HRP20150758T1 - Kimeriäśni vlp ptiäśje gripe - Google Patents

Kimeriäśni vlp ptiäśje gripe Download PDF

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Publication number
HRP20150758T1
HRP20150758T1 HRP20150758TT HRP20150758T HRP20150758T1 HR P20150758 T1 HRP20150758 T1 HR P20150758T1 HR P20150758T T HRP20150758T T HR P20150758TT HR P20150758 T HRP20150758 T HR P20150758T HR P20150758 T1 HRP20150758 T1 HR P20150758T1
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Croatia
Prior art keywords
cell
protein
influenza
host cell
avian influenza
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HRP20150758TT
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English (en)
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Gale Smith
Peter Pushko
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Novavax, Inc.
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Publication of HRP20150758T1 publication Critical patent/HRP20150758T1/hr

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Claims (6)

1. Postupak povećanja učinkovitosti proizvodnje čestica nalik na virus gripe („virus-like particle“ - VLP) u stanici domaćina, naznačen time, da obuhvaća ekspresiju proteinske matrice ptičje gripe (M1) te proteina hemagglutinina (HA) i proteina neuraminidaze (NA) sezonske ljudske gripe u stanici domaćina, pri čemu M1-protein ptičje gripe je M1-protein gripe A/Indonezija/5/05 i gdje je navedeno povećanje učinkovitosti VLP-proizvodnje u relaciji sa stanicom domaćina koja eksprimira navedene HA-proteine i NA-proteine s M1-proteinom sezonske gripe.
2. Postupak prema zahtjevu 1, naznačen time, da HA-protein gripe ima djelotvornost hemagglutinina.
3. Postupak prema zahtjevu 1, naznačen time, da NA-protein gripe ima djelotvornost neuraminidaze.
4. Postupak prema zahtjevu 1, naznačen time, da je stanica domaćina odabrana iz skupine koju čine: stanica kvasca, stanica kukca, stanica amfibije, ptičja stanica i stanica sisavca.
5. Postupak prema zahtjevu 4, naznačen time, da stanica domaćina je stanica kukca odabrana iz skupine koju čine: Sf9-stanica, Sf21-stanica i stanica Trichoplusia ni.
6. Postupak prema zahtjevu 5, naznačen time, da stanica kukca je Sf9-stanica.
HRP20150758TT 2007-07-19 2015-07-09 Kimeriäśni vlp ptiäśje gripe HRP20150758T1 (hr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US95070707P 2007-07-19 2007-07-19
US97059207P 2007-09-07 2007-09-07
US7183508P 2008-05-20 2008-05-20
EP20120185712 EP2540312B1 (en) 2007-07-19 2008-07-21 Avian influenza chimeric VLPS

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HRP20150758T1 true HRP20150758T1 (hr) 2015-08-14

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US (1) US20110008838A1 (hr)
EP (3) EP2176427A4 (hr)
JP (1) JP2010533737A (hr)
CN (1) CN101801411A (hr)
CA (1) CA2693899A1 (hr)
CY (1) CY1116583T1 (hr)
DK (1) DK2540312T3 (hr)
ES (1) ES2542644T3 (hr)
HR (1) HRP20150758T1 (hr)
HU (1) HUE025702T2 (hr)
PL (1) PL2540312T3 (hr)
PT (1) PT2540312E (hr)
SI (1) SI2540312T1 (hr)
WO (2) WO2009012489A1 (hr)

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US20120064115A1 (en) * 2009-05-01 2012-03-15 Corinne John Recombinant virus-like particles encoded by multi-gene vector
PL222497B1 (pl) 2009-06-26 2016-08-31 Inst Biochemii I Biofizyki Pan Wektorowa cząsteczka wirusopodobna, sposób jej wytwarzania, kompozycja farmaceutyczna oraz zastosowanie wektorowej cząsteczki wirusopodobnej
AU2010266129B2 (en) 2009-07-02 2016-04-14 Massachusetts Institute Of Technology Compositions and methods for diagnosing and/or treating influenza infection
CA2792537A1 (en) 2010-03-30 2011-10-06 Mount Sinai School Of Medicine Influenza virus vaccines and uses thereof
JP2013541528A (ja) 2010-09-21 2013-11-14 マサチューセッツ インスティテュート オブ テクノロジー ヒト適応ｈａポリペプチド、ワクチン、およびインフルエンザの処置
CA2813078A1 (en) 2010-10-04 2012-04-12 Massachusetts Institute Of Technology Hemagglutinin polypeptides, and reagents and methods relating thereto
TWI526539B (zh) 2010-12-22 2016-03-21 苜蓿股份有限公司 植物中生產類病毒顆粒(vlp)的方法及以該方法生產之vlp
KR20140007404A (ko) * 2011-01-31 2014-01-17 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 신규 허피스 항원을 암호화하는 핵산 분자, 이것을 포함하는 백신 및 이것의 사용 방법
EA201490659A1 (ru) 2011-09-20 2014-11-28 Маунт Синай Скул Оф Медсин Вакцины против вируса гриппа и их применения
CA2849471A1 (en) * 2011-09-30 2013-04-04 Novavax, Inc. Recombinant nanoparticle rsv f vaccine for respiratory syncytial virus
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