BRPI1015053A2 - partículas similares a vírus da influenza quiméricas compreendendo hemaglutinina - Google Patents

partículas similares a vírus da influenza quiméricas compreendendo hemaglutinina

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Publication number
BRPI1015053A2
BRPI1015053A2 BRPI1015053A BRPI1015053A BRPI1015053A2 BR PI1015053 A2 BRPI1015053 A2 BR PI1015053A2 BR PI1015053 A BRPI1015053 A BR PI1015053A BR PI1015053 A BRPI1015053 A BR PI1015053A BR PI1015053 A2 BRPI1015053 A2 BR PI1015053A2
Authority
BR
Brazil
Prior art keywords
chimeric influenza
plant
particles
influenza virus
hemagglutinin
Prior art date
Application number
BRPI1015053A
Other languages
English (en)
Inventor
Vezina Louis-Philippe
Couture Manon
D'aoust Marc-Andre
Dargis Michele
Lavoie Pierre-Olivier
Original Assignee
Medicago Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medicago Inc filed Critical Medicago Inc
Publication of BRPI1015053A2 publication Critical patent/BRPI1015053A2/pt

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16123—Virus like particles [VLP]
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16211—Influenzavirus B, i.e. influenza B virus
    • C12N2760/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16211—Influenzavirus B, i.e. influenza B virus
    • C12N2760/16223—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16211—Influenzavirus B, i.e. influenza B virus
    • C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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Abstract

"partículas similares a vírus da influenza quiméricas compreendendo hemaglutinina". a presente invenção refere-se a um método para sintetização de partículas similares a vírus da influenza quiméricas (vlps) dentro de uma planta ou uma porção de uma planta. o método envolve expressão de ha de influenza quimérica em uma planta ou uma porção de uma planta. a invenção é também direcionada a uma vlp compreendendo proteína de ha de influenza quimérica e lipídeos de plantas. a invenção é também direcionada a um ácido nucleico que codifica ha de influenza quimérica, bem como vetores. as vlps podem ser usadas para formular vacinas da influenza, ou podem ser usadas para enriquecer as vacinas existentes.
BRPI1015053A 2009-06-24 2010-06-25 partículas similares a vírus da influenza quiméricas compreendendo hemaglutinina BRPI1015053A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22016109P 2009-06-24 2009-06-24
PCT/CA2010/000983 WO2010148511A1 (en) 2009-06-24 2010-06-25 Chimeric influenza virus-like particles comprising hemagglutinin

Publications (1)

Publication Number Publication Date
BRPI1015053A2 true BRPI1015053A2 (pt) 2019-07-09

Family

ID=43385835

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1015053A BRPI1015053A2 (pt) 2009-06-24 2010-06-25 partículas similares a vírus da influenza quiméricas compreendendo hemaglutinina

Country Status (25)

Country Link
US (1) US10272148B2 (pt)
EP (2) EP3228627A1 (pt)
JP (2) JP5871796B2 (pt)
KR (1) KR101377725B1 (pt)
CN (1) CN102482328B (pt)
AU (1) AU2010265766B2 (pt)
BR (1) BRPI1015053A2 (pt)
CA (1) CA2762042C (pt)
DK (1) DK2445928T3 (pt)
ES (1) ES2669303T3 (pt)
HK (2) HK1170250A1 (pt)
HR (1) HRP20180706T1 (pt)
HU (1) HUE039100T2 (pt)
IL (1) IL216937A (pt)
IN (1) IN2012DN00650A (pt)
MX (1) MX349924B (pt)
MY (1) MY182643A (pt)
NO (1) NO2445928T3 (pt)
NZ (1) NZ597401A (pt)
PL (1) PL2445928T3 (pt)
PT (1) PT2445928T (pt)
SG (1) SG176820A1 (pt)
SI (1) SI2445928T1 (pt)
WO (1) WO2010148511A1 (pt)
ZA (1) ZA201200481B (pt)

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