: 41. SEQ ID NO: 43, SEQ ID NO: 44, SEQ ID NO: 45, SEQ ID NO: 46, SEQ ID NO: 48, SEQ ID NO: 49, SEQ ID NO: 50, SEQ ID NO:51, SEQ ID NO: 53, SEQ ID NO: 54, SEQ ID NO: 55, SEQ ID NO: 56, SEQ ID NO: 58, SEQ ID NO: 59, SEQ ID NO: 60, SEQ ID NO: 61, SEQ ID NO: 63, SEQ ID NO: 64, SEQ ID NO: 65, SEQ ID NO: 66, SEQ ID NO: 68, SEQ ID NO: 69, SEQ ID NO: 70, SEQ ID NO: 71, SEQ ID NO: 73, SEQ ID NO: 74, SEQ ID NO: 75, SEQ ID NO: 76, SEQ ID NO: 78, SEQ ID NO: 79, SEQ ID NO: 80, SEQ ID NO: 81, SEQ ID NO: 83, SEQ ID NO: 84, SEQ ID NO:85, SEQ ID NO: 86, SEQ ID NO: 88, SEQ ID NO: 89, SEQ ID NO: 90, SEQ ID NO: 91, i njihove kombinacije.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4225908P | 2008-04-03 | 2008-04-03 | |
| EP09727817.0A EP2271767B1 (en) | 2008-04-03 | 2009-04-03 | Amplicon rescue multiplex polymerase chain reaction for amplificaton of multiple targets |
| PCT/US2009/039552 WO2009124293A1 (en) | 2008-04-03 | 2009-04-03 | Amplicon rescue multiplex polymerase chain reaction for amplificaton of multiple targets |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20160923T1 true HRP20160923T1 (hr) | 2016-10-21 |
Family
ID=41133627
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20160923TT HRP20160923T1 (hr) | 2008-04-03 | 2016-07-21 | Oslobađanje amlikona višestrukom (multiplex) lančanom reakcijom polimeraze za umnožavanje više ciljeva |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US7999092B2 (hr) |
| EP (1) | EP2271767B1 (hr) |
| JP (2) | JP5811483B2 (hr) |
| CN (3) | CN104928335A (hr) |
| AU (1) | AU2009231582B2 (hr) |
| BR (1) | BRPI0911082A2 (hr) |
| CY (1) | CY1117891T1 (hr) |
| DK (1) | DK2271767T3 (hr) |
| ES (1) | ES2586457T3 (hr) |
| HK (1) | HK1245846A1 (hr) |
| HR (1) | HRP20160923T1 (hr) |
| HU (1) | HUE029914T2 (hr) |
| LT (1) | LT2271767T (hr) |
| PL (1) | PL2271767T3 (hr) |
| PT (1) | PT2271767T (hr) |
| SI (1) | SI2271767T1 (hr) |
| WO (1) | WO2009124293A1 (hr) |
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2009
- 2009-04-03 PL PL09727817T patent/PL2271767T3/pl unknown
- 2009-04-03 PT PT97278170T patent/PT2271767T/pt unknown
- 2009-04-03 CN CN201510250072.6A patent/CN104928335A/zh active Pending
- 2009-04-03 ES ES09727817.0T patent/ES2586457T3/es active Active
- 2009-04-03 CN CN2009801189681A patent/CN102066573A/zh active Pending
- 2009-04-03 JP JP2011503231A patent/JP5811483B2/ja active Active
- 2009-04-03 BR BRPI0911082-8A patent/BRPI0911082A2/pt not_active Application Discontinuation
- 2009-04-03 EP EP09727817.0A patent/EP2271767B1/en active Active
- 2009-04-03 CN CN201710627329.4A patent/CN107385040B/zh active Active
- 2009-04-03 WO PCT/US2009/039552 patent/WO2009124293A1/en active Application Filing
- 2009-04-03 HU HUE09727817A patent/HUE029914T2/en unknown
- 2009-04-03 LT LTEP09727817.0T patent/LT2271767T/lt unknown
- 2009-04-03 SI SI200931497A patent/SI2271767T1/sl unknown
- 2009-04-03 US US12/418,532 patent/US7999092B2/en active Active
- 2009-04-03 DK DK09727817.0T patent/DK2271767T3/en active
- 2009-04-03 AU AU2009231582A patent/AU2009231582B2/en active Active
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2011
- 2011-08-15 US US13/210,331 patent/US20120171725A1/en not_active Abandoned
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2015
- 2015-09-04 JP JP2015174617A patent/JP2016013133A/ja active Pending
-
2016
- 2016-07-21 HR HRP20160923TT patent/HRP20160923T1/hr unknown
- 2016-08-09 CY CY20161100781T patent/CY1117891T1/el unknown
-
2018
- 2018-04-19 HK HK18105098.0A patent/HK1245846A1/zh unknown
-
2022
- 2022-04-28 US US17/732,384 patent/US20220251618A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20220251618A1 (en) | 2022-08-11 |
| DK2271767T3 (en) | 2016-08-29 |
| WO2009124293A1 (en) | 2009-10-08 |
| HUE029914T2 (en) | 2017-04-28 |
| EP2271767B1 (en) | 2016-06-29 |
| US20090253183A1 (en) | 2009-10-08 |
| PT2271767T (pt) | 2016-08-18 |
| LT2271767T (lt) | 2016-09-26 |
| CN107385040B (zh) | 2022-02-15 |
| JP2016013133A (ja) | 2016-01-28 |
| AU2009231582A1 (en) | 2009-10-08 |
| CN104928335A (zh) | 2015-09-23 |
| AU2009231582B2 (en) | 2015-02-26 |
| CN107385040A (zh) | 2017-11-24 |
| US7999092B2 (en) | 2011-08-16 |
| EP2271767A4 (en) | 2011-08-24 |
| BRPI0911082A2 (pt) | 2015-08-04 |
| EP2271767A1 (en) | 2011-01-12 |
| CY1117891T1 (el) | 2017-05-17 |
| US20120171725A1 (en) | 2012-07-05 |
| JP2011516069A (ja) | 2011-05-26 |
| JP5811483B2 (ja) | 2015-11-11 |
| HK1245846A1 (zh) | 2018-08-31 |
| CN102066573A (zh) | 2011-05-18 |
| SI2271767T1 (sl) | 2016-12-30 |
| PL2271767T3 (pl) | 2017-01-31 |
| ES2586457T3 (es) | 2016-10-14 |
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