HRP20100195T1 - 1,4-dihidropiridinski kondenzirani heterocikli, postupak njihovog dobivanja, upotreba i pripravci koji ih sadrže - Google Patents

1,4-dihidropiridinski kondenzirani heterocikli, postupak njihovog dobivanja, upotreba i pripravci koji ih sadrže Download PDF

Info

Publication number: HRP20100195T1
Authority: HR; Croatia
Prior art keywords: heteroaryl; compound according; aryl; substituted; alkyl
Prior art date: 2005-07-20

Application number

HR20100195T

Other languages

English (en)

Croatian (hr)

Inventor

Mauger Jacques

Nair Anil

Ma Nina

Bjergarde Kirsten

Filoche-Romme Bruno

Angouillant-Boniface Odile

Mignani Serge

Original Assignee

Aventis Pharma S.A.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-07-20

Filing date

2010-04-07

Publication date

2010-05-31

2010-04-07 Application filed by Aventis Pharma S.A. filed Critical Aventis Pharma S.A.

2010-05-31 Publication of HRP20100195T1 publication Critical patent/HRP20100195T1/hr

Links

238000004519 manufacturing process Methods 0.000 title claims 2
125000000623 heterocyclic group Chemical group 0.000 title 1
239000000203 mixture Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 claims abstract 14
125000001424 substituent group Chemical group 0.000 claims abstract 14
125000001072 heteroaryl group Chemical group 0.000 claims abstract 10
229910052760 oxygen Inorganic materials 0.000 claims abstract 5
125000003118 aryl group Chemical group 0.000 claims abstract 4
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract 4
229910052717 sulfur Inorganic materials 0.000 claims abstract 3
125000004169 (C1-C6) alkyl group Chemical group 0.000 claims abstract 2
229910052794 bromium Inorganic materials 0.000 claims abstract 2
229910052801 chlorine Inorganic materials 0.000 claims abstract 2
229910052731 fluorine Inorganic materials 0.000 claims abstract 2
229910052739 hydrogen Inorganic materials 0.000 claims abstract 2
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 4
230000001575 pathological effect Effects 0.000 claims 3
206010028980 Neoplasm Diseases 0.000 claims 2
201000011510 cancer Diseases 0.000 claims 2
KPPVNWGJXFMGAM-UUILKARUSA-N (e)-2-methyl-1-(6-methyl-3,4-dihydro-2h-quinolin-1-yl)but-2-en-1-one Chemical compound CC1=CC=C2N(C(=O)C(/C)=C/C)CCCC2=C1 KPPVNWGJXFMGAM-UUILKARUSA-N 0.000 claims 1
UUFQTNFCRMXOAE-UHFFFAOYSA-N 1-methylmethylene Chemical group C[CH] UUFQTNFCRMXOAE-UHFFFAOYSA-N 0.000 claims 1
101100167062 Caenorhabditis elegans chch-3 gene Chemical group 0.000 claims 1
101100134927 Gallus gallus COR8 gene Proteins 0.000 claims 1
201000004681 Psoriasis Diseases 0.000 claims 1
101100054666 Streptomyces halstedii sch3 gene Proteins 0.000 claims 1
239000002246 antineoplastic agent Substances 0.000 claims 1
229940041181 antineoplastic drug Drugs 0.000 claims 1
125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 1
125000004786 difluoromethoxy group Chemical group [H]C(F)(F)O* 0.000 claims 1
IPZJQDSFZGZEOY-UHFFFAOYSA-N dimethylmethylene Chemical group C[C]C IPZJQDSFZGZEOY-UHFFFAOYSA-N 0.000 claims 1
239000003814 drug Substances 0.000 claims 1
229940079593 drug Drugs 0.000 claims 1
125000004785 fluoromethoxy group Chemical group [H]C([H])(F)O* 0.000 claims 1
125000002541 furyl group Chemical group 0.000 claims 1
125000002883 imidazolyl group Chemical group 0.000 claims 1
208000032839 leukemia Diseases 0.000 claims 1
206010025135 lupus erythematosus Diseases 0.000 claims 1
229940127554 medical product Drugs 0.000 claims 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
229940002612 prodrug Drugs 0.000 claims 1
239000000651 prodrug Substances 0.000 claims 1
150000003839 salts Chemical class 0.000 claims 1
125000001544 thienyl group Chemical group 0.000 claims 1
125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
101100439662 Arabidopsis thaliana CHR5 gene Proteins 0.000 abstract 1
-1 O -allyl Chemical group 0.000 abstract 1
229910052736 halogen Chemical group 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Dermatology (AREA)
Hematology (AREA)
Oncology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

HR20100195T 2005-07-20 2010-04-07 1,4-dihidropiridinski kondenzirani heterocikli, postupak njihovog dobivanja, upotreba i pripravci koji ih sadrže HRP20100195T1 (hr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP05291558A EP1746097B1 (en)	2005-07-20	2005-07-20	1,4-dihydropyridine-fused heterocycles, process for preparing the same, use and compositions containing them

Publications (1)

Publication Number	Publication Date
HRP20100195T1 true HRP20100195T1 (hr)	2010-05-31

Family

ID=35510894

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20100195T HRP20100195T1 (hr)	2005-07-20	2010-04-07	1,4-dihidropiridinski kondenzirani heterocikli, postupak njihovog dobivanja, upotreba i pripravci koji ih sadrže

Country Status (37)

Country	Link
US (1)	US8163768B2 (es)
EP (2)	EP1746097B1 (es)
JP (2)	JP2009501778A (es)
KR (1)	KR101286796B1 (es)
CN (1)	CN101243087B (es)
AR (1)	AR054845A1 (es)
AT (2)	ATE455115T1 (es)
AU (1)	AU2006273692B8 (es)
BR (1)	BRPI0614002A2 (es)
CA (1)	CA2615700C (es)
CR (1)	CR9663A (es)
CY (1)	CY1109964T1 (es)
DE (1)	DE602005018911D1 (es)
DK (1)	DK1746097T3 (es)
DO (1)	DOP2006000175A (es)
EA (1)	EA016815B1 (es)
EC (1)	ECSP078062A (es)
ES (1)	ES2339676T3 (es)
HN (1)	HN2008000088A (es)
HR (1)	HRP20100195T1 (es)
IL (1)	IL188861A0 (es)
MA (1)	MA29634B1 (es)
MX (1)	MX2008000902A (es)
MY (1)	MY148617A (es)
NO (1)	NO20080831L (es)
NZ (1)	NZ592766A (es)
PE (2)	PE20070212A1 (es)
PL (1)	PL1746097T3 (es)
PT (1)	PT1746097E (es)
RS (1)	RS51351B (es)
SI (1)	SI1746097T1 (es)
TN (1)	TNSN08020A1 (es)
TW (1)	TWI386411B (es)
UA (1)	UA98928C2 (es)
UY (1)	UY29685A1 (es)
WO (1)	WO2007012972A2 (es)
ZA (1)	ZA200800542B (es)

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FR2945535B1 (fr)	2009-05-18	2011-06-10	Sanofi Aventis	Compose anticancereux et composition pharmaceutique le contenant
FR2967413A1 (fr) *	2010-11-17	2012-05-18	Sanofi Aventis	Compose 8-oxo-9-[3-(1h-benzimidazol-2-yloxy)-phenyl]-4,5,6,7,8,9-hexahydro-2h-pyrrolo[3,4-b]quinoline-3-carboxylate d'ethyle, sel, forme cristalline, co-cristal, formulation, procedes de preparation, application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteur des kinases aurora.
EP2858988B1 (en)	2012-05-15	2018-02-28	Novartis AG	Benzamide derivatives for inhibiting the activity of abl1, abl2 and bcr-abl1
JP6078639B2 (ja)	2012-05-15	2017-02-08	ノバルティスアーゲー	Ａｂｌ１、ａｂｌ２およびｂｃｒ−ａｂｌ１の活性を阻害するためのベンズアミド誘導体
EA026559B1 (ru)	2012-05-15	2017-04-28	Новартис Аг	Соединения и композиции для ингибирования активности abl1, abl2 и bcr-abl1
US9340537B2 (en)	2012-05-15	2016-05-17	Novatis Ag	Benzamide derivatives for inhibiting the activity of ABL1, ABL2 and BCR-ABL1
SI2909204T1 (sl) *	2012-10-12	2019-06-28	The Broad Institute, Inc.	Inhibitorji GSK3 in postopki njihove uporabe
EP3230279A1 (en) *	2014-12-10	2017-10-18	Massachusetts Institute of Technology	Fused 1,3-azole derivatives useful for the treatment of proliferative diseases
US11046692B2 (en)	2015-04-30	2021-06-29	Memorial Sloan-Kettering Cancer Center	Mitragynine analogs and uses thereof
RU2619932C1 (ru) *	2015-11-25	2017-05-22	федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный университет" (ФГБОУ ВО "ВГУ")	ЗАМЕЩЕННЫЕ ПИРАЗОЛО[1,5-а]ПИРИДО[3,4-е]ПИРИМИДИНЫ И ИХ ИСПОЛЬЗОВАНИЕ В КАЧЕСТВЕ ИНГИБИТОРОВ ПРОТЕИНКИНАЗ
WO2017124087A1 (en)	2016-01-15	2017-07-20	Memorial Sloan-Kettering Cancer Center	Anti-parasitic compounds and uses thereof
WO2017143059A1 (en)	2016-02-16	2017-08-24	Massachusetts Institute Of Technology	Max binders as myc modulators and uses thereof
BR112019020810A2 (pt)	2017-04-05	2020-04-28	Biogen Ma Inc	compostos tricíclicos como inibidores de glicogênio sintase cinase 3 (gsk3) e usos dos mesmos

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ATE355841T1 (de) *	1997-12-13	2007-03-15	Bristol Myers Squibb Co	Verwendung von pyrazolo ( 3,4-b) pyridin als cyclin-abhängige kinase hemmer
MXPA02005016A (es)	1999-11-19	2003-01-28	Abbott Lab	Abridores de canal de potasio de dihidropirimidina triciclica.
US6538004B2 (en)	2000-03-03	2003-03-25	Abbott Laboratories	Tricyclic dihydropyrazolone and tricyclic dihydroisoxazolone potassium channel openers
CA2402179A1 (en)	2000-03-03	2001-09-13	Abbott Laboratories	Tricyclic dihydropyrazolone and tricyclic dihydroisoxazolone potassium channel openers
JP2005501800A (ja)	2001-02-02	2005-01-20	三菱ウェルファーマ株式会社	ジヒドロピラゾロピリジン化合物およびその医薬用途
FR2823854A1 (fr)	2001-04-18	2002-10-25	Centre Nat Rech Scient	Nouveau procede de criblage d'inhibiteurs de la liaison entre la proteine oxyde nitrique synthase neuronale et la proteine inhibitrice de l'oxyde nitrique synthase neuronale
FR2825091B1 (fr) *	2001-05-23	2003-07-04	Servier Lab	Nouveaux derives tricycliques de dihydro-quinnoleines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US7037902B2 (en) *	2002-07-03	2006-05-02	Receptron, Inc.	Affinity small molecules for the EPO receptor
SE0301371D0 (sv)	2003-05-09	2003-05-09	Astrazeneca Ab	New Compounds
CN1823067A (zh) *	2003-06-13	2006-08-23	赞塔里斯有限公司	具有抑制磷脂酰肌醇3－激酶活性的化合物及其使用方法

2005
- 2005-07-20 RS RSP-2010/0159A patent/RS51351B/en unknown
- 2005-07-20 DK DK05291558.4T patent/DK1746097T3/da active
- 2005-07-20 EP EP05291558A patent/EP1746097B1/en active Active
- 2005-07-20 PL PL05291558T patent/PL1746097T3/pl unknown
- 2005-07-20 ES ES05291558T patent/ES2339676T3/es active Active
- 2005-07-20 SI SI200530964T patent/SI1746097T1/sl unknown
- 2005-07-20 AT AT05291558T patent/ATE455115T1/de active
- 2005-07-20 DE DE602005018911T patent/DE602005018911D1/de active Active
- 2005-07-20 PT PT05291558T patent/PT1746097E/pt unknown
2006
- 2006-07-18 AT AT06808922T patent/ATE521611T1/de not_active IP Right Cessation
- 2006-07-18 NZ NZ592766A patent/NZ592766A/xx not_active IP Right Cessation
- 2006-07-18 ZA ZA200800542A patent/ZA200800542B/xx unknown
- 2006-07-18 KR KR1020087003945A patent/KR101286796B1/ko not_active IP Right Cessation
- 2006-07-18 JP JP2008522098A patent/JP2009501778A/ja not_active Withdrawn
- 2006-07-18 EP EP06808922A patent/EP1910366B1/en active Active
- 2006-07-18 AU AU2006273692A patent/AU2006273692B8/en not_active Ceased
- 2006-07-18 AR ARP060103065A patent/AR054845A1/es not_active Application Discontinuation
- 2006-07-18 UA UAA200802146A patent/UA98928C2/ru unknown
- 2006-07-18 CA CA2615700A patent/CA2615700C/en not_active Expired - Fee Related
- 2006-07-18 EA EA200800374A patent/EA016815B1/ru not_active IP Right Cessation
- 2006-07-18 MY MYPI20063429A patent/MY148617A/en unknown
- 2006-07-18 BR BRPI0614002-5A patent/BRPI0614002A2/pt not_active IP Right Cessation
- 2006-07-18 CN CN2006800303826A patent/CN101243087B/zh not_active Expired - Fee Related
- 2006-07-18 PE PE2006000862A patent/PE20070212A1/es not_active Application Discontinuation
- 2006-07-18 PE PE2010000153A patent/PE20100718A1/es not_active Application Discontinuation
- 2006-07-18 WO PCT/IB2006/002734 patent/WO2007012972A2/en active Application Filing
- 2006-07-18 MX MX2008000902A patent/MX2008000902A/es active IP Right Grant
- 2006-07-19 TW TW095126453A patent/TWI386411B/zh not_active IP Right Cessation
- 2006-07-20 UY UY29685A patent/UY29685A1/es unknown
- 2006-07-20 DO DO2006000175A patent/DOP2006000175A/es unknown
2007
- 2007-12-27 EC EC2007008062A patent/ECSP078062A/es unknown
2008
- 2008-01-15 CR CR9663A patent/CR9663A/es unknown
- 2008-01-15 US US12/014,516 patent/US8163768B2/en active Active
- 2008-01-16 MA MA30580A patent/MA29634B1/fr unknown
- 2008-01-17 IL IL188861A patent/IL188861A0/en unknown
- 2008-01-18 TN TNP2008000020A patent/TNSN08020A1/en unknown
- 2008-01-21 HN HN2008000088A patent/HN2008000088A/es unknown
- 2008-02-15 NO NO20080831A patent/NO20080831L/no not_active Application Discontinuation
2010
- 2010-04-07 HR HR20100195T patent/HRP20100195T1/hr unknown
- 2010-04-09 CY CY20101100327T patent/CY1109964T1/el unknown
2012
- 2012-11-05 JP JP2012243375A patent/JP2013063987A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
EA200800374A1 (ru)	2008-08-29
ES2339676T3 (es)	2010-05-24
TNSN08020A1 (en)	2009-07-14
CA2615700C (en)	2013-06-18
TW200740812A (en)	2007-11-01
EP1746097B1 (en)	2010-01-13
EP1910366B1 (en)	2011-08-24
PE20100718A1 (es)	2010-10-20
ATE521611T1 (de)	2011-09-15
HN2008000088A (es)	2011-05-31
KR20080026658A (ko)	2008-03-25
US20080261969A1 (en)	2008-10-23
ECSP078062A (es)	2008-01-23
IL188861A0 (en)	2008-04-13
NO20080831L (no)	2008-04-03
ATE455115T1 (de)	2010-01-15
AU2006273692B2 (en)	2012-11-22
BRPI0614002A2 (pt)	2011-03-01
CY1109964T1 (el)	2014-09-10
JP2013063987A (ja)	2013-04-11
AU2006273692B8 (en)	2012-12-13
KR101286796B1 (ko)	2013-07-17
RS51351B (en)	2011-02-28
PL1746097T3 (pl)	2010-06-30
CN101243087B (zh)	2013-07-24
PT1746097E (pt)	2010-04-15
DE602005018911D1 (de)	2010-03-04
EP1910366A2 (en)	2008-04-16
JP2009501778A (ja)	2009-01-22
UA98928C2 (ru)	2012-07-10
PE20070212A1 (es)	2007-03-21
CR9663A (es)	2008-02-21
MX2008000902A (es)	2008-03-26
UY29685A1 (es)	2007-02-28
WO2007012972A3 (en)	2007-04-05
US8163768B2 (en)	2012-04-24
NZ592766A (en)	2012-12-21
CN101243087A (zh)	2008-08-13
AU2006273692A8 (en)	2012-12-13
TWI386411B (zh)	2013-02-21
DK1746097T3 (da)	2010-05-25
WO2007012972A2 (en)	2007-02-01
AR054845A1 (es)	2007-07-18
ZA200800542B (en)	2010-02-24
AU2006273692A1 (en)	2007-02-01
CA2615700A1 (en)	2007-02-01
MY148617A (en)	2013-05-15
SI1746097T1 (sl)	2010-05-31
EA016815B1 (ru)	2012-07-30
MA29634B1 (fr)	2008-07-01
DOP2006000175A (es)	2007-03-31
EP1746097A1 (en)	2007-01-24

Publication	Publication Date	Title
HRP20100195T1 (hr)	2010-05-31	1,4-dihidropiridinski kondenzirani heterocikli, postupak njihovog dobivanja, upotreba i pripravci koji ih sadrže
HRP20161498T1 (hr)	2016-12-16	Inhibitori kinaza i njihova upotreba u liječenju raka
ES2528451T3 (es)	2015-02-10	Inhibidores de esfingosina cinasa
HRP20210926T4 (hr)	2022-03-18	Derivati 1h-indazol-3-karboksamida i povezani spojevi kao inhibitori faktora d za liječenje bolesti karakteriziranih pojačanom djelatnošću sustava komplemenata, kao npr. imunološki poremećaji
HRP20090280T1 (en)	2009-06-30	Phenoxyacetic acid derivatives
EA200701991A1 (ru)	2008-02-28	НОВЫЕ ПРОИЗВОДНЫЕ ИМИДАЗО [1,5-a]ПИРИДИНОВ, СПОСОБ ИХ ПОЛУЧЕНИЯ И СОДЕРЖАЩИЕ ИХ ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ
WO2008041053A3 (en)	2009-12-23	Inhibitors of vegf receptor and hgf receptor signaling
MX2010007746A (es)	2010-08-18	Compuestos de 3h-[1,2,3]triazolo[4,5-d]pirimidina, su uso como inhibidores de diana de rapamicina de mamifero quinasa y fosfatidilinositol quinasa y su sintesis.
WO2007058832A3 (en)	2008-06-19	Pyrrolo (2, 3-b) pyridine derivatives useful as tec kinase inhibitors
NZ578876A (en)	2012-12-21	3-amino-pyrrolo[3,4-c]pyrazole-5 (1h, 4h, 6h) carbaldehyde derivatives as pkc inhibitors
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