HRP20110697T1 - Uporaba flibanserina za liječenje poremećaja seksualne želje u pre-menopauzi - Google Patents
Uporaba flibanserina za liječenje poremećaja seksualne želje u pre-menopauzi Download PDFInfo
- Publication number
- HRP20110697T1 HRP20110697T1 HR20110697T HRP20110697T HRP20110697T1 HR P20110697 T1 HRP20110697 T1 HR P20110697T1 HR 20110697 T HR20110697 T HR 20110697T HR P20110697 T HRP20110697 T HR P20110697T HR P20110697 T1 HRP20110697 T1 HR P20110697T1
- Authority
- HR
- Croatia
- Prior art keywords
- sexual desire
- menopause
- acid
- disorders
- flibanserin
- Prior art date
Links
- PPRRDFIXUUSXRA-UHFFFAOYSA-N flibanserin Chemical compound FC(F)(F)C1=CC=CC(N2CCN(CCN3C(NC4=CC=CC=C43)=O)CC2)=C1 PPRRDFIXUUSXRA-UHFFFAOYSA-N 0.000 title claims abstract 8
- 229960002053 flibanserin Drugs 0.000 title claims abstract 8
- 208000030047 Sexual desire disease Diseases 0.000 title claims abstract 7
- 239000002253 acid Substances 0.000 claims abstract 5
- 239000003814 drug Substances 0.000 claims abstract 4
- 239000012458 free base Substances 0.000 claims abstract 4
- 150000003839 salts Chemical class 0.000 claims abstract 4
- 229940079593 drug Drugs 0.000 claims abstract 2
- 150000004677 hydrates Chemical class 0.000 claims abstract 2
- 239000012453 solvate Substances 0.000 claims abstract 2
- 230000009245 menopause Effects 0.000 claims 12
- 230000035946 sexual desire Effects 0.000 claims 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 208000035475 disorder Diseases 0.000 claims 6
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- 208000006262 Psychological Sexual Dysfunctions Diseases 0.000 claims 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims 2
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims 1
- 206010011953 Decreased activity Diseases 0.000 claims 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 1
- 208000021663 Female sexual arousal disease Diseases 0.000 claims 1
- 206010024419 Libido decreased Diseases 0.000 claims 1
- 208000030663 Libido disease Diseases 0.000 claims 1
- 206010024870 Loss of libido Diseases 0.000 claims 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims 1
- 208000029899 Sexual aversion disease Diseases 0.000 claims 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 1
- SXDBWCPKPHAZSM-UHFFFAOYSA-N bromic acid Chemical compound OBr(=O)=O SXDBWCPKPHAZSM-UHFFFAOYSA-N 0.000 claims 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 claims 1
- 235000019253 formic acid Nutrition 0.000 claims 1
- 208000017020 hypoactive sexual desire disease Diseases 0.000 claims 1
- 239000004310 lactic acid Substances 0.000 claims 1
- 235000014655 lactic acid Nutrition 0.000 claims 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 1
- 239000011976 maleic acid Substances 0.000 claims 1
- 230000008018 melting Effects 0.000 claims 1
- 238000002844 melting Methods 0.000 claims 1
- 229940098779 methanesulfonic acid Drugs 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000011975 tartaric acid Substances 0.000 claims 1
- 235000002906 tartaric acid Nutrition 0.000 claims 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Uporaba, naznačena time, da se koristi flibanserin, po izboru u obliku slobodne baze, farmakološki prihvatljivih kiselinskih adicijskih soli i/ili po izboru u obliku svojih hidrata i/ili solvata za izradu lijeka za liječenje poremećaja seksualne želje u pre-menopauzi kod žena, pri čemu se lijek primjenjuje jednom dnevno uzastopno tijekom određenog vremenskog razdoblja. Patent sadrži još 13 patentnih zahtjeva.
Claims (14)
1. Uporaba, naznačena time, da se koristi flibanserin, po izboru u obliku slobodne baze, farmakološki prihvatljivih kiselinskih adicijskih soli i/ili po izboru u obliku svojih hidrata i/ili solvata za izradu lijeka za liječenje poremećaja seksualne želje u pre-menopauzi kod žena, pri čemu se lijek primjenjuje jednom dnevno uzastopno tijekom određenog vremenskog razdoblja.
2. Uporaba u skladu sa zahtjevom 1, naznačena time, da je poremećaj seksualne želje u pre-menopauzi izabran iz skupine koju čine poremećaj hipoaktivne seksualne želje u pre-menopauzi, poremećaj seksualne averzije u pre-menopauzi, gubitak seksualne želje u pre-menopauzi, manjak seksualne želje u pre-menopauzi, smanjena seksualna želja u pre-menopauzi, inhibirana seksualna želja u pre-menopauzi, gubitak libida u pre-menopauzi, poremećaj libida u pre-menopauzi i frigidnost u pre-menopauzi-
3. Uporaba u skladu sa zahtjevom 1, naznačena time, da poremećaj seksualne želje u pre-menopauzi je poremećaj hipoaktivne seksualne želje u pre-menopauzi.
4. Uporaba u skladu sa zahtjevom 1, 2 ili 3, naznačena time, da poremećaji seksualne želje u pre-menopauzi su cjeloživotnog tipa.
5. Uporaba u skladu sa zahtjevom 1, 2 ili 3, naznačena time, da poremećaji seksualne želje u pre-menopauzi su stečenog tipa.
6. Uporaba u skladu s jednim ili više prethodnih zahtjeva, naznačena time, da poremećaji seksualne želje u pre-menopauzi su općeg subtipa.
7. Uporaba u skladu s jednim ili više prethodnih zahtjeva, naznačena time, da poremećaji seksualne želje u pre-menopauzi su situacijskog subtipa.
8. Uporaba u skladu s jednim ili više prethodnih zahtjeva, naznačena time, da poremećaji seksualne želje u pre-menopauzi su zbog psiholoških faktora.
9. Uporaba u skladu s jednim ili više prethodnih zahtjeva, naznačena time, da poremećaji seksualne želje u pre-menopauzi su zbog organskih faktora.
10. Uporaba u skladu s jednim ili više prethodnih zahtjeva, naznačena time, da poremećaji seksualne želje u pre-menopauzi su zbog spojenih faktora.
11. Uporaba u skladu s jednim ili više prethodnih zahtjeva, naznačena time, da se flibanserin primjenjuje u obliku farmaceutski prihvatljive kiselinske adicijske soli izabrane između soli formiranih pomoću kiselina izabranih iz skupine koju čine sukcinska kiselina, bromidna kiselina, octena kiselina, mravlja kiselina, maleinska kiselina, metansulfonska kiselina, mliječna kiselina, fosforna kiselina, kloridna kiselina, sumporna kiselina, vinska kiselina, limunska kiselina i njihove mješavine.
12. Uporaba u skladu s jednim ili više prethodnih zahtjeva, naznačena time, da se flibanserin primjenjuje u obliku svoje slobodne baze.
13. Uporaba u skladu sa zahtjevom 12, naznačena time, da se flibanserin primjenjuje u obliku polimorfa A slobodne baze koji ima točku tališta na oko 161 °C izmjerenu uporabom DSC.
14. Uporaba u skladu s jednim ili više prethodnih zahtjeva, naznačena time, da se flibanserin primjenjuje isključivo jednom navečer (50 ili 100 mg flibanserina) uzastopno tijekom određenog vremenskog razdoblja.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73440505P | 2005-11-08 | 2005-11-08 | |
US83101506P | 2006-07-14 | 2006-07-14 | |
PCT/EP2006/068118 WO2007054476A1 (en) | 2005-11-08 | 2006-11-06 | Use of flibanserin for the treatment of pre-menopausal sexual desire disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20110697T1 true HRP20110697T1 (hr) | 2011-10-31 |
Family
ID=37807895
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20110697T HRP20110697T1 (hr) | 2005-11-08 | 2011-09-29 | Uporaba flibanserina za liječenje poremećaja seksualne želje u pre-menopauzi |
Country Status (30)
Country | Link |
---|---|
US (4) | US20070105869A1 (hr) |
EP (1) | EP1948177B1 (hr) |
JP (2) | JP5386173B2 (hr) |
KR (2) | KR101436793B1 (hr) |
CN (1) | CN103251598A (hr) |
AR (1) | AR059390A1 (hr) |
AT (1) | ATE521352T1 (hr) |
AU (1) | AU2006311038B2 (hr) |
BR (1) | BRPI0618239A8 (hr) |
CA (1) | CA2626797C (hr) |
CY (1) | CY1112067T1 (hr) |
DK (1) | DK1948177T3 (hr) |
EA (1) | EA014189B1 (hr) |
EC (1) | ECSP088504A (hr) |
ES (1) | ES2372421T3 (hr) |
HR (1) | HRP20110697T1 (hr) |
IL (1) | IL191245A0 (hr) |
MY (1) | MY145439A (hr) |
NO (1) | NO20081527L (hr) |
NZ (1) | NZ568822A (hr) |
PE (1) | PE20070800A1 (hr) |
PL (1) | PL1948177T3 (hr) |
PT (1) | PT1948177E (hr) |
RS (1) | RS51961B (hr) |
SG (1) | SG166820A1 (hr) |
SI (1) | SI1948177T1 (hr) |
TW (1) | TWI389689B (hr) |
UY (1) | UY29899A1 (hr) |
WO (1) | WO2007054476A1 (hr) |
ZA (1) | ZA200802542B (hr) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7183410B2 (en) * | 2001-08-02 | 2007-02-27 | Bidachem S.P.A. | Stable polymorph of flibanserin |
US20030060475A1 (en) * | 2001-08-10 | 2003-03-27 | Boehringer Ingelheim Pharma Kg | Method of using flibanserin for neuroprotection |
US10675280B2 (en) | 2001-10-20 | 2020-06-09 | Sprout Pharmaceuticals, Inc. | Treating sexual desire disorders with flibanserin |
UA78974C2 (en) | 2001-10-20 | 2007-05-10 | Boehringer Ingelheim Pharma | Use of flibanserin for treating disorders of sexual desire |
US20040048877A1 (en) * | 2002-05-22 | 2004-03-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmaceutical compositions containing flibanserin |
CA2563743A1 (en) * | 2004-04-22 | 2005-11-03 | Boehringer Ingelheim International Gmbh | New pharmaceutical compositions for the treatment of sexual disorders ii |
US20050239798A1 (en) * | 2004-04-22 | 2005-10-27 | Boehringer Ingelheim Pharmaceuticals, Inc. | Method for the treatment of premenstrual and other female sexual disorders |
US20060025420A1 (en) * | 2004-07-30 | 2006-02-02 | Boehringer Ingelheimn International GmbH | Pharmaceutical compositions for the treatment of female sexual disorders |
WO2006024471A1 (en) * | 2004-09-03 | 2006-03-09 | Boehringer Ingelheim International Gmbh | Method for the treatment of attention deficit hyperactivity disorder |
US20060211685A1 (en) * | 2005-03-04 | 2006-09-21 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for the treatment and/or prevention of depression |
WO2006096439A2 (en) * | 2005-03-04 | 2006-09-14 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for the treatment and/or prevention of schizophrenia and related diseases |
EP1858515A2 (en) * | 2005-03-04 | 2007-11-28 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for the treatment and/or prevention of anxiety disorders |
JP2008540356A (ja) * | 2005-05-06 | 2008-11-20 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 薬物乱用の治療方法 |
US20060264511A1 (en) * | 2005-05-19 | 2006-11-23 | Boehringer Ingelheim International Gmbh | Method for the treatment of drug-induced sexual dysfunction |
CA2608713A1 (en) * | 2005-05-19 | 2006-11-23 | Boehringer Ingelheim International Gmbh | Method for the treatment of sexual dysfunctions due to medical conditions |
JP2009503020A (ja) | 2005-08-03 | 2009-01-29 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 肥満症の治療におけるフリバンセリンの使用 |
WO2007048803A1 (en) * | 2005-10-29 | 2007-05-03 | Boehringer Ingelheim International Gmbh | Benzimidazolone derivatives for the treatment of premenstrual and other female sexual disorders |
US20070123540A1 (en) * | 2005-10-29 | 2007-05-31 | Angelo Ceci | Sexual desire enhancing medicaments comprising benzimidazolone derivatives |
NZ573382A (en) * | 2006-05-09 | 2012-02-24 | Boehringer Ingelheim Int | Use of flibanserin for the treatment of post-menopausal sexual desire disorders |
EP2037927B1 (en) * | 2006-06-30 | 2010-01-27 | Boehringer Ingelheim International GmbH | Flibanserin for the treatment of urinary incontinence and related diseases |
WO2008006838A1 (en) * | 2006-07-14 | 2008-01-17 | Boehringer Ingelheim International Gmbh | Use of flibanserin for the treatment of sexual disorders in females |
BRPI0716439B8 (pt) * | 2006-08-14 | 2021-05-25 | Boehringer Ingelheim Int | sistemas de liberação farmacêutico compreendendo flibanserina, processo para preparação e uso dos mesmos |
CL2007002214A1 (es) * | 2006-08-14 | 2008-03-07 | Boehringer Ingelheim Int | Composicion farmaceutica en la forma de comprimido, donde al menos la longitud del comprimido en el estado anterior de la aplicacion es al menos 7/12 del diametro pilorico del paciente y despues de ingerirlo en estado alimentado, la longitud del comp |
MX2009002031A (es) * | 2006-08-25 | 2009-03-06 | Boehringer Ingelheim Int | Sistema de liberacion controlada y metodo para fabricarlo. |
JP2010513390A (ja) | 2006-12-20 | 2010-04-30 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 混合セロトニン受容体親和性を有する硫酸化ベンズイミダゾロン誘導体 |
WO2008090742A1 (ja) * | 2007-01-23 | 2008-07-31 | National University Corporation Hokkaido University | 眼疾患モデル用非ヒト動物 |
CL2008002693A1 (es) * | 2007-09-12 | 2009-10-16 | Boehringer Ingelheim Int | Uso de flibanserina para el tratamiento de sintomas vasomotores seleccionados de sofocos, sudores nocturnos, cambios de estado de animo e irritabilidad |
WO2017055935A1 (en) * | 2015-09-30 | 2017-04-06 | Symed Labs Limited | Amorphous co-precipitates of flibanserin |
US20170369475A1 (en) * | 2016-06-23 | 2017-12-28 | Sandoz Ag | Flibanserin Hydrate |
US20230038035A1 (en) * | 2021-08-09 | 2023-02-09 | Globalwafers Co., Ltd. | Ingot jig assembly and ingot edge-polishing machine tool |
Family Cites Families (84)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3096248A (en) * | 1959-04-06 | 1963-07-02 | Rexall Drug & Chemical Company | Method of making an encapsulated tablet |
US3406178A (en) * | 1964-02-04 | 1968-10-15 | Monsanto Chem Australia Ltd | Preparation of 2-substituted benzimidazoles |
US3362956A (en) * | 1965-08-19 | 1968-01-09 | Sterling Drug Inc | 1-[(heterocyclyl)-lower-alkyl]-4-substituted-piperazines |
US4200641A (en) * | 1976-12-21 | 1980-04-29 | Janssen Pharmaceutica, N.V. | 1-[(Heterocyclyl)-alkyl]-4-diarylmethoxy piperidine derivatives |
DE3000979A1 (de) * | 1980-01-12 | 1981-07-23 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue dipyridamol-retardformen und verfahren zu ihrer herstellung |
IT1176613B (it) * | 1984-08-14 | 1987-08-18 | Ravizza Spa | Derivati piperazinici farmacologicamente attivi e processo per la loro preparazione |
GB8607294D0 (en) * | 1985-04-17 | 1986-04-30 | Ici America Inc | Heterocyclic amide derivatives |
HUT43600A (en) * | 1985-06-22 | 1987-11-30 | Sandoz Ag | Process for production of new thiazole derivatives and medical compound containing those |
GB8601160D0 (en) * | 1986-01-17 | 1986-02-19 | Fujisawa Pharmaceutical Co | Heterocyclic compounds |
US5036088A (en) * | 1986-06-09 | 1991-07-30 | Pfizer Inc. | Antiallergy and antiinflammatory agents, compositions and use |
JPH0784462B2 (ja) * | 1986-07-25 | 1995-09-13 | 日清製粉株式会社 | ベンゾイミダゾ−ル誘導体 |
US4968508A (en) * | 1987-02-27 | 1990-11-06 | Eli Lilly And Company | Sustained release matrix |
US4792452A (en) * | 1987-07-28 | 1988-12-20 | E. R. Squibb & Sons, Inc. | Controlled release formulation |
GB8830312D0 (en) * | 1988-12-28 | 1989-02-22 | Lundbeck & Co As H | Heterocyclic compounds |
US4954503A (en) * | 1989-09-11 | 1990-09-04 | Hoechst-Roussel Pharmaceuticals, Inc. | 3-(1-substituted-4-piperazinyl)-1H-indazoles |
NZ241613A (en) * | 1991-02-27 | 1993-06-25 | Janssen Pharmaceutica Nv | Highlighting intagliations in tablets |
SE9100860D0 (sv) * | 1991-03-22 | 1991-03-22 | Kabi Pharmacia Ab | New use |
IT1251144B (it) * | 1991-07-30 | 1995-05-04 | Boehringer Ingelheim Italia | Derivati del benzimidazolone |
US5407686A (en) * | 1991-11-27 | 1995-04-18 | Sidmak Laboratories, Inc. | Sustained release composition for oral administration of active ingredient |
US5225417A (en) * | 1992-01-21 | 1993-07-06 | G. D. Searle & Co. | Opioid agonist compounds |
US5492907A (en) * | 1992-12-09 | 1996-02-20 | The United States Of America As Represented By The Department Of Health & Human Services | Antipsychotic composition and method of treatment |
FR2707294B1 (fr) * | 1993-07-06 | 1995-09-29 | Pf Medicament | Nouveaux dérivés de la 3,5-dioxo-(2H,4H)-1,2,4-triazine, leur préparation et leur application en thérapeutique humaine. |
FR2727682A1 (fr) * | 1994-12-02 | 1996-06-07 | Pf Medicament | Nouveaux derives de 3,5-dioxo-(2h,4h)-1,2,4-triazines, leur preparation et leur application a titre de medicament |
US5552412A (en) * | 1995-01-09 | 1996-09-03 | Pfizer Inc | 5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen2-ol compounds which are useful for treating osteoporosis |
US5883094A (en) * | 1995-04-24 | 1999-03-16 | Pfizer Inc. | Benzimidazolone derivatives with central dopaminergic activity |
US5854290A (en) * | 1995-09-21 | 1998-12-29 | Amy F. T. Arnsten | Use of guanfacine in the treatment of behavioral disorders |
US6083947A (en) * | 1996-01-29 | 2000-07-04 | The Regents Of The University Of California | Method for treating sexual dysfunctions |
US5916916A (en) * | 1996-10-10 | 1999-06-29 | Eli Lilly And Company | 1-aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods |
CA2273351A1 (en) * | 1996-12-02 | 1998-06-11 | Merck Sharp & Dohme Limited | Use of nk-1 receptor antagonists for treating sexual dysfunction |
US20040023948A1 (en) * | 1997-03-24 | 2004-02-05 | Green Richard David | Fast-dispersing dosage form containing 5-HT1 agonists |
NZ503946A (en) * | 1997-06-11 | 2003-02-28 | Procter & Gamble | Oral dosage form in an oval or caplet shape for administration of bisphosphonates and other known medicaments |
ATE241341T1 (de) * | 1997-09-10 | 2003-06-15 | Takeda Chemical Industries Ltd | Stabilisierte pharmazeutische zusammensetzung |
JP3724157B2 (ja) * | 1997-10-30 | 2005-12-07 | コニカミノルタホールディングス株式会社 | 映像観察装置 |
FR2775188B1 (fr) * | 1998-02-23 | 2001-03-09 | Lipha | Forme galenique a liberation immediate ou liberation prolongee administrable par voie orale comprenant un agent promoteur d'absorption et utilisation de cet agent promoteur d'absorption |
US20020151543A1 (en) * | 1998-05-28 | 2002-10-17 | Sepracor Inc. | Compositions and methods employing R (-) fluoxetine and other active ingredients |
US6068846A (en) * | 1998-08-05 | 2000-05-30 | Melaleuca, Incorporated | Methods and materials for treating depression and mood disorder |
EP0982030A3 (en) * | 1998-08-17 | 2000-05-10 | Pfizer Products Inc. | 2,7-substituted octahydro-pyrrolo 1,2-a]pyrazine derivatives as 5ht 1a ligands |
US6680071B1 (en) * | 1999-03-03 | 2004-01-20 | R. P. Scherer Technologies, Inc. | Opioid agonist in a fast dispersing dosage form |
US6346548B1 (en) * | 1999-08-16 | 2002-02-12 | Cephalon, Inc. | Compositions including modafinil for treatment of attention deficit hyperactivity disorder and multiple sclerosis fatigue |
IT1313625B1 (it) * | 1999-09-22 | 2002-09-09 | Boehringer Ingelheim Italia | Derivati benzimidazolonici aventi affinita' mista per i recettori diserotonina e dopamina. |
CN1660435A (zh) * | 2000-02-24 | 2005-08-31 | 法玛西雅厄普约翰美国公司 | 新的药物联合形式 |
US6586435B2 (en) * | 2000-09-19 | 2003-07-01 | Boehringer Ingelheim Pharma Kg | Benzimidazolone derivatives displaying affinity at the serotonin and dopamine receptors |
US6521623B1 (en) * | 2000-09-19 | 2003-02-18 | Boehringer Ingelheim Pharma Kg | N,N'-disubstituted benzimidazolone derivatives with affinity at the serotonin and dopamine receptors |
DE60121301T2 (de) * | 2001-05-11 | 2007-07-19 | Beck, Jürgen, Dr. | Flibanserin zur Behandlung extrapyramidaler Bewegungsstörungen |
US6627646B2 (en) * | 2001-07-17 | 2003-09-30 | Sepracor Inc. | Norastemizole polymorphs |
US7183410B2 (en) * | 2001-08-02 | 2007-02-27 | Bidachem S.P.A. | Stable polymorph of flibanserin |
SI1414816T1 (en) * | 2001-08-02 | 2005-06-30 | Bidachem S.P.A. | Stable polymorph of flibanserin, technical process for its preparation and the use thereof for preparing medicaments |
US20030060475A1 (en) * | 2001-08-10 | 2003-03-27 | Boehringer Ingelheim Pharma Kg | Method of using flibanserin for neuroprotection |
HUP0202719A3 (en) * | 2001-08-21 | 2006-01-30 | Pfizer Prod Inc | Pharmaceutical compositions for the treatment of female sexual dysfunctions |
DE10149674A1 (de) * | 2001-10-09 | 2003-04-24 | Apogepha Arzneimittel Gmbh | Orale Darreichungsformen für Propiverin oder seinen pharmazeutisch annehmbaren Salzen mit verlängerter Wirkstoffreisetzung |
UA78974C2 (en) * | 2001-10-20 | 2007-05-10 | Boehringer Ingelheim Pharma | Use of flibanserin for treating disorders of sexual desire |
DE10209982A1 (de) * | 2002-03-07 | 2003-09-25 | Boehringer Ingelheim Pharma | Oral zu applizierende Darreichungsform für schwerlösliche basische Wirkstoffe |
US20040048877A1 (en) * | 2002-05-22 | 2004-03-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmaceutical compositions containing flibanserin |
EP1511489B1 (en) * | 2002-05-22 | 2011-03-02 | Boehringer Ingelheim Pharma GmbH & Co.KG | New pharmaceutical compositions containing flibanserin polymorph a |
US20040116532A1 (en) * | 2002-09-13 | 2004-06-17 | Craig Heacock | Pharmaceutical formulations of modafinil |
US20040132697A1 (en) * | 2002-11-06 | 2004-07-08 | Pfizer Inc. | Treatment of female sexual dysfunction |
US20040147581A1 (en) * | 2002-11-18 | 2004-07-29 | Pharmacia Corporation | Method of using a Cox-2 inhibitor and a 5-HT1A receptor modulator as a combination therapy |
WO2004063864A2 (en) * | 2003-01-06 | 2004-07-29 | Laura Berman | Method and system for computerized sexual function assessment of female users |
US20050004105A1 (en) * | 2003-01-29 | 2005-01-06 | Emer Leahy | Treatment for a attention-deficit hyperactivity disorder |
US20050037983A1 (en) * | 2003-03-11 | 2005-02-17 | Timothy Dinan | Compositions and methods for the treatment of depression and other affective disorders |
US20050065158A1 (en) * | 2003-07-16 | 2005-03-24 | Pfizer Inc. | Treatment of sexual dysfunction |
US20050239798A1 (en) * | 2004-04-22 | 2005-10-27 | Boehringer Ingelheim Pharmaceuticals, Inc. | Method for the treatment of premenstrual and other female sexual disorders |
CA2563743A1 (en) | 2004-04-22 | 2005-11-03 | Boehringer Ingelheim International Gmbh | New pharmaceutical compositions for the treatment of sexual disorders ii |
US20060014757A1 (en) * | 2004-07-14 | 2006-01-19 | Boehringer Ingelheim Pharmaceuticals | Method for the treatment of anorexia nervosa |
US20060025420A1 (en) * | 2004-07-30 | 2006-02-02 | Boehringer Ingelheimn International GmbH | Pharmaceutical compositions for the treatment of female sexual disorders |
WO2006024471A1 (en) * | 2004-09-03 | 2006-03-09 | Boehringer Ingelheim International Gmbh | Method for the treatment of attention deficit hyperactivity disorder |
WO2006096439A2 (en) * | 2005-03-04 | 2006-09-14 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for the treatment and/or prevention of schizophrenia and related diseases |
US20060211685A1 (en) * | 2005-03-04 | 2006-09-21 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for the treatment and/or prevention of depression |
EP1858515A2 (en) * | 2005-03-04 | 2007-11-28 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for the treatment and/or prevention of anxiety disorders |
JP2008540356A (ja) * | 2005-05-06 | 2008-11-20 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 薬物乱用の治療方法 |
US20060258640A1 (en) * | 2005-05-13 | 2006-11-16 | Boehringer Ingelheim International Gmbh | Use of Flibanserin in the treatment of chronic pain |
CA2608713A1 (en) * | 2005-05-19 | 2006-11-23 | Boehringer Ingelheim International Gmbh | Method for the treatment of sexual dysfunctions due to medical conditions |
US20060264511A1 (en) * | 2005-05-19 | 2006-11-23 | Boehringer Ingelheim International Gmbh | Method for the treatment of drug-induced sexual dysfunction |
JP2009503020A (ja) * | 2005-08-03 | 2009-01-29 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 肥満症の治療におけるフリバンセリンの使用 |
US20070123540A1 (en) * | 2005-10-29 | 2007-05-31 | Angelo Ceci | Sexual desire enhancing medicaments comprising benzimidazolone derivatives |
WO2007048803A1 (en) * | 2005-10-29 | 2007-05-03 | Boehringer Ingelheim International Gmbh | Benzimidazolone derivatives for the treatment of premenstrual and other female sexual disorders |
US20090023712A1 (en) * | 2006-02-18 | 2009-01-22 | Boehringer Ingelheim International Gmbh | Pharmaceutical Compositions for the Treatment of Attention Deficit Hyperactivity Disorder Comprising Flibanserin |
EP1988897A1 (en) * | 2006-02-20 | 2008-11-12 | Boehringer Ingelheim International GmbH | Benzimidazolone derivatives for the treatment of urinary incontinence |
CA2642368A1 (en) * | 2006-02-28 | 2007-09-07 | Boehringer Ingelheim International Gmbh | Treatment of prevention of valvular heart disease with flibanserin |
EP2037927B1 (en) * | 2006-06-30 | 2010-01-27 | Boehringer Ingelheim International GmbH | Flibanserin for the treatment of urinary incontinence and related diseases |
WO2008006838A1 (en) * | 2006-07-14 | 2008-01-17 | Boehringer Ingelheim International Gmbh | Use of flibanserin for the treatment of sexual disorders in females |
WO2008006839A2 (en) * | 2006-07-14 | 2008-01-17 | Boehringer Ingelheim International Gmbh | Combinations of flibanserin with caffeine, process for their preparation and use thereof as medicaments |
CL2007002214A1 (es) * | 2006-08-14 | 2008-03-07 | Boehringer Ingelheim Int | Composicion farmaceutica en la forma de comprimido, donde al menos la longitud del comprimido en el estado anterior de la aplicacion es al menos 7/12 del diametro pilorico del paciente y despues de ingerirlo en estado alimentado, la longitud del comp |
BRPI0716439B8 (pt) * | 2006-08-14 | 2021-05-25 | Boehringer Ingelheim Int | sistemas de liberação farmacêutico compreendendo flibanserina, processo para preparação e uso dos mesmos |
-
2006
- 2006-10-31 US US11/554,855 patent/US20070105869A1/en not_active Abandoned
- 2006-11-06 WO PCT/EP2006/068118 patent/WO2007054476A1/en active Application Filing
- 2006-11-06 EA EA200801138A patent/EA014189B1/ru not_active IP Right Cessation
- 2006-11-06 JP JP2008539417A patent/JP5386173B2/ja active Active
- 2006-11-06 KR KR1020087013699A patent/KR101436793B1/ko active IP Right Grant
- 2006-11-06 UY UY29899A patent/UY29899A1/es not_active Application Discontinuation
- 2006-11-06 CA CA2626797A patent/CA2626797C/en not_active Expired - Fee Related
- 2006-11-06 RS RS20110405A patent/RS51961B/en unknown
- 2006-11-06 DK DK06829937.9T patent/DK1948177T3/da active
- 2006-11-06 NZ NZ568822A patent/NZ568822A/en unknown
- 2006-11-06 CN CN2013100746775A patent/CN103251598A/zh active Pending
- 2006-11-06 PE PE2006001362A patent/PE20070800A1/es not_active Application Discontinuation
- 2006-11-06 MY MYPI20081488A patent/MY145439A/en unknown
- 2006-11-06 PL PL06829937T patent/PL1948177T3/pl unknown
- 2006-11-06 PT PT06829937T patent/PT1948177E/pt unknown
- 2006-11-06 AT AT06829937T patent/ATE521352T1/de active
- 2006-11-06 KR KR1020137033147A patent/KR20140003659A/ko not_active Application Discontinuation
- 2006-11-06 AU AU2006311038A patent/AU2006311038B2/en active Active
- 2006-11-06 ES ES06829937T patent/ES2372421T3/es active Active
- 2006-11-06 SG SG201008096-8A patent/SG166820A1/en unknown
- 2006-11-06 EP EP06829937A patent/EP1948177B1/en active Active
- 2006-11-06 BR BRPI0618239A patent/BRPI0618239A8/pt not_active Application Discontinuation
- 2006-11-06 SI SI200631156T patent/SI1948177T1/sl unknown
- 2006-11-07 TW TW095141075A patent/TWI389689B/zh not_active IP Right Cessation
- 2006-11-08 AR ARP060104891A patent/AR059390A1/es active Pending
-
2008
- 2008-03-19 ZA ZA2008/02542A patent/ZA200802542B/en unknown
- 2008-03-28 NO NO20081527A patent/NO20081527L/no not_active Application Discontinuation
- 2008-05-05 IL IL191245A patent/IL191245A0/en unknown
- 2008-06-05 EC EC2008008504A patent/ECSP088504A/es unknown
-
2011
- 2011-09-29 HR HR20110697T patent/HRP20110697T1/hr unknown
- 2011-11-18 CY CY20111101115T patent/CY1112067T1/el unknown
-
2012
- 2012-11-13 US US13/675,164 patent/US20130225604A1/en not_active Abandoned
-
2013
- 2013-05-07 JP JP2013097886A patent/JP2013177412A/ja active Pending
-
2014
- 2014-03-04 US US14/196,431 patent/US20140329827A1/en not_active Abandoned
-
2015
- 2015-03-23 US US14/665,083 patent/US20150366862A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HRP20110697T1 (hr) | Uporaba flibanserina za liječenje poremećaja seksualne želje u pre-menopauzi | |
AU2007247094B2 (en) | Use of flibanserin for the treatment of post-menopausal Sexual Desire Disorders | |
US20060264511A1 (en) | Method for the treatment of drug-induced sexual dysfunction | |
RU2018133298A (ru) | Способы применения агонистов fxr | |
RU2015110470A (ru) | Фармацевтическая композиция для местного нанесения, включающая тенофовир, антибактериальный агент и необязательно циклопирокс | |
US20060211685A1 (en) | Pharmaceutical compositions for the treatment and/or prevention of depression | |
HRP20201405T1 (hr) | Derivat 5-etil-4-metil-pirazol-3-karboksamida, koji djeluje kao agonist taar-a | |
HRP20050544A2 (en) | Solid drug for oral use | |
SI2600851T1 (en) | PHARMACEUTICAL FORM OF DOSAGE COVERING 6'-FLUORO- (N-METHYLLINE N, N-DIMETHYL-4-PHENYL-4 ', 9'-DIHYDRO-3'H-SPIRO- (CYCLOHEXANE-1,1'- PIRANO (3,4, B) INDOL) -4-AMIN, FOR NON-PROPHETIC DISEASE TREATMENT | |
CA2608713A1 (en) | Method for the treatment of sexual dysfunctions due to medical conditions | |
HRP20171917T1 (hr) | Terapeutski pripravci koji sadrže macitentan | |
MX2019011491A (es) | Formulaciones de niraparib. | |
JP2010530376A5 (hr) | ||
JP2009527525A (ja) | 尿失禁治療用のベンゾイミダゾロン誘導体 | |
RU2011137131A (ru) | Производные 1-аминоалкилциклогексана для лечения тиннитуса, связанного с потерей слуха или незначительной потерей слуха | |
CO5060477A1 (es) | Forma de dosificacion de nefazodona | |
US20220347157A1 (en) | Sustained release pharmaceutical compositions comprising (1r, 5s)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane | |
HRP20100577T1 (hr) | Uporaba agomelatina za dobivanje lijeka s ciljem liječenja općeg poremećaja anksioznosti | |
JP2005516904A5 (hr) | ||
JP2010522714A (ja) | 新規な医薬組成物 | |
RU2013153140A (ru) | Новая ассоциация между 4-{3-[цис-гексагидроциклопента[c] пиррол-2 (1н )- ил] пропокси} бензамидом и ингибитором ацетилхолинэстеразы и фармацевтические композиции, которые ее содержат | |
EA202191061A1 (ru) | фармацевтическая композиция для перорального введения, содержащая диметиламинA или его соль | |
MX2022012898A (es) | Ecomposición farmacéutica para administración oral que comprende derivado de aminopirimidina o sal, hidrato o solvato farmacéuticamente aceptable de esta. | |
MX2021014161A (es) | Metodos de tratamiento del sindrome de sjogren utilizando un inhibidor de la tirosina quinasa de bruton. | |
HRP20201412T1 (hr) | Trostruka kombinacija čistih antagonista receptora 5-ht6, inhibitora acetilkolinesteraze i antagonista receptora nmda |