HRP20100240T1 - Polipeptidi za indukciju zaštitnog imunitetnog odgovora protiv staphylococcus aureus - Google Patents

Polipeptidi za indukciju zaštitnog imunitetnog odgovora protiv staphylococcus aureus Download PDF

Info

Publication number: HRP20100240T1
Authority: HR; Croatia
Prior art keywords: seq; polypeptide; sequence; amino acid; immunogen
Prior art date: 2003-07-24

Application number

HR20100240T

Other languages

English (en)

Croatian (hr)

Inventor

S. Anderson Annaliesa

Ute Jansen Kathrin

Kelly Rosemarie

D. Schultz Loren

L. Montgomery Donna

L. Mcclements William

Original Assignee

Merck Sharp & Dohme Corp.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-07-24

Filing date

2010-04-26

Publication date

2010-09-30

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34107815&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20100240(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2010-04-26 Application filed by Merck Sharp & Dohme Corp. filed Critical Merck Sharp & Dohme Corp.

2010-09-30 Publication of HRP20100240T1 publication Critical patent/HRP20100240T1/hr

Links

108090000765 processed proteins & peptides Proteins 0.000 title claims abstract 37
229920001184 polypeptide Polymers 0.000 title claims abstract 36
102000004196 processed proteins & peptides Human genes 0.000 title claims abstract 36
230000001681 protective effect Effects 0.000 title claims abstract 6
230000028993 immune response Effects 0.000 title claims abstract 4
230000001939 inductive effect Effects 0.000 title claims 2
241000191967 Staphylococcus aureus Species 0.000 title 1
125000003275 alpha amino acid group Chemical group 0.000 claims abstract 14
230000002163 immunogen Effects 0.000 claims 13
108020004707 nucleic acids Proteins 0.000 claims 8
102000039446 nucleic acids Human genes 0.000 claims 8
150000007523 nucleic acids Chemical class 0.000 claims 8
210000004027 cell Anatomy 0.000 claims 4
238000000034 method Methods 0.000 claims 4
230000036039 immunity Effects 0.000 claims 3
239000002773 nucleotide Substances 0.000 claims 3
125000003729 nucleotide group Chemical group 0.000 claims 3
108090000623 proteins and genes Proteins 0.000 claims 3
238000006467 substitution reaction Methods 0.000 claims 3
108010076504 Protein Sorting Signals Proteins 0.000 claims 2
240000004808 Saccharomyces cerevisiae Species 0.000 claims 2
150000001413 amino acids Chemical class 0.000 claims 2
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
239000012634 fragment Substances 0.000 claims 2
208000015181 infectious disease Diseases 0.000 claims 2
238000000746 purification Methods 0.000 claims 2
230000004044 response Effects 0.000 claims 2
FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
108020004705 Codon Proteins 0.000 claims 1
241000191940 Staphylococcus Species 0.000 claims 1
239000002671 adjuvant Substances 0.000 claims 1
210000002421 cell wall Anatomy 0.000 claims 1
239000003814 drug Substances 0.000 claims 1
239000003937 drug carrier Substances 0.000 claims 1
239000013604 expression vector Substances 0.000 claims 1
230000006698 induction Effects 0.000 claims 1
230000002458 infectious effect Effects 0.000 claims 1
238000004519 manufacturing process Methods 0.000 claims 1
238000002360 preparation method Methods 0.000 claims 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
238000002560 therapeutic procedure Methods 0.000 claims 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/085—Staphylococcus
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2/00—Peptides of undefined number of amino acids; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
- C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Mycology (AREA)
Oncology (AREA)
Epidemiology (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Microbiology (AREA)
Communicable Diseases (AREA)
Gastroenterology & Hepatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pulmonology (AREA)
Dermatology (AREA)
Ophthalmology & Optometry (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

HR20100240T 2003-07-24 2010-04-26 Polipeptidi za indukciju zaštitnog imunitetnog odgovora protiv staphylococcus aureus HRP20100240T1 (hr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US48984003P	2003-07-24	2003-07-24
US52011503P	2003-11-14	2003-11-14
PCT/US2004/023523 WO2005009379A2 (en)	2003-07-24	2004-07-22	Polypeptides for inducing a protective immune response against staphylococcus aureus

Publications (1)

Publication Number	Publication Date
HRP20100240T1 true HRP20100240T1 (hr)	2010-09-30

Family

ID=34107815

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20100240T HRP20100240T1 (hr)	2003-07-24	2010-04-26	Polipeptidi za indukciju zaštitnog imunitetnog odgovora protiv staphylococcus aureus

Country Status (23)

Country	Link
US (2)	US20060177462A1 (sl)
EP (1)	EP1651166B8 (sl)
JP (1)	JP2007502101A (sl)
KR (1)	KR20060065643A (sl)
AT (1)	ATE457737T1 (sl)
AU (1)	AU2004258979B2 (sl)
BR (1)	BRPI0412799A (sl)
CA (1)	CA2532370A1 (sl)
CY (1)	CY1110028T1 (sl)
DE (1)	DE602004025579D1 (sl)
DK (1)	DK1651166T3 (sl)
ES (1)	ES2342778T3 (sl)
HR (1)	HRP20100240T1 (sl)
IL (1)	IL173253A0 (sl)
IS (1)	IS8213A (sl)
MX (1)	MXPA06000854A (sl)
NO (1)	NO20060898L (sl)
NZ (2)	NZ570750A (sl)
PL (1)	PL1651166T3 (sl)
PT (1)	PT1651166E (sl)
RU (1)	RU2337108C2 (sl)
SI (1)	SI1651166T1 (sl)
WO (1)	WO2005009379A2 (sl)

Families Citing this family (30)

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AT410798B (de)	2001-01-26	2003-07-25	Cistem Biotechnologies Gmbh	Verfahren zur identifizierung, isolierung und herstellung von antigenen gegen ein spezifisches pathogen
US20070134263A1 (en) *	2004-02-18	2007-06-14	Anderson Annaliesa S	Polypeptides for inducing a protective immune response against staphyloococcus aureus
CA2581746A1 (en) *	2004-10-25	2006-06-08	The University Of Western Ontario	Staphylococcus aureus isd protein-based anti-infectives
GB0526038D0 (en) *	2005-12-21	2006-02-01	Glaxosmithkline Biolog Sa	Immunogenic composition
CN101375161A (zh) *	2006-01-27	2009-02-25	默克公司	靶定金黄色葡萄球菌ORF0657n的抗原结合蛋白
WO2008140632A2 (en)	2007-01-24	2008-11-20	Merck & Co., Inc.	Polypeptides for inducing a protective immune response against staphylococcus epidermidis
ATE537839T1 (de) *	2007-05-04	2012-01-15	Martin Kroenke	Impfstoff zum schutz gegen staphylococcus aureus auf der basis zellwandassoziierter proteine
RU2009149294A (ru) *	2007-05-31	2011-07-10	Мерк энд Ко., Инк. (US)	Антиген-связывающие белки, нацеленные на orf0657n s.aureus
US8071561B2 (en)	2007-08-16	2011-12-06	Chrontech Pharma Ab	Immunogen platform
JP5658564B2 (ja)	2007-08-31	2015-01-28	ザ・ユニバーシティ・オブ・シカゴＴｈｅＵｎｉｖｅｒｓｉｔｙＯｆＣｈｉｃａｇｏ	ブドウ球菌肺疾患および状態に対する免疫に関連した方法および組成物
US9181329B2 (en)	2007-08-31	2015-11-10	The University Of Chicago	Methods and compositions related to immunizing against Staphylococcal lung diseases and conditions
US8758765B2 (en)	2008-07-29	2014-06-24	The University Of Chicago	Compositions and methods related to Staphylococcal bacterium proteins
EP2376111A4 (en)	2008-11-26	2013-01-09	Merck Sharp & Dohme	POLYPEPTIDES FOR INDUCING PROTECTIVE IMMUNE RESPONSE AGAINST STAPHYLOCOCCUS AUREUS
BRPI1010307B1 (pt)	2009-04-03	2021-07-27	University Of Chicago	Polipeptídeos variantes de proteína a (spa), composição imunogênica compreendendo os mesmos, vacina, método de produção da referida vacina, bem como uso dos referidos polipeptídeos
NZ612315A (en)	2009-04-14	2014-10-31	Novartis Ag	Compositions for immunising against staphylococcus aureus
GB0913680D0 (en)	2009-08-05	2009-09-16	Glaxosmithkline Biolog Sa	Immunogenic composition
GB0913681D0 (en)	2009-08-05	2009-09-16	Glaxosmithkline Biolog Sa	Immunogenic composition
CA2779798C (en)	2009-09-30	2019-03-19	Novartis Ag	Conjugation of staphylococcus aureus type 5 and type 8 capsular polysaccharides
CN102971009A (zh)	2009-10-30	2013-03-13	诺华有限公司	金黄色葡萄球菌5型和8型荚膜多糖的纯化
GB0919690D0 (en)	2009-11-10	2009-12-23	Guy S And St Thomas S Nhs Foun	compositions for immunising against staphylococcus aureus
US20130004539A1 (en) *	2010-03-12	2013-01-03	Jeffrey Weiser	Methods for preventing and treating staphylococcus aureus colonization, infection, and disease
ES2655701T3 (es)	2010-07-02	2018-02-21	The University Of Chicago	Composiciones y métodos relacionados con variantes de la proteína A (SpA)
US8747858B2 (en)	2010-07-13	2014-06-10	Merck Sharp & Dohme Corp.	Staphylococcus aureus surface protein SA1789 and protective vaccine based thereon
WO2012065034A1 (en)	2010-11-12	2012-05-18	Merck Sharp & Dohme Corp.	Enolase peptide conjugate vaccines against staphylococcus aureus
US8945588B2 (en)	2011-05-06	2015-02-03	The University Of Chicago	Methods and compositions involving protective staphylococcal antigens, such as EBH polypeptides
CA2847204A1 (en)	2011-09-01	2013-03-07	Novartis Ag	Adjuvanted formulations of staphylococcus aureus antigens
WO2013066731A2 (en)	2011-10-31	2013-05-10	Merck Sharp & Dohme Corp.	Protective vaccine based on staphylococcus aureus sa2451 protein
JP6203838B2 (ja)	2012-06-27	2017-09-27	エフ．ホフマン−ラロシュアーゲーＦ．Ｈｏｆｆｍａｎｎ−ＬａＲｏｃｈｅＡｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ	少なくとも２つの異なる結合実体を含む、テーラーメイドの高度に選択的かつ多重特異的なターゲティング実体を選択および作製するための方法、ならびにその使用
WO2014001325A1 (en)	2012-06-27	2014-01-03	F. Hoffmann-La Roche Ag	Method for making antibody fc-region conjugates comprising at least one binding entity that specifically binds to a target and uses thereof
EP2872173A4 (en)	2012-07-10	2016-03-23	Merck Sharp & Dohme	STAPHYLOCOCCUS AUREUS SA2493 PROTEIN PROTECTIVE VACCINE

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Publication number	Priority date	Publication date	Assignee	Title
US6248329B1 (en) *	1998-06-01	2001-06-19	Ramaswamy Chandrashekar	Parasitic helminth cuticlin nucleic acid molecules and uses thereof
GB0014907D0 (en) *	2000-06-20	2000-08-09	Univ Sheffield	Antigenic polypeptides
AT410798B (de) *	2001-01-26	2003-07-25	Cistem Biotechnologies Gmbh	Verfahren zur identifizierung, isolierung und herstellung von antigenen gegen ein spezifisches pathogen
MXPA03011701A (es) *	2001-06-15	2004-12-06	Nhibitex Inc	Anticuerpos monoclonales y policlonales de reaccion que reconocen las proteinas de superficie a partir de estafilococos coagulasa-negativos y staphylococcus aureus.
CN101979413A (zh) *	2001-11-12	2011-02-23	诺沃挪第克公司	通过金属离子亲和层析法的肽纯化
US20080050361A1 (en) *	2004-10-25	2008-02-28	Heinrichs David E	Staphylococcus aureas specific anti-infectives
AU2007281934B2 (en) *	2006-01-18	2012-11-15	University Of Chicago	Compositions and methods related to Staphylococcal bacterium proteins

2004
- 2004-07-22 NZ NZ570750A patent/NZ570750A/en not_active IP Right Cessation
- 2004-07-22 AU AU2004258979A patent/AU2004258979B2/en not_active Ceased
- 2004-07-22 US US10/564,458 patent/US20060177462A1/en not_active Abandoned
- 2004-07-22 AT AT04778847T patent/ATE457737T1/de active
- 2004-07-22 PL PL04778847T patent/PL1651166T3/pl unknown
- 2004-07-22 DK DK04778847.6T patent/DK1651166T3/da active
- 2004-07-22 MX MXPA06000854A patent/MXPA06000854A/es active IP Right Grant
- 2004-07-22 ES ES04778847T patent/ES2342778T3/es not_active Expired - Lifetime
- 2004-07-22 CA CA002532370A patent/CA2532370A1/en not_active Abandoned
- 2004-07-22 EP EP04778847A patent/EP1651166B8/en not_active Expired - Lifetime
- 2004-07-22 PT PT04778847T patent/PT1651166E/pt unknown
- 2004-07-22 SI SI200431389T patent/SI1651166T1/sl unknown
- 2004-07-22 RU RU2006105498/13A patent/RU2337108C2/ru not_active IP Right Cessation
- 2004-07-22 NZ NZ544542A patent/NZ544542A/en not_active IP Right Cessation
- 2004-07-22 KR KR1020067001610A patent/KR20060065643A/ko not_active Application Discontinuation
- 2004-07-22 WO PCT/US2004/023523 patent/WO2005009379A2/en active Application Filing
- 2004-07-22 BR BRPI0412799-4A patent/BRPI0412799A/pt not_active Application Discontinuation
- 2004-07-22 DE DE602004025579T patent/DE602004025579D1/de not_active Expired - Lifetime
- 2004-07-22 JP JP2006521226A patent/JP2007502101A/ja active Pending
2005
- 2005-12-30 IS IS8213A patent/IS8213A/is unknown
2006
- 2006-01-19 IL IL173253A patent/IL173253A0/en unknown
- 2006-02-23 NO NO20060898A patent/NO20060898L/no not_active Application Discontinuation
2010
- 2010-04-26 HR HR20100240T patent/HRP20100240T1/hr unknown
- 2010-04-30 US US12/771,345 patent/US20100247561A1/en not_active Abandoned
- 2010-05-14 CY CY20101100419T patent/CY1110028T1/el unknown

Also Published As

Publication number	Publication date
WO2005009379A3 (en)	2006-11-30
BRPI0412799A (pt)	2006-09-26
NZ570750A (en)	2009-12-24
RU2337108C2 (ru)	2008-10-27
MXPA06000854A (es)	2006-03-30
US20100247561A1 (en)	2010-09-30
SI1651166T1 (sl)	2010-06-30
AU2004258979A1 (en)	2005-02-03
PL1651166T3 (pl)	2010-08-31
NO20060898L (no)	2006-04-24
EP1651166B1 (en)	2010-02-17
ATE457737T1 (de)	2010-03-15
EP1651166B8 (en)	2010-05-19
WO2005009379A2 (en)	2005-02-03
EP1651166A2 (en)	2006-05-03
JP2007502101A (ja)	2007-02-08
CA2532370A1 (en)	2005-02-03
RU2006105498A (ru)	2006-09-10
IL173253A0 (en)	2006-06-11
KR20060065643A (ko)	2006-06-14
AU2004258979B2 (en)	2007-12-06
NZ544542A (en)	2009-01-31
ES2342778T3 (es)	2010-07-14
EP1651166A4 (en)	2008-03-05
DK1651166T3 (da)	2010-05-31
IS8213A (is)	2005-12-30
CY1110028T1 (el)	2015-01-14
PT1651166E (pt)	2010-04-23
US20060177462A1 (en)	2006-08-10
DE602004025579D1 (de)	2010-04-01

Publication	Publication Date	Title
HRP20100240T1 (hr)	2010-09-30	Polipeptidi za indukciju zaštitnog imunitetnog odgovora protiv staphylococcus aureus
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